Article ; Online: Is dopexamine superior to dopamine in the treatment of multiple trauma patients--a prospective, double-blind, randomised study.
2010 Volume 41, Issue 5, Page(s) 499–505
Abstract: Background: The goal of this prospective, randomised, double-blind clinical trial study was to assess the effects of dopexamine hydrochloride on organ failure, inflammatory mediators and splanchnic oxygenation in blunt multiple trauma patients at high ... ...
| Abstract | Background: The goal of this prospective, randomised, double-blind clinical trial study was to assess the effects of dopexamine hydrochloride on organ failure, inflammatory mediators and splanchnic oxygenation in blunt multiple trauma patients at high risk of multiple organ dysfunction syndrome (MODS). Methods: We performed a prospective randomised controlled trial on 30 consecutive blunt multiple trauma patients with ISS>or=16, age 18-60 years and initial blood pressure >or=120 mmHg initially admitted to our level I trauma centre. Patients were randomised to treatment with dopamine (n=15) or dopexamine (n=15) for 48 h after admission. Outcome in terms of mortality, MODS, splanchnic perfusion, complications, duration of stay was statistically analysed. Results: Dopexamine treatment was associated with impaired organ function and an increased duration of ventilation and ICU stay compared with patients who received dopamine treatment. The acute inflammatory response was increased in the Dopexamine group while a decreased pHi and MEGX formation and increased serum lactate levels were measured. Conclusions: The indication to use dopexamine hydrochloride appears questionable. In the absence of an antiinflammatory effect, dopexamine demonstrated a disadvantageous ICU course in regards to the organ function and the duration of treatment. In addition, a decreased pHi and MEGX formation suggested a deterioration of splanchnic oxygenation. |
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| MeSH term(s) | Adolescent ; Adult ; Blood Pressure/drug effects ; Critical Care ; Dopamine/analogs & derivatives ; Dopamine/therapeutic use ; Double-Blind Method ; Female ; Gastric Mucosa/metabolism ; Humans ; Length of Stay ; Lidocaine/analogs & derivatives ; Lidocaine/metabolism ; Male ; Middle Aged ; Multiple Organ Failure/drug therapy ; Multiple Organ Failure/metabolism ; Multiple Organ Failure/mortality ; Multiple Trauma/complications ; Multiple Trauma/metabolism ; Multiple Trauma/mortality ; Oxygen Consumption/drug effects ; Prospective Studies ; Respiration, Artificial ; Splanchnic Circulation/drug effects ; Trauma Severity Indices ; Vasodilator Agents/therapeutic use ; Viscera/blood supply ; Wounds, Nonpenetrating/complications ; Wounds, Nonpenetrating/metabolism ; Wounds, Nonpenetrating/mortality ; Young Adult | ||||||||||
| Chemical Substances | Vasodilator Agents ; dopexamine (398E7Z7JB5) ; Lidocaine (98PI200987) ; monoethylglycinexylidide (D8Q99HC770) ; Dopamine (VTD58H1Z2X) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2010-05 | ||||||||||
| Publishing country | Netherlands | ||||||||||
| Document type | Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 218778-4 | ||||||||||
| ISSN | 1879-0267 ; 0020-1383 | ||||||||||
| ISSN (online) | 1879-0267 | ||||||||||
| ISSN | 0020-1383 | ||||||||||
| DOI | 10.1016/j.injury.2009.06.018 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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