LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 10

Search options

  1. Article ; Online: Digitalising patient reported outcome collection tools in orthopaedic trauma-A scoping review.

    Saleem, Jawaad / Beak, Philip / Eardley, William / Trompeter, Alex

    Injury

    2023  Volume 54, Issue 7, Page(s) 110792

    Abstract: Aims: The aim of this study was to provide a scoping review to the role of digital technology in the collection of orthopaedic trauma related patient reported outcome measures (PROMs) METHODS: The Preferred Reporting Items for Systematic Reviews and ... ...

    Abstract Aims: The aim of this study was to provide a scoping review to the role of digital technology in the collection of orthopaedic trauma related patient reported outcome measures (PROMs) METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews and Arksey and O'Malley frameworks were followed. A search strategy identified relevant literature, with the identified criteria screened for acceptability for inclusion. Data was extracted to form a descriptive analysis.
    Results: Six studies met the criteria for inclusion. All were quantitative, the majority were published in the United States of America and the use of iPads was the commonest form of digital technology used. Heterogeneity existed in the type of outcomes collected between studies. All studies aimed to compare traditional methods of PROMs collection to digital methods, with an overall thematic summary suggestive of the positive impact of electronic methods of collecting patient reported outcomes.
    Conclusion: This paper has demonstrated the dearth of ePROM implementation in the orthopaedic trauma setting, however its use has proved successful and therefore further evidence is needed to demonstrate its effectiveness. Furthermore, the types of PROMs in orthopaedic trauma varies significantly, and efforts to standardise the type of digital trauma PROMs used are recommended.
    MeSH term(s) Humans ; Orthopedic Procedures ; Orthopedics ; Patient Reported Outcome Measures
    Language English
    Publishing date 2023-05-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2023.05.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: A traumatic wrist injury.

    Beak, Philip / Umarji, Shamim

    BMJ (Clinical research ed.)

    2018  Volume 361, Page(s) k2574

    MeSH term(s) Adult ; Closed Fracture Reduction/methods ; Humans ; Joint Dislocations/complications ; Joint Dislocations/diagnostic imaging ; Joint Dislocations/physiopathology ; Lunate Bone/diagnostic imaging ; Lunate Bone/injuries ; Male ; Median Nerve/injuries ; Median Nerve/physiopathology ; Radiography/methods ; Range of Motion, Articular/physiology ; Surgical Fixation Devices/adverse effects ; Treatment Outcome ; Wrist/diagnostic imaging ; Wrist/pathology ; Wrist Injuries/diagnostic imaging ; Wrist Injuries/pathology ; Wrist Injuries/physiopathology ; Wrist Injuries/surgery ; Wrist Joint/abnormalities ; Wrist Joint/diagnostic imaging ; Wrist Joint/pathology
    Language English
    Publishing date 2018-06-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.k2574
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Intra-medullary nail insertion accuracy: A comparison of the infra-patellar and supra-patellar approach.

    Anderson, Thomas R E / Beak, Philip A / Trompeter, Alex J

    Injury

    2018  Volume 50, Issue 2, Page(s) 484–488

    Abstract: Aims: The anatomical safe zone for intra-medullary nail insertion through the tibial plateau is small, insertion outside of this area risks damage to intra-articular structures and poor fracture reduction. The purpose of this retrospective study was to ... ...

    Abstract Aims: The anatomical safe zone for intra-medullary nail insertion through the tibial plateau is small, insertion outside of this area risks damage to intra-articular structures and poor fracture reduction. The purpose of this retrospective study was to determine if the new supra-patella (SP) approach confers improved nail insertion accuracy, when compared with the standard infra-patella (IP) technique.
    Patients and methods: Two hundred cases were included in the study (SP 95, IP 105). Insertion accuracy was assessed on AP and lateral radiographic imaging, and measured as the distances between the central axis of the proximal nail and the ideal entry point.
    Results: The median distance from the ideal entry point was 4.4 mm (SP) and 5.1 mm (IP) (p = 0.046) in the coronal plane, and 4.0 mm (SP) and 3.7 mm (IP) (p = 0.527) in the sagittal plane. A narrower range in measurements was observed in the SP technique in both sagittal and coronal planes, 17.8 mm vs 28.6 mm, and 19.7 mm vs 30.3 mm respectively.
    Conclusion: We found that the SP technique achieved significantly improved nail insertion accuracy in the coronal plane. Insertion accuracy was equivocal between the two techniques in the sagittal plane. A narrower range in entry points was observed in the SP cohort in both planes suggesting improved control in nail insertion using this technique.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bone Nails ; Female ; Fracture Fixation, Intramedullary/methods ; Humans ; Lysholm Knee Score ; Male ; Middle Aged ; Patella/diagnostic imaging ; Patella/surgery ; Radiography ; Reproducibility of Results ; Retrospective Studies ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/physiopathology ; Tibial Fractures/surgery ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2018-12-20
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2018.12.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Four years of experience as a major trauma centre results in no improvement in patient selection for whole-body CT scans following blunt trauma.

    Beak, Philip / Gabbott, Ben / Williamson, Michael / Hing, Caroline B

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

    2019  Volume 30, Issue 3, Page(s) 473–477

    Abstract: Introduction: Management of major trauma patients with evidence of polytrauma involves the use of immediate whole-body CT (WBCT). Identification of patients appropriate for immediate WBCT remains challenging. Our study aimed to assess for improvement in ...

    Abstract Introduction: Management of major trauma patients with evidence of polytrauma involves the use of immediate whole-body CT (WBCT). Identification of patients appropriate for immediate WBCT remains challenging. Our study aimed to assess for improvement in patient selection for WBCT over time as a major trauma centre (MTC).
    Methods: We conducted a retrospective study of patients who presented to our MTC during distinct two-month periods, one in 2013 and the other in 2017. Patients over 18 years of age who presented primarily following blunt trauma and activated a major trauma call were included. All patients underwent either immediate WBCT or standard ATLS workup. Those undergoing WBCT had the results of their scan recorded as positive or negative.
    Results: A total of 516 patients were included, 232 from 2 months in 2013 and 284 from 2 months in 2017. There was no significant difference in the proportion of patients undergoing WBCT (61.6% vs 59.5%), selective CT (31.9% vs 32.4%) or no CT (6.5% vs 8.1%) between the cohorts. There was no improvement in the rate of negative WBCT observed between 2013 and 2017 (47.6% vs 39.6%, p = 0.17).
    Conclusion: There was no improvement in patient selection for WBCT following trauma at our institution over a three-year period. Optimal patient selection presents an ongoing clinical challenge, with 39-47% of patients undergoing a scan demonstrating no injuries.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Quality Improvement/statistics & numerical data ; Retrospective Studies ; Tomography, X-Ray Computed/statistics & numerical data ; Trauma Centers/statistics & numerical data ; Unnecessary Procedures/statistics & numerical data ; Whole Body Imaging/statistics & numerical data ; Wounds, Nonpenetrating/diagnostic imaging ; Young Adult
    Language English
    Publishing date 2019-11-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 1231084-0
    ISSN 1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
    ISSN (online) 1432-1068
    ISSN 1633-8065 ; 0948-4817 ; 0940-3264
    DOI 10.1007/s00590-019-02592-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Painful locking screws with tibial nailing, an underestimated complication.

    Beak, Philip / Moudhgalya, Shyam / Anderson, Thomas / Hing, Caroline B

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

    2019  Volume 29, Issue 8, Page(s) 1795–1799

    Abstract: Background: Tibial fractures represent approximately 3-4% of reported fractures. Locked, intramedullary nails are commonly used to restore length and alignment and provide rotational stability. Few studies have assessed the complication rate of locking ... ...

    Abstract Background: Tibial fractures represent approximately 3-4% of reported fractures. Locked, intramedullary nails are commonly used to restore length and alignment and provide rotational stability. Few studies have assessed the complication rate of locking screws.
    Materials and methods: We conducted a retrospective observational study of all patients who underwent tibial nailing at our institution between the 01/01/15 and 30/06/17. All patients were followed up for at least 1 year post-operatively. For inclusion, patients had to be over 16 years of age and had undergone tibial nail fixation following a traumatic fracture. Post-operative radiographs were used to assess the configuration and features of locking screws.
    Results: One hundred and twenty-six individuals underwent tibial nailing over the 30-month period, with 95 followed up at least 1 year. Twenty-seven per cent of individuals reported pain attributed to locking screws at follow-up. Upon radiographic assessment, no significant difference was seen between symptomatic and asymptomatic cohorts in terms of proud screw heads proximally (7% vs 5%, p > 0.99) or distally (14% vs 17%, p > 0.99), long screw tips proximally (52% vs 48%, p = 0.81) or distally (51% vs 50%, p > 0.99), or tibiofibular joint penetration proximally (31% vs 23%, p = 0.60). However, there was a higher incidence of distal tibiofibular joint penetration in symptomatic versus asymptomatic individuals (4% vs 25%, p = 0.025).
    Conclusion: Twenty-seven per cent of patients with a tibial nail report painful locking screws. Patients with symptomatic distal locking screws had a higher incidence of radiographic distal tibiofibular joint penetration.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bone Nails ; Bone Screws/adverse effects ; Female ; Follow-Up Studies ; Fracture Fixation, Internal/adverse effects ; Fracture Fixation, Internal/instrumentation ; Humans ; Male ; Middle Aged ; Pain, Postoperative/etiology ; Prosthesis Implantation/adverse effects ; Retrospective Studies ; Tibia/diagnostic imaging ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/surgery ; Young Adult
    Language English
    Publishing date 2019-07-16
    Publishing country France
    Document type Journal Article ; Observational Study
    ZDB-ID 1231084-0
    ISSN 1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
    ISSN (online) 1432-1068
    ISSN 1633-8065 ; 0948-4817 ; 0940-3264
    DOI 10.1007/s00590-019-02501-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Novel techniques demonstrate superior fixation of simple transverse patella fractures - A biomechanical study.

    Lenihan, Jonathan / Ramos-Pascual, Sonia / Silvestros, Pavlos / Beak, Philip / Miles, Anthony W / Trompeter, Alex

    Injury

    2020  Volume 51, Issue 6, Page(s) 1288–1293

    Abstract: Introduction: Traditional tension band wiring (TBW) remains the gold standard treatment for simple transverse patella fractures. Challenges include appropriately siting and bending Kirschner wires without damaging surrounding soft tissues. Damage to ... ...

    Abstract Introduction: Traditional tension band wiring (TBW) remains the gold standard treatment for simple transverse patella fractures. Challenges include appropriately siting and bending Kirschner wires without damaging surrounding soft tissues. Damage to soft tissues and malposition of metalwork can lead to complications. We propose three novel techniques for fixation of simple transverse patella fractures to ease application without additional resources to traditional TBW. We tested their biomechanical integrity against traditional TBW.
    Method: Four configurations were tested; two with longitudinal Kirschner Wires (LKW) and two with cross Kirschner Wires (CKW) fixed with either standard figure-of-eight (AO) or side TBW (STBW). An initial proof of concept human cadaveric study was conducted to ensure real world application of the constructs was feasible. The fracture fixations were tested in a biomechanical study using porcine knees. The knees were cyclically loaded in a specially designed test rig through flexion from 90 to 45 degrees. Fracture gap displacement was measured and data blindly analyzed for all tests reaching 100 cycles.
    Results: 17/22 specimens reached 100 cycles with peak loading ranging from 75 to 80 N. CKW with STBW performed best with average fracture displacement of 0.43 mm. LKW with STBW performed worst with average fracture displacement of 1.93 mm. The incremental displacement/cycle for both CKW configurations was 0.27 mm compared to 0.41 & 0.60 mm for both LKW constructs showing that the CKW configuration conferred greater fixation stiffness under cyclic loading.
    Discussion: Previous studies have compared alternative methods of patella fracture fixation to TBW through biomechanical superiority often requiring new resources. The methods tested here utilize the same resources as those for standard AO TBW. Reorientating the plane of the wires and position of the cerclage TBW may reduce iatrogenic soft tissue injury; reduce operating time and the risk of complications.
    Conclusion: This study shows biomechanical superiority for CKW with either AO or STBW compared to LKW.
    MeSH term(s) Animals ; Biomechanical Phenomena ; Bone Wires ; Cadaver ; Fracture Fixation, Internal/instrumentation ; Fracture Fixation, Internal/methods ; Fractures, Bone/surgery ; Humans ; Knee Injuries/physiopathology ; Knee Injuries/surgery ; Patella/injuries ; Patella/surgery ; Range of Motion, Articular ; Swine
    Language English
    Publishing date 2020-03-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 218778-4
    ISSN 1879-0267 ; 0020-1383
    ISSN (online) 1879-0267
    ISSN 0020-1383
    DOI 10.1016/j.injury.2020.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Is Research in Simulation as Accessible as Traditional Clinical Research? A Review of the 'Association for Simulated Practice in Healthcare' Conference.

    Gabbott, Ben / Beak, Philip / Stoddart, Michael / Morgan, Rebecca V / Malik, Dean / Eastwood, Deborah M

    Cureus

    2020  Volume 12, Issue 8, Page(s) e9798

    Abstract: Background Meta-analysis of simulation teaching has shown to be an effective teaching methodology. The Association for Simulated Practice in Healthcare (ASPIH) annual international, multidisciplinary conference is recognised as the leading UK meeting for ...

    Abstract Background Meta-analysis of simulation teaching has shown to be an effective teaching methodology. The Association for Simulated Practice in Healthcare (ASPIH) annual international, multidisciplinary conference is recognised as the leading UK meeting for simulation-based education. We hypothesise that simulation-based research presented at this conference is currently less accessible than more traditional clinical research presentations. Method We reviewed the abstracts of all research presented at the 5
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.9798
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Comprehensive cardiac magnetic resonance imaging and spectroscopy reveals a high burden of myocardial disease in HIV infection

    Holloway Cameron / Ntusi Ntobeko / Suttie Joseph / Mahmod Masliza / Wainwright Emma / Clutton Genevieve / Hancock Gemma / Beak Philip / Tajar Abdelouahid / Piechnik Stefan K / Schneider Jurgen E / Clarke Kieran / Dorrell Lucy / Neubauer Stefan

    Journal of Cardiovascular Magnetic Resonance, Vol 15, Iss Suppl 1, p O

    2013  Volume 25

    Keywords Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  9. Article ; Online: Comprehensive cardiac magnetic resonance imaging and spectroscopy reveal a high burden of myocardial disease in HIV patients.

    Holloway, Cameron J / Ntusi, Ntobeko / Suttie, Joseph / Mahmod, Masliza / Wainwright, Emma / Clutton, Genevieve / Hancock, Gemma / Beak, Philip / Tajar, Abdelouahid / Piechnik, Stefan K / Schneider, Jurgen E / Angus, Brian / Clarke, Kieran / Dorrell, Lucy / Neubauer, Stefan

    Circulation

    2013  Volume 128, Issue 8, Page(s) 814–822

    Abstract: Background: HIV infection continues to be endemic worldwide. Although treatments are successful, it remains controversial whether patients receiving optimal therapy have structural, functional, or biochemical cardiac abnormalities that may underlie ... ...

    Abstract Background: HIV infection continues to be endemic worldwide. Although treatments are successful, it remains controversial whether patients receiving optimal therapy have structural, functional, or biochemical cardiac abnormalities that may underlie their increased cardiac morbidity and mortality. The purpose of this study was to characterize myocardial abnormalities in a contemporary group of HIV-infected individuals undergoing combination antiretroviral therapy.
    Methods and results: Volunteers with HIV who were undergoing combination antiretroviral therapy and age-matched control subjects without a history of cardiovascular disease underwent cardiac magnetic resonance imaging and spectroscopy for the determination of cardiac function, myocardial fibrosis, and myocardial lipid content. A total of 129 participants were included in this analysis. Compared with age-matched control subjects (n=39; 30.23%), HIV-infected subjects undergoing combination antiretroviral therapy (n=90; 69.77%) had 47% higher median myocardial lipid levels (P <0.003) and 74% higher median plasma triglyceride levels (both P<0.001). Myocardial fibrosis, predominantly in the basal inferolateral wall of the left ventricle, was observed in 76% of HIV-infected subjects compared with 13% of control subjects (P<0.001). Peak myocardial systolic and diastolic longitudinal strain were also lower in HIV-infected individuals than in control subjects and remained statistically significant after adjustment for available confounders.
    Conclusions: Comprehensive cardiac imaging revealed cardiac steatosis, alterations in cardiac function, and a high prevalence of myocardial fibrosis in a contemporary group of asymptomatic HIV-infected subjects undergoing combination antiretroviral therapy. Cardiac steatosis and fibrosis may underlie cardiac dysfunction and increased cardiovascular morbidity and mortality in subjects with HIV.
    MeSH term(s) Adult ; Anti-Retroviral Agents/therapeutic use ; Cardiomyopathies/diagnosis ; Cardiomyopathies/epidemiology ; Cardiomyopathies/pathology ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Fibrosis ; HIV Infections/complications ; HIV Infections/drug therapy ; Heart/physiopathology ; Humans ; Lipid Metabolism/physiology ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; Myocardium/metabolism ; Myocardium/pathology ; Prevalence
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2013-07-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.113.001719
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

    Nepogodiev, Dmitri / C Glasbey, James / Li, Elizabeth / Omar, M Omar / FF Simoes, Joana / EF Abbott, Tom / Alser, Osaid / P Arnaud, Alexis / K Bankhead-Kendall, Brittany / A Breen, Kerry / F Cunha, Miguel / H Davidson, Giana / Di Saverio, Salomone / Gallo, Gaetano / A Griffiths, Ewen / R Gujjuri, Rohan / J Hutchinson, Peter / MA Kaafarani, Haytham / Lederhuber, Hans /
    W Löffler, Markus / N Mashbari, Hassan / Minaya-Bravo, Ana / G Morton, Dion / Moszkowicz, David / Pata, Francesco / Tsoulfas, George / L Venn, Mary / M Omar, Aneel Bhangu Omar / Bhangu, Aneel / Siaw-Acheampong, Kwabena / Chaudhry, Daoud / E Dawson, Brett / P Evans, Jonathan / Heritage, Emily / S Jones, Conor / K Kamarajah, Sivesh / Khatri, Chetan / M Keatley, James / Lawday, Samuel / C Mckay, Siobhan / Pellino, Gianluca / Tiwari, Abhinav / M Trout, Isobel / JW Wilkin, Richard / Dissemination Committee: Michel Adamina, Aneel Bhangu. / O Ademuyiwa, Adesoji / Agarwal, Arnav / Alameer, Ehab / Alderson, Derek / Alakaloko, Felix / Magne Augestad, Knut / Barlow, Emma / A Benson, Ruth / Blanco-Colino, Ruth / Brar, Amanpreet / Minaya- Bravo, Ana / Lima Buarque, Igor / J Caruana, Edward / Chakrabortee, Sohini / Cox, Daniel / Desai, Anant / D Drake, Thomas / G Edwards, John / Elhadi, Muhammed / Farik, Shebani / Fiore, Marco / Edward Fitzgerald, J / Ford, Samuel / Ghosh, Dhruv / Mendonça Ataíde Gomes, Gustavo / Halkias, Constantine / M Harrison, Ewen / Isik, Arda / D Jenkinson, Michael / Kolias, Angelos / Lawani, Ismail / Leventoglu, Sezai / Martin, Janet / Mazingi, Dennis / Metallidis, Symeon / M Mohan, Helen / Moore, Rachel / Moug, Susan / S Ng-Kamstra, Joshua / Niquen, Milagros / Ntirenganya, Faustin / Outani, Oumaima / D Pinkney, Thomas / Pockney, Peter / Radenkovic, Dejan / Ramos-De la Medina, Antonio / Roberts, Keith / C Roslani, April / Santos, Irene / Schache, Andrew / A Schnitzbauer, Andreas / D Stewart, Grant / Shaw, Richard / Shu, Sebastian / Soreide, Kjetil / Spinelli, Antonino / Sundar, Sudha / Tabiri, Stephen / Townend, Philip / Tsoulfas, Georgios / H van Ramshorst, Gabrielle / Vidya, Raghavan / Vimalachandran, Dale / J Warren, Oliver / Wright, Naomi / EuroSurg, / Society of Coloproctology (ESCP), European / GlobalPaedSurg, GlobalSurg / PTSurg, ItSURG / SpainSurg, / Society of Colorectal Surgery (SICCR), Italian / of Surgeons in Training (ASiT), Association / Surgical Research Collaborative (ISRC), Irish / Azerbaijan:Elgun Samadov, Joana FF Simoes (Chair). 2 Collaborators: (denotes Local Principal Investigator) Algeria: Faraj S Almaadany (Établissement Hospitalier Spécialisé en Cancérologie - Centre Pierre-et- Marie-Curie). / Namazov, Ilgar / Belgium: Gabrielle H van Ramshorst, Sevda Jafarova (Leyla Medical Center). / Pattyn, Piet / Desender (Ghent University Hospital), Liesbeth / A de Gheldere, Charles / Croatia: Jakov Mihanovic, Nicolas Duchateau (Heilig Hart Ziekenhuis Lier). / Sulen, Nina / Andabaka, Tatjana / Rakvin, Ivan / Denmark: Henry G Smith, Bernarda Bakmaz (Zadar General Hospital). / L Jönsson (Bispebjerg Hospital, Maria / Egypt: Mohamed El Kassas, University of Copenhagen). / Tawheed (Endemic Medicine Department, Ahmed / University), Helwan / Shehata, Sameh / M Ashoush, Fouad / S Abdelaal (Alexandria Main University Hospital), Ahmed / Cairo University), Mahmoud MA Elfiky (Kasr Alainy Faculty of Medicine / H Emile, Sameh / H Elfallal, Ahmed / Elfeki, Hossam / Shalaby (Mansoura University Hospital), Mostafa / M Alrahawy (Menofiya University Hospital), Mahmoud / Gamal Amira, Ibrahim Sallam / Sherief, Ahmed / France: Zaher Lakkis, Mohamed Sherief (MISR Cancer Center/MISR International Hospital). / Doussot, Alexandre / Turco, Celia / Heyd, Bruno / Mathieu (CHU Besançon), Pierre / Chebaro, Alexandre / Lecolle, Katia / Zerbib, Philippe / Truant, Stéphanie / Saudemont, Alain / Pruvot (Lille University Hospital), François-René / Bergeat, Damien / Merdrignac (Rennes University Hospital), Aude / Scalabre, Aurelien / Le Roy, Bertrand / Perotto (CHU Saint Etienne), Ornella / Tzedakis, Stylianos / Gaujoux, Sebastien / - AP-HP), Bertrand Dousset (Hôpital Cochin / Frédéric Bretagnol (Hôpital Louis-Mourier - GHU AP-HP. Nord - Université de Paris), David Moszkowicz / Hervieux, Erik / Maisonneuve, Emeline / Clermidi, Pauline / Aubry, Emmanuelle / - APHP), Anne Thomin (Hôpital Trousseau / Seguin-Givelet, Agathe / Zadegan, Frederic / Conso, Christel / Germany: Carsten Kamphues, Didier Ollat (Institut Mutualiste Montsouris). / C Lauscher, Johannes / Schineis (Charité University Medicine, Christian / Benjamin Franklin), Campus / Thoenissen, Philipp / El Youzouri, Hanan / Schreckenbach, Teresa / A Nguyen (Frankfurt University Hospital, Truong / University), Goethe / Modabber, Ali / Hölzle, Frank / Winnand (University Hospital Aachen), Philipp / Königsrainer, Alfred / Quante, Markus / Yurttas, Can / Greece: Konstantinos Bouchagier, Markus W Löffler (University Hospital Tübingen). / Klimopoulos (Evangelismos General Hospital), Serafeim / Tzovaras, George / Baloyiannis, Ioannis / Perivoliotis (General University Hospital of Larissa), Konstantinos / Lostoridis, Eftychios / Ireland: Arnold DK Hill, Paraskevi Tourountzi (Kavala General Hospital). / A De Marchi, Joshua / Farrell, Tony / F Davis, Niall / Kearney (Beaumont Hospital), David / O Larkin, John / J Mehigan, Brian / A Fahey, Brian / James's Hospital), Conor P Barry (St. / A Elliott, Jessie / A Bass, Gary / M Connolly, Tara / O Kavanagh, Dara / Elkady, Ramy / C Neary, Paul / F Ridgway, Paul / P Joyce, Doireann / Tierney, Sean / Boyle, Emily / 3 University Hospital), Bridget Egan (Tallaght / J Lowery, Aoife / G Collins, Chris / Hogan, Aisling / L McKevitt, Kevin / J Ryan, Éanna / L Fowler, Amy / Israel: Oded Zmora, Thomas M Aherne (Galway University Hospital). / Italy: Maurizio Zizzo, Nadav Kugler (Shamir Medical Center). / Falco, Giuseppe / Castro Ruiz, Carolina / Mele, Simone / Annessi, Valerio / Ferrari, Guglielmo / T Montella (Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia), Maria / Andrea Pisani Ceretti (ASST Santi Paolo e Carlo), Nicolò M Mariani / Lomiento, Daniele / Taglietti, Lucio / Del Giudice, Roberto / Compagnoni, Bruno / Dester (ASST Valcamonica Ospedale di Esine), Sara / Christian Cotsoglou (ASST Vimercate), Stefano Granieri / Campagnaro, Tommaso / Turri, Giulia / Guglielmi, Alfredo / Ruzzenente, Andrea / Pedrazzani, Corrado / Salvia, Roberto / Paiella, Salvatore / Nobile (Azienda Ospedaliera Universitaria Integrata di Verona), Sara / V Marino, Marco / Mirabella, Antonello / Vaccarella (Azienda Ospedaliera, Gianpaolo / Riuniti Villa Sofia-Cervello, Ospedali / Palermo), / Francone, Elisa / Gentilli, Sergio / Nikaj (Azienda Ospedaliero Universitaria Maggiore della Carità, Herald / Novara), / Morelli, Luca / Di Franco, Gregorio / Palmeri, Matteo / Tartaglia, Dario / Coccolini, Federico / Chiarugi (Azienda Ospedaliero Universitaria Pisana), Massimo / Anania, Gabriele / Chiozza, Matteo / Urbani (Azienda Ospedaliero Universitaria San'Anna, Alessia / Ferrara), / Adolfo Pisanu (Cagliari University Hospital), Mauro Podda / Porcu, Alberto / Perra, Teresa / Fancellu (Cliniche San Pietro, Alessandro / Sassari), A. O. U. / Familiari, Pietro / D'Andrea, Giancarlo / Bàmbina (Fabrizio Spaziani Hospital, Fabrizio / Frosinone), / Macchi, Alberto / Citterio, Davide / Mosca, Angelo / Martinelli, Fabio / Rolli, Luigi / Guaglio, Marcello / V Comini, Lara / Capizzi, Vita / Mazzaferro (Fondazione IRCCS Istituto Nazionale dei Tumori, Vincenzo / Milan), / Cozza, Valerio / Gordini, Luca / De Simone, Veronica / Marzi, Federica / A Marra (Fondazione Policlinico Universitario Agostino Gemelli), Angelo / Baldini, Edoardo / Conti, Luigi / Ribolla, Marta / M Isolani, Simone / da Saliceto”, Patrizio Capelli (Ospedale “G. / Piacenza), / Carvello, Michele / Di Candido, Francesca / Kurihara, Hayato / Marrano, Enrico / Torzilli, Guido / Castoro, Carlo / Da Roit, Anna / Mercante, Giuseppe / Spriano, Giuseppe / – IRCCS, Francesca Gaino (Humanitas Clinical and Research Center / Manzoni 56, Via / – Italy), 20089 Rozzano (MI) / Bonavina, Luigi / Asti (IRCCS Policlinico San Donato, Emanuele / of Milan), University / V Feo, Carlo / Fabbri, Nicoló / Righini (Ospedale del Delta, Erminio / Unità Sanitaria Locale di Ferrara, Azienda / of Ferrara), University / Scorza, Antonella / Iovino, Domenico / Carcano (Ospedale di Circolo, Giulio / of Insubria, University / Hospital of Varese, University / Sette Laghi, Asst / Lombardia), Regione / Baldi, Caterina / M Sampietro, Gianluca / - ASST Rhodense), Carlo Corbellin (Ospedale Di Rho / Cellerino, Paola / A Zappa, Marco / Ardito, Antonella / Galfrascoli, Elisa / e Oftalmico), Giulio Iacob (Ospedale Fatebenefratelli / Zanini, Nicola / Palini, Gianmarco / Garulli (Ospedale Infermi di Rimini), Gianluca / Ballabio, Michele / Bisagni, Pietro / Pizzini, Paolo / Gagliano, Annalisa / Armao, Teodora / Longhi, Marco / Madonini, Marco / Luraghi, Marco / Galimberti, Luca / Romano, Silvio / Bastazza, Marco / Trotta, Francesco / Gipponi, Manuel / Malabarba, Stefano / Centinaio (Ospedale Maggiore di Lodi), Giovanna / Mochet, Sylvie / Morelli, Lucia / Usai, Antonella / Grivon, Manuela / Barmasse (Ospedale Regionale Umberto Parini), Roberto / Luigi MP Marino Cosentino (PO San Filippo Neri - ASL ROMA 1), Andrea Sagnotta / Galleano, Raffaele / Malerba, Michele / Baldo (Ospedale Santa Corona, Stefano / Ligure (SV), Pietra / Casati, Massimiliano / Abate, Emmanuele / Laface (Ospedale Vittorio Emanuele III, Letizia / Brianza), Carate / Lizzi, Vincenzo / Vovola, Fernanda / Arminio (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia), Armando / Vergari (Ospedali Riuniti di Ancona), Roberto / Rausa, Emanuele / Bianco, Federica / Lucianetti (Papa Giovanni XXIII Hospital), Alessandro / Guaitoli (Perrino), Eleonora / Pinotti, Enrico / Carissimi, Francesca / Montuori, Mauro / Baronio (Policlinico San Pietro), Gianluca / Campanelli, Michela / S Sica, Giuseppe / Siragusa (Policlinico Tor Vergata Hospital, Leandro / Rome), / 4 Lapolla, Pierfrancesco / Mingoli, Andrea / De Toma, Giorgio / Fiori, Enrico / La Torre, Filippo / Sapienza, Paolo / Brachini, Gioia / Cirillo, Bruno / Iannone, Immacolata / Zambon, Martina / Chiappini, Ambra / Meneghini, Simona / B Fonsi, Giovanni / M Cicerchia, Pierfranco / Bruzzaniti, Placido / Santoro, Antonio / I, Alessandro Di Bartolomeo (Policlinico Umberto / University of Rome), Sapienza / Sasia, Diego / Migliore, Marco / Gattolin (Regina Montis Regalis Hospital, Andrea / Mondovì), / Rottoli, Matteo / Ravaioli, Matteo / Schiavina, Riccardo / Solli, Piergiorgio / Frio (Institute of Neurological Sciences of Bologna, Federico / Bologna), Ausl / Neri, Jacopo / Poggioli, Gilberto / Belvedere, Angela / P Pezzuto, Anna / Parlanti, Daniele / Violante, Tommaso / Tonini, Valeria / Cervellera, Maurizio / Sartarelli (Sant’Orsola Hospital, Lodovico / Mater Studiorum University of Bologna), Alma / Giacometti, Marco / Zonta (Ospedale San Biagio, Sandro / Domodossola, / VCO), Asl / Ferrara, Francesco / Stella, Marco / Gobatti (San Carlo Borromeo Hospital, Davide / e Carlo, ASST Santi Paolo / Costanzi, Andrea / Confalonieri, Marco / Colletti, Gaia / Frattaruolo, Colomba / Monteleone (Ospedale San Leopoldo Mandic, Michela / Merate, / Lecco), Asst / Candiani, Massimo / Bonavina, Giulia / Valsecchi, Luca / Ottolina, Jessica / Mortini, Pietro / Gagliardi, Filippo / Piloni, Martina / Medone, Marzia / Carlucci, Michele / Negri, Giampiero / Bandiera, Alessandro / De Nardi, Paola / Elmore, Ugo / Sileri (San Raffaele Scientific Institute, Pierpaolo / Lisi, Giorgio / Carlini, Massimo / Spoletini (Sant'Eugenio Hospital), Domenico / Carmela Giuffrida, Maria / Borghi, Felice / Puppo, Andrea / D'Agruma, Michele / Marano, Alessandra / Testa, Valentina / e Carle Hospital, Chiara Peluso (Santa Croce / Cuneo), / Barra, Fabio / Ferrero, Simone / Gustavino (Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa), Claudio / Sammarco, Giuseppe / Vescio (University 'Magna Graecia' of Catanzaro), Giuseppina / Fontana (Vittorio Emanuele, Tommaso / Jordan: Mahmoud Al-Masri, Gela). / K Abou Chaar, Mohamad / Libya: Ghadah Z Alkadeeki, Hani Al-Najjar (King Hussein Cancer Center). / S Al Maadany, Faraj / Nasef, Emmhamed / Elkhafeefi, Fatimah / Eljareh (Aljalaa Hospital), Mohammed / EM Bouhuwaish, Ahmad / SA Taher, Ahmed / B Yousuf (Tobruk Medical Center), Farhat / M Morgom (Tripoli Central Hospital), Marwa / A Salamah, Abdulrauf / A Salama, Hiba / Netherlands: Suzanne S Gisbertz, Mustafa R Bulugma (Zawia Teaching Hospital). Mexico: Fernando Cordera (ABC Medical Center). / BJ Borgstein, Alexander / I van Berge Henegouwen (Amsterdam UMC, Mark / of Amsterdam, University / Center Amsterdam), Cancer / Martine Uittenbogaart (Máxima Medical Center), Wouter KG Leclercq / Kruijff, Schelto / PM de Vries, Jean-Paul / Y van der Plas, Willemijn / J Steinkamp, Pieter / KC Jonker (University Medical Center Groningen (University of Groningen), Pascal / Maarten van Heinsbergen (VieCuri Medisch Centrum), Joop Konsten / Portugal: Hugo Santos-Sousa, Pakistan: Mariyah Anwer (Jinnah postgraduate medical center). / Cavaleiro, Salomé / M Leite-Moreira, André / Pereira, André / Pereira-Neves, António / S Faria, Carlos / M Monteiro, Joana / Nogueiro, Jorge / Sampaio-Alves, Mafalda / Magalhães Maia, Mariana / Vieira (Centro Hospital Universitário SãoJoão), Paula / Lázaro, André / Martins, Ricardo / Oliveira, Ana / Costa, Marta / e Universitário de Coimbra), Ana C Almeida (Centro Hospitalar / Tobias Teles (Hospital de Cascais - Dr. José de Almeida), Pedro A Serralheiro / Borges, Filipe / João Lima, Maria / 5 Spain: Eduardo E Rubio, Susana Henriques (Hospital Garcia de Orta). / A Vivas, Alfredo / A Vega (12 de Octubre University Hospital), Viviana / Navarro-Sánchez, Antonio / Martel Lozano, Saida / Camacho Fernández-Pacheco (Complejo Hospitalario Universitario Insular-Materno Infantil), Borja / Carlos Bernal-Sprekelsen, Juan / Martínez Pérez, Carolina / Carlos Catalá Bauset (Consorcio Hospital General Universitario), Juan / Turrado- Rodriguez, Victor / Morales, Xavier / Gracia, Isabel / Pujol-Muncunill, Roger / Borja De Lacy (Hospital Clinic Barcelona), F / M Muguerza, Jose / Dziakova, Jana / Sanchez del Pueblo, Cristina / B Avellana, Rocio / Catalan, Vanesa / Picazo, Sara / Garcia Fernandez, Andres / L Romera, Jose / L Garcia Galocha, Jose / Rojo, Mikel / J Torres, Antonio / Munoz Rivas, Ana / Camarero, Enrique / Saez, Carlos / Lopez Antonanzas (Hospital Clinico San Carlos, Leyre / Madrid), / De Andrés-Asenjo, Beatriz / Beltrán de Heredia, Juan / Vázquez- Fernández, Andrea / Trujillo-Díaz, Jeancarlos / Ruiz-Soriano (Hospital Clínico Universitario de Valladolid), María / San Miguel-Mendez, Carlos / Galván-Pérez, Armando / Robin-Valle, Alvaro / Gonzalez-Gonzalez, Enrique / Calcerrada-Alises, Enrique / Hospital Universitario del Henares), Miguel Angel Garcia-Ureña (Universidad Francisco de Vitoria / Carrasco, Milagros / Giménez, Clara / Medina, Esther / J Fernández, Antonio / Ruiz (Hospital General Universitario Reina Sofía, Miguel / Murcia), / Estaire-Gomez, Mercedes / Martínez-dePaz, Fernando / Sanchez-Pelaez, Daniel / Jimenez-Higuera, Elisa / Martinez-Pinedo, Carlos / Picon-Rodriguez, Rafael / Fernandez-Camuñas, Angel / Padilla-Valverde (Hospital General Universitario De Ciudad Real), David / Rey-Valcarcel, Cristina / Perez-Diaz, Md / Fernández- Martínez, María / Martín-Román, Lorena / Fanjul Gómez, María / Rio-Gomez, Javier / Tousidonis, Manuel / Alonso-Ortuño, Paula / Ayuso-Herrera, Esther / Martin-Albo, Lorena / Aragon-Chamizo, Juan / Lowy- Benoliel, Alejandro / Quintana-Villamandos, Begoña / Sanchez-Perez, Coral / Mateos-Sierra (Hospital General Universitario Gregorio Marañón), Olga / Corral, Javier / Caballero, Albert / i Pujol), Alba Zarate (Hospital Germans Trias / M Diez-Alonso, Manuel / Mendoza-Moreno, Fernando / Vera-Mansilla, Cristina / Ruiz- Grande, Fernando / Hernandez-Juara, Pilar / Blazquez-Martin (Hospital Principe De Asturias), Alma / Soto Montesinos, Cristina / J Gómez Díaz, Carlos / A Guariglia, Claudio / Sanchon Fructuoso, Lorena / L Osorio, Alexander / Farré Font, Roser / - Xarxa Assistencial Universitària de Manresa), Pablo Collera Ormazabal (Fundació Althaia / Mora-Guzmán (Hospital Santa Bárbara), Ismael / Serrano González, Javier / Díaz Pérez, David / Ángel Hernández Bartolomé, Miguel / Gutiérrez Samaniego, María / Galindo Jara (Hospital Universitario de Torrejón, Pablo / de Medicina, Facultad / Francisco de Vitoria, Universidad / Hernandez Garcia, Miguel / Losada Ruiz, Manuel / Dieguez Fernandez, Beatriz / Garcia-Conde Delgado, Maria / Alonso Poza (Hospital Universitario del Sureste), Alfredo / Duque-Mallen, Victoria / Gracia-Roche, Carlos / Martinez-German, Antonio / Santero-Ramirez, Maria-Pilar / Matute-Najarro, Maria-Soledad / De Miguel-Ardevines, Maria-Carmen / Sanchez-Fuentes, Maria-Nieves / Saudi-Moro, Sef / Gascon-Ferrer, Isabel / Herrero-Lopez, Maria / Delgado-Oliver, Eduardo / Sanchez-Rubio, Maria / Cantalejo-Diaz (Hospital Universitario Miguel Servet), Miguel / E Pérez-Sánchez, Luis / Concepción-Martín, Vanesa / Díaz-García (Hospital Universitario Nuestra Señora de Candelaria), Alberto / Ramos, Diego / G Barranquero, Alberto / Ocaña, Juan / Núñez, Jordi / y Cajal), Cristina Cerro (Hospital Universitario Ramón / J Tejero-Pintor, Francisco / Pérez-Saborido, Baltasar / Marcos-Santos, Pablo / Choolani-Bhojwani, Ekta / Acebes-Garcia, Fernando / D Bueno-Cañones, Alejandro / Pacheco-Sanchez, David / Bailon-Cuadrado (Hospital Universitario Río Hortega), Martin / Senent-Boza, Ana / Benítez-Linero, Inmaculada / Ramallo-Solís, Irene / Sánchez- Arteaga, Alejandro / Melero-Cortés, Lidia / Fernández-Marín, Reyes / M Durán-Muñoz-Cruzado (Hospital Universitario Virgen del Rocio), Virginia / Gomez-Rosado, Juan-Carlos / Dolores Del Toro, M / Valdes- Hernandez, Javier / Reguera-Rosal, Julio / Oliva-Mompean (Hospital Universitario Virgen Macarena), Fernando / Sancho-Muriel, Jorge / Cholewa, Hanna / y Politécnico La Fe), Blas Flor (Hospital Universitario / Landaluce-Olavarria, Aitor / Gonzalez-De Miguel, Melania / Fernández-Gomez Cruzado (Hospital Urduliz), Laura / Jimeno, Jaime / Toledo, Enrique / Pascual, Angela / Carrillo, Mariana / Morales, Dieter / 6 Gómez, Marcos / C Rodriguez-Sanjuan (Marqués de Valdecilla University Hospital), Juan / Melody Baeza (Morales Meseguer University Hospital), José Aguilar / Rey-Biel, Juan / Pingarrón-Martín, Lorena / Moliner-Sánchez, Carmen / Ruiz-Martin (Rey Juan Carlos University Hospital), Irene / Escartin, Jorge / luis Blas Laina, Juan / Nogues Pevidal (Royo Villanova), Ana / T Enjuto, Diego / Ramos-Bonilla, Antonio / Pérez-González, Marta / Diaz-Peña, Patricia / Garcés-García, Raúl / Marqueta De Salas, Maria / Sudan: Osman M Ali, Elima P Cagigal- Ortega (Hospital Universitario Severo Ochoa). / Switzerland: Dimitri Christoforidis, Ali A Ali karar (Al-rajhi). / Arigoni, Michele / Mongelli, Francesco / Bernasconi, Matteo / Di Giuseppe (Ente Ospedaliero Cantonale del Canton Ticino), Matteo / Adamina, Michel / Turkey: Volkan Ozben, Georgios Peros (Kantonsspital Winterthur). / Aytac, Erman / Aliyeva (Acibadem Mehmet Ali Aydinlar University, Zumrud / Hospital), Atakent / Kara, Yasin / A Bozkurt, Mehmet / Kocataş (Kanuni Sultan Suleyman Training and Research Hospital), Ali / Altintoprak (Sakarya University Faculty of Medicine), Fatih / Gonullu, Emre / Mantoglu (Sakarya University Research and Educational Hospital), Baris / United Kingdom: Richard J Davies, Alp Yildiz (Yildirim Beyazit University Yenimahalle Training and Research Hospital). / Ashcroft, James / J Baker, Olivia / HV Byrne, Matthew / A Coughlin, Patrick / ZE Durst, Alexander / Georgiades, Fanourios / Habeeb, Amir / E Hudson, Victoria / Luke, Louis / Mitrasinovic, Stefan / Mohan, Midhun / H Murphy, Suzanne / WT Ngu, Albert / R O’Neill, John / Ramzi, Joussi / M Rooney, Siobhan / A Singh, Aminder / Waseem, Saima / Wong (Addenbrooke's Hospital), Ken / Lunevicius, Raimundas / RG Sheel, Andrea / P Jones, Robert / M Nunes, Quentin / L Hughes, Jane / Haq, Iram / Misra, Nikhil / MAS Baig, Mirza / Sundhu (Aintree University Hospital), Matthew / Brendan L Skelly (Altnagelvin Area Hospital), Catherine Rossborough / TA Neely, David / Angelou, Dimitrios / McCanny (Antrim Area Hospital), Andrew / J Pachl (Birmingham Children's Hospital), Max / Elaine YL Leung (The Pan Birmingham Gynaecological Cancer Centre), Sudha Sundar / Vashisht, Rajiv / Amalina Che Bakri, Nur / Nazarian (Bupa Cromwell Hospital), Scarlet / Kontovounisios, Christos / Grove (Department of Colorectal Surgery, Thomas / and Westminster Hospital NHS FT and Imperial College London), Chelsea / Manu, Nichola / J Eardley, Nicola / Krishnan, Emily / L Serevina, Olivia / Martin, Emmeline / G Povey, Meical / P Jones, Andrew / Smith (Countess of Chester Hospital), Claire / Mannan, Syed / A Ayeni, Funbi / Houston, Roy / Tustin (Cumberland Infirmary), Harry / J Rogers, Luke / Minto, Gary / Marchbank, Adrian / Miller, Douglas / Ho, Beatrice / Gohil, Kajal / L Labib, Peter / M Emslie, Katy / CS Clough, Ethan / Enemosah, Ibrahim / Perkins, Clare / Pedram Panahi (University Hospitals Plymouth NHS Trust), Mariam Rela / P Baker, Markus / J Holme, Thomas / J Abbott, Sarah / N Bence, Matthew / Razik, Aisha / Osagie-Clouard (Epsom & / Liza / Helier University Hospitals NHS Trust), St / M Holbrook, Charlotte / Kufeji, Dorothy / Chong (Evelina London Children's Hospital), Clara / S Hammond, John / AG Moir, John / McPherson, Iain / Booth (Freeman Hospital), Karen / K Patel, Panna / Kler, Aaron / Handa, Siddhartha / Redfern (Furness General Hospital), Jennifer / Morgan, Richard / Maw, Andrew / Gala, Tanzeela / Abdelkarim, Mostafa / Asqalan, Ahmad / M Mithany, Reda H / Ibrahim, Sherif / Venkatesan (Glan Clwyd Hospital), Gowtham / Mohammad, Adam / Acharya, Metesh / Rathinam, Sridhar / Nakas (Glenfield Hospital, Apostolos / Leicester), / Higgs, Simon / D Brown, Oliver / Boal, Matthew / Stanger, Sophie / Abdalaziz (Gloucestershire Royal Hospital), Hossam / Sayasneh, Ahmad / Najdy, Manhal / Nath, Rahul / Mehra (Guy's and St Thomas’ NHS Foundation Trust), Gautam / Fehervari, Matyas / R Spalding, Duncan / Pai (Hammersmith Hospital), Madhava / N Naumann, David / Maninder Kalkat, 7 / Syed, Arooj / Alam (Heartlands Hospital), Ruhina / Tayeh, Salim / JG Chase, Thomas / OO Ayorinde, John / Cuming, Tamzin / Ghanbari (Homerton University Hospital), Amir / Loubani, Mahmoud / Aboelkassem-Ibrahim, Ahmad / Cao, Han / Ross, Elizabeth / Totty, Joshua / Wilkins, Alex / Hitchman (Hull University Teaching Hospitals NHS Trust), Louise / R Dixon, Jan / Dunning, Joel / KS Viswanath, Yirupaiahgari / Jha Shane Lester (James Cook University Hospital), Madan / Bond-Smith, Giles / Lami, Mariam / D Tebala, Giovanni / C Tucker, Sarah / V Shaw, Abigail / C Winter, Stuart / Cernei, Cristina / Qureshi, Ali / Belcher, Elizabeth / Wallwork, Kate / Stavroulias, Dionisios / Di Chiara, Francesco / Dare, Oliver / S Jeyaretna, Deva / Ganau, Mario / Chidambaram, Swathikan / Sravanam, Sanskrithi / Sinha, Sanjay / Smillie, Robert / Shah, Karishma / Shankar (Oxford University Hospitals NHS Foundation Trust, Sushma / Dunstan, Matt / Beak, Philip / Gerogiannis (Kingston Hospital NHS Foundation Trust), Ioannis / P Boddy, Alexander / Hossain, Tanvir / Ashmore, Christopher / Annamalai, Seethalakshmi / Kourdouli (Leicester Royal Infirmary), Amar / H Kirmani, Bilal / J Shackcloth, Michael / Harky (Liverpool Heart and Chest Hospital), Amer / A Stylianides, Nicholas / OM Abdalla, Mutwakil / Newton (Manchester Royal Infirmary), Katy / M Bajomo, Oreoluwa / Rizvi, Sana / Darko, Ebenezer / Rahman Saad (Medway Maritime Hospital), Abdel / Li, Zoe / Motter, Dema / Hurt, Libor / Egan, Richard / Harries (Morriston Hospital, Rhiannon / Swansea), / Luke Evans (Norfolk and Norwich University Hospital), Mina MG Youssef / Shah, Jigar / Anthoney, James / Amjad, Rabbia / Harrison, Joseph / Mabrouk, Islam / Hebblethwaite, Bethany / Emmerson (North Manchester General Hospital), Oliver / D Bosch, Karen / Kalidindi, Venugopala / Bashkirova (North Middlesex University Hospital), Varvara / N Rao, Jagan / N Hopkinson, David / Chetty, Govind / Forlani, Stefano / Guha, Soumya / Sherif, Mohamed / Giblin, Anna-Victoria / Lye, George / Whitehall, Emma / M Blundell, Chris / Ward, Alex / Tadross, Daniel / Wells, Fiona / Majkowski (Northern General Hospital, Lawrence / Sheffield), / N Townshend, David / J Mills, Sarah / Seymour, Keith / Shenfine, Amy / McLarty (Northumbria NHS Hospital Trust), Nicola / Kashora, Florence / E Lewis, Sophia / K Ubhi, Harmony / Exley, Rebecca / Singh, Abhinav / Basgaran, Amedra / Bartsch, Anne-Marie / Okechukwu, Valentine / Basha, Amr / Barmpagianni, Christina / Gallagher, Phoebe / Khan, Umul / Maqsood, Afnan / Shah, Preena / Saxena, Shobhit / Sahnan, Kapil / Zafar (Northwick Park Hospital), Noman / A Rollett, Rebecca / L Collins, Michelle / S Tamimy, Muhammad / Riyat, Harjoat / Neil-Dwyer, Jason / Wen, Jiaxin / Burnside, Nathan / Weaver, Helen / Hawari, Mohammad / Addae-Boateng, Emmanuel / P Duffy (Nottingham City Hospital), John / Catriona R Luney (Nuffield Orthopaedic Centre), Benjamin JF Dean / Sarveswaran, Janahan / Patil, Sangram / Ravindran, Sharanya / Scott, Lucy / Michel (Pinderfields Hospital), Martin / Yousra Ahmed (Portsmouth Hospital NHS Trust), Simon Toh / Vijay, Vardhini / Shakir, Taner / Hasan, Raashad / Tansey (Princess Alexandra Hospital), Rosamond / Patel, Mahul / Shabana, Amanda / Paisley (Brighton and Sussex NHS Trust, Samuel / Royal Hospital), Princess / S Khan (Queen Alexandra Hospital), Jim / P Kisiel, Aaron / Kamal, Mona / D Cato, Liam / Parente, Alessandro / Kulkarni, Rugved / A Saeed, Samerah / Mak (Queen Elizabeth Hospital Birmingham), Jason / Liew, Ignatius / Al-Sukaini, Ahmad / Saxena, Dolly / Mediratta, Saniya / Ali Mohamed Ali (Queen Elizabeth Hospital King's Lynn), Inthekab / Smith, Andrew / Fell, Adam / English, Camilla / Kristinsson, Sverrir / Goatly, Giles / Evans (Queen Elizabeth the Queen Mother Hospital Margate), Jessica / Glen, Paul / Al-Azzawi, Marwa / Aitken (Queen Elizabeth University Hospital), Emma / Mukherjee, Samrat / Singh, Shailendra / Smith, Christopher / English, William / Vulliamy, Paul / Karam, Edward / Chui, Karen / Mansuri, Ahmer / Sivayoganathan, Sriharan / A Aaraj, Mahmoud / El-Ali (Queen's Hospital, Abess / Romford), / H Chowdhury, Abeed / Worku (Queen’s Medical Centre, Dawit / University Hospitals NHS Trust), Nottingham / Hampton (Rotherham District General Hospital), Matthew / Manson, Joanna / Findlay, Laura / Majkowska, Agata / Brixton, Genevieve / Potter (Royal Bournemouth Hospital), Ryan / C De Souza, Anthony / Rochon, Melissa / Cannoletta (Royal Brompton Hospital), Marina / Bhalla, Ashish / Prita Daliya, 8 / Chia (Royal Derby Hospital), Zoe / M Pollok, Joerg / A Raptis, Dimitri / R Davidson, Brian / K Fusai, Giuseppe / E Xyda, Souzana / Soggiu, Fiammetta / Machairas (Royal Free Hospital), Nikolaos / C Bosanquet, David / M Tang, Alethea / J Beamish, Andrew / Nassa, Heeam / Price, Claire / Williams, Gethin / Magowan, Drew / Solari (Royal Gwent Hospital), Francesca / J Davies, Emma / Ryska, Ondrej / Hawkin, Paul / Raymond (Royal Lancaster Infirmary), Thomas / D Baron, Ryan / Szatmary, Peter / Gahunia, Sukhpreet / J Thomas, Amy / FJ Dunne, Declan / E Nita, George / Sochorova (Royal Liverpool University Hospital), Dana / Sivaprakasam, Rajesh / Sohrabi, Catrin / SJ Ledesma, Frances / A Thaha, Mohamed / BB Sullivan (The Royal London Hospital), Tom / Rachel Baumber (Royal National Orthopaedic Hospital), James T Parry / Stewart, Robbie / Ullah, Ramzan / Armstrong, Lara / Jones, Mark / Aljanadi, Firas / Moawad (Royal Victoria Hospital), Nader / JM Ferguson, Henry / Ramcharan, Sean / Yershov (South Warwickshire NHS Foundation Trust), Danylo / C Hopkins, James / J Doe, Matthew / K Ambler, Graeme / Lostis, Emilie / Lawday (Southmead Hospital), Samuel / H Babu, Bheemanakone / D Liyanage, Aloka S / K Weerasinghe, Chamindri / Blake (Southport and Formby District General Hospital), Iain / Sanders, Julie / Bueser, Teofila / Curtis, Miles / Y Oo (Department of Cardiothoracic Surgery, Aung / Bartholomew's Hospital), St / Anwar, Sibtain / Sohrabi (St Bartholomew's Hospital), Catrin / J Williams, Katherine / A Chung, Eric / Hagger, Robert / Karim, Ahmed / J Hainsworth, Alison / Flatman, Michael / B Hing, Caroline / Trompeter (St George's Hospital), Alex / Lo, Terence / G Wade, Ryckie / Bourke, Grainne / R Burke, Joshua / L Young, Alastair / JS Wall, Joshua / Johnstone, Jack / Peckham- Cooper, Adam / Elkadi, Hannah / R Kowal, Mikolaj / Pompili, Cecilia / WS Ho (Leeds Teaching Hospitals NHS Trust, Michael / Leeds), / Kinross, James / AH Ibrahim, Mohamed / Abuown, Ala / Denning, Max / Ereidge, Simon / Yalamanchili, Seema / Martin (St Mary's Hospital), Guy / James RW Hall (Stepping Hill Hospital), Claire Hall / J Baldwin, Alexander / Gammeri, Emanuele / West, Raha / CR Wormald, Justin / B Catton, Andrew / Kudsk-Iversen, Søren / Marinos Kouris (Buckinghamshire Healthcare NHS Trust), Spyros / Nugent, Michael / J Lin, Daniel / Kang, Chong / J Scurrah, Rachel / D Rajgor, Amarkumar / Steel (Sunderland Royal Hospital), Ben / Day, Andrew / P Belgaumkar, Ajay / Oyewole, Bankole / Gilbert (Surrey and Sussex Healthcare NHS Trust), Catherine / Ford (The Robert Jones and Agnes Hunt Orthopaedic Hospital), David / Duff, Sarah / Khan, Azam / Asaad, Peter / S Moura, Francisco / C Brown (Manchester University NHS Foundation Trust, Benjamin / Hospital), Wythenshawe / Zakaria, Rasheed / Elmoslemany (The Walton Centre NHS Foundation Trust), Tarek / Parmar, Chetan / J McCluney, Simon / Shah (The Whittington Hospital), Sujay / Deepti Sinha (University College London Hospital), Nicholas Kalavrezos / Tewari, Nilanjana / JM Dunne, Naomi / J Carlos, William / K Gill, Charn / Godbole, Chintamani / E Dickson, Kathryn / Khajuria, Apoorva / Connolly, Hannah / Naredla, Pradyumna / R Sarma, Diwakar / Robertson (University Hospitals Coventry and Warwickshire), Stuart / Morris, Chris / Richards, Tomos / Torkington, Jared / Williams, Matthew / Shinkwin, Michael / Jayaraju (University Hospital of Wales), Ullas / P Singh, Rabindra / Aftab, Raiyyan / Warwick (University Hospital Southampton), David / A Khalefa, Mohamed / S Hossain, Fahad / Osman (Walsall Manor Hospital), Khabab / M Andreani, Stefano / F Bath, Michael / Sahni, Arun / Judkins, Nicholas / R Springford, Laurie / Sohrabi (Whipps Cross University Hospital), Catrin / S Wadley, Martin / Tyler, Jayne / Wild, Laura / Wall, Rosemary / Jenner, Edward / Chamberlain, Stephanie / Thrush, Jessica / Brain, Jessie / Townsend, Catherine / Stringer, Sally / Breckles, Lisa / Flindall, Ian / Phenix, George / Thomas (Worcestershire Acute Hospitals NHS Trust), Kane / Young, Richard / MacDonald, Luisa / Green, Susanna / Miu, Victor / Sheridan, Kelda / United States: John RT Monson (AdventHealth Orlando), Lavinia Onos (York Teaching Hospitals NHS Trust). / Maha H Haqqani (Boston Medical Center), Frederick T Drake / Cooper, Zara / Salim, Ali / A Hirji, Sameer / K Brown, Allison / Chung, Choyin / Laura Hansen, 9 / Okafor, Barbara U. / I Roxo (Brigham and Women's Hospital), Vanessa / E Rice, Henry / Shelley Hwang, E. / G Blazer III, Dan / J Hall, Bria / A Olson (Duke University Medical Center), Steven / Nehra, Deepika / Cuschieri, Joseph / M Walters (Harborview Medical Center, Andrew / of Washington), University / M Nygaard, Rachel / T Colonna, Emily / W Endorf (Hennepin Healthcare), Frederick / Gabriel Kinnaman (IU Health Methodist Hospital), Ashley D Meagher / McKenzie, Katherine / R Fretwell, Kenneth / Chan, Jeffrey / C Nugent III, William / Chen (Jamaica Hospital), David / A Stevens, Kent / W Etchill, Eric / E Jenny (Johns Hopkins Hospital), Hillary / Dehal (Kaiser Permanente Panorama City Medical Center), Ahmed / C Velmahos (Massachusetts General Hospital), George / Chang, Grace / Dehart, Dustin / Ourieff (Mount Sinai Hospital), Jared / Anita Volpe (New York Presbyterian Queens), Stephen Merola / Podolsky, Dina / L Coleman, Natasha / / Columbia University Medical Center), Miriam Callahan (NewYork-Presbyterian / EM Brathwaite, Collin / H Liu, Helen / Petrone, Patrizio / Baltazar, Gerard / Hakmi, Hazim / - NYU Winthrop Hospital), Amir H Sohail (NYU Langone Health / P Hazelton, Joshua / E Ssentongo, Anna / Ssentongo (Pennsylvania State University), Paddy / Jamil, Tahir / Al-Embideen, Somya / Seegert (ProMedica Toledo Hospital), Sara / Anuradha R Bhama (Rush University Medical Center), Alfonso Torquati / L Biffl, Walter / B Schaffer, Kathryn / L Marsh (Scripps Memorial Hospital), Christopher / M Philp, Matthew / Ross, Howard / Santora, Thomas / Pathak, Abhijit / M Sewards, Joseph / Pontari, Michael / L Engel (Temple University Hospital), Jamie / Giorgakis, Emmanouil / V Bhavaraju, Avi / J Kalkwarf, Kyle / Roberts, Matthew / Robertson (University of Arkansas for Medical Sciences), Ronald / A Callcut, Rachael / E Canova, Michaela / Suri (University of California Davis Health, Avni / of Surgery), Department / G Velopulos, Catherine / Carmichael, Heather / C McIntyre, Robert / L Wright, Franklin / Urban (University of Colorado Hospital), Shane / Neal Bhutiani (University of Louisville Hospital and Norton Hospital), Robert CG Martin / J Diaz, Jose / Abdou, Hossam / B O'Meara, Lindsay / Richmond (University of Maryland Medical Center), Michael / Almasri, Murad / Marwan, Hisham / Q Mehdi (University of Texas Medical Branch), Mohammad / Shen Ban, Vin / G Aoun, Salah / Data Monitoring and Ethics Committee: Deborah S Keller, H. Hunt Batjer (University of Texas Southwestern). / J Smart, Neil

    an international cohort study

    2020  

    Abstract: Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and ... ...

    Abstract Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 82·6% (219 of 265) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28-2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65-3·22], p<0·0001), American Society of Anesthesiologists grades 3-5 versus grades 1-2 (2·35 [1·57-3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01-2·39], p=0·046), emergency versus elective surgery (1·67 [1·06-2·63], p=0·026), and major versus minor surgery (1·52 [1·01-2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery.
    Keywords covid19
    Subject code 616 ; 610
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top