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  1. Book ; Online: Staatsverschuldung und Stabilisierungspolitik in der Demokratie

    Baum, Thomas Michael

    2018  

    Abstract: Die neoinstitutionalistische Kritik wendet sich gegen die durch den Keynesianismus eingeführte Möglichkeit der Defizitfinanzierung von Staatsausgaben, welche aufgrund politisch-ökonomischer Interdependenzen in westlichen Demokratien zu immer neuen und ... ...

    Abstract Die neoinstitutionalistische Kritik wendet sich gegen die durch den Keynesianismus eingeführte Möglichkeit der Defizitfinanzierung von Staatsausgaben, welche aufgrund politisch-ökonomischer Interdependenzen in westlichen Demokratien zu immer neuen und höheren Defiziten, einem wachsenden Staatsanteil und ständig steigenden Inflationsraten führt. Auf der Basis dieser Kritik wird eine Rückkehr zur Regel des jährlichen materiellen Haushaltsausgleichs gefordert. Die vorliegende Arbeit setzt sich kritisch mit der neoinstitutionalistischen Analyse und der Forderung eines jährlichen Budgetausgleichs auseinander. Der Autor relativiert diese Forderung durch allokative und stabilisatorische Argumente und schlägt Ergänzungsregelungen vor
    Keywords Economic theory. Demography ; Political science (General)
    Size 1 electronic resource (242 p.)
    Publisher Peter Lang International Academic Publishing Group
    Document type Book ; Online
    Note German ; Open Access
    HBZ-ID HT020100469
    ISBN 9783820457827 ; 3820457828
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Thesis: Untersuchungen zur Verteilung und Biomorphose des elastischen Fasersystems menschlicher Herzklappen im Niederdrucksystem

    Baum, Thomas

    2005  

    Author's details eingereicht von Thomas Baum
    Language German
    Size 83, XX, [10] Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Diss., 2005
    HBZ-ID HT014626517
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 E 78 order for loan Magazin

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  3. Article: Editorial on Special Issue "Spine Imaging: Novel Image Acquisition Techniques and Analysis Tools".

    Sollmann, Nico / Baum, Thomas

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 6

    Abstract: Imaging of the spine, including radiography, computed tomography (CT), and magnetic resonance imaging (MRI), is frequently performed in clinical routine [ ... ]. ...

    Abstract Imaging of the spine, including radiography, computed tomography (CT), and magnetic resonance imaging (MRI), is frequently performed in clinical routine [...].
    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12061361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CT image-based biomarkers for opportunistic screening of osteoporotic fractures: a systematic review and meta-analysis.

    Praveen, Anitha D / Sollmann, Nico / Baum, Thomas / Ferguson, Stephen J / Benedikt, Helgason

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2024  

    Abstract: The use of opportunistic computed tomography (CT) image-based biomarkers may be a low-cost strategy for screening older individuals at high risk for osteoporotic fractures and populations that are not sufficiently targeted. This review aimed to assess ... ...

    Abstract The use of opportunistic computed tomography (CT) image-based biomarkers may be a low-cost strategy for screening older individuals at high risk for osteoporotic fractures and populations that are not sufficiently targeted. This review aimed to assess the discriminative ability of image-based biomarkers derived from existing clinical routine CT scans for hip, vertebral, and major osteoporotic fracture prediction. A systematic search in PubMed MEDLINE, Embase, Cochrane, and Web of Science was conducted from the earliest indexing date until July 2023. The evaluation of study quality was carried out using a modified Quality Assessment Tool for Diagnostic Accuracy Studies (QUADAS-2) checklist. The primary outcome of interest was the area under the curve (AUC) and its corresponding 95% confidence intervals (CIs) obtained for four main categories of biomarkers: areal bone mineral density (BMD), image attenuation, volumetric BMD, and finite element (FE)-derived biomarkers. The meta-analyses were performed using random effects models. Sixty-one studies were included in this review, among which 35 were synthesized in a meta-analysis and the remaining articles were qualitatively synthesized. In comparison to the pooled AUC of areal BMD (0.73 [95% CI 0.71-0.75]), the pooled AUC values for predicting osteoporotic fractures for FE-derived parameters (0.77 [95% CI 0.72-0.81]; p < 0.01) and volumetric BMD (0.76 [95% CI 0.71-0.81]; p < 0.01) were significantly higher, but there was no significant difference with the pooled AUC for image attenuation (0.73 [95% CI 0.66-0.79]; p = 0.93). Compared to areal BMD, volumetric BMD and FE-derived parameters may provide a significant improvement in the discrimination of osteoporotic fractures using opportunistic CT assessments.
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-024-07029-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Unlocking the development- and physiology-altering 'effector toolbox' of plant-parasitic nematodes.

    Molloy, Beth / Baum, Thomas / Eves-van den Akker, Sebastian

    Trends in parasitology

    2023  Volume 39, Issue 9, Page(s) 732–738

    Abstract: Plant parasites take advantage of host developmental plasticity to elicit profound developmental and physiological changes. In the case of plant-parasitic nematodes (PPNs), these changes can result in the development of new plant organs. Despite the ... ...

    Abstract Plant parasites take advantage of host developmental plasticity to elicit profound developmental and physiological changes. In the case of plant-parasitic nematodes (PPNs), these changes can result in the development of new plant organs. Despite the importance of the development- and physiology-altering abilities of these parasites in pathology, research has historically focused on their abilities to suppress immunity. We argue that, given the dramatic changes involved in feeding site establishment, it is entirely possible that development- and physiology-altering abilities of PPNs may, in fact, dominate effector repertoires - highlighting the need for novel high-throughput screens for development- and physiology-altering 'tools'. Uncovering this portion of the nematode 'toolbox' can enable biotechnology, enhance crop protection, and shed light on fundamental host biology itself.
    MeSH term(s) Animals ; Parasites ; Host-Parasite Interactions/physiology ; Nematoda/physiology ; Plants/parasitology
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

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  6. Article ; Online: Unlocking the development- and physiology-altering ‘effector toolbox’ of plant-parasitic nematodes

    Molloy, Beth / Baum, Thomas / Eves-van den Akker, Sebastian

    Trends in Parasitology. 2023 Sept., v. 39, no. 9 p.732-738

    2023  

    Abstract: Plant parasites take advantage of host developmental plasticity to elicit profound developmental and physiological changes. In the case of plant-parasitic nematodes (PPNs), these changes can result in the development of new plant organs. Despite the ... ...

    Abstract Plant parasites take advantage of host developmental plasticity to elicit profound developmental and physiological changes. In the case of plant-parasitic nematodes (PPNs), these changes can result in the development of new plant organs. Despite the importance of the development- and physiology-altering abilities of these parasites in pathology, research has historically focused on their abilities to suppress immunity. We argue that, given the dramatic changes involved in feeding site establishment, it is entirely possible that development- and physiology-altering abilities of PPNs may, in fact, dominate effector repertoires – highlighting the need for novel high-throughput screens for development- and physiology-altering ‘tools’. Uncovering this portion of the nematode ‘toolbox’ can enable biotechnology, enhance crop protection, and shed light on fundamental host biology itself.
    Keywords Nematoda ; biotechnology ; immunity ; parasitology ; plant parasitic nematodes ; plant protection ; plant-parasitic nematodes ; effectors ; developmental-plasticity ; development-altering effectors
    Language English
    Dates of publication 2023-09
    Size p. 732-738.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2023.06.005
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

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  7. Article ; Online: Recognition and Response in Plant-Nematode Interactions.

    Siddique, Shahid / Coomer, Alison / Baum, Thomas / Williamson, Valerie Moroz

    Annual review of phytopathology

    2022  Volume 60, Page(s) 143–162

    Abstract: Plant-parasitic nematodes spend much of their lives inside or in contact with host tissue, and molecular interactions constantly occur and shape the outcome of parasitism. Eggs of these parasites generally hatch in the soil, and the juveniles must locate ...

    Abstract Plant-parasitic nematodes spend much of their lives inside or in contact with host tissue, and molecular interactions constantly occur and shape the outcome of parasitism. Eggs of these parasites generally hatch in the soil, and the juveniles must locate and infect an appropriate host before their stored energy is exhausted. Components of host exudate are evaluated by the nematode and direct its migration to its infection site. Host plants recognize approaching nematodes before physical contact through molecules released by the nematodes and launch a defense response. In turn, nematodes deploy numerous mechanisms to counteract plant defenses. This review focuses on these early stages of the interaction between plants and nematodes. We discuss how nematodes perceive and find suitable hosts, how plants perceive and mount a defense response against the approaching parasites, and how nematodes fight back against host defenses.
    MeSH term(s) Animals ; Host-Parasite Interactions ; Plant Diseases ; Plants ; Tylenchoidea
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207934-3
    ISSN 1545-2107 ; 0066-4286
    ISSN (online) 1545-2107
    ISSN 0066-4286
    DOI 10.1146/annurev-phyto-020620-102355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1911: Show issues

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  8. Article ; Online: miR778 mediates gene expression, histone modification, and DNA methylation during cyst nematode parasitism.

    Bennett, Morgan / Piya, Sarbottam / Baum, Thomas J / Hewezi, Tarek

    Plant physiology

    2022  Volume 189, Issue 4, Page(s) 2432–2453

    Abstract: Despite the known critical regulatory functions of microRNAs, histone modifications, and DNA methylation in reprograming plant epigenomes in response to pathogen infection, the molecular mechanisms underlying the tight coordination of these components ... ...

    Abstract Despite the known critical regulatory functions of microRNAs, histone modifications, and DNA methylation in reprograming plant epigenomes in response to pathogen infection, the molecular mechanisms underlying the tight coordination of these components remain poorly understood. Here, we show how Arabidopsis (Arabidopsis thaliana) miR778 coordinately modulates the root transcriptome, histone methylation, and DNA methylation via post-transcriptional regulation of the H3K9 methyltransferases SU(var)3-9 homolog 5 (SUVH5) and SUVH6 upon infection by the beet cyst nematode Heterodera schachtii. miR778 post-transcriptionally silences SUVH5 and SUVH6 upon nematode infection. Manipulation of the expression of miR778 and its two target genes significantly altered plant susceptibility to H. schachtii. RNA-seq analysis revealed a key role of SUVH5 and SUVH6 in reprograming the transcriptome of Arabidopsis roots upon H. schachtii infection. In addition, chromatin immunoprecipitation (ChIP)-seq analysis established SUVH5 and SUVH6 as the main enzymes mediating H3K9me2 deposition in Arabidopsis roots in response to nematode infection. ChIP-seq analysis also showed that these methyltransferases possess distinct DNA binding preferences in that they are targeting transposable elements under noninfected conditions and protein-coding genes in infected plants. Further analyses indicated that H3K9me2 deposition directed by SUVH5 and SUVH6 contributes to gene expression changes both in roots and in nematode feeding sites and preferentially associates with CG DNA methylation. Together, our results uncovered multi-layered epigenetic regulatory mechanisms coordinated by miR778 during Arabidopsis-H. schachtii interactions.
    MeSH term(s) Animals ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Cysts/genetics ; Cysts/metabolism ; DNA Methylation/genetics ; Gene Expression ; Gene Expression Regulation, Plant ; Histone Code ; Methyltransferases/metabolism ; Plant Diseases/genetics ; Plant Roots/genetics ; Plant Roots/metabolism ; Tylenchoidea
    Chemical Substances Arabidopsis Proteins ; Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiac228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  9. Article: Multibody Models of the Thoracolumbar Spine: A Review on Applications, Limitations, and Challenges.

    Lerchl, Tanja / Nispel, Kati / Baum, Thomas / Bodden, Jannis / Senner, Veit / Kirschke, Jan S

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 2

    Abstract: Numerical models of the musculoskeletal system as investigative tools are an integral part of biomechanical and clinical research. While finite element modeling is primarily suitable for the examination of deformation states and internal stresses in ... ...

    Abstract Numerical models of the musculoskeletal system as investigative tools are an integral part of biomechanical and clinical research. While finite element modeling is primarily suitable for the examination of deformation states and internal stresses in flexible bodies, multibody modeling is based on the assumption of rigid bodies, that are connected via joints and flexible elements. This simplification allows the consideration of biomechanical systems from a holistic perspective and thus takes into account multiple influencing factors of mechanical loads. Being the source of major health issues worldwide, the human spine is subject to a variety of studies using these models to investigate and understand healthy and pathological biomechanics of the upper body. In this review, we summarize the current state-of-the-art literature on multibody models of the thoracolumbar spine and identify limitations and challenges related to current modeling approaches.
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10020202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; Thesis: Biomechanische Modellierung des osteoporotischen Frakturrisikos in Niedrigdosis-MDCTs und Muskel-Knochen Interaktion am proximalen Femur und der LWS

    Zoffl, Florian Markus Verfasser] / [Baum, Thomas [Akademischer Betreuer] / Baum, Thomas [Gutachter] / Pfeiffer, Franz [Gutachter]

    2022  

    Author's details Florian Markus Zoffl ; Gutachter: Thomas Baum, Franz Pfeiffer ; Betreuer: Thomas Baum
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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