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  1. Book ; Thesis: Kombinationswirkung von Inhibitoren der Histondeacetylasen und Poly-(ADP-Ribose)-Polymerasen in Ewing-Sarkomzellen

    Voigt, Moritz / Beck, James F. / Löffler, Ivonne / Lode, Holger

    2023  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Moritz Voigt
    Keywords Ewing-Sarkom ; Chemotherapie ; Protein p53
    Subject p53 ; Tumorsuppressor p53 ; p53-Gen ; Omoblastom ; Peritheliom ; Diffuses Endotheliom
    Language German
    Size VII, 101 Seiten, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Note Tag der Verteidigung: 06.02.2023
    HBZ-ID HT030013836
    Database Catalogue ZB MED Medicine, Health

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    2023 E 794

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  2. Article: DRESS syndrome: More than just a rash.

    Beck, James

    JAAPA : official journal of the American Academy of Physician Assistants

    2024  Volume 37, Issue 3, Page(s) 1–4

    Abstract: Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is rare but carries significant mortality and morbidity, making early identification and definitive management crucial. The diagnosis of DRESS is made clinically and ... ...

    Abstract Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is rare but carries significant mortality and morbidity, making early identification and definitive management crucial. The diagnosis of DRESS is made clinically and involves consideration of a broad list of differential diagnoses. Given variable clinical presentations among patients with DRESS syndrome, clinicians should look for common findings and other hallmarks of the syndrome while monitoring for known complications. Additionally, clinicians should maintain a high index of suspicion to avoid missing more mild presentations, such as in this case patient with DRESS syndrome minor.
    MeSH term(s) Humans ; Drug Hypersensitivity Syndrome/diagnosis ; Drug Hypersensitivity Syndrome/etiology ; Eosinophilia/chemically induced ; Eosinophilia/diagnosis ; Eosinophilia/complications ; Exanthema/etiology
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2415226-2
    ISSN 0893-7400 ; 1547-1896
    ISSN (online) 0893-7400
    ISSN 1547-1896
    DOI 10.1097/01.JAA.0000997696.41400.4d
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  3. Article: Thirteenth District Medical Society.

    Beck, James

    The North-Western medical and surgical journal

    2023  Volume 3, Issue 6, Page(s) 285–286

    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
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  4. Book: Fetoneonatale Neurologie

    Beck, James F. / Jorch, Gerhard

    Erkrankungen des Nervensystems von der 20 SSW bis zum 20. Lebensmonat

    2013  

    Author's details hrsg. von Gerhard Jorch. Mit Beitr. von James F. Beck
    Keywords Fetus ; Kleinstkind ; Gehirn ; Entwicklung ; Nervensystem ; Krankheit
    Subject Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Systema nervosum ; NS ; Ursprung ; Entwicklungsstadium ; Cerebrum ; Hirn ; Encephalon ; Enzephalon ; Hirngewebe ; Hirnmasse ; Gehirnmasse ; Kind ; Fötus
    Language German
    Size 370 S. : Ill., graph. Darst.
    Publisher Thieme
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017673410
    ISBN 978-3-13-165311-6 ; 3-13-165311-6 ; 9783131653215 ; 3131653213
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    2013 A 1451

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  5. Book ; Thesis: Blutdruckregulation bei Kindern und Jugendlichen mit Typ 1 Diabetes mellitus

    Dost, Axel / Beck, James F. / Müller, Ulrich Alfons / Dötsch, Jörg

    2021  

    Abstract: Die Entwicklung eines Diabetes mellitus Typ1 (T1DM) ist mit einem stark erhöhten Risiko für die spätere Entwicklung kardiovaskulärer und mikrovaskulärer Begleiterkrankungen verbunden. Obwohl diese Begleiterkrankungen meist erst im Erwachsenenalter ... ...

    Title variant eins
    Institution Friedrich-Schiller-Universität Jena
    Author's details von Dr. med. Axel Günter Dost
    Abstract Die Entwicklung eines Diabetes mellitus Typ1 (T1DM) ist mit einem stark erhöhten Risiko für die spätere Entwicklung kardiovaskulärer und mikrovaskulärer Begleiterkrankungen verbunden. Obwohl diese Begleiterkrankungen meist erst im Erwachsenenalter klinisch Bedeutung gewinnen, mehren sich Hinweise, dass ihre Entwicklung bereits mit dem Zeitpunkt der Manifestation des T1DM im Kindesalter ihren Anfang nimmt. Als Hauptrisikofaktoren für die Entwicklung der kardiovaskulären und mikrovaskulären Begleiterkrankungen gelten neben der T1DM-assoziierten, chronischen Hyperglykämie vor allem Störungen der Blutdruckregulation, insbesondere die der Form der arteriellen Hypertonie (HTN). So sind Störungen der Regulation des Blutdrucks („Blood pressure“, BP) mit einem höheren Auftreten mikrovaskulärer Komplikationen, wie der diabetischen Nephropathie und Retinopathie vergesellschaftet. Um das Ausmaß und den Krankheitswert von Störungen der Blutdruckregulation bei Kindern und Jugendlichen mit T1DM zu verstehen, wurden ausgesuchte Daten aus dem deutschsprachigen Register für die Verlaufsbeobachtung von Patienten mit Diabetes (DPV-Register) auf mögliche Korrelationen hin betrachtet. Das DPV-Register umfasst inzwischen Dokumentationsdaten von nahezu 90% der an T1DM erkrankten Kinder und Jugendlichen aus Deutschland, Österreich, Luxemburg und Teilen der Schweiz. Im DPV-Register werden die aus heutiger Sicht wesentlichen diabetes-relevanten Daten erfasst. Hierzu gehören: Basisdaten, diabetes-spezifische Parameter, Parameter mit Bezug zu assoziierten Erkrankungen oder Folgeerkrankungen und zusätzliche Medikamente. Diese Daten werden lokal erhoben, dokumentiert und anonymisiert. Die anonymisierten Daten werden zweimal jährlich an das Institut für Epidemiologie und medizinische Biometrie der Universität Ulm versandt und dort zentral auf ihre Qualität hin überprüft.
    Keywords Diabetes mellitus ; Kind ; Blutdruck
    Subject Kindheit ; Kindesalter ; Kindschaft ; Kinder ; Diabetes verus ; Zuckerharnruhr ; Zuckerkrankheit
    Language German ; English
    Size 104 Seiten, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Friedrich-Schiller-Universität Jena, 2021
    Note Zeitschriftenaufsätze in englischer Sprache ; Kumulative Habilitationsschrift, enthält Zeitschriftenaufsätze. - Tag der Lehrbefähigung: 14.12.2021
    HBZ-ID HT021365584
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    2022 E 525

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  6. Article: Acute liver failure.

    Beck, James / Bolina, Jasleen K / Boyd, Lisa H

    JAAPA : official journal of the American Academy of Physician Assistants

    2024  Volume 37, Issue 5, Page(s) 22–27

    Abstract: Abstract: Acute liver failure, commonly caused by acetaminophen overdose, is associated with numerous systemic complications including cerebral edema, hypotension, acute kidney injury, and infection. Management is primarily supportive, with an emphasis ... ...

    Abstract Abstract: Acute liver failure, commonly caused by acetaminophen overdose, is associated with numerous systemic complications including cerebral edema, hypotension, acute kidney injury, and infection. Management is primarily supportive, with an emphasis on excellent neurocritical care. Although some antidotes and targeted treatments exist, the only definitive treatment remains orthotopic liver transplant.
    MeSH term(s) Humans ; Liver Failure, Acute/therapy ; Liver Failure, Acute/chemically induced ; Liver Failure, Acute/diagnosis ; Acetaminophen/adverse effects ; Liver Transplantation ; Drug Overdose/therapy ; Brain Edema/etiology ; Brain Edema/therapy ; Analgesics, Non-Narcotic/adverse effects ; Acute Kidney Injury/therapy ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/etiology ; Acute Kidney Injury/diagnosis ; Antidotes
    Chemical Substances Acetaminophen (362O9ITL9D) ; Analgesics, Non-Narcotic ; Antidotes
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2415226-2
    ISSN 0893-7400 ; 1547-1896
    ISSN (online) 0893-7400
    ISSN 1547-1896
    DOI 10.1097/01.JAA.0000000000000001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Why Do People (Not) Take Breaks? An Investigation of Individuals' Reasons for Taking and for Not Taking Breaks at Work.

    Phan, Vincent / Beck, James W

    Journal of business and psychology

    2022  Volume 38, Issue 2, Page(s) 259–282

    Abstract: Although breaks can help employees stay energized and maintain high levels of performance throughout the day, employees sometimes refrain from taking a break despite wanting to do so. Unfortunately, few studies have investigated individuals' reasons for ... ...

    Abstract Although breaks can help employees stay energized and maintain high levels of performance throughout the day, employees sometimes refrain from taking a break despite wanting to do so. Unfortunately, few studies have investigated individuals' reasons for taking and for
    Supplementary information: The online version contains supplementary material available at 10.1007/s10869-022-09866-4.
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016738-6
    ISSN 1573-353X ; 0889-3268
    ISSN (online) 1573-353X
    ISSN 0889-3268
    DOI 10.1007/s10869-022-09866-4
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  8. Article ; Online: The effects of contracting Covid-19 on cognitive failures at work: implications for task performance and turnover intentions.

    Beck, James W / Flow, Arden

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 8826

    Abstract: Individuals who contract Covid-19 often experience problems with memory, attention, and concentration, even after recovering from the initial illness. In the current manuscript, we argue that these symptoms are likely to manifest as cognitive failures in ...

    Abstract Individuals who contract Covid-19 often experience problems with memory, attention, and concentration, even after recovering from the initial illness. In the current manuscript, we argue that these symptoms are likely to manifest as cognitive failures in the workplace. Downstream, cognitive failures were expected to be associated with decreased task performance and increased turnover intentions. We collected data from a sample of working adults who either had (n = 45) or had not (n = 49) contracted Covid-19 at least one month prior to the study. Both groups were matched on key demographic characteristics. As anticipated, individuals who had contracted Covid-19 reported significantly more cognitive failures at work, relative to individuals who did not. More so, having contracted Covid-19 had significant indirect effects on task performance and turnover intentions via cognitive failure. These results indicate that beyond physical harm, Covid-19 can also have a detrimental influence on an individual's capacity to perform at work.
    MeSH term(s) Adult ; COVID-19 ; Cognition ; Humans ; Intention ; Personnel Turnover ; Task Performance and Analysis
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-13051-1
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  9. Article ; Online: Association between blood markers and the progression of osseointegration in percutaneous prostheses patients-A pilot study.

    Miller, Andrew / Jeyapalina, Sujee / Agarwal, Jayant P / Beck, James Peter

    Journal of biomedical materials research. Part B, Applied biomaterials

    2024  Volume 112, Issue 3, Page(s) e35398

    Abstract: Patients implanted with osseointegrated (OI) prosthetic systems have reported vastly improved upper and lower extremity prosthetic function compared with their previous experience with socket-suspension systems. However, OI systems have been associated ... ...

    Abstract Patients implanted with osseointegrated (OI) prosthetic systems have reported vastly improved upper and lower extremity prosthetic function compared with their previous experience with socket-suspension systems. However, OI systems have been associated with superficial and deep-bone infections and implant loosening due, in part, to a failure of the osseointegration process. Although monitoring the osseointegration using circulating biomarkers has clinical relevance for understanding the progression of osseointegration with these devices, it has yet to be established. Ten patients were enrolled in this study. Blood samples were collected at pre-selected times, starting before implantation surgery, and continuing to 12 months after the second surgery. Bone formation markers, bone resorption markers, and circulating amino acids were measured from blood samples. A linear mixed model was generated for each marker, incorporating patient ID and age with the normalized marker value as the response variable. Post hoc comparisons were made between 1 week before Stage 1 Surgery and all subsequent time points for each marker, followed by multiple testing corrections. Serial radiographic imaging of the residual limb containing the implant was obtained during follow-up, and the cortical index (CI) was calculated for the bone at the porous region of the device. Two markers of bone formation, specifically bone-specific alkaline phosphatase (Bone-ALP) and amino-terminal propeptide of type I procollagen (PINP), exhibited significant increases when compared with the baseline levels of unloaded residual bone prior to the initial surgery, and they subsequently returned to their baseline levels by the 12-month mark. Patients who experienced clinically robust osseointegration experienced increased cortical bone thickness at the porous coated region of the device. A medium correlation was observed between Bone-ALP and the porous CI values up to PoS2-M1 (p = .056), while no correlation was observed for PINP. An increase in bone formation markers and the lack of change observed in bone resorption markers likely reflect increased cortical bone formation induced by the end-loading design of the Utah OI device used in this study. A more extensive study is required to validate the correlation observed between Bone-ALP and porous CI values.
    MeSH term(s) Humans ; Osseointegration ; Pilot Projects ; Artificial Limbs ; Biomarkers ; Alkaline Phosphatase ; Bone Resorption
    Chemical Substances Biomarkers ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2099992-6
    ISSN 1552-4981 ; 1552-4973 ; 0021-9304
    ISSN (online) 1552-4981
    ISSN 1552-4973 ; 0021-9304
    DOI 10.1002/jbm.b.35398
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6196: Show issues Location:
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  10. Article ; Online: Sintered fluorapatite scaffolds as an autograft-like engineered bone graft.

    Nielson, Clark / Agarwal, Jayant / Beck, James Peter / Shea, Jill / Jeyapalina, Sujee

    Journal of biomedical materials research. Part B, Applied biomaterials

    2024  Volume 112, Issue 2, Page(s) e35374

    Abstract: Hydroxyapatite (HA)-based materials are widely used as bone substitutes due to their inherent biocompatibility, osteoconductivity, and bio-absorption properties. However, HA scaffolds lack compressive strength when compared to autograft bone. It has been ...

    Abstract Hydroxyapatite (HA)-based materials are widely used as bone substitutes due to their inherent biocompatibility, osteoconductivity, and bio-absorption properties. However, HA scaffolds lack compressive strength when compared to autograft bone. It has been shown that the fluoridated form of HA, fluorapatite (FA), can be sintered to obtain this desired strength as well as slower degradation properties. Also, FA surfaces have been previously shown to promote stem cell differentiation toward an osteogenic lineage. Thus, it was hypothesized that FA, with and without stromal vascular fraction (SVF), would guide bone healing to an equal or better extent than the clinical gold standard. The regenerative potentials of these scaffolds were tested in 32 Lewis rats in a femoral condylar defect model with untreated (negative), isograft (positive), and commercial HA as controls. Animals were survived for 12 weeks post-implantation. A semi-quantitative micro-CT analysis was developed to quantify the percent new bone formation within the defects. Our model showed significantly higher (p < .05) new bone depositions in all apatite groups compared to the autograft group. Overall, the FA group had the most significant new bone deposition, while the differences between HA, FA, and FA + SVF were insignificant (p > .05). Histological observations supported the micro-CT findings and highlighted the presence of healthy bone tissues without interposing capsules or intense immune responses for FA groups. Most importantly, the regenerating bone tissue within the FA + SVF scaffolds resembled the architecture of the surrounding trabecular bone, showing intertrabecular spaces, while the FA group presented a denser cortical bone-like architecture. Also, a lower density of cells was observed near FA granules compared to HA surfaces, suggesting a reduced immune response. This first in vivo rat study supported the tested hypothesis, illustrating the utility of FA as a bone scaffold material.
    MeSH term(s) Rats ; Animals ; Autografts ; Rats, Inbred Lew ; Apatites/pharmacology ; Durapatite/pharmacology ; Bone Regeneration ; Osteogenesis ; Tissue Scaffolds
    Chemical Substances fluorapatite (M4CM1H238J) ; Apatites ; Durapatite (91D9GV0Z28)
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2099992-6
    ISSN 1552-4981 ; 1552-4973 ; 0021-9304
    ISSN (online) 1552-4981
    ISSN 1552-4973 ; 0021-9304
    DOI 10.1002/jbm.b.35374
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