LIVIVO - Search results -

Search results

Result 1 - 10 of total 205

Search options

Article ; Online: Alzheimer's-related brain damage shows sex-specific links with risk factors.

Beckett, Laurel A

2022 Volume 20, Issue 12, Page(s) e3001905

Abstract: Alzheimer's disease is marked by brain damage from tau and amyloid aggregates, particularly to the hippocampus and the default network. A new study in PLOS Biology shows sex differences in the patterns of damage and in their association with risk and ... ...

Abstract	Alzheimer's disease is marked by brain damage from tau and amyloid aggregates, particularly to the hippocampus and the default network. A new study in PLOS Biology shows sex differences in the patterns of damage and in their association with risk and protective factors.
MeSH term(s)	Female ; Humans ; Male ; Alzheimer Disease/etiology ; tau Proteins/metabolism ; Sex Characteristics ; Alleles ; Brain/metabolism ; Brain Injuries ; Apolipoproteins E ; Risk Factors
Chemical Substances	tau Proteins ; Apolipoproteins E
Language	English
Publishing date	2022-12-14
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3001905
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6193: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Stroke prevention: An uphill battle.

Beckett, Laurel A / Berglund, Lars F

Neurology

2019 Volume 93, Issue 23, Page(s) 987–988

MeSH term(s)	Cohort Studies ; Humans ; Stroke
Language	English
Publishing date	2019-10-31
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000008566
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui II Zs.153: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 18: Show issues
Zs.MO 374: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Perspectives of emergency department attendees on outcomes of resuscitation efforts: origins and impact on cardiopulmonary resuscitation preference.

Bandolin, Norkamari Shakira / Huang, Weixiao / Beckett, Laurel / Wintemute, Garen

Emergency medicine journal : EMJ

2020 Volume 37, Issue 10, Page(s) 611–616

Abstract: Background: Previous studies have shown that individuals overestimate the success of cardiopulmonary resuscitation (CPR) while underestimating its morbidity. Although perceptions of CPR success affect medical care in the emergency department (ED), no ED- ...

Abstract	Background: Previous studies have shown that individuals overestimate the success of cardiopulmonary resuscitation (CPR) while underestimating its morbidity. Although perceptions of CPR success affect medical care in the emergency department (ED), no ED-based studies have been done. Objective: To survey ED patients and their companions to assess their expectations, hypothesising that variation in information sources, prior exposure to CPR, and healthcare experience would influence predicted CPR success rates. Methods: A survey was carried out of adults (age >18 years) in the ED waiting area of a tertiary care hospital between June and September 2016. An optimism scale was created to reflect expected likelihood of survival after CPR, or CPR success, under several sets of circumstances. Potential predictors of optimism for CPR outcome were examined using linear regression. Associations between optimism and CPR preference were evaluated using a Wilcoxon rank-sum test. Results: There were 500 respondents and 53% had performed or witnessed CPR, and/or participated in a CPR course (64%). Television was the main source of information about CPR for >95% of respondents. At least half (51-64%) of respondents estimated the success rate of CPR as over 75% in all situations. Estimated CPR success rates were unrelated to age, sex, race, spiritual beliefs or personal healthcare experience. More than 90% of respondents wanted to receive CPR. Less than one-third of respondents had discussed CPR with a medical provider, but most wished to do so. Conclusion: Consistent with prior studies, individuals overestimate the success rate of CPR. Healthcare experience does not appear to mitigate optimism about CPR, and individuals overwhelmingly want CPR for themselves. Though few had talked about CPR with a medical provider, most wanted to have informed decision-making conversations. Such discussions could help patients obtain a more realistic view of CPR outcomes.
MeSH term(s)	Adult ; California ; Cardiopulmonary Resuscitation/methods ; Decision Making ; Emergency Service, Hospital ; Female ; Humans ; Male ; Patient Preference ; Prospective Studies ; Surveys and Questionnaires ; Tertiary Care Centers
Language	English
Publishing date	2020-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2018-208084
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1941: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Injection-site Reactions to Sustained-release Meloxicam in Sprague-Dawley Rats.

Stewart, Leslie A / Imai, Denise M / Beckett, Laurel / Li, Yueju / Lloyd, K C / Grimsrud, Kristin N

Journal of the American Association for Laboratory Animal Science : JAALAS

2020 Volume 59, Issue 6, Page(s) 726–731

Abstract: An extended-release formulation of the NSAID meloxicam (MSR) is used to provide 72 h of continuous analgesia in many species, including rodents. Although standard formulations of meloxicam are frequently used in rats with no observable injection-site ... ...

Abstract	An extended-release formulation of the NSAID meloxicam (MSR) is used to provide 72 h of continuous analgesia in many species, including rodents. Although standard formulations of meloxicam are frequently used in rats with no observable injection-site reactions, the potential adverse effects from MSR have not been characterized sufficiently nor has a prospective study of these effects been performed in rats. To address this deficiency, we evaluated injection-site reactions after a single subcutaneous administration of MSR (
MeSH term(s)	Analgesia/methods ; Analgesia/veterinary ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Delayed-Action Preparations/adverse effects ; Female ; Male ; Meloxicam/adverse effects ; Pain/drug therapy ; Prospective Studies ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Delayed-Action Preparations ; Meloxicam (VG2QF83CGL)
Language	English
Publishing date	2020-09-14
Publishing country	United States
Document type	Journal Article
ISSN	1559-6109
ISSN	1559-6109
DOI	10.30802/AALAS-JAALAS-20-000014
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A novel gamma GLM approach to MRI relaxometry comparisons.

Kapre, Rohan / Zhou, Junhan / Li, Xinzhe / Beckett, Laurel / Louie, Angelique Y

Magnetic resonance in medicine

2020 Volume 84, Issue 3, Page(s) 1592–1604

Abstract: Purpose: To demonstrate that constant coefficient of variation (CV), but nonconstant absolute variance in MRI relaxometry (T: Methods: Eight models including OLS and GGLM-ID were initially fit to data obtained on sulfated dextran iron oxide (SDIO) ... ...

Abstract	Purpose: To demonstrate that constant coefficient of variation (CV), but nonconstant absolute variance in MRI relaxometry (T Methods: Eight models including OLS and GGLM-ID were initially fit to data obtained on sulfated dextran iron oxide (SDIO) nanoparticles. Both a resampling simulation on the data as well as two separate Monte Carlo simulations (with and without concentration error) were performed to determine mean square error (MSE) and type I error rate. We then evaluated the performance of OLS/GGLM-ID on R Results: OLS had an MSE of 4-5× that of GGLM-ID as well as a type I error rate of 20-30%, whereas GGLM-ID was near the nominal 5% level in the relaxivity study. Only OLS found statistically significant effects of MRI facility on relaxivity in an R Conclusions: OLS leads to erroneous conclusions when analyzing MRI relaxometry data. GGLM-ID factors in the inherent CV of an MRI experiment, leading to more reproducible conclusions.
MeSH term(s)	Contrast Media ; Humans ; Iron ; Iron Overload ; Liver ; Magnetic Resonance Imaging
Chemical Substances	Contrast Media ; Iron (E1UOL152H7)
Language	English
Publishing date	2020-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605774-3
ISSN	1522-2594 ; 0740-3194
ISSN (online)	1522-2594
ISSN	0740-3194
DOI	10.1002/mrm.28192
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1959: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Ideal Worker and Academic Professional Identity: Perspectives from a Career Flexibility Educational Intervention.

Howell, Lydia Pleotis / Beckett, Laurel A / Villablanca, Amparo C

The American journal of medicine

2017 Volume 130, Issue 9, Page(s) 1117–1125

MeSH term(s)	Adult ; California ; Career Choice ; Career Mobility ; Faculty, Medical/psychology ; Female ; Humans ; Inservice Training ; Job Satisfaction ; Male ; Middle Aged ; Organizational Culture ; Organizational Policy ; Personal Satisfaction ; Professional Practice ; Surveys and Questionnaires ; Work-Life Balance
Language	English
Publishing date	2017-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2017.06.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.289: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease.

Scalco, Rebeca / Saito, Naomi / Beckett, Laurel / Nguyen, My-Le / Huie, Emily / Wang, Hsin-Pei / Flaherty, Delaney A / Honig, Lawrence S / DeCarli, Charles / Rissman, Robert A / Teich, Andrew F / Jin, Lee-Way / Dugger, Brittany N

Acta neuropathologica communications

2023 Volume 11, Issue 1, Page(s) 105

Abstract: Despite the increasing demographic diversity of the United States' aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological landscape of Alzheimer Disease (AD). Most ... ...

Abstract	Despite the increasing demographic diversity of the United States' aging population, there remain significant gaps in post-mortem research investigating the ethnoracial heterogeneity in the neuropathological landscape of Alzheimer Disease (AD). Most autopsy-based studies have focused on cohorts of non-Hispanic White decedents (NHWD), with few studies including Hispanic decedents (HD). We aimed to characterize the neuropathologic landscape of AD in NHWD (n = 185) and HD (n = 92) evaluated in research programs across three institutions: University of California San Diego, University of California Davis, and Columbia University. Only persons with a neuropathologic diagnosis of intermediate/high AD determined by NIA Reagan and/or NIA-AA criteria were included. A frequency-balanced random sample without replacement was drawn from the NHWD group using a 2:1 age and sex matching scheme with HD. Four brain areas were evaluated: posterior hippocampus, frontal, temporal, and parietal cortices. Sections were stained with antibodies against Aβ (4G8) and phosphorylated tau (AT8). We compared the distribution and semi-quantitative densities for neurofibrillary tangles (NFTs), neuropil threads, core, diffuse, and neuritic plaques. All evaluations were conducted by an expert blinded to demographics and group status. Wilcoxon's two-sample test revealed higher levels of neuritic plaques in the frontal cortex (p = 0.02) and neuropil threads (p = 0.02) in HD, and higher levels of cored plaques in the temporal cortex in NHWD (p = 0.02). Results from ordinal logistic regression controlling for age, sex, and site of origin were similar. In other evaluated brain regions, semi-quantitative scores of plaques, tangles, and threads did not differ statistically between groups. Our results demonstrate HD may be disproportionately burdened by AD-related pathologies in select anatomic regions, particularly tau deposits. Further research is warranted to understand the contributions of demographic, genetic, and environmental factors to heterogeneous pathological presentations.
MeSH term(s)	Humans ; Aged ; Alzheimer Disease ; Plaque, Amyloid ; White ; Neuropathology ; Neurofibrillary Tangles
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-023-01574-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Relationship between per capita births of Cook Inlet belugas and summer salmon runs: age‐structured population modeling

Norman, Stephanie A / Hobbs, Roderick C / Beckett, Laurel A / Trumble, Stephen J / Smith, Woutrina A

Ecosphere. 2020 Jan., v. 11, no. 1

2020

Abstract: Anthropogenic disturbances may alter a population's conservation status if the ability of individuals to survive and breed is affected. We used an adaptation of the Heligman‐Pollard model to estimate survival at age of Cook Inlet belugas (CIB; ... ...

Abstract	Anthropogenic disturbances may alter a population's conservation status if the ability of individuals to survive and breed is affected. We used an adaptation of the Heligman‐Pollard model to estimate survival at age of Cook Inlet belugas (CIB; Delphinapterus leucas), an endangered population in south‐central Alaska. We developed an age‐structured Leslie matrix model, based on the life history parameters survival and fecundity probability, to evaluate the sensitivity of population size and growth of CIB, to variation in estimate values of Chinook and coho salmon abundance in the Deshka River, a major tributary of the Susitna River. Birth effect (eb) was regressed against Chinook and coho salmon levels for the year of, the year before, and two years before a beluga calf birth. The effect of a range of modifications of salmon availability was illustrated in CIB with a series of simulations. The maximum annual population growths (λ) were set at 1.036 (3.6%). Ranges of CIB survival and fecundity probabilities indicated small changes in survival probabilities have a greater impact on population growth than similar changes in birth probability. As either survival (eₛ) or fecundity (eb) was reduced, the annual growth declined, with either eₛ = 0.961 or eb = 0.388, causing a decreased annual growth of −0.4%. Regressions of Chinook salmon for the year of, the year before, and two years before a birth were all significant at the 5% level as was coho in the year of and year prior to birth. The mechanism model with the best fit was the sum of Chinook and coho in the year of birth and year prior to birth. Simulations showed that if salmon runs remained at their current levels, the CIB population would likely continue its current slow decline and per capita births would continue to be low. The results from this study suggest reproductive success in CIB is tied to salmon abundance in the Deshka River. Current management practices should consider this when setting research priorities, designing new studies, and developing management actions to achieve CIB population recovery targets.
Keywords	Delphinapterus leucas ; Oncorhynchus kisutch ; Oncorhynchus tshawytscha ; age structure ; anthropogenic activities ; calves ; conservation status ; fecundity ; life history ; models ; population growth ; population size ; probability ; reproductive success ; rivers ; salmon ; summer ; Alaska
Language	English
Dates of publication	2020-01
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2572257-8
ISSN	2150-8925
ISSN	2150-8925
DOI	10.1002/ecs2.2955
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Injection Reactions after Administration of Sustained-release Meloxicam to BALB/cJ, C57BL/6J, and Crl:CD1(ICR) Mice.

Fuetsch, Stephanie R / Stewart, Leslie A / Imai, Denise M / Beckett, Laurel A / Li, Yueju / Lloyd, K C Kent / Grimsrud, Kristin N

Journal of the American Association for Laboratory Animal Science : JAALAS

2021 Volume 60, Issue 2, Page(s) 176–183

Abstract: The sustained-release formulation of meloxicam (MSR) is a compounded NSAID that may provide pain relief for as long as 72 h after administration. MSR injection-site skin reactions have occurred in several species but have not previously been observed in ... ...

Abstract	The sustained-release formulation of meloxicam (MSR) is a compounded NSAID that may provide pain relief for as long as 72 h after administration. MSR injection-site skin reactions have occurred in several species but have not previously been observed in mice. We investigated the development and progression of localized skin reactions after a single injection of MSR in Crl:CD1(ICR), C57BL/6J, and BALB/cJ mice. Each mouse received a subcutaneous injection of MSR (
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Delayed-Action Preparations ; Female ; Injections, Subcutaneous ; Male ; Meloxicam/administration & dosage ; Meloxicam/adverse effects ; Mice ; Mice, Inbred Strains ; Sex Characteristics
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Delayed-Action Preparations ; Meloxicam (VG2QF83CGL)
Language	English
Publishing date	2021-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2769-6677
ISSN (online)	2769-6677
DOI	10.30802/AALAS-JAALAS-20-000042
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A Landscape of Subjective and Objective Stress in African-American Dementia Family Caregivers.

Cothran, Fawn A / Chang, Emily / Beckett, Laurel / Bidwell, Julie T / Price, Candice A / Gallagher-Thompson, Dolores

Western journal of nursing research

2021 Volume 44, Issue 3, Page(s) 239–249

Abstract: Stress is a significant part of daily life, and systemic social inequities, such as racism and discrimination, are well-established contributors of chronic stress for African Americans. Added exposure to the stress of caregiving may exacerbate adverse ... ...

Abstract	Stress is a significant part of daily life, and systemic social inequities, such as racism and discrimination, are well-established contributors of chronic stress for African Americans. Added exposure to the stress of caregiving may exacerbate adverse health outcomes. This secondary analysis describes subjective and objective stress in African American family caregivers, and relationships of subjective and objective stress to health outcomes. Baseline data from 142 African American dementia family caregivers from the "Great Village" study were described using means and frequencies; regression models and Pearson's correlation were used to examine associations between demographics, social determinants of health, and health outcomes. Mixed models were used to examine change and change variation in cortisol. Most caregivers had moderate degrees of stress. Stress was associated with sleep disruption and depressive symptoms, and discrimination appeared to be an independent contributor to depressive symptoms. This work provides a foundation for interpreting subjective and objective indicators of stress to tailor existing multicomponent interventions.
MeSH term(s)	Black or African American ; Caregivers ; Dementia ; Humans ; Hydrocortisone ; Stress, Psychological
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2021-12-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	632788-6
ISSN	1552-8456 ; 0193-9459
ISSN (online)	1552-8456
ISSN	0193-9459
DOI	10.1177/01939459211062956
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2899: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito