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  1. Article: Blutströmung und Thrombogenese. Wechselwirkungen zwischen Blutlättchen, Gerinnungsfaktoren und Gefässwand.

    Baumgartner, H R

    Der Internist

    1984  Volume 25, Issue 2, Page(s) 75–81

    Title translation Blood flow and thrombogenesis. Correlation of blood platelets, blood coagulation factors and the vascular wall.
    MeSH term(s) Adenosine Diphosphate/metabolism ; Arteriosclerosis/blood ; Blood Coagulation Factors/metabolism ; Blood Flow Velocity ; Blood Platelets/physiology ; Connective Tissue/physiopathology ; Cyclic AMP/metabolism ; Endothelium/physiopathology ; Fibrin/metabolism ; Humans ; Ischemia/blood ; Platelet Adhesiveness ; Platelet Aggregation ; Rheology ; Thrombosis/blood
    Chemical Substances Blood Coagulation Factors ; Adenosine Diphosphate (61D2G4IYVH) ; Fibrin (9001-31-4) ; Cyclic AMP (E0399OZS9N)
    Language German
    Publishing date 1984-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: HISTOCHEMICAL EVIDENCE OF MONOAMINE OXIDASE ACTIVITY IN RATS OF DIFFERENT AGES.

    STUDER, A / BAUMGARTNER, H R / REVER, K

    Zeitschrift fur Zellforschung und Mikroskopische Anatomie. Abteilung Histochemie

    2003  Volume 79, Page(s) 43–47

    MeSH term(s) Aging ; Histocytochemistry ; Kidney ; Liver/enzymology ; Monoamine Oxidase ; Muscles ; Myocardium ; Rats ; Research
    Chemical Substances Monoamine Oxidase (EC 1.4.3.4)
    Language English
    Publishing date 2003-08-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6016-1
    ISSN 0340-0239
    ISSN 0340-0239
    DOI 10.1007/bf00304177
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  3. Article: Recollections of the development of flow devices for studying mechanisms of hemostasis and thrombosis in flowing whole blood.

    Sakariassen, K S / Turitto, V T / Baumgartner, H R

    Journal of thrombosis and haemostasis : JTH

    2003  Volume 2, Issue 10, Page(s) 1681–1690

    MeSH term(s) Animals ; Blood Cells/cytology ; Blood Cells/physiology ; Endothelium, Vascular/cytology ; Hemorheology/history ; Hemorheology/instrumentation ; Hemorheology/methods ; Hemostasis/drug effects ; Hemostasis/physiology ; History, 20th Century ; History, 21st Century ; Humans ; Perfusion/history ; Perfusion/instrumentation ; Research ; Thrombosis/drug therapy ; Thrombosis/history ; Thrombosis/pathology
    Language English
    Publishing date 2003-07-14
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/j.1538-7836.2004.00907.x
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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  4. Article: Effects of acetylsalicylic acid, sulfinpyrazone and dipyridamole on platelet adhesion and aggregation in flowing native and anticoagulated blood.

    Baumgartner, H R

    Haemostasis

    1979  Volume 8, Issue 3-5, Page(s) 340–352

    Abstract: The interaction of rabbit platelets with subendothelium of rabbit aorta was investigated under controlled blood flow conditions. Platelet adhesion and thrombus formation were compared after perfusion of native blood and of blood anticoagulated with ... ...

    Abstract The interaction of rabbit platelets with subendothelium of rabbit aorta was investigated under controlled blood flow conditions. Platelet adhesion and thrombus formation were compared after perfusion of native blood and of blood anticoagulated with citrate, heparin or heparin plus citrate. 15 mM citrate in plasma caused significant reduction of aggregation, thrombus volume and thrombus height; adhesion was concomitantly increased. Heparin (500 U/kg) had no significant effect on adhesion and thrombus dimensions. Treatment of rabbits with acetylsalicylic acid or sulfinpyrazone caused a significant reduction of thrombus volume and thrombus height in the presence of citrate. However, no significant effects were observed in native or heparinized blood. It is concluded that low citrate concentrations: (1) inhibit thrombus growth; (2) enhance thrombus breakdown; (3) therefore increase adhesion, and (4) strongly enhance a possible inhibitory effect of acetylsalicylic acid and sulfinpyrazone on thrombus growth.
    MeSH term(s) Animals ; Aspirin/pharmacology ; Blood Platelets/physiology ; Blood Vessels/physiology ; Citrates/pharmacology ; Dipyridamole/pharmacology ; Dose-Response Relationship, Drug ; Endothelium/physiology ; Female ; Male ; Platelet Adhesiveness/drug effects ; Platelet Aggregation/drug effects ; Rabbits ; Sulfinpyrazone/pharmacology ; Thrombosis/epidemiology
    Chemical Substances Citrates ; Dipyridamole (64ALC7F90C) ; Aspirin (R16CO5Y76E) ; Sulfinpyrazone (V6OFU47K3W)
    Language English
    Publishing date 1979
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 185252-8
    ISSN 1423-0038 ; 0301-0147
    ISSN (online) 1423-0038
    ISSN 0301-0147
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 896: Show issues Location:
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  5. Article: Arteriosklerose und Thrombose, neue pathogenetische Gesichtspunkte.

    Baumgartner, H R

    Der Internist

    1978  Volume 19, Issue 11, Page(s) 627–631

    Title translation Arteriosclerosis and thrombosis, new pathogenetic viewpoints.
    MeSH term(s) Arteriosclerosis/complications ; Arteriosclerosis/prevention & control ; Aspirin/administration & dosage ; Blood Circulation ; Endothelium/pathology ; Epoprostenol/physiology ; Factor VIII/physiology ; Humans ; Thrombosis/etiology
    Chemical Substances Factor VIII (9001-27-8) ; Epoprostenol (DCR9Z582X0) ; Aspirin (R16CO5Y76E)
    Language German
    Publishing date 1978-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
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  6. Article: Platelet interaction with collagen fibrils in flowing blood. I. Reaction of human platelets with alpha chymotrypsin-digested subendothelium.

    Baumgartner, H R

    Thrombosis and haemostasis

    1977  Volume 37, Issue 1, Page(s) 1–16

    Abstract: The subendothelial surface of rabbit aorta and alpha chymotrypsin-digested subendothelium were exposed to anticoagulated human blood in an annular flow chamber. The wall shear rate was similar to that observed in large arteries (830 sec-1) and exposure ... ...

    Abstract The subendothelial surface of rabbit aorta and alpha chymotrypsin-digested subendothelium were exposed to anticoagulated human blood in an annular flow chamber. The wall shear rate was similar to that observed in large arteries (830 sec-1) and exposure times varied from 2 1/2 to 40 min. The platelet reactive substrate of alpha chymotrypsin-digested subendothelium consists of a three-dimensional meshwork of collagen fibrils which form islands of variable size and height in a matrix of virtually unreactive elastin. Collagen-induced aggregation in the aggregometer was similar with or without prior alpha chymotrypsin-digestion of a highly dispersed preparation of fibrillar collagen. The rate of platelet adhesion was decreased on the fibrallar collagen of alpha chymotrypsin-digested subendothelium as compared to intact subendothelium. On the other hand the rate of aggregation was increased once platelets adhered to the fibrillar collagen. Mural thrombi (aggregates) disappeared on subendothelium whereas they grew progressively on the fibrillar collagen. Thus the fibrillar collagen of alpha chymotrypsin-digested subendothelium appears to be a more thrombogenic surface. It is suggested that physical (loose three-dimensional meshwork versus a comparatively solid surface) and/or chemical (number of platelet reactive sites per unit surface area) differences between the two surfaces may explain the platelet-surface-interaction patterns which are characteristic for each surface.
    MeSH term(s) Adult ; Animals ; Aorta/ultrastructure ; Chymotrypsin ; Collagen ; Elastin ; Endothelium/ultrastructure ; Humans ; Platelet Adhesiveness ; Platelet Aggregation ; Rabbits ; Rheology ; Surface Properties
    Chemical Substances Collagen (9007-34-5) ; Elastin (9007-58-3) ; Chymotrypsin (EC 3.4.21.1)
    Language English
    Publishing date 1977-02-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
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    Uh III Zs.192: Show issues Location:
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    Zs.MO 433: Show issues

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  7. Article: Wirkungsmechanismen von Plättcheninhibitoren

    Baumgartner, H R

    Therapeutische Umschau. Revue therapeutique

    1977  Volume 34, Issue 5, Page(s) 341–346

    Title translation Inhibition of platelet function (mode of action of platelet inhibitors) (author's transl).
    MeSH term(s) Blood Platelets/drug effects ; Fibrinolytic Agents/pharmacology ; Humans ; Platelet Adhesiveness/drug effects ; Platelet Aggregation/drug effects
    Chemical Substances Fibrinolytic Agents
    Language German
    Publishing date 1977-05
    Publishing country Switzerland
    Document type English Abstract ; Journal Article
    ZDB-ID 82044-1
    ISSN 1664-2864 ; 0040-5930
    ISSN (online) 1664-2864
    ISSN 0040-5930
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    Ue I Zs.180: Show issues Location:
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  8. Article: Zur Pathogenese der Atherosklerose Beitrag aus Zellbiologischer Sicht

    Baumgartner, H R

    Schweizerische medizinische Wochenschrift

    1977  Volume 107, Issue 21, Page(s) 717–722

    Title translation The pathogenesis of atherosclerosis. Contribution from a cytobiological viewpoint.
    MeSH term(s) Animals ; Arteries/cytology ; Arteriosclerosis/etiology ; Blood Platelets/metabolism ; Blood Platelets/physiopathology ; Diabetes Complications ; Dietary Fats/adverse effects ; Endothelium/cytology ; Glucosephosphate Dehydrogenase/metabolism ; Humans ; Hyperlipidemias/complications ; Hypertension/complications ; Isoenzymes ; Muscle, Smooth/physiopathology ; Obesity/complications ; Platelet Adhesiveness ; Smoking/complications ; Swine
    Chemical Substances Dietary Fats ; Isoenzymes ; Glucosephosphate Dehydrogenase (EC 1.1.1.49)
    Language German
    Publishing date 1977-05-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 200461-6
    ISSN 0036-7672
    ISSN 0036-7672
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    Ua VI Zs.152: Show issues Location:
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  9. Article: Effects of anticoagulation on the interaction of human platelets with subendothelium in flowing blood.

    Baumgartner, H R

    Schweizerische medizinische Wochenschrift

    1976  Volume 106, Issue 40, Page(s) 1367–1368

    Abstract: The subendothelial surface of rabbit aorta was exposed to a laminar stream of native human blood using a perfusion chamber. The blood was drawn at a constant flow rate and 37 degrees C from a cubital vein through the annular space of the chamber by means ...

    Abstract The subendothelial surface of rabbit aorta was exposed to a laminar stream of native human blood using a perfusion chamber. The blood was drawn at a constant flow rate and 37 degrees C from a cubital vein through the annular space of the chamber by means of a roller pump. Platelet interaction with subendothelium and fibrin deposition were measured morphometrically. Native blood and blood anticoagulated with 15 mM citrate obtained from the same donor was investigated at arterial blood flow conditions. Platelet adhesion was significantly increased by the anticoagulation. In contrast, platelet spreading and adhesion-induced aggregation were significantly inhibited by citrate. The extent of fibrin deposition varied greatly from one donor to another and did not correlate with platelet adhesion. It is concluded that initially, the two hemostatic systems platelet adhesion-aggregation and coagulation function independently.
    MeSH term(s) Animals ; Aorta ; Citrates/pharmacology ; Endothelium/drug effects ; Fibrin ; Humans ; Platelet Adhesiveness/drug effects ; Platelet Aggregation/drug effects ; Rabbits
    Chemical Substances Citrates ; Fibrin (9001-31-4)
    Language English
    Publishing date 1976-10-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 200461-6
    ISSN 0036-7672
    ISSN 0036-7672
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  10. Article: Pathophysiologische und experimentelle Grundlagen der Thrombogenese.

    Baumgartner, H R

    Schweizerische medizinische Wochenschrift

    1974  Volume 104, Issue 4, Page(s) 109–113

    Title translation Pathophysiological and experimental basis of thrombogenesis.
    MeSH term(s) Animals ; Anticoagulants/therapeutic use ; Basement Membrane ; Blood Flow Velocity ; Blood Vessels/physiopathology ; Collagen ; Connective Tissue/physiopathology ; Elastin ; Endothelium/drug effects ; Endothelium/physiopathology ; Endotoxins/pharmacology ; Epithelial Cells ; Epithelium/drug effects ; Humans ; Microscopy, Electron ; Platelet Adhesiveness ; Rabbits ; Thrombophlebitis/prevention & control ; Thrombosis/physiopathology ; Thrombosis/prevention & control
    Chemical Substances Anticoagulants ; Endotoxins ; Collagen (9007-34-5) ; Elastin (9007-58-3)
    Language German
    Publishing date 1974-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 200461-6
    ISSN 0036-7672
    ISSN 0036-7672
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