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  1. Conference proceedings: Elovanoids are novel photoreceptor survival signals relevant to AMD

    Bazan, Nicolas

    2020  , Page(s) 19amd22

    Event/congress 7th International Symposium on AMD: Age-related Macular Degeneration - Understanding Pathogenetic Mechanisms of Disease; Baden-Baden; German Society of Ophthalmology; 2019
    Keywords Medizin, Gesundheit
    Publishing date 2020-02-05
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/19amd22
    Database German Medical Science

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  2. Article: Elovanoids are neural resiliency epigenomic regulators targeting histone modifications, DNA methylation, tau phosphorylation, telomere integrity, senescence programming, and dendrite integrity.

    Bazan, Nicolas / Bhattacharjee, Surjyadipta / Kala-Bhattacharjee, Sayantani / Ledet, Alexander / Mukherjee, Pranab

    Research square

    2023  

    Abstract: Cellular identity, developmental reorganization, genomic structure modulation, and susceptibility to diseases are determined by epigenomic regulation by multiple signaling interplay. Here we demonstrate that elovanoids (ELVs), mediators derived from very- ...

    Abstract Cellular identity, developmental reorganization, genomic structure modulation, and susceptibility to diseases are determined by epigenomic regulation by multiple signaling interplay. Here we demonstrate that elovanoids (ELVs), mediators derived from very-long-chain polyunsaturated fatty acids (VLC-PUFAs, n-3, C > 28), and their precursors in neurons in culture overcome the damage triggered by oligomeric amyloid-beta (OAβ), erastin (ferroptosis-dependent cell death), or other insults that target epigenomic signaling. We uncover that ELVs counteract damage targeting histones H3K9 and H3K27 methylation and acetylation; tau hyperphosphorylation (pThr181, pThr217, pThr231, and pSer202/pThr205 (AT8)); senescence gene programming (p16INK4a, p27KIP, p21CIP1, and p53); DNA methylation (DNAm) modifying enzymes: TET (DNA hydroxymethylase), DNA methyltransferase, DNA demethylase, and DNAm (5mC) phenotype. Moreover, ELVs revert OAβ-triggered telomere length (TL) attrition as well as upregulation of telomerase reverse transcriptase (TERT) expression fostering dendrite protection and neuronal survival. Thus, ELVs modulate epigenomic resiliency by pleiotropic interrelated signaling.
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3185942/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival.

    Bazan, N G

    Prostaglandins, leukotrienes, and essential fatty acids

    2012  Volume 88, Issue 1, Page(s) 127–129

    Abstract: The onset of neurodegenerations and nervous system injury both trigger cell signaling perturbations that lead to damage of neuronal circuits and synapic connections, as well as protective signaling that aims to halt disease onset. Here we review recent ... ...

    Abstract The onset of neurodegenerations and nervous system injury both trigger cell signaling perturbations that lead to damage of neuronal circuits and synapic connections, as well as protective signaling that aims to halt disease onset. Here we review recent findings that support the role of the docosanoid mediator neuroprotectin D1 (NPD1) as an early response or sentinel during the initial phase of nervous system damage. NPD1 is derived from docosahexaenoic acid that is selectively concentrated and retained in the nervous system. The protein misfolding triggers the biosynthesis of NPD1 which in turn downregulates pathways that lead to cell death and changes the outcome to cell survival. Proteotoxic stress as a result of protein misfolding is a widespread event in many neurodegenerative diseases. Therefore, mechanisms and mediators such as NPD1 that curtail consequences of these events are of interest as leads in the search for novel preventive and or therapeutic approaches.
    MeSH term(s) Animals ; Cell Survival ; Central Nervous System/immunology ; Central Nervous System/injuries ; Central Nervous System/metabolism ; Docosahexaenoic Acids/metabolism ; Homeostasis ; Humans ; Neuritis/immunology ; Neuritis/metabolism ; Neurodegenerative Diseases/immunology ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/physiopathology ; Neurons/immunology ; Neurons/metabolism ; Protein Unfolding ; Proteostasis Deficiencies/etiology ; Up-Regulation
    Chemical Substances protectin D1 ; Docosahexaenoic Acids (25167-62-8)
    Language English
    Publishing date 2012-09-28
    Publishing country Scotland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 286714-x
    ISSN 1532-2823 ; 0952-3278
    ISSN (online) 1532-2823
    ISSN 0952-3278
    DOI 10.1016/j.plefa.2012.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of ascorbic acid in reducing the incidence of vancomycin associated nephrotoxicity in critically ill patients: A preliminary randomized controlled trial.

    Hesham El-Sherazy, Nouran / Samir Bazan, Naglaa / Mahmoud Shaheen, Sara / A Sabri, Nagwa

    F1000Research

    2021  Volume 10, Page(s) 929

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Anti-Bacterial Agents ; Ascorbic Acid/therapeutic use ; Critical Illness ; Humans ; Incidence ; Kidney/drug effects ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Vancomycin/adverse effects
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2021-09-16
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.55619.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Ranwel Caputto (January 1, 1914-April 19, 1994). A life of commitment to science.

    Bazan, N

    Molecular neurobiology

    1996  Volume 12, Issue 2, Page(s) i–iii

    MeSH term(s) Argentina ; Biochemistry/history ; History, 20th Century ; Neurobiology/history ; Neurochemistry/history
    Language English
    Publishing date 1996-04
    Publishing country United States
    Document type Biography ; Historical Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/bf02740647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: In memoriam: Ranwel Caputto (January 1, 1914-April 19, 1994): a life of commitment to science.

    Bazan, N

    Journal of neuroscience research

    1996  Volume 46, Issue 3, Page(s) 393–394

    MeSH term(s) Argentina ; Biochemistry/history ; History, 20th Century ; Neurochemistry/history
    Language English
    Publishing date 1996-11-01
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 195324-2
    ISSN 1097-4547 ; 0360-4012
    ISSN (online) 1097-4547
    ISSN 0360-4012
    DOI 10.1002/(SICI)1097-4547(19961101)46:3<393::AID-JNR13>3.0.CO;2-2
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    Zs.A 1232: Show issues Location:
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  7. Article: Long-chain acyl coenzyme A synthetase activity during the postnatal development of the mouse brain.

    Reddy, T S / Bazan, N G

    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

    2014  Volume 2, Issue 5, Page(s) 447–450

    Abstract: Palmitic, linoleic, arachidonic, and docosahexaenoic acids were used as substrates to study fatty acid activation in the mouse brain and liver during postnatal development. Long-chain acyl coenzyme A synthetase showed peak activity during the period of ... ...

    Abstract Palmitic, linoleic, arachidonic, and docosahexaenoic acids were used as substrates to study fatty acid activation in the mouse brain and liver during postnatal development. Long-chain acyl coenzyme A synthetase showed peak activity during the period of rapid oligodendroglial proliferation and myelination. In brain, activation of linoleic and arachidonic acids was highest, followed by palmitic and docosahexaenoic acids. In liver, no appreciable change in enzyme activity was seen during the period of development studied. Palmitic and arachidonic acids showed the highest rate of activation, followed by docosahexaenoic acid. These ontogenic data suggest the presence of a single long-chain acyl coenzyme A synthetase in brain.
    Language English
    Publishing date 2014-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605533-3
    ISSN 1873-474X ; 0736-5748
    ISSN (online) 1873-474X
    ISSN 0736-5748
    DOI 10.1016/0736-5748(84)90046-7
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    Zs.A 1883: Show issues Location:
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  8. Article ; Online: Heart Failure Prescribing Quality at Discharge from a Critical Care Unit in Egypt: The Impact of Multidisciplinary Care.

    El Hadidi, Seif / Samir Bazan, Naglaa / Byrne, Stephen / Darweesh, Ebtissam / Bermingham, Margaret

    Pharmacy (Basel, Switzerland)

    2020  Volume 8, Issue 3

    Abstract: Discharge prescriptions for heart failure (HF) patients may not adhere to the clinical practice guidelines. This study aimed to assess the impact of the clinical pharmacist as a member of a multidisciplinary team on the quality of prescribing to HF ... ...

    Abstract Discharge prescriptions for heart failure (HF) patients may not adhere to the clinical practice guidelines. This study aimed to assess the impact of the clinical pharmacist as a member of a multidisciplinary team on the quality of prescribing to HF patients at discharge from a Critical Care Unit (CCU) in Egypt. This was a retrospective cohort study of HF patients discharged from the CCU between January 2013 and December 2017. Guideline Adherence Index (GAI-3) was used to assess guideline-directed prescribing at discharge. Multidisciplinary care was introduced to the CCU on 1 January 2016. The study included 284 HF patients, mean (±SD) age 66.7 ± 11.5 years, 53.2% male. Heart failure with reduced ejection fraction affected 100 patients (35.2%). At discharge, loop diuretics were prescribed to 85.2% of patients; mineralocorticoid receptor antagonists to 54.9%; angiotensin-converting enzyme inhibitors/angiotensin receptor blockers to 51.4%; and β-blockers to 29.9%. Population Guideline Adherence Index (GAI-3) was 45.5%. High-GAI was prescribed to 136 patients (47.9%). Patients with High-GAI were younger; less affected by chronic kidney disease and had fewer comorbidities than those without High-GAI. Prescription of β-blocker increased (24.1% vs. 38.6%,
    Language English
    Publishing date 2020-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737194-3
    ISSN 2226-4787 ; 2226-4787
    ISSN (online) 2226-4787
    ISSN 2226-4787
    DOI 10.3390/pharmacy8030159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Transcriptomic signature, bioactivity and safety of a non-hepatoxic analgesic generating AM404 in the mid-brain PAG region.

    Bazan, Hernan / Bhattacharjee, Surjyadipta / Reid, Madigan / Jun, Bokkyoo / Polk, Connor / Strain, Madeleine / Pierre, Linsey St / Desai, Neehar / Daly, Patrick / Cucinello-Ragland, Jessica / Edwards, Scott / Alvarez-Builla, Julio / Cai, James / Bazan, Nicolas

    Research square

    2023  

    Abstract: The safe and effective management of pain is a critical healthcare and societal need. The potential for misuse and addiction associated with opioids, nephrotoxicity, and gastrointestinal damage from chronic non-steroidal anti-inflammatory drug (NSAID) ... ...

    Abstract The safe and effective management of pain is a critical healthcare and societal need. The potential for misuse and addiction associated with opioids, nephrotoxicity, and gastrointestinal damage from chronic non-steroidal anti-inflammatory drug (NSAID) use, as well as acute liver injury from paracetamol (ApAP) overdose, are unresolved challenges. To address them, we developed a non-opioid and non-hepatotoxic small molecule, SRP-001. Compared to ApAP, SRP-001 is not hepatotoxic as it does not produce N-acetyl-p-benzoquinone-imine (NAPQI) and maintains hepatic tight junction integrity at high doses. SRP-001 has comparable analgesia in pain models, including the complete Freund's adjuvant (CFA) inflammatory von Frey. Both induce analgesia via N-arachidonoylphenolamine (AM404) formation in the midbrain periaqueductal grey (PAG) nociception area, with SRP-001 generating higher amounts of AM404 than ApAP. Single-cell transcriptomics of PAG uncovered that SRP-001 and ApAP also share modulation of pain-related gene expression and cell signaling pathways, including the endocannabinoid, mechanical nociception, and fatty acid amide hydrolase (FAAH) pathways. Both regulate the expression of key genes encoding FAAH, 2-AG, CNR1, CNR2, TRPV4, and voltage-gated Ca2+ channel. Interim Phase 1 trial results demonstrate SRP-001's safety, tolerability, and favorable pharmacokinetics (NCT05484414). Given its non-hepatotoxicity and clinically validated analgesic mechanisms, SRP-001 offers a promising alternative to ApAP, NSAIDs, and opioids for safer pain treatment.
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2883310/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: In memoriam Yasutomi Nishizuka 1932-2004.

    Bazan, Nicolas

    Molecular neurobiology

    2005  Volume 30, Issue 3, Page(s) i–iv

    MeSH term(s) History, 20th Century ; History, 21st Century ; Japan ; Neurobiology/history
    Language English
    Publishing date 2005-03-11
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-004-0015-2
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