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Article ; Online: Comparing Luminex NxTAG-Respiratory Pathogen Panel and RespiFinder-22 for multiplex detection of respiratory pathogens.

Beckmann, Christiane / Hirsch, Hans H

2016 Volume 88, Issue 8, Page(s) 1319–1324

Abstract: Respiratory tract infection (RTI) involves a variety of viruses and bacteria, which can be conveniently detected by multiplex nucleic acid amplification testing (NAT). To compare the novel Luminex-based NxTAG-Respiratory Pathogen Panel (NxTAG-RPP) with ... ...

Abstract	Respiratory tract infection (RTI) involves a variety of viruses and bacteria, which can be conveniently detected by multiplex nucleic acid amplification testing (NAT). To compare the novel Luminex-based NxTAG-Respiratory Pathogen Panel (NxTAG-RPP) with the routine multiplex-ligation-NAT based RespiFinder-22® (RF-22), 282 respiratory specimens including nasopharyngeal swabs (71%), broncho-alveolar lavage (27%), throat swabs, tracheal secretions, and sputum (2%) from 116 children and 155 adults were extracted using a Corbett CAS1200 (Qiagen), and analyzed in parallel by the routine RF-22 and NxTAG-RPP. Concordant results were obtained in 263 (93.3%) cases consisting of concordant positives in 167 (59.2%) and concordant negatives in 96 (34%). Results were discordant in 19 (6.7%) consisting of 15 positive:negative, and 4 negative:positive results by NxTAG-RPP versus RF-22, respectively. Co-infections were observed in 10.3% with NxTAG-RPP and in 5.9% with RF-22. Most additional viral pathogens identified by the NxTAG-RPP involved dual infections with rhinovirus and RSV. Discordant samples were mainly due to low genome signals of Ct less than 36, when retested by QNAT suggesting a higher sensitivity of the NxTAG-RPP, also when detecting multiple infections. Hands-on time after extraction for 24 and 96 samples was 0.25 and <0.5 hr for the NxTAG-RPP, and 2 and 4 hr for the RF-22, respectively. The median turn-around time was 6 hr (range 5-7 hr) for NxTAG-RPP and 12 hr (range 8-16 hr) for RF-22. The NxTAG-RPP showed comparable detection rates for most respiratory pathogens, while hands-on and turn-around time were considerably shorter. The clinical significance of detecting multiple viruses needs further clinical evaluation. J. Med. Virol. 88:1319-1324, 2016. © 2016 Wiley Periodicals, Inc.
MeSH term(s)	Aged ; Bronchoalveolar Lavage Fluid/virology ; Child, Preschool ; Coinfection/diagnosis ; Coinfection/virology ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Molecular Diagnostic Techniques/methods ; Molecular Diagnostic Techniques/standards ; Multiplex Polymerase Chain Reaction/methods ; Nasopharynx/virology ; Reagent Kits, Diagnostic ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/virology ; Retrospective Studies ; Rhinovirus/genetics ; Rhinovirus/pathogenicity ; Sensitivity and Specificity ; Sputum/virology ; Time Factors ; Trachea/virology ; Virus Diseases/diagnosis ; Virus Diseases/virology ; Viruses/classification ; Viruses/genetics ; Viruses/isolation & purification
Chemical Substances	Reagent Kits, Diagnostic
Keywords	covid19
Language	English
Publishing date	2016-02-18
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.24492
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Article ; Online: COVID salivary diagnostics: A comparative technical study.

Nguyen-Kim, Hanh / Beckmann, Christiane / Redondo, Maurice / Ziliox, Jérémy / Vallet, Virginie / Berger-Sturm, Karin / Overbeck, Jan Von / Alberi Auber, Lavinia

Journal of medical virology

2022 Volume 94, Issue 9, Page(s) 4277–4286

Abstract: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, molecular diagnostics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have taken center stage in the detection of infected individuals for isolation purposes but ... ...

Abstract	Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, molecular diagnostics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have taken center stage in the detection of infected individuals for isolation purposes but also in the mass surveillance as a preventive strategy to contain the virus spread. While nasopharyngeal swabs (NPS) have remained the golden standard substrate, salivary diagnostic for SARS-CoV-2 has been proposed as an alternative and noninvasive measure in vulnerable individuals. Nevertheless, there is a widespread assumption that salivary reverse-transcription polymerase chain reaction (RT-PCR) does not match the quality of testing using NPS and particular care should be taken in respect to food or beverage intake, when sampling saliva. Our study indicates that without any precaution in the selection of 190 patients, nor restriction over the time window of sampling, there is 99% match in the COVID-19 positivity between NPS and saliva when using RT-PCR, with a reported Delta in thermal cycles (Cts) values for the viral genes Envelope (E) and Open reading frame 1ab (Orf1ab) between 0 and 2, a 98.7% sensitivity and 100% specificity. This high accuracy is maintained in pooling configurations that can be used for mass-testing purposes in professional and educational settings. The further advantage to using crude saliva as compared to NPS or mouthwash is that direct methods yield robust results. Overall, our study validates and promotes the use of salivary diagnostic for COVID-19 eliminating the need of a medical practitioner for the sampling, resolving the unpleasantness of the NPS intervention and empowering the patient to do self-testing in times of need.
MeSH term(s)	COVID-19/diagnosis ; COVID-19 Testing ; Humans ; Nasopharynx ; Pandemics ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Saliva ; Specimen Handling/methods
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27883
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Article ; Online: Diagnostic performance of near-patient testing for influenza.

Beckmann, Christiane / Hirsch, Hans H

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2015 Volume 67, Page(s) 43–46

Abstract: Background: Rapid diagnosis of influenza is important for controlling outbreaks and starting antiviral therapy. Direct antigen detection (DAD) is rapid, but lacks sensitivity, whereas nucleic acid amplification testing (NAT) is more sensitive, but also ... ...

Abstract	Background: Rapid diagnosis of influenza is important for controlling outbreaks and starting antiviral therapy. Direct antigen detection (DAD) is rapid, but lacks sensitivity, whereas nucleic acid amplification testing (NAT) is more sensitive, but also more time-consuming. Objectives: To evaluate the performance of a rapid isothermal NAT and two DADs. Study design: During February-May 2014, we tested 211 consecutive patients with influenza-like illness using a commercial isothermal NAT (Alere™ Influenza A&B) as well as the DAD Sofia(®) Influenza A+B and BinaxNOW(®) Influenza A&B for detection of influenza-A and -B virus. RespiFinder-22(®) a commercial multiplex NAT served as reference test. Serial 10-fold dilutions of influenza-A and -B cell culture supernatants were examined. Another 225 patient samples were tested during December 2014-February 2015. Results: Compared to RespiFinder-22(®), the isothermal NAT Alere™ Influenza A&B, and the DAD Sofia(®) Influenza A+B and BinaxNOW(®) Influenza A&B had sensitivities of 77.8%, 59.3% and 29.6%, and specificities of 99.5%, 98.9% and 100%, respectively, for the first 211 patient samples. Alere™ Influenza A&B showed 85.7% sensitivity and 100% specificity in the second cohort. Isothermal NAT was 10-100-fold more sensitive compared to DAD for influenza virus culture supernatants with a lower limit of detection of 5000-50,000 copies/mL. The average turn-around time (TAT) of isothermal NAT and DADs was 15min, but increased to 110min for Alere™ Influenza A&B, 30min for BinaxNOW(®) Influenza A&B, and 45min for Sofia(®) Influenza A+B, when analyzing batches of 6 samples. Conclusion: Simple sample processing and a TAT of 15min render isothermal NAT Alere™ Influenza A&B suitable for sequential near-patient testing, but the TAT advantage is lost when testing of larger series.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Diagnostic Tests, Routine/methods ; Female ; Humans ; Immunoassay/methods ; Infant ; Influenza, Human/diagnosis ; Male ; Middle Aged ; Nucleic Acid Amplification Techniques/methods ; Point-of-Care Systems ; Prospective Studies ; Sensitivity and Specificity ; Time Factors ; Young Adult
Keywords	covid19
Language	English
Publishing date	2015-03-31
Publishing country	Netherlands
Document type	Comparative Study ; Evaluation Study ; Journal Article
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2015.03.024
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Article ; Online: Antibiotic treatment of pertussis: are 7 days really sufficient?

Dierig, Alexa / Beckmann, Christiane / Heininger, Ulrich

The Pediatric infectious disease journal

2015 Volume 34, Issue 4, Page(s) 444–445

Abstract: Short courses of antibiotic therapy are recommended for treatment of pertussis. We report 2 young unvaccinated infants with persistently positive Bordetella pertussis by polymerase chain reaction from nasopharyngeal swabs despite 7 days of clarithromycin ...

Abstract	Short courses of antibiotic therapy are recommended for treatment of pertussis. We report 2 young unvaccinated infants with persistently positive Bordetella pertussis by polymerase chain reaction from nasopharyngeal swabs despite 7 days of clarithromycin (15 mg/kg/d) therapy. In 1 patient, quantitative polymerase chain reaction was 7.02 (log GEq/mL) at the onset of treatment, 6.26 at the end of treatment and remained positive with 2.64 and 2.69 during and after a second 7-day course, respectively. The generally believed assumption that contagiousness of pertussis is terminated after 5 days of antibiotic treatment should be challenged, at least in young infants.
MeSH term(s)	Anti-Bacterial Agents/administration & dosage ; Bordetella pertussis/isolation & purification ; Clarithromycin/administration & dosage ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Nasopharynx/microbiology ; Polymerase Chain Reaction ; Time Factors ; Whooping Cough/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Clarithromycin (H1250JIK0A)
Language	English
Publishing date	2015-04
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000000567
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Article ; Online: Safety and effects of two mistletoe preparations on production of Interleukin-6 and other immune parameters - a placebo controlled clinical trial in healthy subjects

Huber Roman / Lüdtke Holger / Wieber Johannes / Beckmann Christiane

BMC Complementary and Alternative Medicine, Vol 11, Iss 1, p

2011 Volume 116

Abstract: Abstract Background In Germany, Iscucin ® Populi (IP), a preparation from mistletoe growing on the poplar tree, is used in cancer therapy while Viscum Mali e planta tota (VM), a preparation from mistletoe growing on the apple tree, is used in patients ... ...

Abstract	Abstract Background In Germany, Iscucin ® Populi (IP), a preparation from mistletoe growing on the poplar tree, is used in cancer therapy while Viscum Mali e planta tota (VM), a preparation from mistletoe growing on the apple tree, is used in patients with osteoarthritis. Since mistletoe preparations are suspected to induce production of potentially tumor promoting cytokines like interleukin (IL)-6, further studies on the immunological effects are of interest. Methods In this 3-armed randomized, double blind clinical trial healthy volunteers received increasing doses of either IP (strength F, 0.0125%, G, 0.25% and H, 5%, each for 4 weeks), or VM (1:1000 [D3], 1:100 [D2] and 2% each for 4 weeks) or placebo (isotonic solution) subcutaneously twice per week over a period of 12 weeks. Physical examination was performed weekly. Routine laboratory parameters and immunological parameters (C-reactive protein (CRP), differential blood count, lymphocyte subsets, immunoglobulins, IL-6 and tumor necrosis factor (TNF)-α) were analysed every 4 weeks. Results 71 subjects were included in the study (IP = 30, VM = 21, placebo = 20) of whom 69 concluded it according to protocol. Application of IP strengths G and H caused strong local reactions at the site of injection. In parallel, a distinct eosinophilia (p < 0.001 compared to placebo) occurred. Furthermore, application of all IP concentrations resulted in an increase of CD4 cell counts (p < 0.05) compared to placebo. Stimulation of IL-6 production, CRP or relevant deviations in other laboratory parameters were not observed. Because of local reactions, IP strengths G and H were considered less tolerable than placebo. VM 2% was slightly less tolerable than placebo, caused only mild local reactions and an only small increase in eosinophile counts. Conclusion Treatment with IP results in eosinophilia and an increase of CD4 cells but not in an increase of IL-6 or CRP. No safety concerns regarding the two mistletoe preparations have been raised by this study. EudraCT-Number ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2011-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: In-vitro-Untersuchungen zur Weidenmistel an verschiedenen humanen Tumorzelllinien

Felenda, Jennifer E. / Gruber, Kim / Pacifico, Severina / Turek, Claudia / Beckmann, Christiane / Stintzing, Florian C.

Zeitschrift für Phytotherapie

2019 Volume 40, Issue 03, Page(s) 112–119

Abstract: Traditionell werden pharmazeutische Zubereitungen der Weidenmistel häufig bei der Therapie von Blasen- und Nierenzellkarzinomen eingesetzt. Dennoch existieren bislang nur wenige wissenschaftliche Untersuchungen zu Wirkmechanismen von ... ...

Abstract	Traditionell werden pharmazeutische Zubereitungen der Weidenmistel häufig bei der Therapie von Blasen- und Nierenzellkarzinomen eingesetzt. Dennoch existieren bislang nur wenige wissenschaftliche Untersuchungen zu Wirkmechanismen von Weidenmistelpräparaten. Daher wurde mithilfe verschiedener Testverfahren die Hemmung der Viabilität von Tumorzellen durch den Weidenmistelextrakt Iscucin Salicis bestimmt und die beteiligten Mechanismen untersucht. Des Weiteren wurde die Hemmung der Zellmigration analysiert. Ergebnisse: Der Extrakt hemmte Zellwachstum und -migration in vitro, wobei die Sensitivität der einzelnen Tumorzelllinien variierte. Vor allem sprachen neuroepitheliale Tumorzellen und Bronchialkarzinomzellen gut an. Zudem wurden pro-apoptotische Marker aktiviert. Klinische Untersuchungen stehen aus, um zu klären, bei welchen Tumoren das größte Potenzial für eine Behandlung mit Iscucin Salicis besteht.
Keywords	L. ; Mistel ; Iscucin ; Salicis ; antitumoral ; Zellviabilität ; Apoptose ; L. ; mistletoe ; Iscucin ; Salicis ; anti-tumor ; cell viability ; apoptosis
Language	German
Publishing date	2019-07-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	604850-x
ISSN	1438-9584 ; 0722-348X ; 0720-227X
ISSN (online)	1438-9584
ISSN	0722-348X ; 0720-227X
DOI	10.1055/a-0799-7042
Database	Thieme publisher's database

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Article ; Online: Safety and effects of two mistletoe preparations on production of Interleukin-6 and other immune parameters - a placebo controlled clinical trial in healthy subjects.

Huber, Roman / Lüdtke, Holger / Wieber, Johannes / Beckmann, Christiane

BMC complementary and alternative medicine

2011 Volume 11, Page(s) 116

Abstract: Background: In Germany, Iscucin® Populi (IP), a preparation from mistletoe growing on the poplar tree, is used in cancer therapy while Viscum Mali e planta tota (VM), a preparation from mistletoe growing on the apple tree, is used in patients with ... ...

Abstract	Background: In Germany, Iscucin® Populi (IP), a preparation from mistletoe growing on the poplar tree, is used in cancer therapy while Viscum Mali e planta tota (VM), a preparation from mistletoe growing on the apple tree, is used in patients with osteoarthritis. Since mistletoe preparations are suspected to induce production of potentially tumor promoting cytokines like interleukin (IL)-6, further studies on the immunological effects are of interest. Methods: In this 3-armed randomized, double blind clinical trial healthy volunteers received increasing doses of either IP (strength F, 0.0125%, G, 0.25% and H, 5%, each for 4 weeks), or VM (1:1000 [D3], 1:100 [D2] and 2% each for 4 weeks) or placebo (isotonic solution) subcutaneously twice per week over a period of 12 weeks. Physical examination was performed weekly. Routine laboratory parameters and immunological parameters (C-reactive protein (CRP), differential blood count, lymphocyte subsets, immunoglobulins, IL-6 and tumor necrosis factor (TNF)-α) were analysed every 4 weeks. Results: 71 subjects were included in the study (IP = 30, VM = 21, placebo = 20) of whom 69 concluded it according to protocol. Application of IP strengths G and H caused strong local reactions at the site of injection. In parallel, a distinct eosinophilia (p < 0.001 compared to placebo) occurred. Furthermore, application of all IP concentrations resulted in an increase of CD4 cell counts (p < 0.05) compared to placebo. Stimulation of IL-6 production, CRP or relevant deviations in other laboratory parameters were not observed. Because of local reactions, IP strengths G and H were considered less tolerable than placebo. VM 2% was slightly less tolerable than placebo, caused only mild local reactions and an only small increase in eosinophile counts. Conclusion: Treatment with IP results in eosinophilia and an increase of CD4 cells but not in an increase of IL-6 or CRP. No safety concerns regarding the two mistletoe preparations have been raised by this study. EudraCT-Number 2007-002166-35. Trial registration: ClinicalTrials.gov: NCT01378702.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Immunity/drug effects ; Interleukin-6/immunology ; Male ; Middle Aged ; Mistletoe/chemistry ; Plant Extracts/administration & dosage ; Plant Extracts/adverse effects ; Young Adult
Chemical Substances	Interleukin-6 ; Plant Extracts
Language	English
Publishing date	2011-11-24
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/1472-6882-11-116
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nachhaltige Erneuerung der GKV? - Eine Erfolgsrechnung des GMG

Lusk, Michael / Beckmann, Christiane / Stintzing, Florian / Meyer, Ulrich

Der Merkurstab

2014 Volume 67, Issue 3, Page(s) 209

Language	German
Document type	Article
ZDB-ID	392536-5
ISSN	0935-798X
Database	Current Contents Medicine

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Book ; Thesis: Monoklonale und rekombinante Antikörper zur strukturellen und funktionellen Analyse mikrobieller Lebensgemeinschaften

Beckmann, Christiane

1998

Author's details	von Christiane Beckmann
Language	German
Size	IX, 169 Bl., Anh, Ill., graph. Darst
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Techn. Univ., Diss.--Braunschweig, 1998
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Levisticum officinale Koch: Antiinflammatorisches Potenzial und klinischer Einsatz bei Otitis media

Beckmann, Christiane / Staiger, Melanie / Herrick, Anja / Fischer, Anna / Britsch, Maria / Stintzing, Florian Conrad

Zeitschrift für Phytotherapie

2017 Volume 38, Issue 02, Page(s) 65–71

Abstract: Die Wurzel von Liebstöckel ( Levisticum officinale Koch), der v. a. als Gewürzpflanze bekannt ist, wird seit Jahrhunderten zur Herstellung von Arzneimitteln eingesetzt. Neben der traditionellen Verwendung zur Durchspülungstherapie bei Nierenleiden findet ...

Abstract	Die Wurzel von Liebstöckel ( Levisticum officinale Koch), der v. a. als Gewürzpflanze bekannt ist, wird seit Jahrhunderten zur Herstellung von Arzneimitteln eingesetzt. Neben der traditionellen Verwendung zur Durchspülungstherapie bei Nierenleiden findet in der anthroposophischen Medizin ein 5 %iger Auszug der getrockneten Wurzel in nativem Olivenöl Anwendung bei Mittelohrentzündung. Sicherheit und Wirkungen dieses Auszugs waren Ziele einer präklinischen und klinischen Untersuchung. Methoden: Präklinisch wurden die Effekte des 5 %igen Auszugs sowie des Auszugsöls auf die 5-Lipoxygenase und die Cyclooxygenase-2 und die von ihnen katalysierte Synthese von antiinflammatorischen Mediatoren, Leukotrien B 4 und Prostaglandin E 2 untersucht. Klinisch lieferte eine nichtinterventionelle Studie mit 85 Patienten Daten aus der ärztlichen Routineanwendung des Auszugs von Levistici radix bei Otitis media. Ergebnisse: Der 5 %ige Auszug von Levistici radix in nativem Olivenöl reduzierte deutlich die Leukotrien-B 4 - und weniger deutlich die Prostaglandin-E 2 -Synthese. Die Wirkung des parallel getesteten Olivenöls fiel wesentlich geringer aus. Die klinische Anwendung des Auszugs in Form von Ohrentropfen ergab eine als gut bis sehr gut beurteilte Wirkung und Verträglichkeit. Fazit: Die präklinische Untersuchung liefert eine rationale Basis für die lokale klinische Anwendung des 5 %igen Auszugs von Levistici radix in nativem Olivenöl bei Otitis media, die in der Praxis bestätigt wird.
Keywords	Koch ; Phtalide ; Polyacetylene ; Olivenöl ; antiinflammatorisch ; Leukotriene ; Prostaglandine ; NIS ; Otitis media ; Levisticum Ohrentropfen ; Koch ; lovage ; phtalides ; polyacetylenes ; olive oil ; anti-inflammatory ; leukotrienes ; prostaglandins ; NIS ; otitis media ; Levisticum ear drops
Language	German
Publishing date	2017-03-14
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	604850-x
ISSN	1438-9584 ; 0722-348X ; 0720-227X
ISSN (online)	1438-9584
ISSN	0722-348X ; 0720-227X
DOI	10.1055/s-0043-100032
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