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  1. Article ; Online: The Difficulty of Predicting Intensive Care Unit Mortality in Resource-limited Settings.

    Hersh, Andrew M / Beesley, Sarah J

    Annals of the American Thoracic Society

    2018  Volume 15, Issue 11, Page(s) 1282–1284

    MeSH term(s) Critical Care ; Health Resources ; Humans ; Intensive Care Units ; Kenya ; Referral and Consultation
    Language English
    Publishing date 2018-11-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201808-580ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5828: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: A 20-Year-Old Man with e-Cigarette or Vaping Product Use-Associated Lung Injury (EVALI) and Thrombotic Coagulopathy.

    Harada, Holly A / Liu, Jeremy / Shortell, Justin D / Beesley, Sarah J

    The American journal of case reports

    2021  Volume 22, Page(s) e929915

    Abstract: BACKGROUND In 2019, the US Centers for Disease Control and Prevention (CDC) described the criteria for the diagnosis of e-cigarette or vaping product use-associated lung injury (EVALI), which may be caused by contamination of delta-9- ... ...

    Abstract BACKGROUND In 2019, the US Centers for Disease Control and Prevention (CDC) described the criteria for the diagnosis of e-cigarette or vaping product use-associated lung injury (EVALI), which may be caused by contamination of delta-9-tetrahydrocannabinoid (THC) e-liquids with vitamin E acetate. This report describes a case of a 20-year-old man with a history of recreational drug use that included vaping, who presented with EVALI and a coagulopathy associated with thrombotic events. CASE REPORT We present a 20-year-old patient who worked at a cannabidiol (CBD) manufacturing facility with a history of e-cigarette use and polysubstance abuse in remission who presented with respiratory and gastrointestinal symptoms accompanied by 50-pound weight loss over 6 months. The patient had been vaping with nicotine and THC-containing e-cigarettes multiple times per day for 1.5 years. He met the CDC surveillance criteria for EVALI, consisting of respiratory symptoms and infiltrates on imaging within 90 days of vaping, and was found to have eosinophilic pneumonia secondary to THC-containing e-cigarette use. Additionally, thrombi were detected in the pulmonary arteries, right saphenous vein, and right ventricle. A segmental infarct was noted in the inferior pole of the left kidney. CONCLUSIONS We present the second case report potentially linking e-cigarette use with clinically significant thrombogenesis, the first with both arterial and venous thromboses. This report demonstrates the importance of taking a history of e-cigarette use in patients presenting with lung injury. Although EVALI and the diagnostic criteria have only recently been described, systemic effects, including coagulopathy, are now being reported.
    MeSH term(s) Adult ; Blood Coagulation Disorders ; Electronic Nicotine Delivery Systems ; Humans ; Lung Injury/chemically induced ; Male ; Thrombosis ; Vaping/adverse effects ; Young Adult
    Language English
    Publishing date 2021-04-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.929915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Trainees' Experience of Family Presence during Intensive Care Unit Procedures.

    Harris, Benjamin R E / Butler, Allison / Hirshberg, Eliotte L / Hopkins, Ramona O / Butler, Jorie / Orme, James / Brown, Samuel M / Beesley, Sarah J

    ATS scholar

    2023  Volume 4, Issue 4, Page(s) 469–473

    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article
    ISSN 2690-7097
    ISSN (online) 2690-7097
    DOI 10.34197/ats-scholar.2023-0065BR
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  4. Article ; Online: Reply: Let Them In: Family Presence during Intensive Care Unit Procedures.

    Beesley, Sarah J / Brown, Samuel M

    Annals of the American Thoracic Society

    2017  Volume 13, Issue 9, Page(s) 1664

    MeSH term(s) Family ; Intensive Care Units ; Professional-Family Relations
    Language English
    Publishing date 2017-06-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201606-504LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5828: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Identifying predictors and determining mortality rates of septic cardiomyopathy and sepsis-related cardiogenic shock: A retrospective, observational study.

    Hendrickson, Kathryn W / Cirulis, Meghan M / Burk, Rebecca E / Lanspa, Michael J / Peltan, Ithan D / Marshall, Hunter / Groat, Danielle / Jephson, Al / Beesley, Sarah J / Brown, Samuel M

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0299876

    Abstract: Introduction: Septic shock is a severe form of sepsis that has a high mortality rate, and a substantial proportion of these patients will develop cardiac dysfunction, often termed septic cardiomyopathy (SCM). Some SCM patients may develop frank cardiac ... ...

    Abstract Introduction: Septic shock is a severe form of sepsis that has a high mortality rate, and a substantial proportion of these patients will develop cardiac dysfunction, often termed septic cardiomyopathy (SCM). Some SCM patients may develop frank cardiac failure, termed sepsis-related cardiogenic shock (SeRCS). Little is known of SeRCS. This study describes baseline characteristics of patients with SCM and SeRCS compared to patients with septic shock without cardiac dysfunction. We compare clinical outcomes among SCM, SeRCS, and septic shock, and identify risk factors for the development of SCM and SeRCS.
    Methods: Septic patients admitted to the ICU with an echocardiogram obtained within 72 hours were included. Left ventricular ejection fraction of ≤55% was used to define SCM, and cardiac index ≤2.1 L/min/m2 among patients with SCM defined SeRCS. Machine learning was used to identify risk factors for development of SCM and SeRCS. Logistic regression was used to compare mortality among groups.
    Results: Among 1229 patients, 977 patients had septic shock without cardiac dysfunction, 207 had SCM, and 45 had SeRCS. In patients with septic shock, the strongest predictor for developing SCM and SeRCs was a prior history of cardiac dysfunction. Mortality did not significantly differ among the three groups.
    Conclusions: SCM and SeRCS affect a minority of patients with septic shock, disproportionately affecting individuals with a history of cardiac disease. We did not identify a mortality difference associated with SCM or SeRCS. Additional work is needed to define further subtypes and treatment options for this patient population.
    MeSH term(s) Humans ; Male ; Female ; Shock, Cardiogenic/mortality ; Shock, Cardiogenic/complications ; Shock, Cardiogenic/etiology ; Aged ; Cardiomyopathies/mortality ; Cardiomyopathies/complications ; Retrospective Studies ; Middle Aged ; Shock, Septic/mortality ; Shock, Septic/complications ; Risk Factors ; Sepsis/mortality ; Sepsis/complications ; Echocardiography ; Aged, 80 and over
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299876
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  6. Article ; Online: Can Big Data Deliver on Its Promises?-Leaps but Not Bounds.

    Peltan, Ithan D / Beesley, Sarah J / Brown, Samuel M

    JAMA network open

    2018  Volume 1, Issue 8, Page(s) e185694

    MeSH term(s) Big Data ; Critical Care Outcomes ; Electronic Health Records ; Natural Language Processing
    Language English
    Publishing date 2018-12-07
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2018.5694
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  7. Article: Why we need a new definition of sepsis.

    Beesley, Sarah J / Lanspa, Michael J

    Annals of translational medicine

    2015  Volume 3, Issue 19, Page(s) 296

    Abstract: On April 23, 2015, Kaukonen and colleagues published an article in the New England Journal of Medicine entitled "Systemic inflammatory response syndrome criteria in defining severe sepsis", which investigated the sensitivity and validity of using SIRS ... ...

    Abstract On April 23, 2015, Kaukonen and colleagues published an article in the New England Journal of Medicine entitled "Systemic inflammatory response syndrome criteria in defining severe sepsis", which investigated the sensitivity and validity of using SIRS criteria to define intensive care unit (ICU) patients with severe sepsis. This study used admission data of over 100,000 patients in order to investigate patients with severe sepsis who either met or didn't meet SIRS criteria. The investigators found that in-hospital mortality increased linearly with the number of SIRS criteria met; raising concern that SIRS criterion is not sensitive enough. This study of SIRS criteria raises important questions about the recognition and diagnosis of severe sepsis.
    Language English
    Publishing date 2015-12-14
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.3978/j.issn.2305-5839.2015.11.02
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evaluation of potential COVID-19 recurrence in patients with late repeat positive SARS-CoV-2 testing.

    Peltan, Ithan D / Beesley, Sarah J / Webb, Brandon J / Lopansri, Bert K / Sinclair, Will / Jacobs, Jason R / Brown, Samuel M

    PloS one

    2021  Volume 16, Issue 5, Page(s) e0251214

    Abstract: Background: SARS-CoV-2 reinfection and reactivation has mostly been described in case reports. We therefore investigated the epidemiology of recurrent COVID-19 SARS-CoV-2.: Methods: Among patients testing positive for SARS-CoV-2 between March 11 and ... ...

    Abstract Background: SARS-CoV-2 reinfection and reactivation has mostly been described in case reports. We therefore investigated the epidemiology of recurrent COVID-19 SARS-CoV-2.
    Methods: Among patients testing positive for SARS-CoV-2 between March 11 and July 31, 2020 within an integrated healthcare system, we identified patients with a recurrent positive SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) assay ≥60 days after an initial positive test. To assign an overall likelihood of COVID-19 recurrence, we combined quantitative data from initial and recurrent positive RT-PCR cycle thresholds-a value inversely correlated with viral RNA burden- with a clinical recurrence likelihood assigned based on independent, standardized case review by two physicians. "Probable" or "possible" recurrence by clinical assessment was confirmed as the final recurrence likelihood only if a cycle threshold value obtained ≥60 days after initial testing was lower than its preceding cycle threshold or if the patient had an interval negative RT-PCR.
    Results: Among 23,176 patients testing positive for SARS-CoV-2, 1,301 (5.6%) had at least one additional SARS-CoV-2 RT-PCRs assay ≥60 days later. Of 122 testing positive, 114 had sufficient data for evaluation. The median interval to the recurrent positive RT-PCR was 85.5 (IQR 74-107) days. After combining clinical and RT-PCR cycle threshold data, four patients (3.5%) met criteria for probable COVID-19 recurrence. All four exhibited symptoms at recurrence and three required a higher level of medical care compared to their initial diagnosis. After including six additional patients (5.3%) with possible recurrence, recurrence incidence was 4.3 (95% CI 2.1-7.9) cases per 10,000 COVID-19 patients.
    Conclusions: Only 0.04% of all COVID-19 patients in our health system experienced probable or possible recurrence; 90% of repeat positive SARS-CoV-2 RT-PCRs were not consistent with true recurrence. Our pragmatic approach combining clinical and quantitative RT-PCR data could aid assessment of COVID-19 reinfection or reactivation by clinicians and public health personnel.
    MeSH term(s) Adult ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Testing ; Female ; Humans ; Male ; Middle Aged ; RNA, Viral/analysis ; RNA, Viral/metabolism ; Recurrence ; Reverse Transcriptase Polymerase Chain Reaction/standards ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Time Factors ; Viral Load
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0251214
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  9. Article: Glucose management in the intensive care unit: are we looking for the right sweet spot?

    Beesley, Sarah J / Hirshberg, Eliotte L / Lanspa, Michael J

    Annals of translational medicine

    2016  Volume 4, Issue 18, Page(s) 347

    Abstract: In a recently published issue ... ...

    Abstract In a recently published issue of
    Language English
    Publishing date 2016-10-05
    Publishing country China
    Document type Journal Article ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2016.08.30
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  10. Article ; Online: Association Between Unmet Nonmedication Needs After Hospital Discharge and Readmission or Death Among Acute Respiratory Failure Survivors: A Multicenter Prospective Cohort Study.

    Bose, Somnath / Groat, Danielle / Dinglas, Victor D / Akhlaghi, Narjes / Banner-Goodspeed, Valerie / Beesley, Sarah J / Greene, Tom / Hopkins, Ramona O / Mir-Kasimov, Mustafa / Sevin, Carla M / Turnbull, Alison E / Jackson, James C / Needham, Dale M / Brown, Samuel M

    Critical care medicine

    2023  Volume 51, Issue 2, Page(s) 212–221

    Abstract: Objectives: To characterize early unmet nonmedication discharge needs (UDNs), classified as durable medical equipment (DME), home health services (HHS), and follow-up medical appointments (FUAs) and explore their association with 90-day readmission and ... ...

    Abstract Objectives: To characterize early unmet nonmedication discharge needs (UDNs), classified as durable medical equipment (DME), home health services (HHS), and follow-up medical appointments (FUAs) and explore their association with 90-day readmission and mortality among survivors of acute respiratory failure (ARF) who were discharged home.
    Design: Prospective multicenter cohort study.
    Setting: Six academic medical centers across United States.
    Participants: Adult survivors of ARF who required an ICU stay and were discharged home from hospital.
    Interventions: None. Exposure of interest was the proportion of UDN for the following categories: DME, HHS, and FUA ascertained within 7-28 days after hospital discharge.
    Measurements and main results: Two hundred eligible patients were recruited between January 2019 and August 2020. One-hundred ninety-five patients were included in the analytic cohort: 118 were prescribed DME, 134 were prescribed HHS, and 189 needed at least one FUA according to discharge plans. 98.4% (192/195) had at least one identified nonmedication need at hospital discharge. Median (interquartile range) proportion of unmet needs across three categories were 0 (0-15%) for DME, 0 (0-50%) for HHS, and 0 (0-25%) for FUA, and overall was 0 (0-20%). Fifty-six patients (29%) had 90-day death or readmission. After adjusting for prespecified covariates, having greater than the median level of unmet needs was not associated with an increased risk of readmission or death within 90 days of discharge (risk ratio, 0.89; 0.51-1.57; p = 0.690). Age, hospital length of stay, Acute Physiology and Chronic Health Evaluation II severity of illness score, and Multidimensional Scale Perceived Social Support score were associated with UDN.
    Conclusions: UDN were common among survivors of ARF but not significantly associated a composite outcome of 90-day readmission or death. Our results highlight the substantial magnitude of UDN and identifies areas especially vulnerable to lapses in healthcare coordination.
    MeSH term(s) Adult ; Humans ; United States/epidemiology ; Patient Discharge ; Prospective Studies ; Patient Readmission ; Cohort Studies ; Hospitals ; Survivors ; Respiratory Insufficiency/therapy ; Retrospective Studies ; Length of Stay
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005709
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