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  1. Article: Editorial: Subclassification of AUS/FLUS category for thyroid nodules: trials and evidence-based clinical management.

    Bayraktaroğlu, Taner / Barut, Figen / Çakmak, Güldeniz Karadeniz

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1209776

    MeSH term(s) Humans ; Thyroid Nodule/diagnosis ; Thyroid Nodule/therapy
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1209776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Differences in Clinical Aspects Between Subacute Thyroiditis Associated with COVID-19 Vaccines and Classical Subacute Thyroiditis.

    Topaloğlu, Ömercan / Tekin, Sakin / Topaloğlu, Seda Nur / Bayraktaroglu, Taner

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2022  Volume 54, Issue 6, Page(s) 380–388

    Abstract: Subacute thyroiditis (SAT) developed after SARS-CoV-2 vaccines has been less studied. We aimed to compare classical SAT and SAT developed after SARS-CoV-2 vaccines in the context of clinical aspects. Adults with SAT detected in 90 days of COVID-19 ... ...

    Abstract Subacute thyroiditis (SAT) developed after SARS-CoV-2 vaccines has been less studied. We aimed to compare classical SAT and SAT developed after SARS-CoV-2 vaccines in the context of clinical aspects. Adults with SAT detected in 90 days of COVID-19 vaccination (CoronaVac or Pfizer/BioNTech) were grouped as Vac-SAT. Those with a history of SARS-CoV-2 or upper respiratory tract infection in 6 months before the vaccination, or vaccination with another antiviral vaccine after COVID-19 vaccination were excluded. Those with SAT detected before COVID-19 pandemic were grouped as Classical-SAT. Of total (n=85), female/male (54/31) ratio and age [43 (23-65)] were similar in Vac-SAT (n=23) and Classical-SAT (n=62). Duration between vaccine and SAT was 45 (7-90) days, and similar in CoronaVac-SAT (n=5) and BioNTech-SAT (n=18). SAT-duration was 28 (10-150) days, and higher in Vac-SAT than in Classical-SAT (p=0.023). SAT was developed after the 1st dose vaccine in minority in CoronaVac-SAT (n=2) and BioNTech-SAT (n=3) (p=0.263). Previous LT4 use, and TSH elevation after resolution were more frequent in Vac-SAT than in Classical-SAT (p=0.027 and p=0.041). We included a considerable number of patients with SAT occurred after COVID-19 vaccines. We cannot provide clear evidence regarding the association of COVID-19 vaccines with SAT. SAT associated with CoronaVac or BioNTech seems unlikely to be occurred after the 1st dose, and to have a longer duration, more likely to be associated with previous LT4 use and lead TSH elevation after resolution than Classical-SAT. TSH should be followed-up after the resolution of SAT detected after COVID-19 vaccination.
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Female ; Humans ; Male ; Pandemics ; SARS-CoV-2 ; Thyroiditis, Subacute/etiology ; Thyrotropin
    Chemical Substances COVID-19 Vaccines ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2022-05-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1840-4374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intraoperative ultrasound imaging and sono-scintigraphic concordance improves success rates of minimally invasive parathyroidectomy

    Uslu Erdemir, Rabiye / Taşdöven, İlhan / Bayraktaroğlu, Taner / Karadeniz Çakmak, Güldeniz

    Turkish journal of medical sciences

    2021  Volume 51, Issue 5, Page(s) 2341–2345

    Abstract: Background/aim: This study aimed to evaluate the effect of sono-scintigraphic correlation on the success of minimal invasive parathyroidectomy (MIP) via surgeon performed continuous intraoperative sonographic guidance in patients operated for primary ... ...

    Abstract Background/aim: This study aimed to evaluate the effect of sono-scintigraphic correlation on the success of minimal invasive parathyroidectomy (MIP) via surgeon performed continuous intraoperative sonographic guidance in patients operated for primary hyperparathyroidism (PHPT) without intact parathormone (PTH) measurement.
    Materials and methods: A retrospective analysis of a prospective database was conducted to review patients who underwent MIP (July 2017-October 2019). The screened parameters were preoperative PTH level, preoperative ultrasonography (US), preoperative scintigraphy, intraoperative US, intraoperative frozen section analysis, postoperative PTH level, and permanent pathology rep ort. Intraoperative intact PTH measurement was not employed due to institutional policy.
    Results: Preoperative US alone localized the specific side (right/left, inferior/superior) of abnormality in 54 out of 74 (72.97%) cases. Scintigraphy alone localized the specific side in 58 (78.37%) cases. The sensitivity of preoperative US and scintigraphy alone was 76.05% and 86.56%, respectively. Sono-scintigraphic discordance was present in 6 cases (8.1%) and intraoperative real-time US predicted accurate localization of adenoma in 4 (66.6%) and scintigraphy in 2 (44.4%) patients. The frozen section analysis confirmed parathyroid cells in all cases evaluated.
    Conclusion: Sono-scintigraphic concordance with intraoperative real-time imaging increases surgical success rates in cases where MIP is planned under the circumstances of limited resources regarding unavailability of intact PTH measurement.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures/methods ; Parathyroid Hormone ; Parathyroid Neoplasms/diagnostic imaging ; Parathyroid Neoplasms/surgery ; Parathyroidectomy ; Radionuclide Imaging ; Retrospective Studies ; Technetium Tc 99m Sestamibi ; Ultrasonography/methods
    Chemical Substances Parathyroid Hormone ; Technetium Tc 99m Sestamibi (971Z4W1S09)
    Language English
    Publishing date 2021-10-21
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-2101-126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The COVID-19 and Hypertension ; COVID-19 ve Hipertansiyon

    TAŞKALDIRAN, Işılay / BAYRAKTAROĞLU, Taner

    Volume: 4, Issue: 2 155-159 ; 2587-0335 ; 2587-0572 ; Türkiye Diyabet ve Obezite Dergisi

    2020  

    Abstract: On 31 December 2019, a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in China, caused COVID-19 infection and a pandemic. Hypertension (HT) appeared as an important comorbidity affecting prognosis in COVID-19 infection. ... ...

    Abstract On 31 December 2019, a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in China, caused COVID-19 infection and a pandemic. Hypertension (HT) appeared as an important comorbidity affecting prognosis in COVID-19 infection. SARSCoV-2’s use of angiotensin converting enzyme 2 (‘angiotensin converting enzyme-2’, ACE2) as viral entry receptor in the lung has caused concern in patients diagnosed with hypertension and receiving ACEI / ARB therapy in COVID-19 infection. Studies show that the disease is more serious and more mortal in HT patients diagnosed with COVID-19. Taking ACEI / ARB, does not differ prognosis and mortality in many studies and even has positive effects in some studies. In addition, it seems that other antihypertensive treatments do not make a significant difference in terms of prognosis or mortality. Blood pressure of hypertensive patients must be kept under control. If there is no other reason, antihypertensive treatments of patients should not be changed.

    Çin’de, ilk kez 31 Aralık 2019’da, yeni bir ciddi akut solunum sendromu koronavirüs 2 (SARS-CoV-2)’nin neden olduğu COVID-19 enfeksiyonu tespit edildi ve pandemiye sebep oldu. Hipertansiyon (HT), COVID-19 enfeksiyonunda prognozu etkileyen önemli bir komorbidite olarak karşımıza çıkmaktadır. SARS-CoV-2’nin akciğerde viral giriş reseptörü olarak anjiyotensin dönüştürücü enzim 2’yi (‘angiotensin converting enzyme-2’, ACE2) kullanması, COVID-19 enfeksiyonunda hipertansiyon tanısı olan ve ACEI/ARB tedavisi alan hastalar açısından endişe yaratmıştır. Yapılan çalışmalarda HT tanısı olan COVID-19 hastalarında hastalığın daha ciddi ve daha mortal seyrettiği görülmektedir. ACEI/ARB kullanım gruplarında birçok çalışmada prognoz açısından farklılık oluşturmadığı hatta bazı çalışmalarda olumlu etki oluşturduğu izlenmektedir. Ayrıca diğer antihipertansif tedavilerin de prognoz veya mortalite açısından anlamlı farklılık yaratmadığı görülmektedir. Hipertansif hastaların kan basıncı mutlaka kontrol altında tutulmalıdır. Başka bir neden yoksa hastaların antihipertansif tedavileri değiştirilmemelidir.
    Keywords COVID-19,Hypertension,Prognosis,Mortality ; hipertansiyon,covid 19,Prognoz,Mortalite ; covid19
    Language Turkish
    Publishing date 2020-08-30T00:00:00Z
    Publisher Bülent Ecevit Üniversitesi
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Nursing Services Recommendations in Crisis and Pandemic ; Kriz ve Pandemide Hemşirelik Hizmetleri Önerileri

    FİDAN, Emine / BAYRAKTAROĞLU, Taner

    Volume: 4, Issue: 2 44-50 ; 2587-0602 ; Batı Karadeniz Tıp Dergisi

    2020  

    Abstract: Coronavirus Disease-2019 (‘Coronavirus Disease-2019’, COVID-19) has been spreading withhigh acceleration in Asia, Europe and America continent, especially hospitals have become themost active points in the treatment and spread of the disease. Nurses, ... ...

    Abstract Coronavirus Disease-2019 (‘Coronavirus Disease-2019’, COVID-19) has been spreading withhigh acceleration in Asia, Europe and America continent, especially hospitals have become themost active points in the treatment and spread of the disease. Nurses, which have a vital rolein the provision of health services and influencing public health, are at the forefront in the fightagainst the epidemic and perform their roles in health care as practitioners, managers, educators,researchers and professionals. The fight against the pandemic action plans in coordination with the Ministry of Health and otherMinistries in Turkey are carried out. The nursing services applied during the pandemic in hospitals sağlanarecarried out by considering the recommendations in the circulars of the Ministry of Health. Effective and high-quality nursing services should be targeted by ensuring that nurses and executive nurses working in emergency departments, clinics and intensive care units at the stage of examination, diagnosis and treatment of patients with COVID-19 diagnosis or suspicion are provided with the most up-to-date and evidence-based informations. It is important for nurses to take into account the COVID-19 status and the amount of resources, by sharing their experience, practice and recommendations. In this process, the introduction of good practices that will benefit patients and saving lives is of great importance. Here, we present a review and suggestions to ensure that the system can be supported as nursing services by protecting patients and nursing teams in hospitals during the crisis such as COVID-19 pandemic, taking into account the status of COVID-19 and its resources rationally and dynamically and ensuring the sustainability of nursing services.

    Koronavirüs Hastalığı-2019 (‘Coronavirus Disease-2019’), kıtalar arası yüksek ivme ile yayılımgösterirken, özellikle hastaneler hastalığın tedavi sürecinde ve yayılımı konusunda en aktif roloynayan alanlar hâline gelmiştir. Hemşireler, sağlık hizmetlerinin sunumunda ve toplum sağlığınıetkilemede hayati bir role sahiptirler. Salgına karşı verilen savaşta ön saflarda yer almakta vesağlık hizmeti sunumunda görevlerini uygulayıcı, yönetici, eğitici, araştırıcı ve profesyonel birşekilde gerçekleştirmektedirler.Türkiye’de Sağlık Bakanlığı ile diğer Bakanlıkların koordinasyonuyla pandemi mücadele eylemplanları gerçekleştirilmektedir. Hastanelerde pandemi süresince uygulanan hemşirelik hizmetleri,Sağlık Bakanlığı genelgelerindeki öneriler dikkate alarak yürütülmektedir. COVID-19 tanısı ya daşüphesi olan hastaların tetkik, tanı ve tedavi aşamalarında acil servis, klinikler ve yoğun bakımünitelerinde görev yapan hemşirelerin ve yönetici hemşirelerin en güncel ve kanıta dayalı bilgilereulaşması sağlanarak etkin ve kaliteli hemşirelik hizmeti sunumu hedeflenmelidir. Hemşirelerindeneyim, uygulama ve önerilerinin paylaşılması ile hastanelerin COVID-19 durumunu ve kaynakmiktarını göz önünde bulundurması önemlidir. Bu süreçte, hastalara fayda getirecek doğru vegüvenli protokollerin kullanılması ve yaşama tutunmalarının sağlanması önem arz etmektedir.Bu yazımızda, kriz durumlarında ve COVID-19 pandemisi sürecinde hastanelerde, hemhastaların ve ekibin korunmasını sağlayarak, etkin ve verimli hemşirelik hizmetleri olarak destekverilebilmesini, hem de COVID-19 durumunu ve kaynaklarını verimli ve dinamik bir şekilde elealarak, hemşirelik hizmetlerinin sürdürülebilirliğini sağlamak amaçlı öneriler sunmaktayız.
    Keywords COVID-19,Pandemic,Nurse,Nursing,Hospital ; Covid-19,pandemi,Hemşire,Hemşirelik Hizmetleri,Hastane ; covid19
    Language Turkish
    Publishing date 2020-08-31T00:00:00Z
    Publisher Bülent Ecevit Üniversitesi
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Association between IL-18 gene polymorphisms and Hashimoto thyroiditis

    Karakaya, Dilek / Çakmak Genc, Gunes / Karakas Celik, Sevim / Aktas, Tugba / Bayraktaroglu, Taner / Dursun, Ahmet

    Molecular biology reports. 2021 Oct., v. 48, no. 10

    2021  

    Abstract: BACKGROUND: Hashimoto’s thyroiditis (HT), which is also called lymphocytic thyroiditis, is the most frequent autoimmune thyroid disease (AITD), in which T helper-1 lymphocytes mediate the disease. IL-18 is expressed in thyroid follicular cells (TFCs) ... ...

    Abstract BACKGROUND: Hashimoto’s thyroiditis (HT), which is also called lymphocytic thyroiditis, is the most frequent autoimmune thyroid disease (AITD), in which T helper-1 lymphocytes mediate the disease. IL-18 is expressed in thyroid follicular cells (TFCs) during HT. The findings of studies aimed at investigating the relationship between IL-18 and HT are highly contradictory. In this study, we aimed to investigate the association between IL-18 gene polymorphisms and HT. METHODS AND RESULTS: The study included 97 patients diagnosed with HT and 86 volunteers in the healthy control group. The IL18-607C/A (rs1946518) and -137G/C (rs187238) genotypes were determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) method. No significant difference in the mean age or sex was observed between the groups (p = 0.763 and p = 0.658, respectively). The -137 IL18 CG genotype was more frequent in HT patients than in controls. In HT patients, the risk of the IL-18 CG genotype was more than 2.237 times higher (OR 2.237%95 Cl 1.195–4.187, p = 0.039) than that of the G/G genotype. Additionally, the -607 AC genotype was more frequent in the control group than in the HT group (in individuals with the IL18 CG genotype). CONCLUSIONS: According to our results, the CG genotype might be a risk factor for HT. Conversely, there is a possibility that the AC genotype plays a protective role against the condition. However, further studies will contribute to new solutions by revealing the molecular and cellular mechanisms of HT.
    Keywords genes ; genotype ; interleukin-18 ; molecular biology ; polymerase chain reaction ; protective effect ; risk factors
    Language English
    Dates of publication 2021-10
    Size p. 6703-6708.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-021-06659-5
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: [No title information]

    Topaloğlu, Ömercan / Tekin, Sakin / Topaloğlu, Seda Nur / Bayraktaroglu, Taner

    Hormone and Metabolic Research

    2022  Volume 54, Issue 06, Page(s) 380–388

    Abstract: Subacute thyroiditis (SAT) developed after SARS-CoV-2 vaccines has been less studied. We aimed to compare classical SAT and SAT developed after SARS-CoV-2 vaccines in the context of clinical aspects. Adults with ... ...

    Abstract Subacute thyroiditis (SAT) developed after SARS-CoV-2 vaccines has been less studied. We aimed to compare classical SAT and SAT developed after SARS-CoV-2 vaccines in the context of clinical aspects. Adults with SAT detected in 90 days of COVID-19 vaccination (CoronaVac or Pfizer/BioNTech) were grouped as Vac-SAT. Those with a history of SARS-CoV-2 or upper respiratory tract infection in 6 months before the vaccination, or vaccination with another antiviral vaccine after COVID-19 vaccination were excluded. Those with SAT detected before COVID-19 pandemic were grouped as Classical-SAT. Of total (n=85), female/male (54/31) ratio and age [43 (23–65)] were similar in Vac-SAT (n=23) and Classical-SAT (n=62). Duration between vaccine and SAT was 45 (7–90) days, and similar in CoronaVac-SAT (n=5) and BioNTech-SAT (n=18). SAT-duration was 28 (10–150) days, and higher in Vac-SAT than in Classical-SAT (p=0.023). SAT was developed after the 1st dose vaccine in minority in CoronaVac-SAT (n=2) and BioNTech-SAT (n=3) (p=0.263). Previous LT4 use, and TSH elevation after resolution were more frequent in Vac-SAT than in Classical-SAT (p=0.027 and p=0.041). We included a considerable number of patients with SAT occurred after COVID-19 vaccines. We cannot provide clear evidence regarding the association of COVID-19 vaccines with SAT. SAT associated with CoronaVac or BioNTech seems unlikely to be occurred after the 1st dose, and to have a longer duration, more likely to be associated with previous LT4 use and lead TSH elevation after resolution than Classical-SAT. TSH should be followed-up after the resolution of SAT detected after COVID-19 vaccination.
    Keywords subacute thyroiditis ; vaccine ; thyroiditis ; COVID-19 ; COVID-19 vaccine ; SARS-CoV-2
    Language English
    Publishing date 2022-05-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1840-4374
    Database Thieme publisher's database

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  8. Article ; Online: Association between IL-18 gene polymorphisms and Hashimoto thyroiditis.

    Karakaya, Dilek / Çakmak Genc, Gunes / Karakas Celik, Sevim / Aktas, Tugba / Bayraktaroglu, Taner / Dursun, Ahmet

    Molecular biology reports

    2021  Volume 48, Issue 10, Page(s) 6703–6708

    Abstract: Background: Hashimoto's thyroiditis (HT), which is also called lymphocytic thyroiditis, is the most frequent autoimmune thyroid disease (AITD), in which T helper-1 lymphocytes mediate the disease. IL-18 is expressed in thyroid follicular cells (TFCs) ... ...

    Abstract Background: Hashimoto's thyroiditis (HT), which is also called lymphocytic thyroiditis, is the most frequent autoimmune thyroid disease (AITD), in which T helper-1 lymphocytes mediate the disease. IL-18 is expressed in thyroid follicular cells (TFCs) during HT. The findings of studies aimed at investigating the relationship between IL-18 and HT are highly contradictory. In this study, we aimed to investigate the association between IL-18 gene polymorphisms and HT.
    Methods and results: The study included 97 patients diagnosed with HT and 86 volunteers in the healthy control group. The IL18-607C/A (rs1946518) and -137G/C (rs187238) genotypes were determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. No significant difference in the mean age or sex was observed between the groups (p = 0.763 and p = 0.658, respectively). The -137 IL18 CG genotype was more frequent in HT patients than in controls. In HT patients, the risk of the IL-18 CG genotype was more than 2.237 times higher (OR 2.237%95 Cl 1.195-4.187, p = 0.039) than that of the G/G genotype. Additionally, the -607 AC genotype was more frequent in the control group than in the HT group (in individuals with the IL18 CG genotype).
    Conclusions: According to our results, the CG genotype might be a risk factor for HT. Conversely, there is a possibility that the AC genotype plays a protective role against the condition. However, further studies will contribute to new solutions by revealing the molecular and cellular mechanisms of HT.
    MeSH term(s) Adult ; Alleles ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Haplotypes/genetics ; Hashimoto Disease/genetics ; Humans ; Interleukin-18/genetics ; Male ; Polymorphism, Single Nucleotide/genetics
    Chemical Substances IL18 protein, human ; Interleukin-18
    Language English
    Publishing date 2021-08-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-021-06659-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The effects of glucagon-like peptide 1 receptor agonist (exenatide) on memory impairment, and anxiety- and depression-like behavior induced by REM sleep deprivation.

    Turan, Inci / Sayan Ozacmak, Hale / Ozacmak, V Haktan / Ergenc, Meryem / Bayraktaroğlu, Taner

    Brain research bulletin

    2021  Volume 174, Page(s) 194–202

    Abstract: Previous investigations have shown that REM sleep deprivation impairs the hippocampus-dependent memory, long-term potentiation and causing mood changes. The aim of the present study was to explore the effects of exenatide on memory performance, anxiety- ... ...

    Abstract Previous investigations have shown that REM sleep deprivation impairs the hippocampus-dependent memory, long-term potentiation and causing mood changes. The aim of the present study was to explore the effects of exenatide on memory performance, anxiety- and depression like behavior, oxidative stress markers, and synaptic protein levels in REM sleep deprived rats. A total of 40 male Wistar rats were randomly divided to control, exenatide-treated control, sleep deprivation (SD), wide platform (WP) and exenatide-treated SD groups. During experiments, exenatide treatment (0.5 μg/kg, subcutaneously) was applied daily in a single dose for 9 days. Modified multiple platform method was employed to generate REM sleep deprivation for 72 h. The Morris water maze test was used to assess memory performance. Anxiety- and depression-like behaviors were evaluated by open field test (OFT), elevated plus maze (EPM) forced swimming test (FST), respectively 72 h after REMSD. The levels of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and postsynaptic density proteins 95 (PSD95) were measured in tissues of hippocampus and prefrontal cortex. The content of malondialdehyde (MDA) and reduced glutathione (GSH) were also measured. In the present study, an impairment in memory was observed in SD rats at the 24th hour of SD in compare to those of other groups. REMSD increased depression-like behavior in FST as well as the number of rearing and crossing square in OFT. Anxiety is the most common comorbid condition with depressive disorders. Contents of CaMKII and PSD95 decreased in hippocampus of SD rats. Exenatide treatment improved the impaired memory of SD rats and increased CaMKII content in hippocampus There was no difference in MDA and GSH levels among groups. Exenatide treatment also diminished locomotor activity in OFT. In conclusion, treatment with exenatide, at least in part, prevented from these cognitive and behavioral changes possibly through normalizing CaMKII levels in the hippocampus.
    MeSH term(s) Animals ; Antioxidants/metabolism ; Anxiety/drug therapy ; Anxiety/etiology ; Anxiety/psychology ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Depression/drug therapy ; Depression/etiology ; Depression/psychology ; Disks Large Homolog 4 Protein/metabolism ; Exenatide/therapeutic use ; Glucagon-Like Peptide-1 Receptor/agonists ; Glutathione/metabolism ; Male ; Malondialdehyde/metabolism ; Memory Disorders/drug therapy ; Memory Disorders/etiology ; Memory Disorders/psychology ; Psychomotor Performance/drug effects ; Rats ; Rats, Wistar ; Sleep Deprivation/complications ; Sleep, REM ; Swimming/psychology
    Chemical Substances Antioxidants ; Disks Large Homolog 4 Protein ; Dlg4 protein, rat ; Glucagon-Like Peptide-1 Receptor ; Malondialdehyde (4Y8F71G49Q) ; Exenatide (9P1872D4OL) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197620-5
    ISSN 1873-2747 ; 0361-9230
    ISSN (online) 1873-2747
    ISSN 0361-9230
    DOI 10.1016/j.brainresbull.2021.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Pituitary Apoplexy due to the Diagnostic Test in a Cushing"s Disease Patient.

    Kuzu, Fatih / Unal, Mustafa / Gul, Sanser / Bayraktaroglu, Taner

    Turkish neurosurgery

    2018  Volume 28, Issue 2, Page(s) 323–325

    Abstract: Pituitary apoplexy is a medical condition that needs urgent diagnosis and treatment. It may occur spontaneously or may be precipitated by a variety of reasons including dynamic endocrine tests. Although pituitary apoplexy is usually seen in nonfunctional ...

    Abstract Pituitary apoplexy is a medical condition that needs urgent diagnosis and treatment. It may occur spontaneously or may be precipitated by a variety of reasons including dynamic endocrine tests. Although pituitary apoplexy is usually seen in nonfunctional pituitary adenoma, it can also be seen in ACTH secreting macroadenomas. ACTH secreting adenomas present usually as microadenomas and in these patients apoplexy is rarely seen. In this paper we present a 30-year-old male patient with a history of Cushing"s disease who suffered from pituitary apoplexy after the 1 mg dexamethasone suppression test. He underwent endoscopic endonasal transsphenoidal surgery and his symptoms and signs were significantly improved.
    MeSH term(s) ACTH-Secreting Pituitary Adenoma/complications ; ACTH-Secreting Pituitary Adenoma/surgery ; Adenoma/complications ; Adenoma/surgery ; Adult ; Dexamethasone/adverse effects ; Diagnostic Tests, Routine/adverse effects ; Humans ; Male ; Pituitary ACTH Hypersecretion/diagnosis ; Pituitary ACTH Hypersecretion/surgery ; Pituitary Apoplexy/etiology ; Pituitary Apoplexy/surgery
    Chemical Substances Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2018
    Publishing country Turkey
    Document type Case Reports ; Journal Article
    ZDB-ID 1203779-5
    ISSN 1019-5149
    ISSN 1019-5149
    DOI 10.5137/1019-5149.JTN.16730-15.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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