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  1. Article ; Online: Autism and Socioeconomic Status-An Immune Link?

    Becker, Kevin G

    American journal of public health

    2018  Volume 108, Issue 3, Page(s) e16

    MeSH term(s) Autism Spectrum Disorder ; Autistic Disorder/immunology ; Child ; Ethnic Groups ; Humans ; Social Class ; Socioeconomic Factors
    Language English
    Publishing date 2018-02-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2017.304271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sequential Early-Life Infections Alter Peripheral Blood Transcriptomics in Aging Female Mice but Not the Response to De Novo Infection with Influenza Virus or M. tuberculosis.

    Lanzer, Kathleen G / Cookenham, Tres / Lehrmann, Elin / Zhang, Yongqing / Duso, Debbie / Xie, Qingqing / Reiley, William W / Becker, Kevin G / Blackman, Marcia A

    ImmunoHorizons

    2023  Volume 7, Issue 8, Page(s) 562–576

    Abstract: To determine the impact of accumulating Ag exposure on immunity in the aging mouse, and to develop a model more relevant to humans who are exposed to multiple pathogens during life, we sequentially infected young female mice with four distinct pathogens ... ...

    Abstract To determine the impact of accumulating Ag exposure on immunity in the aging mouse, and to develop a model more relevant to humans who are exposed to multiple pathogens during life, we sequentially infected young female mice with four distinct pathogens at 8-wk intervals: murine γ-herpesvirus 68, Sendai virus, murine CMV, and Heligmosomoides polygyrus. Mock-infected mice received PBS. After aging the sequentially infected and mock-infected mice to 18-25 mo under specific pathogen-free conditions, we analyzed multiple immune parameters. We assessed transcriptional activity in peripheral blood, T cell phenotype, the diversity of influenza epitopes recognized by CD8 T cells, and the response of the animals to infection with influenza virus and Mycobacterium tuberculosis. Our data show enhanced transcriptional activation in sequentially infected aged mice, with changes in some CD8 T cell subsets. However, there was no measurable difference in the response of mock-infected and sequentially infected aged mice to de novo infection with either influenza virus or M. tuberculosis at 18-21 mo. Unexpectedly, a single experiment in which 25-mo-old female mice were challenged with influenza virus revealed a significantly higher survival rate for sequentially infected (80%) versus mock-infected (20%) mice. These data suggest that although exposure to a variety of pathogen challenges in the mouse model does not overtly impact cellular markers of immunity in aged female mice following de novo respiratory infection, subtle changes may emerge in other compartments or with increasing age.
    MeSH term(s) Animals ; Female ; Mice ; Aging ; Mycobacterium tuberculosis ; Orthomyxoviridae ; Transcriptome ; Tuberculosis
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2200066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Male gender bias in autism and pediatric autoimmunity.

    Becker, Kevin G

    Autism research : official journal of the International Society for Autism Research

    2012  Volume 5, Issue 2, Page(s) 77–83

    Abstract: Male bias in both autism and pediatric autoimmune disease is thought to involve hormonal perturbations in pregnancy or early childhood in the context of genetic control. These early molecular events, at a time of rapid development, are intimately linked ... ...

    Abstract Male bias in both autism and pediatric autoimmune disease is thought to involve hormonal perturbations in pregnancy or early childhood in the context of genetic control. These early molecular events, at a time of rapid development, are intimately linked to concurrent development in the brain and immune system. It is suggested here that these early regulatory events may overlap between autism and autoimmunity in determining male sex bias and may provide evidence of an etiological link among autism, immune dysregulation, and autoimmune disease.
    MeSH term(s) Autistic Disorder/epidemiology ; Autistic Disorder/genetics ; Autistic Disorder/immunology ; Autoimmune Diseases/epidemiology ; Central Nervous System/growth & development ; Child ; Child Development Disorders, Pervasive/epidemiology ; Child Development Disorders, Pervasive/immunology ; Female ; Genetic Diseases, X-Linked ; Genetic Predisposition to Disease ; Humans ; Male ; Sex Ratio ; Testosterone/immunology
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2012-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.1227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Autism, immune dysfunction and Vitamin D.

    Becker, Kevin G

    Acta psychiatrica Scandinavica

    2011  Volume 124, Issue 1, Page(s) 74; author reply 74–5

    MeSH term(s) Autistic Disorder ; Emigrants and Immigrants ; Ethnic Groups ; Female ; Humans ; Pregnancy ; Pregnancy Complications ; Vitamin D Deficiency
    Language English
    Publishing date 2011-07
    Publishing country United States
    Document type Comment ; Letter ; Research Support, N.I.H., Intramural
    ZDB-ID 103-x
    ISSN 1600-0447 ; 0001-690X
    ISSN (online) 1600-0447
    ISSN 0001-690X
    DOI 10.1111/j.1600-0447.2011.01688.x
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  5. Article ; Online: Autism and urbanization.

    Becker, Kevin G

    American journal of public health

    2010  Volume 100, Issue 7, Page(s) 1156–7; author reply 1157

    MeSH term(s) Autistic Disorder/epidemiology ; Autistic Disorder/ethnology ; Child ; European Continental Ancestry Group ; Female ; Humans ; Male ; Mexican Americans ; Pregnancy ; Prevalence ; Rural Population/statistics & numerical data ; Texas/epidemiology ; Urban Population/statistics & numerical data ; Urbanization
    Language English
    Publishing date 2010-05-13
    Publishing country United States
    Document type Comment ; Letter ; Research Support, N.I.H., Intramural
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2009.191007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer's mouse model.

    Chu, Xixia / Hou, Yujun / Meng, Qiong / Croteau, Deborah L / Wei, Yong / De, Supriyo / Becker, Kevin G / Bohr, Vilhelm A

    Frontiers in aging neuroscience

    2022  Volume 14, Page(s) 993615

    Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease. Growing evidence suggests an important role for gut dysbiosis and gut microbiota-host interactions in aging and neurodegeneration. Our previous works have demonstrated that ... ...

    Abstract Alzheimer's disease (AD) is the most common neurodegenerative disease. Growing evidence suggests an important role for gut dysbiosis and gut microbiota-host interactions in aging and neurodegeneration. Our previous works have demonstrated that supplementation with the nicotinamide adenine dinucleotide (NAD
    Language English
    Publishing date 2022-09-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2022.993615
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  7. Article: Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation.

    Weiler, Marina / Stieger, Kevin C / Shroff, Kavisha / Klein, Jessie P / Wood, William H / Zhang, Yongqing / Chandrasekaran, Prabha / Lehrmann, Elin / Camandola, Simonetta / Long, Jeffrey M / Mattson, Mark P / Becker, Kevin G / Rapp, Peter R

    Frontiers in human neuroscience

    2023  Volume 17, Page(s) 1215291

    Abstract: Introduction: Transcranial Magnetic Stimulation (TMS) is a noninvasive technique that uses pulsed magnetic fields to affect the physiology of the brain and central nervous system. Repetitive TMS (rTMS) has been used to study and treat several ... ...

    Abstract Introduction: Transcranial Magnetic Stimulation (TMS) is a noninvasive technique that uses pulsed magnetic fields to affect the physiology of the brain and central nervous system. Repetitive TMS (rTMS) has been used to study and treat several neurological conditions, but its complex molecular basis is largely unexplored.
    Methods: Utilizing three experimental rat models (
    Results: These effects are observed across various stimulation protocols, in diverse tissues, and are influenced by time and age. Notably, rTMS-induced alterations in gene expression span a wide range of biological pathways, such as glutamatergic, GABAergic, and anti-inflammatory pathways, ion channels, myelination, mitochondrial energetics, multiple neuron-and synapse-specific genes.
    Discussion: This comprehensive transcriptional analysis induced by rTMS stimulation serves as a foundational characterization for subsequent experimental investigations and the exploration of potential clinical applications.
    Language English
    Publishing date 2023-11-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2023.1215291
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  8. Article: Autism, asthma, inflammation, and the hygiene hypothesis.

    Becker, Kevin G

    Medical hypotheses

    2007  Volume 69, Issue 4, Page(s) 731–740

    Abstract: Inflammation and the genes, molecules, and biological pathways that lead to inflammatory processes influence many important and disparate biological processes and disease states that are quite often not generally considered classical inflammatory or ... ...

    Abstract Inflammation and the genes, molecules, and biological pathways that lead to inflammatory processes influence many important and disparate biological processes and disease states that are quite often not generally considered classical inflammatory or autoimmune disorders. These include development, reproduction, aging, tumor development and tumor rejection, cardiovascular pathologies, metabolic disorders, as well as neurological and psychiatric disorders. This paper compares parallel aspects of autism and inflammatory disorders with an emphasis on asthma. These comparisons include epidemiological, morphometric, molecular, and genetic aspects of both disease types, contributing to a hypothesis of autism in the context of the immune based hygiene hypothesis. This hypothesis is meant to address the apparent rise in the prevalence of autism in the population.
    MeSH term(s) Asthma/epidemiology ; Asthma/etiology ; Asthma/genetics ; Autistic Disorder/epidemiology ; Autistic Disorder/etiology ; Autistic Disorder/genetics ; Birth Order ; Body Size ; Head/anatomy & histology ; Humans ; Hygiene ; Inflammation/epidemiology ; Inflammation/etiology ; Inflammation/genetics ; Models, Biological ; Prevalence ; Receptors, Adrenergic, beta-2/genetics
    Chemical Substances Receptors, Adrenergic, beta-2
    Language English
    Publishing date 2007-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2007.02.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: NF-κB subunits direct kinetically distinct transcriptional cascades in antigen receptor-activated B cells.

    Zhao, Mingming / Chauhan, Prashant / Sherman, Cheryl A / Singh, Amit / Kaileh, Mary / Mazan-Mamczarz, Krystyna / Ji, Hongkai / Joy, Jaimy / Nandi, Satabdi / De, Supriyo / Zhang, Yongqing / Fan, Jinshui / Becker, Kevin G / Loke, Png / Zhou, Weiqiang / Sen, Ranjan

    Nature immunology

    2023  Volume 24, Issue 9, Page(s) 1552–1564

    Abstract: The nuclear factor kappa B (NF-κB) family of transcription factors orchestrates signal-induced gene expression in diverse cell types. Cellular responses to NF-κB activation are regulated at the level of cell and signal specificity, as well as ... ...

    Abstract The nuclear factor kappa B (NF-κB) family of transcription factors orchestrates signal-induced gene expression in diverse cell types. Cellular responses to NF-κB activation are regulated at the level of cell and signal specificity, as well as differential use of family members (subunit specificity). Here we used time-dependent multi-omics to investigate the selective functions of Rel and RelA, two closely related NF-κB proteins, in primary B lymphocytes activated via the B cell receptor. Despite large numbers of shared binding sites genome wide, Rel and RelA directed kinetically distinct cascades of gene expression in activated B cells. Single-cell RNA sequencing revealed marked heterogeneity of Rel- and RelA-specific responses, and sequential binding of these factors was not a major mechanism of protracted transcription. Moreover, nuclear co-expression of Rel and RelA led to functional antagonism between the factors. By rigorously identifying the target genes of each NF-κB subunit, these studies provide insights into exclusive functions of Rel and RelA in immunity and cancer.
    MeSH term(s) NF-kappa B/metabolism ; Transcription Factor RelA/genetics ; Transcription Factor RelA/metabolism ; B-Lymphocytes/metabolism ; Binding Sites ; Receptors, Antigen/metabolism
    Chemical Substances NF-kappa B ; Transcription Factor RelA ; Receptors, Antigen
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-023-01561-7
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  10. Article ; Online: Sex-specific transcriptome differences in a middle-aged frailty cohort.

    Pacheco, Natasha L / Noren Hooten, Nicole / Zhang, Yongqing / Prince, Calais S / Mode, Nicolle A / Ezike, Ngozi / Becker, Kevin G / Zonderman, Alan B / Evans, Michele K

    BMC geriatrics

    2022  Volume 22, Issue 1, Page(s) 651

    Abstract: Background: Frailty is a clinical syndrome described as reduced physiological reserve and increased vulnerability. Typically examined in older adults, recent work shows frailty occurs in middle-aged individuals and is associated with increased mortality. ...

    Abstract Background: Frailty is a clinical syndrome described as reduced physiological reserve and increased vulnerability. Typically examined in older adults, recent work shows frailty occurs in middle-aged individuals and is associated with increased mortality. Previous investigation of global transcriptome changes in a middle-aged cohort from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study demonstrated inflammatory genes and pathways were significantly altered by frailty status and race. Transcriptome differences in frailty by sex remain unclear. We sought to discover novel genes and pathways associated with sex and frailty in a diverse middle-aged cohort using RNA-Sequencing.
    Methods: Differential gene expression and pathway analyses were performed in peripheral blood mononuclear cells for 1) frail females (FRAF, n = 4) vs non-frail females (NORF, n = 4), 2) frail males (FRAM, n = 4) vs non-frail males (NORM, n = 4), 3) FRAM vs FRAF, and 4) NORM vs NORF. We evaluated exclusive significant genes and pathways, as well as overlaps, between the comparison groups.
    Results: Over 80% of the significant genes exclusive to FRAF vs NORF, FRAM vs NORM, and FRAM vs FRAF, respectively, were novel and associated with various biological functions. Pathways exclusive to FRAF vs NORF were associated with reduced inflammation, while FRAM vs NORM exclusive pathways were related to aberrant musculoskeletal physiology. Pathways exclusive to FRAM vs FRAF were associated with reduced cell cycle regulation and activated catabolism and Coronavirus pathogenesis.
    Conclusions: Our results indicate sex-specific transcriptional changes occur in middle-aged frailty, enhancing knowledge on frailty progression and potential therapeutic targets to prevent frailty.
    MeSH term(s) Aged ; Female ; Frail Elderly ; Frailty/diagnosis ; Frailty/genetics ; Healthy Aging ; Humans ; Leukocytes, Mononuclear ; Male ; Middle Aged ; Sex Characteristics ; Transcriptome/genetics
    Language English
    Publishing date 2022-08-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-022-03326-7
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