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  1. Article ; Online: The "great imitator": IgG4-related disease of the oral cavity. Two case reports and scoping review.

    Azzi, Lorenzo / Magnoli, Francesca / Krepysheva, Diana / Fontana, Federico / Coppola, Andrea / Cappelli, Antonella / Dani, Marta / Battaglia, Paolo / Rabbiosi, Dimitri

    Head & neck

    2024  

    Abstract: This study aimed to review the lesser-known intraoral manifestations of immunoglobulin G4-related disease (IgG4-RD). In this paper we report an unprecedented case of oral IgG4-RD mimicking angiolymphoid hyperplasia with eosinophilia (ALHE), and another ... ...

    Abstract This study aimed to review the lesser-known intraoral manifestations of immunoglobulin G4-related disease (IgG4-RD). In this paper we report an unprecedented case of oral IgG4-RD mimicking angiolymphoid hyperplasia with eosinophilia (ALHE), and another case presenting as plasma cell gingivitis. We then performed a scoping review of published cases of IgG4-RD involving the oral cavity. The following data were collected for each case: age, sex, intraoral site(s) involved, clinical appearance, imaging features, serum IgG4 values, histopathology, treatment, and follow-up duration. Fifty-one cases of oral IgG4-RD were published in literature. The hard palate and jaw bones were the two main locations reported, while the histological identification of a IgG4/IgG plasma cells ratio ≥40% was fundamental for diagnosis. Conversely, the pathological features of storiform fibrosis and obliterative phlebitis were not common. Future reports regarding oral IgG4-RD should report clear adherence to the recognized international diagnostic criteria of the disease.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27763
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  2. Article ; Online: Management of recurrent cerebrospinal fluid leak, current practices and open challenges. A systematic literature review.

    Castelnuovo, Paolo / Valentini, Marco / Sileo, Giorgio / Battaglia, Paolo / Bignami, Maurizio / Turri-Zanoni, Mario

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

    2023  Volume 43, Issue Suppl 1, Page(s) S14–S27

    Language English
    Publishing date 2023-09-12
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 604898-5
    ISSN 1827-675X ; 0392-100X
    ISSN (online) 1827-675X
    ISSN 0392-100X
    DOI 10.14639/0392-100X-suppl.1-43-2023-02
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  3. Article ; Online: Transnasal Endoscopic Surgery: Surgical Techniques and Complications.

    Battaglia, Paolo / Lambertoni, Alessia / Castelnuovo, Paolo

    Advances in oto-rhino-laryngology

    2020  Volume 84, Page(s) 46–55

    Abstract: Nowadays, surgeons have a wide armamentarium of surgical approaches available to safely treat sinonasal malignancies, which includes open approaches, with the traditional craniofacial resection (CFR), and endoscopic transnasal techniques. The correct ... ...

    Abstract Nowadays, surgeons have a wide armamentarium of surgical approaches available to safely treat sinonasal malignancies, which includes open approaches, with the traditional craniofacial resection (CFR), and endoscopic transnasal techniques. The correct choice depends on the features of the pathology. It is well known that endoscopic approaches have a lower morbidity compared with traditional open techniques, due to a shorter hospitalization, absence of facial incisions, and avoidance of brain retraction. Moreover, endoscopic surgery presents clear technical advantages. For example, magnification of the surgical field allows the surgeon to carefully identify tumor margins, the site of origin, and the anatomical structures involved by the lesion. Nevertheless, a purely endoscopic approach cannot always provide successful resection of the tumor; the patient must be informed about the possibility of switching to a combined cranioendoscopic resection or CRF, depending on the effective extension of the disease evaluated intraoperatively. Despite these advantages, postoperative complications can occur after endoscopic endonasal surgery, as in any surgical intervention; however, complications after these procedures are less severe and less frequent compared with traditional open approaches. The most common complications observed include skull base reconstruction failure, intraoperative vascular lesions, and orbital or central nervous system complications. Thus, endoscopic endonasal resection, when properly planned and performed by experienced surgeons, is an acceptable treatment for well-selected skull base malignancies with long-term outcomes comparable to those achieved with traditional external approaches.
    MeSH term(s) Humans ; Natural Orifice Endoscopic Surgery/adverse effects ; Natural Orifice Endoscopic Surgery/methods ; Orbital Neoplasms/surgery ; Paranasal Sinus Neoplasms/surgery ; Postoperative Complications ; Skull Base/surgery ; Skull Base Neoplasms/surgery
    Language English
    Publishing date 2020-07-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-2847 ; 0065-3071
    ISSN (online) 1662-2847
    ISSN 0065-3071
    DOI 10.1159/000457924
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  4. Article ; Online: Comprehensive access strategies to the frontal sinus.

    Turri-Zanoni, Mario / Battaglia, Paolo / Bignami, Maurizio / Castelnuovo, Paolo / Arosio, Alberto D

    Current opinion in otolaryngology & head and neck surgery

    2022  Volume 31, Issue 1, Page(s) 57–64

    Abstract: Purpose of review: Despite the impressive evolutions in endoscopic endonasal approaches and instrumentations, the frontal sinus remains a challenging area. Different surgical options have been described over the years, but the main criticism lies in ... ...

    Abstract Purpose of review: Despite the impressive evolutions in endoscopic endonasal approaches and instrumentations, the frontal sinus remains a challenging area. Different surgical options have been described over the years, but the main criticism lies in choosing the most suitable approach for a given case, based on the anatomy of each patient and the disease to treat. The purpose of this study is to provide a comprehensive review of surgical access strategies currently available to address the frontal sinus, including both endonasal and traditional external procedures, analysing indications, contraindications, complications and outcomes.
    Recent findings: Frontal sinus surgery includes minimally invasive endonasal approaches (balloon dilatation, Draf type I); extended endonasal approaches (Draf type IIA-IIB-IIC, Draf type III and their modifications via orbital transposition and contralateral pyriform aperture resection); external procedures (superior eyelid incision, frontal osteoplastic flap, Riedel procedure, Riedel-Mosher operation); and combined approaches.
    Summary: Recent advances in endoscopic endonasal techniques have deeply reshaped the surgical options to manage frontal sinus diseases, in an attempt to minimize the invasiveness of the procedures and maximize their outcomes. Traditional external procedures should be used in selected cases nonamenable for endonasal surgery. The appropriate selection of cases appears to be of paramount importance to obtain successful outcomes.
    MeSH term(s) Humans ; Frontal Sinus/surgery ; Treatment Outcome ; Endoscopy/methods ; Paranasal Sinus Diseases/surgery ; Surgical Flaps
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000864
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    Zs.A 4814: Show issues Location:
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  5. Article: Sinonasal Malignancies Involving the Frontal Sinus: A Mono-Institutional Experience of 84 Cases and Systematic Literature Review.

    Sileo, Giorgio / Valentini, Marco / Gravante, Giacomo / Monti, Giulia / Arosio, Alberto D / Bignami, Maurizio / Battaglia, Paolo / Castelnuovo, Paolo / Turri-Zanoni, Mario

    Journal of clinical medicine

    2023  Volume 12, Issue 9

    Abstract: Frontal sinus involvement by malignant tumors is a rare finding. Therefore, a systematic literature review along with a personal case series may contribute to defining more accurately the epidemiology, treatment options, and outcomes of these neoplasms. ... ...

    Abstract Frontal sinus involvement by malignant tumors is a rare finding. Therefore, a systematic literature review along with a personal case series may contribute to defining more accurately the epidemiology, treatment options, and outcomes of these neoplasms. This is a retrospective review of patients affected by frontal sinus malignancies surgically treated in a tertiary-care referral center over a period of 20 years. Moreover, a systematic literature review of studies describing frontal sinus cancers from 2000 to date was performed according to PRISMA guidelines in order to analyze current evidence about the treatment and outcomes of such a rare disease. Our retrospective review was basedon 84 cases, treated with an exclusive endoscopic approach in 43 cases (51.2%), endoscopic approach with frontal osteoplastic flap in 6 cases (7.1%), and transfacial or transcranial approaches in 35 cases (41.7%). The five-year overall, disease-specific, disease-free, and recurrence-free survivals were 54.6%, 62.6%, 33.1%, and 59.1%, respectively. Age, dural involvement, type of surgical resection, and surgical margin status were significantly associated with the survival endpoints. In conclusion, the involvement of the frontal sinus is associated with a poor prognosis. Multidisciplinary management, including specific histology-driven treatments, represents the gold standard for improving outcomes and minimizing morbidity.
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12093186
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  6. Article ; Online: Pedicled nasal flaps in transnasal endoscopic surgery: review of indications and surgical techniques.

    Russo, Federico / Valentini, Marco / Czaczkes, Camilla / Sileo, Giorgio / Battaglia, Paolo / Turri-Zanoni, Mario / Karligkiotis, Apostolos / Castelnuovo, Paolo

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

    2023  Volume 43, Issue 5, Page(s) 297–309

    MeSH term(s) Humans ; Surgical Flaps ; Nose/surgery ; Endoscopy/methods ; Skull Base/surgery ; Nasal Septum/surgery
    Language English
    Publishing date 2023-05-23
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 604898-5
    ISSN 1827-675X ; 0392-100X
    ISSN (online) 1827-675X
    ISSN 0392-100X
    DOI 10.14639/0392-100X-N2469
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  7. Article ; Online: Nasoseptal flap with extended pedicle dissection based on the maxillary artery: Clinical series of 55 cases.

    Vinciguerra, Alessandro / Turri-Zanoni, Mario / Ferrari, Marco / Mattavelli, Davide / Sileo, Giorgio / Rampinelli, Vittorio / Abbate, Vincenzo / Verillaud, Benjamin / Schreiber, Alberto / Battaglia, Paolo / Bignami, Maurizio / Nicolai, Piero / Castelnuovo, Paolo / Herman, Philippe

    International forum of allergy & rhinology

    2024  

    Abstract: Key points: Nasoseptal flap with extended pedicle dissection is a low morbidity and high success rate flap. It is a flap that can be applied to reconstruct a wide range of ipsilateral skull base defects. ...

    Abstract Key points: Nasoseptal flap with extended pedicle dissection is a low morbidity and high success rate flap. It is a flap that can be applied to reconstruct a wide range of ipsilateral skull base defects.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23326
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  8. Article ; Online: Salvage endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma in a non-endemic area.

    Valentini, Marco / Lambertoni, Alessia / Sileo, Giorgio / Arosio, Alberto Daniele / Dalfino, Gianluca / Pedretti, Fabio / Karligkiotis, Apostolos / Bignami, Maurizio / Battaglia, Paolo / Castelnuovo, Paolo / Turri-Zanoni, Mario

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2024  

    Abstract: Purpose: To analyze oncological outcomes of endoscopic surgical treatment of locally recurrent EBV-related undifferentiated non-keratinizing nasopharyngeal carcinoma (uNK-NPC) in a non-endemic area.: Methods: Retrospective review of patients affected ...

    Abstract Purpose: To analyze oncological outcomes of endoscopic surgical treatment of locally recurrent EBV-related undifferentiated non-keratinizing nasopharyngeal carcinoma (uNK-NPC) in a non-endemic area.
    Methods: Retrospective review of patients affected by recurrent uNK-NPC treated with nasopharyngeal endoscopic resection (NER) in a tertiary-care referral center from 2003 to 2022, by evaluating survival rates, prognostic factors, and follow-up strategies.
    Results: The oncological outcomes of 41 patients were analyzed, over a mean follow-up period of 57 months. The 5-year overall, disease-specific, and disease-free survival of the cohort were 60.7% ± 8.9%, 69% ± 9%, and 39.7% ± 9.2%, respectively. The local (rT) and regional (rN) extension of recurrent disease, stage of disease, and status of resection margins appeared to significantly influence survivals. After a mean follow-up period of 21 months, a further recurrence after NER was observed in 36.6% of cases. Skull base osteonecrosis induced by previous irradiation and post-surgical bone remodeling represent the major challenges for early detection of further local relapses during postoperative follow-up.
    Conclusion: NER appeared as a safe and effective treatment for recurrent uNK-NPC. The adequate selection of patients eligible for NER is essential, to maximize the chances to cure and minimize the risk of local complications.
    Language English
    Publishing date 2024-03-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-024-08500-8
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  9. Article ; Online: Surgical management of advanced sinonasal cancer: a 10-year mono-institutional experience.

    Sileo, Giorgio / Arosio, Alberto Daniele / Lambertoni, Alessia / Battaglia, Paolo / Bignami, Maurizio / Cherubino, Mario / Valdatta, Luigi / Antognoni, Paolo / Locatelli, Davide / Castelnuovo, Paolo / Turri-Zanoni, Mario

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

    2024  Volume 44, Issue 2, Page(s) 128–137

    Abstract: Objective: Endoscopic endonasal surgery is effective in the treatment of sinonasal cancers. However, in cases of well-differentiated locally advanced neoplasms as well as recurrences, the most appropriate treatment is debated. The purpose of this study ... ...

    Abstract Objective: Endoscopic endonasal surgery is effective in the treatment of sinonasal cancers. However, in cases of well-differentiated locally advanced neoplasms as well as recurrences, the most appropriate treatment is debated. The purpose of this study is to report a mono-institutional experience on craniofacial surgery performed in a tertiary-care referral centre.
    Methods: This was a retrospective analysis of 90 patients treated with transcranial and/or transfacial resection for sinonasal cancer between 2010 and 2020. Outcome measures included overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS) and recurrence-free survival (RFS).
    Results: The 5-year OS, DSS and DFS were 48.2%, 60.6% and 28.7%, respectively. Factors correlated with prognosis were pT-classification (p = 0.002), histotype (p = 0.012) and dural involvement (p = 0.004). Independent prognostic factors were orbital apex infiltration (p = 0.03), age (p = 0.002) and adjuvant therapy (p = 0.03).
    Conclusions: When endoscopic endonasal surgery is contraindicated and chemoradiotherapy is not appropriate, craniofacial and transfacial approaches still represent an option to consider, despite the non-negligible morbidity.
    Language English
    Publishing date 2024-04-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 604898-5
    ISSN 1827-675X ; 0392-100X
    ISSN (online) 1827-675X
    ISSN 0392-100X
    DOI 10.14639/0392-100X-N2375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: How to Reorganize an Ear, Nose, and Throat Outpatient Service During the COVID-19 Outbreak: Report From Northern Italy.

    De Bernardi, Francesca / Turri-Zanoni, Mario / Battaglia, Paolo / Castelnuovo, Paolo

    The Laryngoscope

    2020  Volume 130, Issue 11, Page(s) 2544–2545

    MeSH term(s) Ambulatory Care/methods ; Ambulatory Care/organization & administration ; COVID-19/prevention & control ; Disease Transmission, Infectious/prevention & control ; Humans ; Italy ; Otolaryngology/methods ; Otolaryngology/organization & administration ; Practice Patterns, Physicians'/organization & administration ; Retrospective Studies ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.28716
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