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  1. Article: A randomized, open-label, parallel pilot study investigating metabolic product kinetics of the novel ketone ester, bis-hexanoyl (R)-1,3-butanediol, over one week of ingestion in healthy adults.

    Mah, Eunice / Blonquist, Traci M / Kaden, Valerie N / Beckman, Dawn / Boileau, Amy C / Anthony, Joshua C / Stubbs, Brianna J

    Frontiers in physiology

    2023  Volume 14, Page(s) 1196535

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1196535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Trajectory of Weight Patterns in Urban Youth Throughout Their Stay in a Juvenile Justice System.

    Keough, Lori / Cobb, Meghan / Sinclair, Tatum / Beckman, Dawn

    Journal of correctional health care : the official journal of the National Commission on Correctional Health Care

    2017  Volume 23, Issue 3, Page(s) 329–335

    Abstract: Incarceration is associated with health risks including overweight and obesity. This study explored obesity rates and weight gain in incarcerated youth by tracking weight trajectory during continuous stays in juvenile justice facilities. Among 65 youth, ... ...

    Abstract Incarceration is associated with health risks including overweight and obesity. This study explored obesity rates and weight gain in incarcerated youth by tracking weight trajectory during continuous stays in juvenile justice facilities. Among 65 youth, mean weight gain was 17.8 pounds and significant, F(2, 12) = 25.44, p = .03. Youth gained an average of 15.6 pounds (standard deviation [ SD] = 3.6) during the initial incarceration period (mean = 71 days). From the assessment to treatment period (mean = 46 days), mean weight gain was 4.1 pounds ( SD = 4.3), which also was significant, F(2, 12) = 28.57, p = .03. Body mass index z-scores increased significantly for each monthly weight observation. Being incarcerated is associated with significant weight gain and should influence policy and planning in this setting.
    MeSH term(s) Adolescent ; Body Mass Index ; Humans ; Male ; Medical Audit ; Obesity/epidemiology ; Prisoners ; Retrospective Studies ; United States/epidemiology ; Weight Gain ; Young Adult
    Language English
    Publishing date 2017-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2233559-6
    ISSN 1940-5200 ; 1078-3458
    ISSN (online) 1940-5200
    ISSN 1078-3458
    DOI 10.1177/1078345817716176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults

    Chen, Oliver / Blonquist, Traci M. / Mah, Eunice / Sanoshy, Kristen / Beckman, Dawn / Nieman, Kristin M. / Winters, Barbara L. / Anthony, Joshua C. / Verdin, Eric / Newman, John C. / Stubbs, Brianna J.

    Nutrients. 2021 June 16, v. 13, no. 6

    2021  

    Abstract: Nutritional ketosis is a state of mildly elevated blood ketone concentrations resulting from dietary changes (e.g., fasting or reduced carbohydrate intake) or exogenous ketone consumption. In this study, we determined the tolerability and safety of a ... ...

    Abstract Nutritional ketosis is a state of mildly elevated blood ketone concentrations resulting from dietary changes (e.g., fasting or reduced carbohydrate intake) or exogenous ketone consumption. In this study, we determined the tolerability and safety of a novel exogenous ketone diester, bis-hexanoyl-(R)-1,3-butanediol (BH-BD), in a 28-day, randomized, double-blind, placebo-controlled, parallel trial (NCT04707989). Healthy adults (n = 59, mean (SD), age: 42.8 (13.4) y, body mass index: 27.8 (3.9) kg/m²) were randomized to consume a beverage containing 12.5 g (Days 0–7) and 25 g (Days 7–28) of BH-BD or a taste-matched placebo daily with breakfast. Tolerability, stimulation, and sedation were assessed daily by standardized questionnaires, and blood and urine samples were collected at Days 0, 7, 14, and 28 for safety assessment. There were no differences in at-home composite systemic and gastrointestinal tolerability scores between BH-BD and placebo at any time in the study, or in acute tolerability measured 1-h post-consumption in-clinic. Weekly at-home composite tolerability scores did not change when BH-BD servings were doubled. At-home scores for stimulation and sedation did not differ between groups. BH-BD significantly increased blood ketone concentrations 1-h post-consumption. No clinically meaningful changes in safety measures including vital signs and clinical laboratory measurements were detected within or between groups. These results support the overall tolerability and safety of consumption of up to 25 g/day BH-BD.
    Keywords beverages ; blood ; body mass index ; breakfast ; carbohydrate intake ; esters ; gastrointestinal system ; ketosis ; placebos ; randomized clinical trials ; safety assessment ; sedation ; urine
    Language English
    Dates of publication 2021-0616
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13062066
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults.

    Chen, Oliver / Blonquist, Traci M / Mah, Eunice / Sanoshy, Kristen / Beckman, Dawn / Nieman, Kristin M / Winters, Barbara L / Anthony, Joshua C / Verdin, Eric / Newman, John C / Stubbs, Brianna J

    Nutrients

    2021  Volume 13, Issue 6

    Abstract: Nutritional ketosis is a state of mildly elevated blood ketone concentrations resulting from dietary changes (e.g., fasting or reduced carbohydrate intake) or exogenous ketone consumption. In this study, we determined the tolerability and safety of a ... ...

    Abstract Nutritional ketosis is a state of mildly elevated blood ketone concentrations resulting from dietary changes (e.g., fasting or reduced carbohydrate intake) or exogenous ketone consumption. In this study, we determined the tolerability and safety of a novel exogenous ketone diester, bis-hexanoyl-(R)-1,3-butanediol (BH-BD), in a 28-day, randomized, double-blind, placebo-controlled, parallel trial (NCT04707989). Healthy adults (
    MeSH term(s) Adult ; Beverages ; Blood Glucose/analysis ; Butylene Glycols/administration & dosage ; Butylene Glycols/adverse effects ; Butylene Glycols/blood ; Butylene Glycols/pharmacology ; Double-Blind Method ; Female ; Humans ; Ketone Bodies/blood ; Ketosis/chemically induced ; Male ; Surveys and Questionnaires
    Chemical Substances Blood Glucose ; Butylene Glycols ; Ketone Bodies ; bis hexanoyl (R)-1,3-butanediol
    Language English
    Publishing date 2021-06-16
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13062066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Weight patterns of youth entering an urban juvenile justice facility.

    Keough, Lori / Beckman, Dawn / Sinclair, Tatum / Young, Shannah / Baichoo, Shelanda / Cobb, Meghan

    Journal of correctional health care : the official journal of the National Commission on Correctional Health Care

    2015  Volume 21, Issue 1, Page(s) 45–52

    Abstract: Adolescents with a history of incarceration face a disproportionate number of health issues compared with their peers in virtually all areas, including perceived well-being; self-esteem; acute, chronic, and psychosocial disorders; and physical activity. ... ...

    Abstract Adolescents with a history of incarceration face a disproportionate number of health issues compared with their peers in virtually all areas, including perceived well-being; self-esteem; acute, chronic, and psychosocial disorders; and physical activity. Some studies have shown correlates of weight status and incarceration; however, the literature is conflicting. The current study sought to assess weight patterns of primarily minority urban youth (N = 548) entering a juvenile justice facility as well as associations between medications and weight status. Results indicate incarcerated adolescents have higher rates of overweight and obesity (40%) in comparison with nonincarcerated adolescents in the state (20 to 30%) or surrounding community (30 to 34%). Of interest, incarcerated adolescents taking asthma medications have significantly higher rates of overweight and obesity when compared with those not taking asthma medications. The clinical implications of these findings are discussed and implications for future research explored.
    MeSH term(s) Adolescent ; Body Mass Index ; Body Weight ; Continental Population Groups/statistics & numerical data ; Ethnic Groups/statistics & numerical data ; Female ; Humans ; Juvenile Delinquency ; Male ; Obesity/epidemiology ; Overweight/epidemiology ; Overweight/ethnology ; Prisons/statistics & numerical data ; Sex Factors ; Urban Population
    Language English
    Publishing date 2015-01
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 2233559-6
    ISSN 1940-5200 ; 1078-3458
    ISSN (online) 1940-5200
    ISSN 1078-3458
    DOI 10.1177/1078345814557793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Low incidence of complications in asthmatic patients treated with preoperative corticosteroids.

    Su, Fannie W / Beckman, Dawn B / Yarnold, Paul A / Grammer, Leslie C

    Allergy and asthma proceedings

    2004  Volume 25, Issue 5, Page(s) 327–333

    Abstract: The purpose of this study is to establish the incidence of perioperative complications in asthmatic patients treated with preoperative corticosteroids and to compare these rates to the general surgical population at the same hospital. Using a ... ...

    Abstract The purpose of this study is to establish the incidence of perioperative complications in asthmatic patients treated with preoperative corticosteroids and to compare these rates to the general surgical population at the same hospital. Using a retrospective cohort design, we studied 172 patients who underwent 249 procedures at our hospital between 1986 and 2002. Preoperative corticosteroids were administered in 240 of the procedures. The rate of asthma exacerbations, infections, wound infections, delayed wound healing, adrenocortical insufficiency, and mortality was assessed. Thirteen patients (5.2%) developed postoperative bronchospasm. Nine (3.6%) developed postoperative infections, four of which were wound infections (1.6%). There were no patients with adrenal insufficiency. One death occurred intraoperatively as a result of a neurosurgical complication. There was no statistical difference in the incidence of infections between our asthma population and the general surgical population in the same hospital except in gynecologic procedures. We conclude that asthmatic patients who are treated with corticosteroids before undergoing surgery have a low incidence of complications.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Asthma/prevention & control ; Asthma/surgery ; Cohort Studies ; Female ; Glucocorticoids/administration & dosage ; Humans ; Incidence ; Male ; Middle Aged ; Prednisolone/administration & dosage ; Premedication ; Preoperative Care ; Retrospective Studies ; Surgical Wound Infection/epidemiology
    Chemical Substances Glucocorticoids ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2004-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1312445-6
    ISSN 1088-5412
    ISSN 1088-5412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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