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  1. Article ; Online: MINOCA-induced apical ballooning case report: a diagnostic conundrum.

    Dungarwalla, Moez / Demetriades, Polyvios / Been, Martin / Khan, Jamal Nasir

    European heart journal. Case reports

    2021  Volume 5, Issue 7, Page(s) ytab240

    Abstract: Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a recently described phenomenon where no flow-limiting lesions are noted on coronary angiography in a patient with electrocardiogram changes, elevated cardiac ... ...

    Abstract Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a recently described phenomenon where no flow-limiting lesions are noted on coronary angiography in a patient with electrocardiogram changes, elevated cardiac biomarkers, and symptoms suggesting acute myocardial infarction. Patients with MINOCA can also potentially develop structural cardiac defects through ischaemic injury. Therefore, the absence of a flow-limiting lesion on angiography coupled with structural defects (e.g. apical ballooning) can very easily result in a diagnosis of Takotsubo cardiomyopathy (TTC). This can lead to potentially serious consequences since treatment options between TTC and MINOCA are different.
    Case summary: We report a case of a patient presenting with features suggestive of TTC but where the final diagnosis was of a MINOCA that induced an apical ventricular septal defect (VSD). Reaching the correct diagnosis proved challenging given that there is no gold standard diagnostic modality for diagnosing MINOCA.
    Conclusion: Imaging adjuncts played a vital role in both diagnosing the underlying MINOCA as well as revealing and planning closure of the resultant VSD. Cardiovascular magnetic resonance imaging played an instrumental role in establishing the patient's primary pathology and in planning a remediation of the structural defect. Structural myocardial defects in a patient with a diagnosis of TTC should prompt clinicians to further investigate whether there is an underlying infarct aetiology (MINOCA).
    Language English
    Publishing date 2021-07-18
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytab240
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  2. Article ; Online: Percutaneous device closure of a large complex aortic root pseudoaneurysm.

    Tran, Patrick / Khan, Jamal Nasir / Hildick-Smith, David / Been, Martin

    BMJ case reports

    2020  Volume 13, Issue 9

    Abstract: Pseudoaneurysm of the aorta is a rare and high-risk complication of native aortic valve endocarditis and can develop following cardiac surgery for aortic valve and root disease. If left untreated, there is a significant risk of aortic wall rupture and ... ...

    Abstract Pseudoaneurysm of the aorta is a rare and high-risk complication of native aortic valve endocarditis and can develop following cardiac surgery for aortic valve and root disease. If left untreated, there is a significant risk of aortic wall rupture and fatality. Given the high risk of mortality associated with traditional open surgical repair of aortic pseudoaneurysms, endovascular approach is a potentially favourable alternative. We describe a unique case of a young woman with a large and complex paraprosthetic pseudoaneurysm with multiple communicating fistulae which was successfully percutaneously treated with two occluder devices. In this technically challenging case, a minor but unique procedural complication is also illustrated.
    MeSH term(s) Abscess/diagnosis ; Abscess/microbiology ; Abscess/therapy ; Adult ; Aneurysm, False/diagnosis ; Aneurysm, False/microbiology ; Aneurysm, False/therapy ; Anti-Bacterial Agents/administration & dosage ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Disease/diagnosis ; Aortic Valve Disease/microbiology ; Aortic Valve Disease/therapy ; Bacteremia/diagnosis ; Bacteremia/microbiology ; Catheters ; Echocardiography ; Female ; Humans ; Septal Occluder Device ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/therapy ; Staphylococcus aureus/isolation & purification ; Substance Abuse, Intravenous/complications ; Transcatheter Aortic Valve Replacement/instrumentation ; Transcatheter Aortic Valve Replacement/methods ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-09-17
    Publishing country England
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-235545
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  3. Article: Is this a satellite orbiting unchartered territory?

    Salim, Handi / Been, Martin / Hildick-Smith, David / Khan, Jamal Nasir

    Echo research and practice

    2020  Volume 7, Issue 1, Page(s) I1–I3

    Language English
    Publishing date 2020-02-17
    Publishing country England
    Document type Case Reports
    ZDB-ID 2777997-X
    ISSN 2055-0464
    ISSN 2055-0464
    DOI 10.1530/ERP-19-0061
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  4. Article: Langsame ventrikuläre Tachykardie.

    Leitz, Nicolas / Khawaja, Zarqa / Been, Martin

    Praxis

    2009  Volume 98, Issue 25, Page(s) 1532–1534

    Title translation Slow ventricular tachycardia.
    MeSH term(s) Accelerated Idioventricular Rhythm/chemically induced ; Accelerated Idioventricular Rhythm/physiopathology ; Accelerated Idioventricular Rhythm/therapy ; Aged, 80 and over ; Anti-Arrhythmia Agents/adverse effects ; Diagnosis, Differential ; Electrocardiography ; Female ; Humans ; Male ; Practice Guidelines as Topic
    Chemical Substances Anti-Arrhythmia Agents
    Language German
    Publishing date 2009-12-16
    Publishing country Switzerland
    Document type Case Reports ; Comparative Study ; Journal Article ; Review
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
    DOI 10.1024/1661-8157.98.25.1532
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    Ua VI Zs.118: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 12: Show issues

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  5. Article ; Online: Slow ventricular tachycardia.

    Leitz, Nicolas / Khawaja, Zarqa / Been, Martin

    BMJ (Clinical research ed.)

    2008  Volume 337, Page(s) a424

    MeSH term(s) Accelerated Idioventricular Rhythm/chemically induced ; Accelerated Idioventricular Rhythm/diagnosis ; Aged, 80 and over ; Anti-Arrhythmia Agents/adverse effects ; Diagnostic Errors ; Female ; Humans ; Male ; Middle Aged
    Chemical Substances Anti-Arrhythmia Agents
    Language English
    Publishing date 2008-07-03
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.39489.687894.DE
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    Ua VI Zs.10: Show issues Location:
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  6. Article ; Online: Images in cardiovascular medicine. Subacute massive pulmonary embolism diagnosed by transesophageal echocardiography.

    Bilku, Rajinder S / Glennon, Peter E / Been, Martin

    Circulation

    2007  Volume 116, Issue 12, Page(s) e352–3

    MeSH term(s) Aged ; Arrhythmias, Cardiac/etiology ; Coronary Disease/diagnosis ; Diagnostic Errors ; Dyspnea/etiology ; Echocardiography, Transesophageal ; Humans ; Male ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnostic imaging
    Language English
    Publishing date 2007-09-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.107.699132
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    Ui IV Zs.60: Show issues Location:
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  7. Article ; Online: Left ventricular diastolic collapse and late regional cardiac tamponade postcardiac surgery caused by large left pleural effusion.

    Bilku, Rajinder S / Bilku, Dilraj K / Rosin, Michael D / Been, Martin

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

    2008  Volume 21, Issue 8, Page(s) 978.e9–11

    Abstract: Cardiac tamponade is a well-recognized early complication (ie, within 15 days) of cardiac surgery usually a result of the development of a pericardial effusion postoperatively. However, left ventricular diastolic collapse as a result of the presence of a ...

    Abstract Cardiac tamponade is a well-recognized early complication (ie, within 15 days) of cardiac surgery usually a result of the development of a pericardial effusion postoperatively. However, left ventricular diastolic collapse as a result of the presence of a large pleural effusion, but in the absence of any pericardial effusion, is rare, particularly late (ie, after 15 days) after cardiac surgery. We present the echocardiographic findings of a man presenting with recurrent exertional breathlessness, after elective tissue aortic valve replacement, and demonstrate, by echocardiography, the mechanism of left ventricular diastolic collapse and late regional cardiac tamponade, after cardiac surgery, as a result of the effects of a large pleural effusion but in the absence of any pericardial effusion. We discuss and review the literature on this phenomenon.
    MeSH term(s) Aged ; Cardiac Tamponade/diagnostic imaging ; Cardiac Tamponade/etiology ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Male ; Pleural Effusion/diagnostic imaging ; Pleural Effusion/etiology ; Ultrasonography ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology
    Language English
    Publishing date 2008-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1035622-8
    ISSN 1097-6795 ; 0894-7317
    ISSN (online) 1097-6795
    ISSN 0894-7317
    DOI 10.1016/j.echo.2007.10.014
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    Zs.A 2638: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 55: Show issues

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  8. Article ; Online: Giant cell myocarditis: an unusual presentation.

    Ali, Danish / Alzuwam, Abdalla / McCann, Gerry P / Been, Martin / Osman, Faizel

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2011  Volume 13, Issue 12, Page(s) 1793–1794

    Abstract: Giant cell myocarditis is a rare but often devastating disease affecting young, otherwise healthy individuals. Patients often die of heart failure and ventricular arrhythmia unless cardiac transplantation is performed. Cardiac magnetic resonance imaging ... ...

    Abstract Giant cell myocarditis is a rare but often devastating disease affecting young, otherwise healthy individuals. Patients often die of heart failure and ventricular arrhythmia unless cardiac transplantation is performed. Cardiac magnetic resonance imaging with or without cardiac biopsy can be helpful in making the correct diagnosis and ensuring that correct timely treatment is administered.
    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Amiodarone/therapeutic use ; Anti-Arrhythmia Agents/therapeutic use ; Biopsy ; Cardiac Resynchronization Therapy Devices ; Drug Therapy, Combination ; Electrocardiography ; Giant Cells/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Myocarditis/diagnosis ; Myocarditis/pathology ; Myocarditis/therapy ; Myocardium/pathology ; Treatment Outcome
    Chemical Substances Adrenergic beta-Antagonists ; Anti-Arrhythmia Agents ; Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 2011-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/eur202
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    Zs.A 5434: Show issues Location:
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  9. Article ; Online: Strategies to attenuate micro-vascular obstruction during P-PCI: the randomized reperfusion facilitated by local adjunctive therapy in ST-elevation myocardial infarction trial.

    Nazir, Sheraz A / McCann, Gerry P / Greenwood, John P / Kunadian, Vijay / Khan, Jamal N / Mahmoud, Islam Z / Blackman, Daniel J / Been, Martin / Abrams, Keith R / Shipley, Lorraine / Wilcox, Robert / Adgey, A A Jennifer / Gershlick, Anthony H

    European heart journal

    2016  Volume 37, Issue 24, Page(s) 1910–1919

    Abstract: Background: Microvascular obstruction (MVO) following primary percutaneous coronary intervention (PPCI) treatment of ST-segment elevation myocardial infarction (STEMI) contributes to infarct expansion, left ventricular (LV) remodelling, and worse ... ...

    Abstract Background: Microvascular obstruction (MVO) following primary percutaneous coronary intervention (PPCI) treatment of ST-segment elevation myocardial infarction (STEMI) contributes to infarct expansion, left ventricular (LV) remodelling, and worse clinical outcomes. The REFLO-STEMI trial tested whether intra-coronary (IC) high-dose adenosine or sodium nitroprusside (SNP) reduce infarct size and/or MVO determined by cardiac magnetic resonance (CMR).
    Methods and results: REFLO-STEMI, a prospective, open-label, multi-centre trial with blinded endpoints, randomized (1:1:1) 247 STEMI patients with single vessel disease presenting within 6 h of symptom onset to IC adenosine (2-3 mg total) or SNP (500 μg total) immediately following thrombectomy and again following stenting, or to standard PPCI. The primary endpoint was infarct size % LV mass (%LVM) on CMR undertaken 24-96 h after PPCI (n = 197). Clinical follow-up was to 6 months. There was no significant difference in infarct size (%LVM, median, interquartile range, IQR) between adenosine (10.1, 4.7-16.2), SNP (10.0, 4.2-15.8), and control (8.3, 1.9-14.0), P = 0.062 and P = 0.160, respectively, vs.
    Control: MVO (% LVM, median, IQR) was similar across groups (1.0, 0.0-3.7, P = 0.205 and 0.6, 0.0-2.4, P = 0.244 for adenosine and SNP, respectively, vs. control 0.3, 0.0-2.8). On per-protocol analysis, infarct size (%LV mass, 12.0 vs. 8.3, P = 0.031), major adverse cardiac events (hazard ratio, HR, 5.39 [1.18-24.60], P = 0.04) at 30 days and 6 months (HR 6.53 [1.46-29.2], P = 0.01) were increased and ejection fraction reduced (42.5 ± 7.2% vs. 45.7 ± 8.0%, P = 0.027) in adenosine-treated patients compared with control.
    Conclusions: High-dose IC adenosine and SNP during PPCI did not reduce infarct size or MVO measured by CMR. Furthermore, adenosine may adversely affect mid-term clinical outcome.
    Clinical trial registration: ClinicalTrials.gov Identifier: NCT01747174; https://clinicaltrials.gov/ct2/show/NCT01747174.
    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Percutaneous Coronary Intervention ; Prospective Studies ; ST Elevation Myocardial Infarction ; Thrombectomy ; Treatment Outcome
    Language English
    Publishing date 2016-05-04
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehw136
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  10. Article: Resolution of large post-pericardiotomy pericardial effusion with colchicine.

    Vohra, Hunaid A / Nanjaiah, Prakash / Been, Martin / Dimitri, Wade R

    Journal of cardiac surgery

    2006  Volume 21, Issue 3, Page(s) 307–308

    MeSH term(s) Adult ; Aortic Valve Insufficiency/surgery ; Colchicine/therapeutic use ; Echocardiography, Transesophageal ; Follow-Up Studies ; Gout Suppressants/therapeutic use ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Male ; Pericardial Effusion/diagnosis ; Pericardial Effusion/drug therapy ; Pericardial Effusion/etiology ; Postoperative Complications ; Tomography, X-Ray Computed
    Chemical Substances Gout Suppressants ; Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2006-05
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/j.1540-8191.2006.00236.x
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    Zs.A 2221: Show issues Location:
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