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  1. Book: Protein trafficking in neurons

    Bean, Andrew J.

    2007  

    Author's details ed. Andrew J. Bean
    Keywords Protein Transport ; Neurons / metabolism ; Nervenzelle ; Proteintransport
    Subject Proteine ; Proteintranslokation ; Ganglienzelle ; Neurozyt ; Neuron
    Language English
    Size XV, 448 S. : Ill., graph. Darst.
    Publisher Elsevier Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014851427
    ISBN 978-0-12-369437-9 ; 0-12-369437-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 272 order for loan Magazin

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  2. Article ; Online: Racial, socioeconomic, and neighborhood characteristics in relation to COVID-19 severity of illness for adolescents and young adults.

    Dahleh, Ayaat / Bean, Andrew J / Johnson, Tricia J

    PNAS nexus

    2023  Volume 2, Issue 11, Page(s) pgad396

    Abstract: This study tests the hypotheses that insurance status, race and ethnicity, and neighborhood characteristics are associated with hospital admission and severe health outcomes (Intensive Care Unit [ICU] admission and oxygen assistance) for youth and young ... ...

    Abstract This study tests the hypotheses that insurance status, race and ethnicity, and neighborhood characteristics are associated with hospital admission and severe health outcomes (Intensive Care Unit [ICU] admission and oxygen assistance) for youth and young adults who present to the emergency department (ED) with COVID-19 in a single, academic health system in Illinois, Rush University System for Health (RUSH). Demographic and clinical data from the electronic health record were collected for all 13- to 24-y-old patients seen at RUSH who tested positive for COVID-19 between March 2020 and 2021. Individual-level and neighborhood characteristics were analyzed to determine their association with hospital admission and severe health outcomes through generalized estimating equations. As of March 2021, 1,057 patients were seen in the ED within RUSH in which non-Hispanic White (odds ratio [OR], 2.96; 95% CI, 1.61-5.46;
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgad396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Low UBE4B expression increases sensitivity of chemoresistant neuroblastoma cells to EGFR and STAT5 inhibition.

    Memarzadeh, Kimiya / Savage, David J / Bean, Andrew J

    Cancer biology & therapy

    2019  Volume 20, Issue 12, Page(s) 1416–1429

    Abstract: Neuroblastoma is the most common malignancy in infants. Overexpression of the epidermal growth factor receptor (EGFR) in neuroblastoma tumors underlies resistance to chemotherapeutics. UBE4B, an E3/E4 ubiquitin ligase involved in EGFR degradation, is ... ...

    Abstract Neuroblastoma is the most common malignancy in infants. Overexpression of the epidermal growth factor receptor (EGFR) in neuroblastoma tumors underlies resistance to chemotherapeutics. UBE4B, an E3/E4 ubiquitin ligase involved in EGFR degradation, is located on chromosome 1p36, a region in which loss of heterozygosity is observed in approximately one-third of neuroblastoma tumors and is correlated with poor prognosis. In chemoresistant neuroblastoma cells, depletion of UBE4B yielded significantly reduced cell proliferation and migration, and enhanced apoptosis in response to EGFR inhibitor, Cetuximab. We have previously shown that UBE4B levels are inversely correlated with EGFR levels in neuroblastoma tumors. We searched for additional targets of UBE4B that mediate cellular alterations associated with tumorogenesis in chemoresistant neuroblastoma cells depleted of UBE4B using reverse phase protein arrays. The expression of STAT5a, an effector protein downstream of EGFR, doubled in the absence of UBE4B, and verified by quantitative immunoblotting. Chemoresistant neuroblastoma cells were treated with SH-4-54, a STAT5 inhibitor, and observed insignificant effects on cell proliferation, migration, and apoptosis. However, SH-4-54 significantly enhanced the anti-proliferative and anti-migratory effects of Cetuximab in naïve SK-N-AS neuroblastoma cells. Interestingly, in UBE4B depleted SK-N-AS cells, SH-4-54 significantly potentiated the effect of Cetuximab rendering cells increasingly sensitive an otherwise minimally effective Cetuximab concentration. Thus, neuroblastoma cells with low UBE4B levels were significantly more sensitive to combined EGFR and STAT5 inhibition than parental cells. These findings may have potential therapeutic implications for patients with 1p36 chromosome LOH and low tumor UBE4B expression.
    MeSH term(s) Apoptosis/drug effects ; Apoptosis/genetics ; Biomarkers ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation/drug effects ; Cetuximab/pharmacology ; Drug Resistance, Neoplasm/genetics ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Humans ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/pathology ; Protein Array Analysis ; Protein Kinase Inhibitors/pharmacology ; STAT5 Transcription Factor/antagonists & inhibitors ; STAT5 Transcription Factor/genetics ; Tumor Suppressor Proteins/antagonists & inhibitors ; Tumor Suppressor Proteins/genetics ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances Biomarkers ; Protein Kinase Inhibitors ; STAT5 Transcription Factor ; STAT5A protein, human ; Tumor Suppressor Proteins ; UBE4B protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Cetuximab (PQX0D8J21J)
    Language English
    Publishing date 2019-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146305-0
    ISSN 1555-8576 ; 1538-4047
    ISSN (online) 1555-8576
    ISSN 1538-4047
    DOI 10.1080/15384047.2019.1647049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Institutional Interventions That Remove Barriers to Recruit and Retain Diverse Biomedical PhD Students.

    Wilson, Marenda A / DePass, Anthony / Bean, Andrew J

    CBE life sciences education

    2018  Volume 17, Issue 2, Page(s) ar27

    Abstract: The faculty and student populations in academia are not representative of the diversity in the U.S.: Population: Thus, research institutions and funding agencies invest significant funds and effort into recruitment and retention programs that focus on ...

    Abstract The faculty and student populations in academia are not representative of the diversity in the U.S.
    Population: Thus, research institutions and funding agencies invest significant funds and effort into recruitment and retention programs that focus on increasing the flow of historically underrepresented minorities (URMs) into the science, technology, engineering, and mathematics (STEM) pipeline. Here, we outline challenges, interventions, and assessments by the University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (GSBS) that increased the diversity of the student body independently of grade point averages and Graduate Record Examination scores. Additionally, we show these efforts progressively decreased the attrition rates of URM students over time while eliminating attrition in the latest cohort. Further, the majority of URM students who graduate from the GSBS are likely to remain in the STEM pipeline beyond the postdoctoral training period. We also provide specific recommendations based on the data presented to identify and remove barriers that prevent entry, participation, and inclusion of the underrepresented and underserved in the STEM pipeline.
    MeSH term(s) Biomedical Research/education ; Cultural Diversity ; Education, Graduate ; Educational Measurement ; Engineering/education ; Female ; Humans ; Interviews as Topic ; Male ; Mathematics/education ; Minority Groups/education ; Personnel Selection ; Social Support ; Students ; Technology/education
    Language English
    Publishing date 2018-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2465176-X
    ISSN 1931-7913 ; 1931-7913
    ISSN (online) 1931-7913
    ISSN 1931-7913
    DOI 10.1187/cbe.17-09-0210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Model for Holistic Review in Graduate Admissions That Decouples the GRE from Race, Ethnicity, and Gender.

    Wilson, Marenda A / Odem, Max A / Walters, Taylor / DePass, Anthony L / Bean, Andrew J

    CBE life sciences education

    2019  Volume 18, Issue 1, Page(s) ar7

    Abstract: Graduate schools around the United States are working to improve access to science, technology, engineering, and mathematics (STEM) in a manner that reflects local and national demographics. The admissions process has been the focus of examination, as it ...

    Abstract Graduate schools around the United States are working to improve access to science, technology, engineering, and mathematics (STEM) in a manner that reflects local and national demographics. The admissions process has been the focus of examination, as it is a potential bottleneck for entry into STEM. Standardized tests are widely used as part of the decision-making process; thus, we examined the Graduate Record Examination (GRE) in two models of applicant review: metrics-based applicant review and holistic applicant review to understand whether it affected applicant demographics at The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences. We measured the relationship between GRE scores of doctoral applicants and admissions committee scores. Metrics-based review of applicants excluded twice the number of applicants who identified as a historically underrepresented minority compared with their peers. Efforts to implement holistic applicant review resulted in an unexpected result: the GRE could be used as a tool in a manner that did not reflect its reported bias. Applicant assessments in our holistic review process were independent of gender, racial, and citizenship status. Importantly, our recommendations provide a blueprint for institutions that want to implement a data-driven approach to assess applicants in a manner that uses the GRE as part of the review process.
    MeSH term(s) Continental Population Groups ; Education, Graduate ; Educational Measurement ; Ethnic Groups ; Gender Identity ; Humans ; Minority Groups ; Models, Educational ; School Admission Criteria ; Statistics as Topic ; United States
    Language English
    Publishing date 2019-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2465176-X
    ISSN 1931-7913 ; 1931-7913
    ISSN (online) 1931-7913
    ISSN 1931-7913
    DOI 10.1187/cbe.18-06-0103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Regulation of Somatostatin Receptor 2 Trafficking by C-Tail Motifs and the Retromer.

    Olsen, Courtney / Memarzadeh, Kimiya / Ulu, Arzu / Carr, Heather S / Bean, Andrew J / Frost, Jeffrey A

    Endocrinology

    2019  Volume 160, Issue 5, Page(s) 1031–1043

    Abstract: The Gi-coupled somatostatin receptor 2 (SST2) is a G protein-coupled receptor (GPCR) that mediates many of somatostatin's neuroendocrine actions. Upon stimulation, SST2 is rapidly internalized and transported to early endosomes before being recycled to ... ...

    Abstract The Gi-coupled somatostatin receptor 2 (SST2) is a G protein-coupled receptor (GPCR) that mediates many of somatostatin's neuroendocrine actions. Upon stimulation, SST2 is rapidly internalized and transported to early endosomes before being recycled to the plasma membrane. However, little is known about the intracellular itinerary of SST2 after it moves to the early endosomal compartment or the cytoplasmic proteins that regulate its trafficking. As postsynaptic density protein/discs large 1/zonula occludens-1 (PDZ) domain interactions often regulate the trafficking and signaling potential of GPCRs, we examined the role of the SST2 PDZ ligand and additional C-terminal residues in controlling its intracellular trafficking. We determined that SST2 can recycle to the plasma membrane via multiple pathways, including a LAMP1/Rab7-positive late endosome to the trans-Golgi network (TGN) pathway. Trafficking from the late endosome to the TGN is often regulated by the retromer complex of endosomal coat proteins, and disrupting the retromer components sorting nexins 1/2 inhibits the budding of SST2 from late endosomes. Moreover, trafficking through the late endosomal/TGN pathway is dependent on an intact PDZ ligand and C-terminal tail, as truncating either the 3 or 10 C-terminal amino acids of SST2 alters the pathway through which it recycles to the plasma membrane. Moreover, addition of these amino acids to a heterologous receptor is sufficient to redirect it from a degradation pathway to a recycling itinerary. Our results demonstrate that endosomal trafficking of SST2 is dependent on numerous regulatory mechanisms controlled by its C terminus and the retromer machinery.
    MeSH term(s) Amino Acid Motifs ; Amino Acid Sequence ; Base Sequence ; Cell Membrane/metabolism ; Endosomes/metabolism ; HEK293 Cells ; Humans ; Membrane Proteins/metabolism ; Multiprotein Complexes/metabolism ; Nucleotide Motifs ; PDZ Domains ; Protein Transport ; Receptors, Somatostatin/chemistry ; Receptors, Somatostatin/genetics ; Receptors, Somatostatin/metabolism ; Signal Transduction ; trans-Golgi Network/metabolism
    Chemical Substances Membrane Proteins ; Multiprotein Complexes ; Receptors, Somatostatin ; somatostatin receptor 2 (D73QL0OMU2)
    Language English
    Publishing date 2019-02-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2018-00865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.72: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Protein trafficking in neurons

    Bean, Andrew J

    2007  

    Author's details editor, Andrew J. Bean
    Keywords Proteins/Physiological transport. ; Neurons.
    Language English
    Size xv, 448 p. :, ill. (chiefly ill.) ;, 27 cm.
    Publisher Elsevier/Academic Press
    Publishing place Amsterdam ; Boston
    Document type Book
    ISBN 012369437X ; 9780123694379
    Database NAL-Catalogue (AGRICOLA)

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  8. Book: Protein trafficking in neurons

    Bean, Andrew J

    2007  

    Author's details editor, Andrew J. Bean
    MeSH term(s) Protein Transport ; Neurons/metabolism
    Language English
    Size xv, 448 p. :, ill.
    Publisher Elsevier/Academic Press
    Publishing place Amsterdam ; Boston
    Document type Book
    ISBN 9780123694379 ; 012369437X
    Database Catalogue of the US National Library of Medicine (NLM)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Book ; Online: Protein trafficking in neurons

    Bean, Andrew J

    2007  

    Abstract: The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking ...

    Institution ScienceDirect (Online service)
    Author's details editor, Andrew J. Bean
    Abstract The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. Provides a comprehensive examination of membrane/protein movement in neuronal function. Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease Includes a focus on Molecular Mechanisms Illustrated with color summary pictures The only book examining protein trafficking and its functional implications, written by leaders in the field
    MeSH term(s) Neurons/metabolism ; Protein Transport
    Keywords Neurons ; Proteins/Physiological transport
    Language English
    Size Online-Ressource (xv, 448 p), ill. (chiefly ill.), 27 cm
    Publisher Elsevier/Academic Press
    Publishing place Amsterdam ;Boston
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 0080465897 ; 012369437X ; 9780080465890 ; 9780123694379
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book ; Online: Protein trafficking in neurons

    Bean, Andrew J

    2007  

    Abstract: The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking ...

    Institution ScienceDirect (Online service)
    Author's details editor, Andrew J. Bean
    Abstract The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. Provides a comprehensive examination of membrane/protein movement in neuronal function. Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease Includes a focus on Molecular Mechanisms Illustrated with color summary pictures The only book examining protein trafficking and its functional implications, written by leaders in the field
    MeSH term(s) Neurons/metabolism ; Protein Transport
    Keywords Neurons ; Proteins/Physiological transport
    Language English
    Size Online-Ressource (xv, 448 p), ill. (chiefly ill.), 27 cm
    Publisher Elsevier/Academic Press
    Publishing place Amsterdam ;Boston
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 0080465897 ; 012369437X ; 9780080465890 ; 9780123694379
    Database Former special subject collection: coastal and deep sea fishing

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