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  1. Book ; Online: The Biological and Clinical Aspects of Merkel Cell Carcinoma

    Koljonen, Virve / Lui, Weng-Onn / Becker, Jürgen / Becker, Jürgen

    2023  

    Keywords Medicine ; Oncology ; miR-375 ; antagomiRs ; Merkel cell carcinoma ; Hippo signaling ; focal adhesion ; diagnosis ; treatment ; review ; guideline ; Merkel cell polyoma virus ; tumor microenvironment ; CD8 lymphocytes ; ulceration ; E-cadherin ; artesunate ; MCC ; polyomavirus ; ferroptosis ; radiation therapy ; immunotherapy ; surgical intervention ; survival ; multidisciplinary communication ; biomarkers ; cell tropism ; signaling pathways ; therapy ; transgenic mice ; tumorigenesis ; histogenesis ; ATOH1 ; GLI1 ; sonic hedgehog ; hair follicle ; Merkel cell polyomavirus ; skin carcinogenesis ; T antigens ; human polyomaviruses ; DNA tumor viruses ; viral oncoproteins ; merkel cell carcinoma ; merkel cell polyoma virus ; sex ; radiotherapy ; UV ; cell line ; MYC ; TP53 ; RB1 ; whole-exome ; significantly mutated genes ; copy number variation ; virus positive Merkel cell carcinoma ; virus negative Merkel cell carcinoma and copy number variant ; n/a
    Language English
    Size 1 electronic resource (198 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030374816
    ISBN 9783036574479 ; 3036574476
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: 75 years of forensic medicine in Mainz - from barrack No. 18 to the high-tech institute

    Becker, Jürgen / Kaufmann, Thomas / Mattern, Rainer / Riepert, Thomas / Rittner, Christian / Schneider, Peter M. / Röhrich, Jörg

    (Rechtsmedizin)

    2023  

    Author's details Christian Rittner, Peter M. Schneider, Jörg Röhrich (eds.)
    Series title Rechtsmedizin
    Keywords Johannes Gutenberg-Universität Mainz ; 1946-2021
    Subject code 614.109434351 ; 610
    Language English
    Size 106 Seiten, Illustrationen, 21 cm
    Publisher Lehmanns Media
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT030629555
    ISBN 978-3-96543-391-5 ; 3-96543-391-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Thesis: Untersuchung des altersabhängigen systemischen Einflusses spezieller Fettsäuren auf Inflammation und Knochenstoffwechsel bei Parodontitis im Mausmodell

    Domuncu, Anton / Schulze-Späte, Ulrike / Wildemann, Britt / Becker, Jürgen

    2023  

    Institution Friedrich-Schiller-Universität Jena
    Author's details von Anton Sava Domuncu
    Language German
    Size 91 Blätter, Illustrationen, Diagramme, 29,5 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Note Tag der Verteidigung: 05.12.2023
    HBZ-ID HT030704318
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 545 Magazin

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  4. Article: Mikrobiologie. Clostridioides-difficile-Infektion bei Kindern: Positiver Test ungleich krank?

    Becker, Jürgen

    Trillium-Diagnostik

    2022  Volume 20, Issue 3, Page(s) 196

    Language German
    Document type Article
    ZDB-ID 2741151-5
    ISSN 2198-1310
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Book: Periimplantäre Entzündungen

    Schwarz, Frank / Becker, Jürgen

    Ätiologie, Pathogenese, Diagnostik und aktuelle Therapiekonzepte

    (Quintessenz-Bibliothek)

    2007  

    Author's details Frank Schwarz ; Jürgen Becker
    Series title Quintessenz-Bibliothek
    Keywords Zahnimplantation ; Entzündung ; Komplikation
    Subject Inflammatio ; Entzündungsreaktion ; Zahnprothese
    Language German
    Size XIII, 257 S. : zahlr. Ill., graph. Darst.
    Publisher Quintessenz-Verl
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014937390
    ISBN 978-3-938947-32-6 ; 3-938947-32-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 660 order for loan Magazin

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  6. Book: Peri implant infection

    Schwarz, Frank / Becker, Jürgen / Aoki, Akira

    etiology, diagnosis and treatment

    2010  

    Author's details Frank Schwarz ; Jürgen Becker. With contributions from: Akira Aoki
    Keywords Dental Implants ; Inflammation ; Zahnimplantation ; Entzündung ; Komplikation
    Subject Inflammatio ; Entzündungsreaktion ; Zahnprothese
    Language English
    Size XV, 296 S. : zahlr. Ill., graph. Darst., 25 cm
    Edition Updated
    Publisher Quintessence Publ
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    Note Aus dem Dt. übers. ; Literaturverz. S. 271 - 292
    HBZ-ID HT016099175
    ISBN 978-1-85097-193-1 ; 1-85097-193-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 5178 order for loan Magazin

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  7. Article: The lymphatic vascular system: much more than just a sewer.

    Wilting, Jörg / Becker, Jürgen

    Cell & bioscience

    2022  Volume 12, Issue 1, Page(s) 157

    Abstract: Almost 400 years after the (re)discovery of the lymphatic vascular system (LVS) by Gaspare Aselli (Asellius G. De lactibus, sive lacteis venis, quarto vasorum mesaraicorum genere, novo invento Gasparis Asellii Cremo. Dissertatio. (MDCXXIIX), Milan; 1628.) ...

    Abstract Almost 400 years after the (re)discovery of the lymphatic vascular system (LVS) by Gaspare Aselli (Asellius G. De lactibus, sive lacteis venis, quarto vasorum mesaraicorum genere, novo invento Gasparis Asellii Cremo. Dissertatio. (MDCXXIIX), Milan; 1628.), structure, function, development and evolution of this so-called 'second' vascular system are still enigmatic. Interest in the LVS was low because it was (and is) hardly visible, and its diseases are not as life-threatening as those of the blood vascular system. It is not uncommon for patients with lymphedema to be told that yes, they can live with it. Usually, the functions of the LVS are discussed in terms of fluid homeostasis, uptake of chylomicrons from the gut, and immune cell circulation. However, the broad molecular equipment of lymphatic endothelial cells suggests that they possess many more functions, which are also reflected in the pathophysiology of the system. With some specific exceptions, lymphatics develop in all organs. Although basic structure and function are the same regardless their position in the body wall or the internal organs, there are important site-specific characteristics. We discuss common structure and function of lymphatics; and point to important functions for hyaluronan turn-over, salt balance, coagulation, extracellular matrix production, adipose tissue development and potential appetite regulation, and the influence of hypoxia on the regulation of these functions. Differences with respect to the embryonic origin and molecular equipment between somatic and splanchnic lymphatics are discussed with a side-view on the phylogeny of the LVS. The functions of the lymphatic vasculature are much broader than generally thought, and lymphatic research will have many interesting and surprising aspects to offer in the future.
    Language English
    Publishing date 2022-09-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-022-00898-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Merkel Cell Carcinoma: Integrating Epidemiology, Immunology, and Therapeutic Updates.

    Becker, Jürgen C / Stang, Andreas / Schrama, David / Ugurel, Selma

    American journal of clinical dermatology

    2024  

    Abstract: Merkel cell carcinoma (MCC) is a rare skin cancer characterized by neuroendocrine differentiation. Its carcinogenesis is based either on the integration of the Merkel cell polyomavirus or on ultraviolet (UV) mutagenesis, both of which lead to high ... ...

    Abstract Merkel cell carcinoma (MCC) is a rare skin cancer characterized by neuroendocrine differentiation. Its carcinogenesis is based either on the integration of the Merkel cell polyomavirus or on ultraviolet (UV) mutagenesis, both of which lead to high immunogenicity either through the expression of viral proteins or neoantigens. Despite this immunogenicity resulting from viral or UV-associated carcinogenesis, it exhibits highly aggressive behavior. However, owing to the rarity of MCC and the lack of epidemiologic registries with detailed clinical data, there is some uncertainty regarding the spontaneous course of the disease. Historically, advanced MCC patients were treated with conventional cytotoxic chemotherapy yielding a median response duration of only 3 months. Starting in 2017, four programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) immune checkpoint inhibitors-avelumab, pembrolizumab, nivolumab (utilized in both neoadjuvant and adjuvant settings), and retifanlimab-have demonstrated efficacy in treating patients with disseminated MCC on the basis of prospective clinical trials. However, generating clinical evidence for rare cancers, such as MCC, is challenging owing to difficulties in conducting large-scale trials, resulting in small sample sizes and therefore lacking statistical power. Thus, to comprehensively understand the available clinical evidence on various immunotherapy approaches for MCC, we also delve into the epidemiology and immune biology of this cancer. Nevertheless, while randomized studies directly comparing immune checkpoint inhibitors and chemotherapy in MCC are lacking, immunotherapy shows response rates comparable to those previously reported with chemotherapy but with more enduring responses. Notably, adjuvant nivolumab has proven superiority to the standard-of-care therapy (observation) in the adjuvant setting.
    Language English
    Publishing date 2024-04-22
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1502476-3
    ISSN 1179-1888 ; 1175-0561
    ISSN (online) 1179-1888
    ISSN 1175-0561
    DOI 10.1007/s40257-024-00858-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5639: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Rechtliche Grundlagen der zahnärztlichen Röntgendiagnostik

    Becker, Jürgen

    Parodontologie

    2020  Volume 31, Issue 4, Page(s) 363

    Language German
    Document type Article
    ZDB-ID 1033271-6
    ISSN 0937-1532
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2955: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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