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  1. Article ; Online: Mycobacterium abscessus

    Beech, Alison J / Weinberg, Sharon E / Mortimer, Alice E / Lynch, Fiona / Bedford, James / Calisti, Giorgio

    Journal of clinical tuberculosis and other mycobacterial diseases

    2023  Volume 32, Page(s) 100381

    Abstract: Medical tourism is becoming increasingly popular. The most popularly sought operations are cosmetic procedures. With the increase in cosmetic tourism, it is unsurprising that there has also been a rise in skin and soft tissue infections caused by ... ...

    Abstract Medical tourism is becoming increasingly popular. The most popularly sought operations are cosmetic procedures. With the increase in cosmetic tourism, it is unsurprising that there has also been a rise in skin and soft tissue infections caused by nontuberculous mycobacteria (NTM); in particular by the rapidly growing mycobacteria species. Here we provide a case of a 35 year-old woman who presented after autologous fat grafting with multiple painful, violaceous, and purulent nodules on her arms, legs, and breasts. Infection was found to be due to
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Case Reports
    ISSN 2405-5794
    ISSN (online) 2405-5794
    DOI 10.1016/j.jctube.2023.100381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessment and management of secondary bacterial infections complicating Mpox (Monkeypox) using a telemedicine service. A prospective cohort study.

    Moody, Samuel / Lamb, Thomas / Jackson, Eleri / Beech, Alison / Malik, Nabihah / Johnson, Leann / Jacobs, Nathan

    International journal of STD & AIDS

    2023  Volume 34, Issue 7, Page(s) 434–438

    Abstract: Introduction: During spring 2022, an outbreak of Monkeypox (mpox) emerged as an infection of concern in Europe. Due to the overlapping clinical features of mpox and bacterial infections, diagnosis of concomitant bacterial infection is challenging. In ... ...

    Abstract Introduction: During spring 2022, an outbreak of Monkeypox (mpox) emerged as an infection of concern in Europe. Due to the overlapping clinical features of mpox and bacterial infections, diagnosis of concomitant bacterial infection is challenging. In this prospective cohort study, we report the incidence, severity, and progression of patients with secondary bacterial infection complicating mpox infection.
    Method: Data were collected via a bespoke mpox telemedicine service provided by Infection services at North Manchester General Hospital, UK. A diagnosis of secondary bacterial infection was based on the history (balanitis, surrounding erythema, purulent discharge and nasal ulceration) and review of patient-collected medical photography. Patient were reviewed face-to-face where necessary.
    Results: Secondary bacterial infection was diagnosed in 15 of 129 (11.6%) patients with mpox. Three patients with secondary bacterial infection (3/129, 2.3%) required admission to hospital and one patient underwent surgical debridement. Median healing (thus, isolation) times were longer in those with bacterial infection.
    Discussion: In this prospective cohort study of patients with mpox, secondary bacterial infection was infrequent and predominantly mild. The virtual ward and telemedicine follow up allowed for the prompt recognition of secondary bacterial infections and timely antibiotic administration. Due to concerns regarding nosocomial transmission, mild clinical course and limited inpatient bed capacity, we believe this model of outpatient management for mpox (Clade II B.1 lineage) could be replicated in other low risk populations where suitable home isolation facilities exist.
    MeSH term(s) Male ; Humans ; Mpox (monkeypox) ; Prospective Studies ; Bacterial Infections/drug therapy ; Bacterial Infections/epidemiology ; Coinfection ; Hospitals, General
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624231162760
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2829: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Can frailty screening tools predict completion of chemotherapy and chemotherapy toxicity in patients with thoracic malignancy?

    Tivey, Ann / Ullah, Mohammed / Beech, Alison / Ng, Cassandra / Cove-Smith, Laura

    Journal of geriatric oncology

    2020  Volume 11, Issue 7, Page(s) 1154–1156

    MeSH term(s) Aged ; Frail Elderly ; Frailty/chemically induced ; Frailty/diagnosis ; Geriatric Assessment ; Humans ; Mass Screening ; Thoracic Neoplasms/drug therapy
    Language English
    Publishing date 2020-03-11
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2020.03.002
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  4. Article ; Online: The effect of multiple analysers on the biochemical diagnosis of myocardial infarction using a contemporary troponin-I assay.

    Pethick, James / Patel, Prashanth / Davies, Timothy / Thompson, John / Nallagonda, Madhavi / Beech, Alison / Collinson, Paul / Lee, Virginia / Gupta, Pankaj

    Annals of clinical biochemistry

    2016  Volume 53, Issue 6, Page(s) 702–705

    Abstract: Background The measurement of cardiac troponin is central for the diagnosis of myocardial infarction (MI). It is recommended that a coefficient of variation of ≤10% is achieved at the diagnostic threshold and significant change between serial ... ...

    Abstract Background The measurement of cardiac troponin is central for the diagnosis of myocardial infarction (MI). It is recommended that a coefficient of variation of ≤10% is achieved at the diagnostic threshold and significant change between serial measurements reported. Many modern laboratories use multiple analysers linked by automation where samples are randomly assigned to an analyser. It is therefore important to consider the combined effect of all analysers on the analytical performance of troponin measurement. Method The performance of a contemporary troponin-I (cTn-I) assay run on three analysers, linked by an automated track, was undertaken across a range of cTn-I concentrations. The data for the three analysers were aggregated to obtain the combined analytical coefficient of variation (CV
    MeSH term(s) Automation, Laboratory/standards ; Biological Assay/standards ; Biomarkers/blood ; Humans ; Myocardial Infarction/blood ; Myocardial Infarction/diagnosis ; Myocardium/metabolism ; Myocardium/pathology ; Observer Variation ; Reference Values ; Troponin T/blood
    Chemical Substances Biomarkers ; Troponin T
    Language English
    Publishing date 2016-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 390309-6
    ISSN 1758-1001 ; 0004-5632
    ISSN (online) 1758-1001
    ISSN 0004-5632
    DOI 10.1177/0004563216637388
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 889: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Small-Molecule G Protein-Coupled Receptor Kinase Inhibitors Attenuate G Protein-Coupled Receptor Kinase 2-Mediated Desensitization of Vasoconstrictor-Induced Arterial Contractions.

    Rainbow, Richard D / Brennan, Sean / Jackson, Robert / Beech, Alison J / Bengreed, Amal / Waldschmidt, Helen V / Tesmer, John J G / Challiss, R A John / Willets, Jonathon M

    Molecular pharmacology

    2018  Volume 94, Issue 3, Page(s) 1079–1091

    Abstract: Vasoconstrictor-driven G protein-coupled receptor (GPCR)/phospholipase C (PLC) signaling increases intracellular ... ...

    Abstract Vasoconstrictor-driven G protein-coupled receptor (GPCR)/phospholipase C (PLC) signaling increases intracellular Ca
    MeSH term(s) Animals ; Cell Line, Transformed ; Dose-Response Relationship, Drug ; G-Protein-Coupled Receptor Kinase 2/antagonists & inhibitors ; G-Protein-Coupled Receptor Kinase 2/physiology ; Humans ; Male ; Mesenteric Arteries/drug effects ; Mesenteric Arteries/physiology ; Muscle, Smooth, Vascular/drug effects ; Muscle, Smooth, Vascular/physiology ; Protein Kinase Inhibitors/pharmacology ; Rats ; Rats, Wistar ; Vasoconstriction/drug effects ; Vasoconstriction/physiology ; Vasoconstrictor Agents/pharmacology
    Chemical Substances Protein Kinase Inhibitors ; Vasoconstrictor Agents ; Grk2 protein, rat (EC 2.7.11.15) ; G-Protein-Coupled Receptor Kinase 2 (EC 2.7.11.16)
    Language English
    Publishing date 2018-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 124034-1
    ISSN 1521-0111 ; 0026-895X
    ISSN (online) 1521-0111
    ISSN 0026-895X
    DOI 10.1124/mol.118.112524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 525: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Biochemical Screening for Nonadherence Is Associated With Blood Pressure Reduction and Improvement in Adherence.

    Gupta, Pankaj / Patel, Prashanth / Štrauch, Branislav / Lai, Florence Y / Akbarov, Artur / Gulsin, Gaurav S / Beech, Alison / Marešová, Věra / Topham, Peter S / Stanley, Adrian / Thurston, Herbert / Smith, Paul R / Horne, Robert / Widimský, Jiří / Keavney, Bernard / Heagerty, Anthony / Samani, Nilesh J / Williams, Bryan / Tomaszewski, Maciej

    Hypertension (Dallas, Tex. : 1979)

    2017  Volume 70, Issue 5, Page(s) 1042–1048

    Abstract: We hypothesized that screening for nonadherence to antihypertensive treatment using liquid chromatography-tandem mass spectrometry-based biochemical analysis of urine/serum has therapeutic applications in nonadherent hypertensive patients. A ... ...

    Abstract We hypothesized that screening for nonadherence to antihypertensive treatment using liquid chromatography-tandem mass spectrometry-based biochemical analysis of urine/serum has therapeutic applications in nonadherent hypertensive patients. A retrospective analysis of hypertensive patients attending specialist tertiary care centers was conducted in 2 European countries (United Kingdom and Czech Republic). Nonadherence to antihypertensive treatment was diagnosed using biochemical analysis of urine (United Kingdom) or serum (Czech Republic). These results were subsequently discussed with each patient, and data on follow-up clinic blood pressure (BP) measurements were collected from clinical files. Of 238 UK patients who underwent biochemical urine analysis, 73 were nonadherent to antihypertensive treatment. Their initial urinary adherence ratio (the ratio of detected to prescribed antihypertensive medications) increased from 0.33 (0-0.67) to 1 (0.67-1) between the first and the last clinic appointments. The observed increase in the urinary adherence ratio in initially nonadherent UK patients was associated with the improved BP control; by the last clinic appointment, systolic and diastolic BPs were ≈19.5 and 7.5 mm Hg lower than at baseline (
    MeSH term(s) Adult ; Aged ; Antihypertensive Agents/analysis ; Antihypertensive Agents/therapeutic use ; Biomarkers/blood ; Biomarkers/urine ; Blood Pressure/drug effects ; Blood Pressure Determination/methods ; Blood Pressure Determination/psychology ; Chromatography, Liquid/methods ; Czech Republic/epidemiology ; Female ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Hypertension/psychology ; Male ; Medication Adherence/psychology ; Medication Therapy Management/standards ; Middle Aged ; Outcome and Process Assessment, Health Care ; Quality Improvement ; United Kingdom/epidemiology
    Chemical Substances Antihypertensive Agents ; Biomarkers
    Language English
    Publishing date 2017-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.117.09631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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