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  1. Article ; Online: High production MBL2 polymorphisms protect against COVID-19 complications in critically ill patients

    Lorena Viana de Andrade / Mirela Vanessa de Souza Sá / Beatriz Vasconcelos / Luydson Richardson Silva Vasconcelos / Ricardo Khouri / Carlos Dornels Freire de Souza / Anderson da Costa Armstrong / Rodrigo Feliciano do Carmo

    Heliyon, Vol 10, Iss 1, Pp e23670- (2024)

    A retrospective cohort study

    1481  

    Abstract: Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association of MBL2 polymorphisms with the risk of hospitalization ... ...

    Abstract Mannose-binding lectin (MBL) binds to SARS-CoV-2, inhibits infection of susceptible cells, and activates the complement system via the lectin pathway. In this study, we investigated the association of MBL2 polymorphisms with the risk of hospitalization and clinical worsening in patients with COVID-19. A total of 550 patients with COVID-19 were included (94 non-hospitalized and 456 hospitalized). Polymorphisms in MBL2 exon 1 (codons 52, 54 and 57) and promoter region (−550, −221, and +4) were determined by real-time PCR. MBL and complement proteins were measured by Luminex. A higher frequency of the H/H genotype and the HYPA haplotype was observed in non-hospitalized patients when compared to hospitalized. In addition, critically ill patients carrying haplotypes associated with high MBL levels (HYPA/HYPA + HYPA/LYPA + HYPA/LYQA + LYPA/LYQA + LYPA/LYPA + LYQA/LYQA + LXPA/HYPA + LXPA/LYQA + LXPA/LYPA) were protected against lower oxygen saturation levels (P = 0.02), use of invasive ventilation use (P = 0.02, OR 0.38), and shock (P = 0.01, OR 0.40), independent of other potential confounders adjusted by multivariate analysis. Our results suggest that variants in MBL2 associated with high MBL levels may play a protective role in the clinical course of COVID-19.
    Keywords Innate immunity ; Complement system ; Mannose-binding lectin ; Mannan-binding lectin ; Polymorphism ; SARS-CoV-2 ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 616
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Saúde bucal e consultório na rua

    Lílea Marianne Albuquerque Silva / Ive da Silva Monteiro / Ana Beatriz Vasconcelos Lima de Araújo

    Cadernos de Saúde Coletiva, Vol 26, Iss 3, Pp 285-

    o acesso como questão central da discussão

    2018  Volume 291

    Abstract: Resumo Introdução Há uma grande demanda de saúde bucal por parte da população em situação de rua (PSR). Objetivo Este estudo objetivou analisar as principais necessidades e dificuldades relativas ao cuidado de saúde bucal dessa população no Distrito ... ...

    Abstract Resumo Introdução Há uma grande demanda de saúde bucal por parte da população em situação de rua (PSR). Objetivo Este estudo objetivou analisar as principais necessidades e dificuldades relativas ao cuidado de saúde bucal dessa população no Distrito Sanitário I do município do Recife. Método Trata-se de um estudo exploratório, descritivo, com abordagem qualitativa. Para tanto, foram realizadas entrevistas semiestruturadas com 7 moradores de rua, 4 trabalhadores do Consultório na Rua (CnaR) e 12 cirurgiões-dentistas da atenção básica, analisadas, em seguida, de acordo com o método de análise de conteúdo. Resultados Dentre as principais necessidades de saúde bucal, foi relevante o apontamento do acesso ao atendimento clínico odontológico por todos os atores, sendo ele também referenciado como dificuldade e solução para o atendimento da PSR. A adesão ao tratamento foi citada como dificuldade pelos cirurgiões-dentistas. Entretanto, essa citação demonstrou possivelmente ser reflexo tanto de preconceito como de acolhimento precário na consulta odontológica, conforme denunciado pelos trabalhadores do CnaR e moradores de rua. Conclusão Faz-se necessário fortalecer as equipes de saúde bucal e do CnaR por meio de educação permanente, de tal modo que o acesso a ações em serviços de saúde bucal para o morador de rua seja efetivado.
    Keywords acesso aos serviços de saúde ; saúde bucal ; pessoas em situação de rua ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2018-08-01T00:00:00Z
    Publisher Instituto de Estudos em Saúde Coletiva da Universidade Federal do Rio de Janeiro
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Contributions of therapeutic play in the care process for hospitalized children

    Wanderson Alves Ribeiro / Vanessa Vicente Alves Coutinho / Carlos Renan Barboza Eduardo / Pedro Francisco da Silva Neto / Beatriz Vasconcelos de Oliveira Pereira / Vanda Souza Costa / Lucimar Paz Marciano

    Research, Society and Development, Vol 9, Iss 7, Pp e1000974706-e

    a study of the literature

    2020  Volume 1000974706

    Abstract: Childhood is a phase of life in which children have as their main occupation, playing, this action is essential to maintain their physical and mental health and can include objects and occur individually or in a group. It is worth corroborating that, in ... ...

    Abstract Childhood is a phase of life in which children have as their main occupation, playing, this action is essential to maintain their physical and mental health and can include objects and occur individually or in a group. It is worth corroborating that, in childhood, the illness and hospitalization of children are factors that challenge healthy development, since hospitalization allows the manifestation of an early maturation for this phase. The manuscript is a literature review research with a qualitative approach and descriptive character in order to describe the contributions of the therapeutic toy to care for the child in the hospital. After associating all descriptors, 15 articles were selected that maintained coherence with the descriptors and the objectives of the study. After reflective reading, three categories emerged: therapeutic toys and contributions to the hospitalized child; difficulties in inserting therapeutic toys in the care of hospitalized children; therapeutic toys as a subsidy for nursing care for hospitalized children. The therapeutic toy in child hospitalization reduces stress, releases affectivity and allows the child to be able to express his emotions within the hospital environment, being an effective strategy, as the child releases his creativity, reinvents the world and explores its limits. It is concluded that, when confronting the sufferings of the hospitalized child, expressed in the face of pain and in the absence of motivation and human warmth, the therapeutic toy can be used as resources that facilitate and bring out the child's skills and potential and thus seeks to rescue the importance of toys and playing for the well-being of hospitalized children and their families.
    Keywords criança hospitalizada ; enfermagem pediátrica ; jogos e brinquedos ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390 ; Social Sciences ; H
    Subject code 360
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book: Jesuítas portugueses e espanhóis no sul do Brasil e Paraguai coloniais

    Franzen, Beatriz Vasconcelos

    novos estudos

    (Novos estudos)

    2003  

    Institution Jesuits
    Author's details Beatriz Vasconcelos Franzen
    Series title Novos estudos
    Language Portuguese
    Size 125 S
    Publisher Ed. Unisinos
    Publishing place São Leopoldo, RS
    Document type Book
    ISBN 8574311944 ; 9788574311944
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article: Characterization of two peptides isolated from the venom of social wasp Chartergellus communis (Hymenoptera: Vespidae): Influence of multiple alanine residues and C-terminal amidation on biological effects

    Lopes, Kamila Soares / Adolfo Carlos Barros de Souza / Alessa Bembom Garcia / Ana Carolina Martins Magalhães / Beatriz Vasconcelos Ibituruna / Dagon Manoel Ribeiro / Elisabeth Ferroni Schwartz / Fernando Zamudio-Zuniga / Gabriel Avohay Alves Campos / Lourival Domingos Possani / Luana Cristina Camargo / Lucas Ferreira da Rocha / Luciana Marangni Nolli / Márcia Renata Mortari / Manuel Humberto Mera López / Michelle Cruz Costa / Mosar Correa Rodrigues

    Peptides. 2017 Sept., v. 95

    2017  

    Abstract: Chatergellus communis is a wasp species endemic to the neotropical region and its venom constituents have never been described. In this study, two peptides from C. communis venom, denominated Communis and Communis-AAAA, were chemically and biologically ... ...

    Abstract Chatergellus communis is a wasp species endemic to the neotropical region and its venom constituents have never been described. In this study, two peptides from C. communis venom, denominated Communis and Communis-AAAA, were chemically and biologically characterized. In respect to the chemical characterization, the following amino acid sequences and molecular masses were identified:Communis: Ile-Asn-Trp-Lys-Ala-Ile-Leu-Gly-Lys-Ile-Gly-Lys-COOH (1340.9Da)Communis-AAAA: Ile-Asn-Trp-Lys-Ala-Ile-Leu-Gly-Lys-Ile-Gly-Lys-Ala-Ala-Ala-Ala-Val-Xle-NH2 (1836.3Da).Furthermore, their biological effects were compared, accounting for the differences in structural characteristics between the two peptides. To this end, three biological assays were performed in order to evaluate the hyperalgesic, edematogenic and hemolytic effects of these molecules. Communis-AAAA, unlike Communis, showed a potent hemolytic activity with EC50=142.6μM. Moreover, the highest dose of Communis-AAAA (2nmol/animal) induced hyperalgesia in mice. On the other hand, Communis (10nmol/animal) was able to induce edema but did not present hemolytic or hyperalgesic activity. Although both peptides have similarities in linear structures, we demonstrated the distinct biological effects of Communis and Communis-AAAA. This is the first study with Chartegellus communis venom, and both Communis and Communis-AAAA are unpublished peptides.
    Keywords alanine ; amino acid sequences ; bioactive properties ; bioassays ; edema ; hemolysis ; mice ; molecular weight ; Neotropics ; peptides ; social wasps ; somatosensory disorders ; venoms ; Vespidae
    Language English
    Dates of publication 2017-09
    Size p. 84-93.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2017.07.012
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Characterization of two peptides isolated from the venom of social wasp Chartergellus communis (Hymenoptera: Vespidae): Influence of multiple alanine residues and C-terminal amidation on biological effects.

    Lopes, Kamila Soares / Campos, Gabriel Avohay Alves / Camargo, Luana Cristina / de Souza, Adolfo Carlos Barros / Ibituruna, Beatriz Vasconcelos / Magalhães, Ana Carolina Martins / da Rocha, Lucas Ferreira / Garcia, Alessa Bembom / Rodrigues, Mosar Correa / Ribeiro, Dagon Manoel / Costa, Michelle Cruz / López, Manuel Humberto Mera / Nolli, Luciana Marangni / Zamudio-Zuniga, Fernando / Possani, Lourival Domingos / Schwartz, Elisabeth Ferroni / Mortari, Márcia Renata

    Peptides

    2017  Volume 95, Page(s) 84–93

    Abstract: Chatergellus communis is a wasp species endemic to the neotropical region and its venom constituents have never been described. In this study, two peptides from C. communis venom, denominated Communis and Communis-AAAA, were chemically and biologically ... ...

    Abstract Chatergellus communis is a wasp species endemic to the neotropical region and its venom constituents have never been described. In this study, two peptides from C. communis venom, denominated Communis and Communis-AAAA, were chemically and biologically characterized. In respect to the chemical characterization, the following amino acid sequences and molecular masses were identified: Communis: Ile-Asn-Trp-Lys-Ala-Ile-Leu-Gly-Lys-Ile-Gly-Lys-COOH (1340.9Da) Communis-AAAA: Ile-Asn-Trp-Lys-Ala-Ile-Leu-Gly-Lys-Ile-Gly-Lys-Ala-Ala-Ala-Ala-Val-Xle-NH
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2017.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1649: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Nível de evidência e grau de recomendação dos artigos sobre a acurácia diagnóstica da ultrassonografia na síndrome do túnel do carpo

    Kátia Maria Diniz de Carvalho / Evelyne Pessoa Soriano / Marcus Vitor Diniz de Carvalho / Clóvis César de Mendoza / Humberto Gomes Vidal / Ana Beatriz Vasconcelos Lima Araújo

    Radiologia Brasileira, Vol 44, Iss 2, Pp 85-

    2011  Volume 89

    Abstract: OBJETIVO: Este trabalho teve como objetivo avaliar a qualidade dos artigos relacionados com a acurácia diagnóstica da ultrassonografia na síndrome do túnel do carpo idiopática e relacionada com o trabalho. MATERIAIS E MÉTODOS: Realizou-se busca em bases ... ...

    Abstract OBJETIVO: Este trabalho teve como objetivo avaliar a qualidade dos artigos relacionados com a acurácia diagnóstica da ultrassonografia na síndrome do túnel do carpo idiopática e relacionada com o trabalho. MATERIAIS E MÉTODOS: Realizou-se busca em bases de dados eletrônicas, selecionando-se relatórios de revisões sistemáticas, ensaios clínicos randomizados e estudos observacionais. Após quatro etapas de análise, desde a triagem inicial até a avaliação pelo instrumento elaborado pelo Critical Appraisal Skills Programme, os artigos foram classificados em níveis de evidência, com seus respectivos graus de recomendação. RESULTADOS: Dos 68 artigos inicialmente encontrados, apenas 4 preencheram os critérios de qualidade propostos neste estudo. A mensuração da área transversal do nervo mediano foi o critério mais importante para o diagnóstico de síndrome do túnel do carpo (ponto de corte entre 9 e 10 mm²: sensibilidade = 82-86,3%; especificidade = 48-87%). Os quatro artigos obtiveram nível de evidência "1b" e grau de recomendação "A". CONCLUSÃO: A avaliação ultrassonográfica em pacientes com suspeita clínica de síndrome do túnel do carpo pode ser realizada como teste de primeira linha, com boa relação custo-benefício, reduzindo a necessidade de exames eletrodiagnósticos.
    Keywords Ultrassonografia ; Síndrome do túnel do carpo ; Sensibilidade e especificidade ; Medicina baseada em evidências ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2011-04-01T00:00:00Z
    Publisher Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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