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  1. Article ; Online: Second Extensor Compartment Entrapment in an Adult Following Distal Radius Fracture.

    Beenfeldt, Davison M / Delman, Connor M / Bayne, Christopher O

    Journal of hand surgery global online

    2024  Volume 6, Issue 1, Page(s) 137–139

    Abstract: Extensor tendon entrapment in the presence of distal radius fracture is a known but relatively uncommon complication. Single tendon or entire compartment entrapment has been described through the literature in youths and adults. However these findings ... ...

    Abstract Extensor tendon entrapment in the presence of distal radius fracture is a known but relatively uncommon complication. Single tendon or entire compartment entrapment has been described through the literature in youths and adults. However these findings generally are limited to a certain age demographic or are found on advanced imaging but are unable to be confirmed intraoperatively. We describe to our knowledge the first known description of second extensor compartment entrapment in an adult seen on computerized tomography scan and confirmed intraoperatively.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Case Reports
    ISSN 2589-5141
    ISSN (online) 2589-5141
    DOI 10.1016/j.jhsg.2023.10.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Episiotomy-assisted Incarcerated Femoral Nail Removal: Technical Note.

    Beenfeldt, Davison / Johnson, Pierce / Watts, Chad / Shannon, Steven / Swanson, David / Althausen, Peter

    Journal of orthopaedic case reports

    2023  Volume 13, Issue 1, Page(s) 70–73

    Abstract: Introduction: Incarceration of intramedullary nails can pose a significant challenge. There are many reported techniques of nail removal, but when these fail, it can be difficult to determine how to proceed. Here, it is shown that a proximal femoral ... ...

    Abstract Introduction: Incarceration of intramedullary nails can pose a significant challenge. There are many reported techniques of nail removal, but when these fail, it can be difficult to determine how to proceed. Here, it is shown that a proximal femoral episiotomy can be used with great effect.
    Case report: 64-year-old male developed hip arthritis. The patient had a solid antegrade femoral nail placed 22 years ago that required removal for a hip arthroplasty. A proximal femoral episiotomy-assisted approach was used with good results and patient outcome.
    Conclusion: There are several well described techniques to assist with incarcerated nail removal that all trauma surgeons should be familiar with. Proximal femoral episiotomy is a useful technique, every surgeon should have in their arsenal.
    Language English
    Publishing date 2023-04-18
    Publishing country India
    Document type Case Reports
    ZDB-ID 2658169-3
    ISSN 2250-0685
    ISSN 2250-0685
    DOI 10.13107/jocr.2023.v13.i01.3520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds.

    Lumangtad, Liezel A / Claeys, Elisa / Hamal, Sunil / Intasiri, Amarawan / Basrai, Courtney / Yen-Pon, Expedite / Beenfeldt, Davison / Vermeire, Kurt / Bell, Thomas W

    Bioorganic & medicinal chemistry

    2020  Volume 28, Issue 24, Page(s) 115816

    Abstract: CADA compounds selectively down-modulate human cell-surface CD4 protein and are of interest as HIV entry inhibitors and as drugs for asthma, rheumatoid arthritis, diabetes and some cancers. Postulating that fusing a pyridine ring bearing hydrophobic ... ...

    Abstract CADA compounds selectively down-modulate human cell-surface CD4 protein and are of interest as HIV entry inhibitors and as drugs for asthma, rheumatoid arthritis, diabetes and some cancers. Postulating that fusing a pyridine ring bearing hydrophobic substituents into the macrocyclic scaffold of CADA compounds may lead to potent compounds with improved properties, 17 macrocycles were synthesized, 14 with 12-membered rings having an isobutylene head group, two arenesulfonyl side arms, and fused pyridine rings bearing a para substituent. The analogs display a wide range of CD4 down-modulating and anti-HIV potencies, including some with greater potency than CADA, proving that a highly basic nitrogen atom in the 12-membered ring is not required for potency and that hydrophobic substituents enhance potency of pyridine-fused CADA compounds. Cytotoxicities of the new compounds compared favorably with those of CADA, showing that incorporation of a pyridine ring into the macrocyclic scaffold can produce selective compounds for potently down-modulating proteins of medicinal interest.
    MeSH term(s) Animals ; Anti-HIV Agents/chemical synthesis ; Anti-HIV Agents/chemistry ; Anti-HIV Agents/pharmacology ; CD4 Antigens/genetics ; CD4 Antigens/metabolism ; CHO Cells ; Cell Line ; Cell Survival/drug effects ; Cricetinae ; Cricetulus ; Down-Regulation/drug effects ; HIV-1/metabolism ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/chemistry ; Heterocyclic Compounds/pharmacology ; Humans ; Pyridines/chemistry ; Solubility ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Sulfonamides/pharmacology ; Thermodynamics ; Virus Replication/drug effects
    Chemical Substances Anti-HIV Agents ; CD4 Antigens ; Heterocyclic Compounds ; Pyridines ; Sulfonamides ; pyridine (NH9L3PP67S)
    Language English
    Publishing date 2020-10-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2020.115816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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