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Artikel: Recent advances in infectious disease research using cryo-electron tomography.

Asarnow, Daniel / Becker, Vada A / Bobe, Daija / Dubbledam, Charlie / Johnston, Jake D / Kopylov, Mykhailo / Lavoie, Nathalie R / Li, Qiuye / Mattingly, Jacob M / Mendez, Joshua H / Paraan, Mohammadreza / Turner, Jack / Upadhye, Viraj / Walsh, Richard M / Gupta, Meghna / Eng, Edward T

Frontiers in molecular biosciences

2024  Band 10, Seite(n) 1296941

Abstract: With the increasing spread of infectious diseases worldwide, there is an urgent need for novel strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) techniques, particularly electron tomography (cryo-ET), have revolutionized the field ...

Abstract With the increasing spread of infectious diseases worldwide, there is an urgent need for novel strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) techniques, particularly electron tomography (cryo-ET), have revolutionized the field of infectious disease research by enabling multiscale observation of biological structures in a near-native state. This review highlights the recent advances in infectious disease research using cryo-ET and discusses the potential of this structural biology technique to help discover mechanisms of infection in native environments and guiding in the right direction for future drug discovery.
Sprache Englisch
Erscheinungsdatum 2024-01-15
Erscheinungsland Switzerland
Dokumenttyp Journal Article ; Review
ZDB-ID 2814330-9
ISSN 2296-889X
ISSN 2296-889X
DOI 10.3389/fmolb.2023.1296941
Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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