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  1. Article ; Online: Factors Influencing Successful Lumbar Puncture in Alzheimer Research.

    Moulder, Krista L / Besser, Lilah M / Beekly, Duane / Blennow, Kaj / Kukull, Walter / Morris, John C

    Alzheimer disease and associated disorders

    2017  Volume 31, Issue 4, Page(s) 287–294

    Abstract: Objective: Lumbar puncture (LP) is increasingly common in Alzheimer disease research; however, agreement to undergo LP varies. We sought to determine factors influencing LP consent at Alzheimer's Disease Centers (ADCs) in the United States.: Methods: ...

    Abstract Objective: Lumbar puncture (LP) is increasingly common in Alzheimer disease research; however, agreement to undergo LP varies. We sought to determine factors influencing LP consent at Alzheimer's Disease Centers (ADCs) in the United States.
    Methods: A 3-part survey was distributed to each ADC: (1) ADC LP Experience; (2) LP Requestor Experience; and (3) Patient LP Experience (both Initial and Follow-up). In all, 64 LP Requestor, 579 Patient/Initial, and 404 Patient/Follow-up surveys were collected. Logistic regression analyses with generalized estimating equations were used to assess factors associated with LP agreement and post-LP complications.
    Results: Asians and those viewing LP negatively were less likely to agree to LP. Three hundred fifty-two participants had an LP; LP headache occurred in 11.9% (blood patch required in 1.4%) and 9.9% reported other complications. Younger individuals, women, those diagnosed with mild cognitive impairment, use of a Quincke needle, ≤20 mL cerebrospinal fluid drawn, and hemorrhage during LP were associated with LP headache. Use of gravity flow during LP was associated with fewer other complications (nausea, dizziness, vasovagal response, back pain, neck stiffness, and/or nerve root pain).
    Conclusions: LP in Alzheimer disease research is generally safe and well tolerated. Factors influencing LP agreement potentially could be studied to advance participant acceptance of the procedure.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/cerebrospinal fluid ; Female ; Humans ; Male ; Middle Aged ; Patient Acceptance of Health Care/psychology ; Research ; Spinal Puncture/psychology ; Surveys and Questionnaires
    Language English
    Publishing date 2017-09-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0000000000000209
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  2. Article ; Online: Comparison of Alzheimer's disease in American Indians, whites, and African Americans.

    Weiner, Myron F / Hynan, Linda S / Beekly, Duane / Koepsell, Thomas D / Kukull, Walter A

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2009  Volume 3, Issue 3, Page(s) 211–216

    Abstract: Background: The recent development of a national Alzheimer's disease database makes it possible to compare the course of illness in various ethnic groups.: Methods: The National Alzheimer's Coordinating Center database was used to compare the ... ...

    Abstract Background: The recent development of a national Alzheimer's disease database makes it possible to compare the course of illness in various ethnic groups.
    Methods: The National Alzheimer's Coordinating Center database was used to compare the clinical presentation and course of Alzheimer's disease (AD) in American Indians with whites and African-Americans, and to compare findings in American Indians seen in Oklahoma with those seen elsewhere. We ascertained the diagnosis of probable and possible AD, gender, education, history of affected first-degree relative, depression, history of stroke, Parkinson symptoms, age at onset of dementia, initial visit, and death. We also ascertained years from symptom onset and initial evaluation to death, initial Mini-Mental State Exam (MMSE) score adjusted for education, and years from onset of symptoms.
    Results: Data from 30,993 subjects were analyzed. There were statistically significant but only small differences between groups. American Indians had the lowest proportion of affected first-degree relatives, depression, and extrapyramidal symptoms. Whites had the highest proportion of subjects with affected first-degree relatives and depression, but the lowest history of stroke. African Americans had the most frequent history of stroke and extrapyramidal symptoms. Indians seen in Oklahoma had a lower proportion of affected first-degree relatives than did those seen elsewhere.
    Conclusions: Although there were no clinically significant differences in course of illness between these self-identified ethnic groups, this finding with regard to American Indians must be interpreted with caution, because the subjects for whom we had information regarding ancestry reported a smaller proportion of American Indian (25%) than white (75%) heritage.
    Language English
    Publishing date 2009-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1016/j.jalz.2007.04.376
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  3. Article ; Online: Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis.

    Neu, Scott C / Pa, Judy / Kukull, Walter / Beekly, Duane / Kuzma, Amanda / Gangadharan, Prabhakaran / Wang, Li-San / Romero, Klaus / Arneric, Stephen P / Redolfi, Alberto / Orlandi, Daniele / Frisoni, Giovanni B / Au, Rhoda / Devine, Sherral / Auerbach, Sanford / Espinosa, Ana / Boada, Mercè / Ruiz, Agustín / Johnson, Sterling C /
    Koscik, Rebecca / Wang, Jiun-Jie / Hsu, Wen-Chuin / Chen, Yao-Liang / Toga, Arthur W

    JAMA neurology

    2017  Volume 74, Issue 10, Page(s) 1178–1189

    Abstract: Importance: It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are at greater risk of developing Alzheimer disease (AD) than men, and the sex-dependent association of mild cognitive impairment (MCI) and APOE has not been ... ...

    Abstract Importance: It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are at greater risk of developing Alzheimer disease (AD) than men, and the sex-dependent association of mild cognitive impairment (MCI) and APOE has not been established.
    Objective: To determine how sex and APOE genotype affect the risks for developing MCI and AD.
    Data sources: Twenty-seven independent research studies in the Global Alzheimer's Association Interactive Network with data on nearly 58 000 participants.
    Study selection: Non-Hispanic white individuals with clinical diagnostic and APOE genotype data.
    Data extraction and synthesis: Homogeneous data sets were pooled in case-control analyses, and logistic regression models were used to compute risks.
    Main outcomes and measures: Age-adjusted odds ratios (ORs) and 95% confidence intervals for developing MCI and AD were calculated for men and women across APOE genotypes.
    Results: Participants were men and women between ages 55 and 85 years. Across data sets most participants were white, and for many participants, racial/ethnic information was either not collected or not known. Men (OR, 3.09; 95% CI, 2.79-3.42) and women (OR, 3.31; CI, 3.03-3.61) with the APOE ε3/ε4 genotype from ages 55 to 85 years did not show a difference in AD risk; however, women had an increased risk compared with men between the ages of 65 and 75 years (women, OR, 4.37; 95% CI, 3.82-5.00; men, OR, 3.14; 95% CI, 2.68-3.67; P = .002). Men with APOE ε3/ε4 had an increased risk of AD compared with men with APOE ε3/ε3. The APOE ε2/ε3 genotype conferred a protective effect on women (OR, 0.51; 95% CI, 0.43-0.61) decreasing their risk of AD more (P value = .01) than men (OR, 0.71; 95% CI, 0.60-0.85). There was no difference between men with APOE ε3/ε4 (OR, 1.55; 95% CI, 1.36-1.76) and women (OR, 1.60; 95% CI, 1.43-1.81) in their risk of developing MCI between the ages of 55 and 85 years, but women had an increased risk between 55 and 70 years (women, OR, 1.43; 95% CI, 1.19-1.73; men, OR, 1.07; 95% CI, 0.87-1.30; P = .05). There were no significant differences between men and women in their risks for converting from MCI to AD between the ages of 55 and 85 years. Individuals with APOE ε4/ε4 showed increased risks vs individuals with ε3/ε4, but no significant differences between men and women with ε4/ε4 were seen.
    Conclusions and relevance: Contrary to long-standing views, men and women with the APOE ε3/ε4 genotype have nearly the same odds of developing AD from age 55 to 85 years, but women have an increased risk at younger ages.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/epidemiology ; Alzheimer Disease/genetics ; Apolipoproteins E/genetics ; Case-Control Studies ; Databases, Factual/statistics & numerical data ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Risk Factors ; Sex Characteristics
    Chemical Substances ApoE protein, human ; Apolipoproteins E
    Language English
    Publishing date 2017-08-29
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2017.2188
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  4. Article ; Online: Version 3 of the National Alzheimer's Coordinating Center's Uniform Data Set.

    Besser, Lilah / Kukull, Walter / Knopman, David S / Chui, Helena / Galasko, Douglas / Weintraub, Sandra / Jicha, Gregory / Carlsson, Cynthia / Burns, Jeffrey / Quinn, Joseph / Sweet, Robert A / Rascovsky, Katya / Teylan, Merilee / Beekly, Duane / Thomas, George / Bollenbeck, Mark / Monsell, Sarah / Mock, Charles / Zhou, Xiao Hua /
    Thomas, Nicole / Robichaud, Elizabeth / Dean, Margaret / Hubbard, Janene / Jacka, Mary / Schwabe-Fry, Kristen / Wu, Joylee / Phelps, Creighton / Morris, John C

    Alzheimer disease and associated disorders

    2018  Volume 32, Issue 4, Page(s) 351–358

    Abstract: Introduction: In 2015, the US Alzheimer's Disease Centers (ADC) implemented Version 3 of the Uniform Data Set (UDS). This paper describes the history of Version 3 development and the UDS data that are freely available to researchers.: Methods: UDS ... ...

    Abstract Introduction: In 2015, the US Alzheimer's Disease Centers (ADC) implemented Version 3 of the Uniform Data Set (UDS). This paper describes the history of Version 3 development and the UDS data that are freely available to researchers.
    Methods: UDS Version 3 was developed after years of coordination between the National Institute on Aging-appointed Clinical Task Force (CTF), clinicians from ∼30 ADCs, and the National Alzheimer's Coordinating Center (NACC). The CTF recognized the need for updates to align with the state of the science in dementia research, while being flexible to the diverse needs and diseases studied at the ADCs. Version 3 also developed a nonproprietary neuropsychological battery.
    Results: This paper focuses on the substantial Version 3 changes to the UDS forms related to clinical diagnosis and characterization of clinical symptoms to match updated consensus-based diagnostic criteria. Between March 2015 and March 2018, 4820 participants were enrolled using UDS Version 3. Longitudinal data were available for 25,337 of the 37,568 total participants using all UDS versions.
    Discussion: The results from utilization of the UDS highlight the possibility for numerous research institutions to successfully collaborate, produce, and use standardized data collection instruments for over a decade.
    MeSH term(s) Aged ; Alzheimer Disease/diagnosis ; Consensus ; Databases, Factual/standards ; Female ; Humans ; Information Centers/organization & administration ; Male ; Middle Aged ; Neuropsychological Tests/standards ; United States
    Language English
    Publishing date 2018-10-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0000000000000279
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  5. Article: The National Alzheimer's Coordinating Center (NACC) Database: an Alzheimer disease database.

    Beekly, Duane L / Ramos, Erin M / van Belle, Gerald / Deitrich, Woodrow / Clark, Amber D / Jacka, Mary E / Kukull, Walter A

    Alzheimer disease and associated disorders

    2004  Volume 18, Issue 4, Page(s) 270–277

    Abstract: The National Alzheimer's Coordinating Center (NACC) is responsible for developing and maintaining a database of patient information collected from the 29 Alzheimer disease centers (ADCs) funded by the National Institute on Aging. Each of the centers ... ...

    Abstract The National Alzheimer's Coordinating Center (NACC) is responsible for developing and maintaining a database of patient information collected from the 29 Alzheimer disease centers (ADCs) funded by the National Institute on Aging. Each of the centers collects center-determined data elements on patients enrolled into its center and transmits a minimum dataset to NACC. Data are managed differently at each center depending on that center's research needs. The centers' data systems vary from a single personal computer running spreadsheet software to a network of servers running an advanced data management system such as Oracle. The challenge for NACC is to expand and adjust previously collected data elements into an integrated database that could be used for administrative as well as research purposes. In addition, NACC sought to allow the centers to have the flexibility they needed for data submission. To accomplish this task, NACC designed a database that contained separate specific datasets each with individual data elements. NACC also designed a data management system to easily collect and manage these data. The NACC web site (www.alz.washington.edu) was created to allow access to the data.
    MeSH term(s) Alzheimer Disease/pathology ; Brain/pathology ; Data Collection ; Databases, Factual ; Female ; Humans ; Information Dissemination ; Information Systems ; Internet ; Male
    Language English
    Publishing date 2004-10
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
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  6. Article: The National Alzheimer's Coordinating Center (NACC) database: the Uniform Data Set.

    Beekly, Duane L / Ramos, Erin M / Lee, William W / Deitrich, Woodrow D / Jacka, Mary E / Wu, Joylee / Hubbard, Janene L / Koepsell, Thomas D / Morris, John C / Kukull, Walter A

    Alzheimer disease and associated disorders

    2007  Volume 21, Issue 3, Page(s) 249–258

    Abstract: The National Alzheimer's Coordinating Center (NACC) is responsible for developing and maintaining a database of participant information collected from the 29 Alzheimer's Disease Centers (ADCs) funded by the National Institute on Aging (NIA). The NIA ... ...

    Abstract The National Alzheimer's Coordinating Center (NACC) is responsible for developing and maintaining a database of participant information collected from the 29 Alzheimer's Disease Centers (ADCs) funded by the National Institute on Aging (NIA). The NIA appointed the ADC Clinical Task Force to determine and define an expanded, standardized clinical data set, called the Uniform Data Set (UDS). The goal of the UDS is to provide ADC researchers a standard set of assessment procedures, collected longitudinally, to better characterize ADC participants with mild Alzheimer disease and mild cognitive impairment in comparison with nondemented controls. NACC implemented the UDS (September 2005) by developing data collection forms for initial and follow-up visits based on Clinical Task Force definitions, a relational database, and a data submission system accessible by all ADCs. The NIA requires ADCs to submit UDS data to NACC for all their Clinical Core participants. Thus, the NACC web site (https://www.alz.washington.edu) was enhanced to provide efficient and secure access data submission and retrieval systems.
    MeSH term(s) Alzheimer Disease/diagnosis ; Alzheimer Disease/epidemiology ; Alzheimer Disease/therapy ; Databases, Factual ; Humans ; Information Centers/organization & administration ; United States/epidemiology
    Language English
    Publishing date 2007-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0b013e318142774e
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  7. Article ; Online: A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy.

    Chen, Jason A / Wang, Qing / Davis-Turak, Jeremy / Li, Yun / Karydas, Anna M / Hsu, Sandy C / Sears, Renee L / Chatzopoulou, Doxa / Huang, Alden Y / Wojta, Kevin J / Klein, Eric / Lee, Jason / Beekly, Duane L / Boxer, Adam / Faber, Kelley M / Haase, Claudia M / Miller, Josh / Poon, Wayne W / Rosen, Ami /
    Rosen, Howard / Sapozhnikova, Anna / Shapira, Jill / Varpetian, Arousiak / Foroud, Tatiana M / Levenson, Robert W / Levey, Allan I / Kukull, Walter A / Mendez, Mario F / Ringman, John / Chui, Helena / Cotman, Carl / DeCarli, Charles / Miller, Bruce L / Geschwind, Daniel H / Coppola, Giovanni

    JAMA neurology

    2015  Volume 72, Issue 4, Page(s) 414–422

    Abstract: Importance: Previous studies have indicated a heritable component of the etiology of neurodegenerative diseases such as Alzheimer disease (AD), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP). However, few have examined the ... ...

    Abstract Importance: Previous studies have indicated a heritable component of the etiology of neurodegenerative diseases such as Alzheimer disease (AD), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP). However, few have examined the contribution of low-frequency coding variants on a genome-wide level.
    Objective: To identify low-frequency coding variants that affect susceptibility to AD, FTD, and PSP.
    Design, setting, and participants: We used the Illumina HumanExome BeadChip array to genotype a large number of variants (most of which are low-frequency coding variants) in a cohort of patients with neurodegenerative disease (224 with AD, 168 with FTD, and 48 with PSP) and in 224 control individuals without dementia enrolled between 2005-2012 from multiple centers participating in the Genetic Investigation in Frontotemporal Dementia and Alzheimer's Disease (GIFT) Study. An additional multiancestral replication cohort of 240 patients with AD and 240 controls without dementia was used to validate suggestive findings. Variant-level association testing and gene-based testing were performed.
    Main outcomes and measures: Statistical association of genetic variants with clinical diagnosis of AD, FTD, and PSP.
    Results: Genetic variants typed by the exome array explained 44%, 53%, and 57% of the total phenotypic variance of AD, FTD, and PSP, respectively. An association with the known AD gene ABCA7 was replicated in several ancestries (discovery P=.0049, European P=.041, African American P=.043, and Asian P=.027), suggesting that exonic variants within this gene modify AD susceptibility. In addition, 2 suggestive candidate genes, DYSF (P=5.53×10(-5)) and PAXIP1 (P=2.26×10(-4)), were highlighted in patients with AD and differentially expressed in AD brain. Corroborating evidence from other exome array studies and gene expression data points toward potential involvement of these genes in the pathogenesis of AD.
    Conclusions and relevance: Low-frequency coding variants with intermediate effect size may account for a significant fraction of the genetic susceptibility to AD and FTD. Furthermore, we found evidence that coding variants in the known susceptibility gene ABCA7, as well as candidate genes DYSF and PAXIP1, confer risk for AD.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Alzheimer Disease/genetics ; Exome ; Female ; Frontotemporal Dementia/diagnosis ; Frontotemporal Dementia/genetics ; Genetic Predisposition to Disease ; Genetic Testing/methods ; Genetic Variation/genetics ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; Microarray Analysis ; Middle Aged ; Risk ; Supranuclear Palsy, Progressive/genetics
    Language English
    Publishing date 2015-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2014.4040
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  8. Article ; Online: The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery.

    Weintraub, Sandra / Salmon, David / Mercaldo, Nathaniel / Ferris, Steven / Graff-Radford, Neill R / Chui, Helena / Cummings, Jeffrey / DeCarli, Charles / Foster, Norman L / Galasko, Douglas / Peskind, Elaine / Dietrich, Woodrow / Beekly, Duane L / Kukull, Walter A / Morris, John C

    Alzheimer disease and associated disorders

    2009  Volume 23, Issue 2, Page(s) 91–101

    Abstract: The neuropsychologic test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the National Institute on Aging consists of brief measures of attention, processing speed, executive function, episodic memory, and ... ...

    Abstract The neuropsychologic test battery from the Uniform Data Set (UDS) of the Alzheimer's Disease Centers (ADC) program of the National Institute on Aging consists of brief measures of attention, processing speed, executive function, episodic memory, and language. This paper describes development of the battery and preliminary data from the initial UDS evaluation of 3268 clinically cognitively normal men and women collected over the first 24 months of utilization. The subjects represent a sample of community-dwelling, individuals who volunteer for studies of cognitive aging. Subjects were considered "clinically cognitively normal" based on clinical assessment, including the Clinical Dementia Rating scale and the Functional Assessment Questionnaire. The results demonstrate performance on tests sensitive to cognitive aging and to the early stages of Alzheimer disease in a relatively well-educated sample. Regression models investigating the impact of age, education, and sex on test scores indicate that these variables will need to be incorporated in subsequent normative studies. Future plans include: (1) determining the psychometric properties of the battery; (2) establishing normative data, including norms for different ethnic minority groups; and (3) conducting longitudinal studies on cognitively normal subjects, individuals with mild cognitive impairment, and individuals with Alzheimer disease and other forms of dementia.
    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Aging/psychology ; Alzheimer Disease/diagnosis ; Cognition/classification ; Cognition Disorders/diagnosis ; Data Collection/methods ; Data Collection/statistics & numerical data ; Databases, Factual/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; National Institute on Aging (U.S.)/statistics & numerical data ; Neuropsychological Tests/standards ; Neuropsychological Tests/statistics & numerical data ; Program Development/methods ; Research/statistics & numerical data ; Sex Factors ; United States
    Language English
    Publishing date 2009-04-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/WAD.0b013e318191c7dd
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers.

    Morris, John C / Weintraub, Sandra / Chui, Helena C / Cummings, Jeffrey / Decarli, Charles / Ferris, Steven / Foster, Norman L / Galasko, Douglas / Graff-Radford, Neill / Peskind, Elaine R / Beekly, Duane / Ramos, Erin M / Kukull, Walter A

    Alzheimer disease and associated disorders

    2006  Volume 20, Issue 4, Page(s) 210–216

    Abstract: A Clinical Task Force, composed of clinical leaders from Alzheimer's Disease Centers (ADC), was convened by the National Institute on Aging to develop a uniform set of assessment procedures to characterize individuals with mild Alzheimer disease and mild ...

    Abstract A Clinical Task Force, composed of clinical leaders from Alzheimer's Disease Centers (ADC), was convened by the National Institute on Aging to develop a uniform set of assessment procedures to characterize individuals with mild Alzheimer disease and mild cognitive impairment in comparison with nondemented aging. The resulting Uniform Data Set (UDS) defines a common set of clinical observations to be collected longitudinally on ADC participants in accordance with standard methods. The UDS was implemented at all ADCs on September 1, 2005. Data obtained with the UDS are submitted to the National Alzheimer's Coordinating Center and represent a unique and valuable source of data to support and stimulate collaborative research.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Brain/pathology ; Data Collection/methods ; Female ; Humans ; Information Dissemination ; Male ; Middle Aged ; Neuropsychological Tests/standards
    Language English
    Publishing date 2006-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002700-2
    ISSN 1546-4156 ; 0893-0341
    ISSN (online) 1546-4156
    ISSN 0893-0341
    DOI 10.1097/01.wad.0000213865.09806.92
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies

    Rajabli, Farid / Benchek, Penelope / Tosto, Giuseppe / Kushch, Nicholas / Sha, Jin / Bazemore, Katrina / Zhu, Congcong / Lee, Wan-Ping / Haut, Jacob / Hamilton-Nelson, Kara L / Wheeler, Nicholas R / Zhao, Yi / Farrell, John J / Grunin, Michelle A / Leung, Yuk Yee / Kuksa, Pavel P / Li, Donghe / Lucio da Fonseca, Eder / Mez, Jesse B /
    Palmer, Ellen L / Pillai, Jagan / Sherva, Richard M / Song, Yeunjoo E / Zhang, Xiaoling / Iqbal, Taha / Pathak, Omkar / Valladares, Otto / Kuzma, Amanda B / Abner, Erin / Adams, Perrie M / Aguirre, Alyssa / Albert, Marilyn S / Albin, Roger L / Allen, Mariet / Alvarez, Lisa / Apostolova, Liana G / Arnold, Steven E / Asthana, Sanjay / Atwood, Craig S / Ayres, Gayle / Baldwin, Clinton T / Barber, Robert C / Barnes, Lisa L / Barral, Sandra / Beach, Thomas G / Becker, James T / Beecham, Gary W / Beekly, Duane / Benitez, Bruno A / Bennett, David / Bertelson, John / Bird, Thomas D / Blacker, Deborah / Boeve, Bradley F / Bowen, James D / Boxer, Adam / Brewer, James / Burke, James R / Burns, Jeffrey M / Buxbaum, Joseph D / Cairns, Nigel J / Cantwell, Laura B / Cao, Chuanhai / Carlson, Christopher S / Carlsson, Cynthia M / Carney, Regina M / Carrasquillo, Minerva M / Chasse, Scott / Chesselet, Marie-Francoise / Chin, Nathaniel A / Chui, Helena C / Chung, Jaeyoon / Craft, Suzanne / Crane, Paul K / Cribbs, David H / Crocco, Elizabeth A / Cruchaga, Carlos / Cuccaro, Michael L / Cullum, Munro / Darby, Eveleen / Davis, Barbara / De Jager, Philip L / DeCarli, Charles / DeToledo, John / Dick, Malcolm / Dickson, Dennis W / Dombroski, Beth A / Doody, Rachelle S / Duara, Ranjan / Ertekin-Taner, NIlüfer / Evans, Denis A / Faber, Kelley M / Fairchild, Thomas J / Fallon, Kenneth B / Fardo, David W / Farlow, Martin R / Fernandez-Hernandez, Victoria / Ferris, Steven / Foroud, Tatiana M / Frosch, Matthew P / Fulton-Howard, Brian / Galasko, Douglas R / Gamboa, Adriana / Gearing, Marla / Geschwind, Daniel H / Ghetti, Bernardino / Gilbert, John R / Goate, Alison M / Grabowski, Thomas J / Graff-Radford, Neill R / Green, Robert C / Growdon, John H / Hakonarson, Hakon / Hall, James / Hamilton, Ronald L / Harari, Oscar / Hardy, John / Harrell, Lindy E / Head, Elizabeth / Henderson, Victor W / Hernandez, Michelle / Hohman, Timothy / Honig, Lawrence S / Huebinger, Ryan M / Huentelman, Matthew J / Hulette, Christine M / Hyman, Bradley T / Hynan, Linda S / Ibanez, Laura / Jarvik, Gail P / Jayadev, Suman / Jin, Lee-Way / Johnson, Kim / Johnson, Leigh / Kamboh, M Ilyas / Karydas, Anna M / Katz, Mindy J / Kauwe, John S / Kaye, Jeffrey A / Keene, C Dirk / Khaleeq, Aisha / Kim, Ronald / Knebl, Janice / Kowall, Neil W / Kramer, Joel H / Kukull, Walter A / LaFerla, Frank M / Lah, James J / Larson, Eric B / Lerner, Alan / Leverenz, James B / Levey, Allan I / Lieberman, Andrew P / Lipton, Richard B / Logue, Mark / Lopez, Oscar L / Lunetta, Kathryn L / Lyketsos, Constantine G / Mains, Douglas / Margaret, Flanagan E / Marson, Daniel C / Martin, Eden R R / Martiniuk, Frank / Mash, Deborah C / Masliah, Eliezer / Massman, Paul / Masurkar, Arjun / McCormick, Wayne C / McCurry, Susan M / McDavid, Andrew N / McDonough, Stefan / McKee, Ann C / Mesulam, Marsel / Miller, Bruce L / Miller, Carol A / Miller, Joshua W / Montine, Thomas J / Monuki, Edwin S / Morris, John C / Mukherjee, Shubhabrata / Myers, Amanda J / Nguyen, Trung / O'Bryant, Sid / Olichney, John M / Ory, Marcia / Palmer, Raymond / Parisi, Joseph E / Paulson, Henry L / Pavlik, Valory / Paydarfar, David / Perez, Victoria / Peskind, Elaine / Petersen, Ronald C / Pierce, Aimee / Polk, Marsha / Poon, Wayne W / Potter, Huntington / Qu, Liming / Quiceno, Mary / Quinn, Joseph F / Raj, Ashok / Raskind, Murray / Reiman, Eric M / Reisberg, Barry / Reisch, Joan S / Ringman, John M / Roberson, Erik D / Rodriguear, Monica / Rogaeva, Ekaterina / Rosen, Howard J / Rosenberg, Roger N / Royall, Donald R / Sager, Mark A / Sano, Mary / Saykin, Andrew J / Schneider, Julie A / Schneider, Lon S / Seeley, William W / Slifer, Susan H / Small, Scott / Smith, Amanda G / Smith, Janet P / Sonnen, Joshua A / Spina, Salvatore / St George-Hyslop, Peter / Stern, Robert A / Stevens, Alan B / Strittmatter, Stephen M / Sultzer, David / Swerdlow, Russell H / Tanzi, Rudolph E / Tilson, Jeffrey L / Trojanowski, John Q / Troncoso, Juan C / Tsuang, Debby W / Van Deerlin, Vivianna M / van Eldik, Linda J / Vance, Jeffery M / Vardarajan, Badri N / Vassar, Robert / Vinters, Harry V / Vonsattel, Jean-Paul / Weintraub, Sandra / Welsh-Bohmer, Kathleen A / Whitehead, Patrice L / Wijsman, Ellen M / Wilhelmsen, Kirk C / Williams, Benjamin / Williamson, Jennifer / Wilms, Henrik / Wingo, Thomas S / Wisniewski, Thomas / Woltjer, Randall L / Woon, Martin / Wright, Clinton B / Wu, Chuang-Kuo / Younkin, Steven G / Yu, Chang-En / Yu, Lei / Zhu, Xiongwei / Kunkle, Brian W / Bush, William S / Wang, Li-San / Farrer, Lindsay A / Haines, Jonathan L / Mayeux, Richard / Pericak-Vance, Margaret A / Schellenberg, Gerard D / Jun, Gyungah R / Reitz, Christiane / Naj, Adam C

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer's Disease ( ... ...

    Abstract Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimer's Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within-ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis. We identified 13 loci with cross-ancestry associations including known loci at/near
    Language English
    Publishing date 2023-07-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.06.23292311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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