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Article ; Online: Impact de la grossesse sur la pharmacocinétique des médicaments : quelles répercussions en pratique ?

Beghin, D

Gynecologie, obstetrique, fertilite & senologie

2022 Volume 50, Issue 5, Page(s) 422–425

Abstract: Physiological changes that occur during pregnancy in the maternal body can lead to alterations in the response to drugs in the mother. Pregnancy modifies the volume of distribution of drugs, their binding to plasma proteins, the activity of their ... ...

Title translation	Impact of pregnancy on drug pharmacokinetics: What implication in clinical practice?
Abstract	Physiological changes that occur during pregnancy in the maternal body can lead to alterations in the response to drugs in the mother. Pregnancy modifies the volume of distribution of drugs, their binding to plasma proteins, the activity of their metabolizing enzymes, and their elimination. However, to date, due to the dynamic and complex processes involved, adjustments to the dosage regimen during pregnancy remain impossible to standardize. Knowledge of these modifications will help to better understand the possible loss of drug efficacy during pregnancy, as well as anticipating the clinical and plasma monitoring of drugs with a low therapeutic margin.
MeSH term(s)	Female ; Humans ; Pharmaceutical Preparations ; Pharmacokinetics ; Pregnancy/metabolism
Chemical Substances	Pharmaceutical Preparations
Language	French
Publishing date	2022-02-24
Publishing country	France
Document type	Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2022.02.076
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Article ; Online: Le passage placentaire des anticorps monoclonaux : exemple des anti-TNF alpha.

Beghin, D

Gynecologie, obstetrique, fertilite & senologie

2021 Volume 49, Issue 9, Page(s) 724–726

Abstract: Anti-TNF alpha monoclonal antibodies are used in the treatment of chronic inflammatory diseases, which commonly affect women of childbearing age. Due to their similar structure to native immunoglobulins, the evaluation of their placental transfer by a ... ...

Title translation	Placental transfer of monoclonal antibodies: The example of anti-TNF alpha drugs.
Abstract	Anti-TNF alpha monoclonal antibodies are used in the treatment of chronic inflammatory diseases, which commonly affect women of childbearing age. Due to their similar structure to native immunoglobulins, the evaluation of their placental transfer by a pharmacological approach of the mechanisms involved is an interesting source of information, useful to the risk-benefit assessment of drugs in pregnant women.
MeSH term(s)	Antibodies, Monoclonal/pharmacokinetics ; Female ; Humans ; Maternal-Fetal Exchange ; Placenta ; Pregnancy ; Tumor Necrosis Factor Inhibitors/pharmacokinetics
Chemical Substances	Antibodies, Monoclonal ; Tumor Necrosis Factor Inhibitors
Language	French
Publishing date	2021-06-29
Publishing country	France
Document type	Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2021.06.008
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Article ; Online: Coverage losses of substance in the shoulder.

Auquit-Auckbur, I / Coquerel-Beghin, D / Vanaret, J

Annales de chirurgie plastique et esthetique

2020 Volume 65, Issue 5-6, Page(s) 570–588

Abstract: Losses of substance of the shoulder are less common than elsewhere in the upper limb. They arise essentially from tumors (sarcomas), infectious diseases (hidradenitis) or traumatic events, (burns). The objectives of reconstruction depend on whether the ... ...

Abstract	Losses of substance of the shoulder are less common than elsewhere in the upper limb. They arise essentially from tumors (sarcomas), infectious diseases (hidradenitis) or traumatic events, (burns). The objectives of reconstruction depend on whether the losses of substance are located on the curve of the shoulder or in the axillary area. There exist numerous regional solutions, including perforator, propeller, pedicled and free flaps. The donor region may be the thorax (latissimus dorsi, serratus anterior), the back (trapezium, scapular or subscapular flaps, occipito-cervico-thoracic flap), the anterior surface of the thorax (pectoralis major or minor, supraclavicular, perforators of the acromiothoracic artery, delto-pectoral flap) or arm (brachial lateral or medial). Multitissular reconstructions are also possible in regional and pedicled form, as well as microanastomosed flaps in exceptional conditions.
MeSH term(s)	Humans ; Reconstructive Surgical Procedures/methods ; Shoulder/surgery ; Surgical Flaps
Language	English
Publishing date	2020-08-14
Publishing country	France
Document type	Journal Article
ZDB-ID	605676-3
ISSN	1768-319X ; 0294-1260
ISSN (online)	1768-319X
ISSN	0294-1260
DOI	10.1016/j.anplas.2020.06.008
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Article ; Online: Vaccination contre la varicelle, grossesse et allaitement : un état des lieux.

Vauzelle, Catherine / Elefant, Elisabeth / Coulm, Bénédicte / Latour, Mathilde / Beghin, Delphine / Marin, Benoît

Gynecologie, obstetrique, fertilite & senologie

2024

Abstract: The varicella vaccine is recommended for women with no history of varicella who are planning to become pregnant, as well as for post-pregnancy women, to prevent the occurrence of this illness and its severe complications, especially an embryopathy, when ... ...

Title translation	Varicella vaccination, pregnancy and breastfeeding: The current situation.
Abstract	The varicella vaccine is recommended for women with no history of varicella who are planning to become pregnant, as well as for post-pregnancy women, to prevent the occurrence of this illness and its severe complications, especially an embryopathy, when it occurs in a pregnant woman (congenital varicella syndrome). This live attenuated vaccine should not be administered during pregnancy, nor in the month preceding it. However, when this occurs inadvertently, the data collected on the outcomes of exposed pregnancies, although few in women seronegative at the time of vaccination, allow to reassure the patients to date, as no congenital varicella syndrome has been reported to date following accidental vaccination in early pregnancy. On the other hand, during breastfeeding, a woman may be vaccinated if there is an expected short- or medium-term benefit (varicella exposure, planned pregnancy…).
Language	French
Publishing date	2024-02-01
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2024.01.012
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Article ; Online: Tératogénicité potentielle du modafinil – des données contradictoires, un besoin de recherche.

Marin, B / Arnulf, I / Latour, M / Vauzelle, C / Coulm, B / Beghin, D / Dauvilliers, Y / Elefant, E

Gynecologie, obstetrique, fertilite & senologie

2023 Volume 51, Issue 3, Page(s) 186–189

Abstract: Central disorders of hypersomnolence include narcolepsy type 1, narcolepsy type 2, idiopathic hypersomnia and hypersomnia associated with medical or mental disorders. Treatment is both non-pharmacological and pharmacological, including wake enhancing ... ...

Title translation	Potential teratogenicity of modafinil - Conflicting evidence, need for research.
Abstract	Central disorders of hypersomnolence include narcolepsy type 1, narcolepsy type 2, idiopathic hypersomnia and hypersomnia associated with medical or mental disorders. Treatment is both non-pharmacological and pharmacological, including wake enhancing drugs and stimulants. One of the first-line treatment (modafinil, MODIODAL®) was the subject of a health authority alert in 2019 concerning a risk of major congenital malformations when taken during organogenesis. Since this date, three epidemiological studies have presented contradictory results. Given their methodological weaknesses, it is not possible at this stage to confirm or deny such a risk for the embryo and its nature if there is one. In clinical practice, because of these uncertainties, it is preferable if possible to suspend the treatment of a pregnant woman during the first 10 weeks from last menstrual period (organogenesis). There is an unmet clinical need for research to clarify the potential teratogenic impact of modafinil.
MeSH term(s)	Female ; Humans ; Modafinil/adverse effects ; Narcolepsy/drug therapy ; Narcolepsy/etiology ; Disorders of Excessive Somnolence/chemically induced ; Disorders of Excessive Somnolence/complications ; Disorders of Excessive Somnolence/drug therapy ; Central Nervous System Stimulants/adverse effects ; Idiopathic Hypersomnia/complications ; Idiopathic Hypersomnia/drug therapy
Chemical Substances	Modafinil (R3UK8X3U3D) ; Central Nervous System Stimulants
Language	French
Publishing date	2023-01-13
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2023.01.003
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Article ; Online: Surgical practices of cosmetic breast augmentation by implants among 411 French plastic surgeons.

Vanaret, J / El Ayoubi, M / Cornette De Saint Cyr, B / Auquit-Auckbur, I / Coquerel-Beghin, D

Annales de chirurgie plastique et esthetique

2022 Volume 67, Issue 4, Page(s) 183–188

Abstract: Introduction: Breast augmentation is one of the most frequently performed cosmetic surgeries in the world. However, there is no standardized surgical procedure for performing breast augmentation. Many modalities exist for this surgery which may explain ... ...

Abstract	Introduction: Breast augmentation is one of the most frequently performed cosmetic surgeries in the world. However, there is no standardized surgical procedure for performing breast augmentation. Many modalities exist for this surgery which may explain why practices vary greatly from one surgeon to another. The aim of this study was to evaluate current practices of breast augmentation by implant in France and changes in practices among French plastic surgeons. Material and methods: This observational study was conducted between February 2020 and January 2021. An online questionnaire with 62 questions was sent to 729 French plastic surgeons. The questions concerned: the population of surgeons interviewed, pre-operative aspects, surgical technique and post-operative management. Results: 411 plastic surgeons responded, 5.1% of surgeons impose a nicotine screening test on patients. 99.76% and 95.59% reported that they used silicone gel implants and round prostheses. All used smooth or micro-textured shells. The inframammary approach was the most used by 66.2% of plastic surgeons. The implants placed were between 250 and 300 cc on average and were mainly placed in "Dual plane" by 42% of surgeons. In order to reduce bacterial contamination, 26% of surgeons soaked the implants in a povidone-iodine solution and 23% used an insertion sleeve. The most frequent early complication was hematoma, while capsular contracture was a late complication. Conclusion: This study provides new data on current surgical practices of breast augmentation in France, allowing more informed choices and opening up perspectives for more standardized practices in the future.
MeSH term(s)	Breast Implantation ; Breast Implants ; Humans ; Mammaplasty ; Silicone Gels ; Surgeons
Chemical Substances	Silicone Gels
Language	English
Publishing date	2022-06-25
Publishing country	France
Document type	Journal Article ; Observational Study
ZDB-ID	605676-3
ISSN	1768-319X ; 0294-1260
ISSN (online)	1768-319X
ISSN	0294-1260
DOI	10.1016/j.anplas.2022.05.006
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Article ; Online: Évaluation de la satisfaction des professionnels de santé utilisateurs du site internet du CRAT et lancement d’une nouvelle version.

Marin, Benoît / Coulm, Bénédicte / Beghin, Delphine / Latour, Mathilde / Béloni, Pascale / Toniolo, Jean / Dechartres, Agnès / Tubach, Florence / Vauzelle, Catherine / Elefant, Elisabeth

Therapie

2024

Abstract: In preparation for a new version of the CRAT (Centre de référence sur les agents tératogènes) website, an evaluation of user satisfaction was carried out. An invitation to complete an online questionnaire covering the various dimensions of the website ( ... ...

Title translation	Evaluation of the satisfaction of healthcare professionals using the CRAT website, and launch of a new version.
Abstract	In preparation for a new version of the CRAT (Centre de référence sur les agents tératogènes) website, an evaluation of user satisfaction was carried out. An invitation to complete an online questionnaire covering the various dimensions of the website (appearance, content, interactivity, ease of use, technical performance) was sent in April 2022 to healthcare professionals who referred to CRAT for clinical expertise over the previous two years. After sending out 3224 individual e-mail invitations, 758 evaluators completed the questionnaire in full (response rate: 23.5%). The evaluation revealed a high-level of overall satisfaction among site users (98.0% very satisfied or satisfied). Satisfaction with the site's appearance was also high, although comments were made about the site's lack of a modern web design. Health professionals recognized in their responses the reliable, relevant and up-to-date nature of the content of this free, public online resource, independent of the pharmaceutical industry. On the basis of these highly favorable assessments, with content that has been widely acclaimed and areas for improvement that have caught the attention of site users (evolution of its appearance, of the search tool, implementation of a mobile site), a new version of www.lecrat.fr was launched in the fall of 2023.
Language	French
Publishing date	2024-04-02
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	603474-3
ISSN	1958-5578 ; 0040-5957
ISSN (online)	1958-5578
ISSN	0040-5957
DOI	10.1016/j.therap.2024.03.004
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Article ; Online: État des lieux sur les anti-IL-1 chez la femme enceinte.

Faure-Bardon, Valentine / Beghin, Delphine / Latour, Mathilde / Coulm, Benedicte / Vauzelle, Catherine / Elefant, Elisabeth / Marin, Benoit

Gynecologie, obstetrique, fertilite & senologie

2024

Abstract: Anti-Interleukin-1 (Anti-IL-1) drugs are used to treat some chronic rheumatic diseases that can affect young people, including women of childbearing age. Two anti-IL-1 drugs are available in France: anakinra and canakinumab. Data on their use during ... ...

Title translation	Use of anti-IL-1 drugs during pregnancy.
Abstract	Anti-Interleukin-1 (Anti-IL-1) drugs are used to treat some chronic rheumatic diseases that can affect young people, including women of childbearing age. Two anti-IL-1 drugs are available in France: anakinra and canakinumab. Data on their use during pregnancy are still limited. Based on the published literature, we carried out a review of the use of these anti-IL-1 therapies during pregnancy: therapeutic indications, pharmacological profiles and assessment of embryonic, fetal and neonatal risks. Based on this analysis, and given the absence of any reported concern, it is possible to consider the use of these two treatments during pregnancy if the clinical situation so requires and under certain conditions. Based on the data available to date, anakinra should be preferred to canakinumab whenever possible.
Language	French
Publishing date	2024-04-13
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2024.04.004
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Article ; Online: Comment on "Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature".

Marin, B / Vauzelle, C / Coulm, B / Beghin, D / Latour, M / Tubach, F / Dechartres, A / Elefant, E

Reproductive toxicology (Elmsford, N.Y.)

2021 Volume 104, Page(s) 168

Language	English
Publishing date	2021-06-10
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	639342-1
ISSN	1873-1708 ; 0890-6238
ISSN (online)	1873-1708
ISSN	0890-6238
DOI	10.1016/j.reprotox.2021.05.003
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Article ; Online: Pregnancy and newborn outcomes after exposure to bisphosphonates: a case-control study.

Sokal, A / Elefant, E / Leturcq, T / Beghin, D / Mariette, X / Seror, R

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

2018 Volume 30, Issue 1, Page(s) 221–229

Abstract: We analyzed women and newborn outcome after maternal exposure to BPs. BPs have no teratogenic effect on the 36 analyzed pregnancies compared to unexposed controls matched on women underlying diseases (either systemic disease, either "bone" disease) but ... ...

Abstract	We analyzed women and newborn outcome after maternal exposure to BPs. BPs have no teratogenic effect on the 36 analyzed pregnancies compared to unexposed controls matched on women underlying diseases (either systemic disease, either "bone" disease) but some outcome differed: neonatal complications rate in systemic diseases and live birth rate in bone diseases). Introduction: The effect of bisphosphonates (BPs) during pregnancy remains unclear. We aimed to study pregnancy outcomes in women exposed to BPs during pregnancy. Methods: Data for cases and controls were from the French Reference Centre of Teratogenic Agents. Cases were women who received BPs in the 6 weeks before or during a pregnancy and had systemic or bone diseases. We included two respectively matched control groups: women with systemic diseases not exposed to BPs and healthy women not exposed to BPs or any teratogenic agent. Four controls were assigned to each case. Results: Thirty-six women were exposed to BPs including 5 just before pregnancy and 30 during the first trimester; 23 had systemic diseases (systemic lupus erythematosus, n = 5; rheumatoid arthritis, n = 5; other, n = 13) and 13 had bone diseases. Rate of observed congenital malformations did not differ in women with a systemic or a bone disease compared to their respective controls (respectively 2/23 [8.7%] vs 2/92 [2.2%], p = 0.178 and 0/13 [0%] vs 0/52 [0%], p = 1.00). Among women with systemic diseases, non-specific neonatal complications were more frequent for cases (4/16 [25.0%] vs 4/64 [6.3%], p = 0.027). Among women with bone disorders, the live birth rate was lower for cases than healthy controls (8/10 [80%] vs 50/50 [100%], p = 0.025). Conclusion: We found no major teratogenic effects of BPs, but rates of neonatal complications were increased for women with systemic diseases, as were spontaneous abortions for women with bone diseases likely linked to the severity of the underlying diseases and concomitant medications.
MeSH term(s)	Adult ; Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/therapeutic use ; Case-Control Studies ; Congenital Abnormalities/etiology ; Databases, Factual ; Diphosphonates/adverse effects ; Diphosphonates/therapeutic use ; Female ; Humans ; Infant, Newborn ; Maternal-Fetal Exchange ; Osteoporosis/drug therapy ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Outcome ; Prenatal Exposure Delayed Effects/chemically induced
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates
Language	English
Publishing date	2018-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1064892-6
ISSN	1433-2965 ; 0937-941X
ISSN (online)	1433-2965
ISSN	0937-941X
DOI	10.1007/s00198-018-4672-9
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