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  1. Article ; Online: Síndrome mielodisplásica variante hipoplásica

    Henrique Girão Martins / Karine Sampaio Nunes Barroso / João Paulo de Vasconcelos Leitão / Beatriz Stela Gomes de Souza Pitombeira Araujo / Fernando Barroso Duarte

    Revista de Medicina da UFC, Vol 62, Iss 1, Pp 1-

    análise estatística no serviço de transplante de medula óssea do Hospital Universitário Walter Cantídio

    2022  Volume 7

    Abstract: Objetivos: Analisar, nos pacientes com síndrome mielodisplásica (SMD) variante hipoplásica do serviço de transplante de medula óssea, a resposta ao transplante e realizar comparação com os dados do banco de dados Latino-Americano de SMD. Metodologia: ... ...

    Abstract Objetivos: Analisar, nos pacientes com síndrome mielodisplásica (SMD) variante hipoplásica do serviço de transplante de medula óssea, a resposta ao transplante e realizar comparação com os dados do banco de dados Latino-Americano de SMD. Metodologia: Estudo analítico, corte transversal e retrospectivo por análise de prontuários, incluídos todos os pacientes com diagnóstico de SMD submetidos a transplante de medula óssea, avaliação do seguimento pós-transplante, sobrevida global e complicações. Comparação com dados do banco de dados da Sociedade Latino-Americana de SMD. Análise estatística pelo programa JAMOVI e MedCalc. Resultados: Um total de 13 pacientes com SMD receberam transplante de medula óssea alogênico, dos quais 6 apresentavam variante hipoplásica, correspondendo a 46,15%. Comparado aos dados do banco de dados latino-americano, essa porcentagem é de apenas 12,75%. Conclusões: Nosso serviço apresentou uma frequência maior de SMD variante hipoplásica que a descrita na literatura médica, que corresponde a apenas 10-15%. Dos 6 pacientes portadores de SMDh, dois evoluíram a óbito, chegando a 33,3% contra os 13,5% do banco de dados Latino-Americano. Os outros pacientes transplantados encontram-se em remissão até o presente momento com taxa de sobrevida global em 2 anos de 83,3%, apresentando bons resultados comparados à literatura mundial.
    Keywords síndromes mielodisplásicas ; neoplasias da medula óssea ; transplante de medula óssea ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Universidade Federal do Ceará
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Hodgkin’s Lymphoma - evaluation of patients submitted to Autologous transplantation of hematopoietic cells in the Hematology Service of the Hospital Walter Cantídio – Fortaleza, Brazil.

    Fernando Barroso Duarte / Mabel Gomes de Brito Fernandes / Jacques Kaufmann / Karine Sampaio Nunes Barroso / João Paulo de Vasconcelos Leitão / Beatriz Stela Gomes de Souza Pitombeira Araujo / Clara Maria Bastos Eloy da Costa / Acy Teles Quixadá-medica / Jacqueline de Souza Holanda / Samuel Vasconcelos Landim / Maria Helena Pitombeira

    Revista da Associação Médica Brasileira, Vol 62, Iss suppl 1, Pp 34-38

    Abstract: SUMMARY The Autologous HSCT is an important alternative for refractory or recurrent HL patients in terms of survival and improved quality of life. This study analyzes the results of autologous BMT performed in HL patients in the Transplant Unit of the ... ...

    Abstract SUMMARY The Autologous HSCT is an important alternative for refractory or recurrent HL patients in terms of survival and improved quality of life. This study analyzes the results of autologous BMT performed in HL patients in the Transplant Unit of the HUWC/ HEMOCE (Fortaleza - CE, Brazil). Fifty-two transplanted patients were studied from January 2009 to October 2015, among them, 30 men and 22 women, mean age of 28.2 years. All of them received GCS-F during the mobilization, in some cases associated with Vinorelbine or Plerixafor, with CD34 collection averaging 4.8 CD34/kg. The conditioning was performed with BEAC, NEAM or BEAM and the grafting with an average of 10 days. The evaluation on D + 100 showed: CR - 42 (82.7%), PR - 08 (13.5%) and 02 (3.8%) deaths, three and six days after cell infusion. After the D+100, 08 patients in CR showed HL recurrence from 06 to 36 months; 03 died and 05 are being treated with brentuximab; among the 08 patients in PR, 01 died due to HL activity, 04 months after BMT and 07 patients are undergoing treatment. The final evaluation of HL transplant patients showed an OS of 88.5% and a DFS of 61.5% in 6 years, with OS of the chemosensitive patients of 81% and of the chemoresistant ones, of 72.6%. It is possible to conclude that the Autologous HSCT has shown to be an excellent rescue therapy regarding tolerance, as well as the overall survival.
    Keywords Transplante de células-tronco hematopoiéticas ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Wernicke's encephalopathy in a patient with non-Hodgkin's lymphoma post-Autologous HSCT

    João Paulo de Vasconcelos Leitão / Romélia Pinheiro Gonçalves Lemes / Maritza Cavalcante Barbosa / Beatriz Stela Gomes de Souza Pitombeira Araújo / Karine Sampaio Nunes Barroso / Jacques Kaufman / Talyta Ellen de Jesus dos Santos / Anna Thawanny Gadelha Moura / André Rodrigues Façanha Barreto / Fernando Barroso Duarte

    Revista da Associação Médica Brasileira, Vol 64, Iss 10, Pp 882-884

    Abstract: SUMMARY Wernick's Encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency post hematopoietic stem cell transplant (HSCT). WE is associated with high mortality and morbidity rates, but due to its rare occurrence, it is ... ...

    Abstract SUMMARY Wernick's Encephalopathy (WE) is an acute neuropsychiatric syndrome caused by thiamine deficiency post hematopoietic stem cell transplant (HSCT). WE is associated with high mortality and morbidity rates, but due to its rare occurrence, it is rarely considered in patients submitted to this procedure. Considering that, the manuscript reports the clinical characteristics and the possible factors that predisposed the occurrence of WE in a patient with non-Hodgkin's lymphoma post-Autologous HSCT. We conclude that WE should be considered in patients submitted to autologous HSCT associated with prolonged use of TPN and malnutrition.
    Keywords Wernicke's encephalopathy ; non-hodgkin's lymphoma ; autologous hsct ; thiamine deficiency ; Medicine (General) ; R5-920
    Language English
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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