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  1. Article ; Online: Discriminating alkylbenzene isomers with tandem mass spectrometry using a dielectric barrier discharge ionization source.

    Begley, Alina / Zenobi, Renato

    Journal of mass spectrometry : JMS

    2023  Volume 58, Issue 3, Page(s) e4910

    Abstract: Soft ambient ionization sources generate reactive species that interact with analyte molecules to form intact molecular ions, which allows rapid, sensitive, and direct identification of the molecular mass. We used a dielectric barrier discharge ... ...

    Abstract Soft ambient ionization sources generate reactive species that interact with analyte molecules to form intact molecular ions, which allows rapid, sensitive, and direct identification of the molecular mass. We used a dielectric barrier discharge ionization (DBDI) source with nitrogen at atmospheric pressure to detect alkylated aromatic hydrocarbon isomers (C
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1221763-3
    ISSN 1096-9888 ; 1076-5174
    ISSN (online) 1096-9888
    ISSN 1076-5174
    DOI 10.1002/jms.4910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4254: Show issues Location:
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  2. Article: COVID-19 vaccination requirements for Ireland's healthcare students.

    Monaghan, Lee F / Begley, Aoife

    Critical social policy

    2023  Volume 43, Issue 3, Page(s) 557–569

    Abstract: International debate on COVID-19 policy issues, notably negative social consequences, is vital when grappling with the pandemic legacy. Drawing from the second author's experiences in the Irish healthcare and higher education sectors, this commentary ... ...

    Abstract International debate on COVID-19 policy issues, notably negative social consequences, is vital when grappling with the pandemic legacy. Drawing from the second author's experiences in the Irish healthcare and higher education sectors, this commentary scrutinises measures that discriminated against students who declined novel COVID-19 pharmaceuticals. In so doing, it serves as a point of contrast to fear-based interventions. Connections are made with relevant literature when urging those in authority to ensure that policies intended to maximise vaccine coverage are seen to be fair and convincing. The commentary concludes with some reflections that could underpin more defensible policymaking and inform future research.
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2057734-5
    ISSN 1461-703X ; 0261-0183
    ISSN (online) 1461-703X
    ISSN 0261-0183
    DOI 10.1177/02610183231174846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Discriminating alkylbenzene isomers with tandem mass spectrometry using a dielectric barrier discharge ionization source

    Begley, Alina / Zenobi, Renato

    Journal of Mass Spectrometry. 2023 Mar., v. 58, no. 3 p.e4910-

    2023  

    Abstract: Soft ambient ionization sources generate reactive species that interact with analyte molecules to form intact molecular ions, which allows rapid, sensitive, and direct identification of the molecular mass. We used a dielectric barrier discharge ... ...

    Abstract Soft ambient ionization sources generate reactive species that interact with analyte molecules to form intact molecular ions, which allows rapid, sensitive, and direct identification of the molecular mass. We used a dielectric barrier discharge ionization (DBDI) source with nitrogen at atmospheric pressure to detect alkylated aromatic hydrocarbon isomers (C₈H₁₀ or C₉H₁₂). Intact molecular ions [M]•⁺ were detected at 2.4 kVₚₚ, but at increased voltage (3.4 kVₚₚ), [M + N]⁺ ions were formed, which could be used to differentiate regioisomers by collision‐induced dissociation (CID). At 2.4 kVₚₚ, alkylbenzene isomers with different alkyl‐substituents could be identified by additional product ions: ethylbenzene and ‐toluene formed [M‐2H]⁺, isopropylbenzene formed abundant [M‐H]⁺, and propylbenzene formed abundant C₇H₇⁺. At an operating voltage of 3.4 kVₚₚ, fragmentation of [M + N]⁺ by CID led to neutral loss of HCN and CH₃CN, which corresponded to steric hindrance for excited state N‐atoms approaching the aromatic ring (C‐H). The ratio of HCN to CH₃N loss (interday relative standard deviation [RSD] < 20%) was distinct for ethylbenzene and ethyltoluene isomers. The greater the number of alkyl‐substituents (C‐CH₃) and the more sterically hindered (meta > para > ortho) the aromatic core, the greater the loss of CH₃CN relative to HCN was.
    Keywords atmospheric pressure ; dissociation ; electric potential difference ; ethylbenzene ; ionization ; molecular weight ; nitrogen ; positional isomers ; standard deviation ; tandem mass spectrometry
    Language English
    Dates of publication 2023-03
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 1221763-3
    ISSN 1096-9888 ; 1076-5174
    ISSN (online) 1096-9888
    ISSN 1076-5174
    DOI 10.1002/jms.4910
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Some weighting of publication rates should be used to more fairly reflect the productivity of trainees. Re: Variation in UK Deanery publication rates in the British Journal of Oral and Maxillofacial Surgery: where are the current 'hot spots'?

    Begley, A / Magennis, P

    The British journal of oral & maxillofacial surgery

    2020  Volume 59, Issue 2, Page(s) 261–262

    MeSH term(s) Bibliometrics ; Humans ; Surgery, Oral ; United Kingdom
    Language English
    Publishing date 2020-12-25
    Publishing country Scotland
    Document type Letter ; Comment
    ZDB-ID 605685-4
    ISSN 1532-1940 ; 0266-4356
    ISSN (online) 1532-1940
    ISSN 0266-4356
    DOI 10.1016/j.bjoms.2020.11.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Methodological approaches to exploring the spatial variation in social impacts of protected areas: An intercomparison of Bayesian regression modeling approaches and potential implications.

    Malesios, Chrysovalantis / Jones, Nikoleta / Begley, Alfie / McGinlay, James

    Mathematical biosciences and engineering : MBE

    2024  Volume 21, Issue 3, Page(s) 3816–3837

    Abstract: Protected Areas (PAs) are widely used to conserve biodiversity by protecting and restoring ecosystems while also contributing to socio-economic priorities. An increasing number of studies aim to examine the social impacts of PAs on aspects of people's ... ...

    Abstract Protected Areas (PAs) are widely used to conserve biodiversity by protecting and restoring ecosystems while also contributing to socio-economic priorities. An increasing number of studies aim to examine the social impacts of PAs on aspects of people's well-being, such as, quality of life, livelihoods, and connectedness to nature. Despite the increase in literature on this topic, there are still few studies that explore possible robust methodological approaches to capturing and assessing the spatial distribution of impacts in a PA. This study aims to contribute to this research gap by comparing Bayesian spatial regression models that explore links between perceived social impacts and the relative location of local residents and communities in a PA. We use primary data collected from 227 individuals, via structured questionnaires, living in or near the Peak District National Park, United Kingdom. By comparing different models we were able to show that the location of respondents influences their perception of social impacts and that neighboring communities within the national park can have similar perceptions regarding social impacts. Simulation based on existing data using the Bootstrap sub-sampling was also conducted to validate the association between social impacts and mutual proximity of residents. Our findings suggest that this type of data is better treated, in terms of accounting for potential spatial effects, using models that allow for proximity effects to be stronger between people living nearby, e.g. between neighbors in the same community and have minimum effects otherwise. Understanding the spatial clustering of perceived social impacts in and around PA, is key to understanding their causes and to managing and mitigating them. Our findings highlight therefore the need to develop new methodological approaches to assessing and predicting accurately the spatial distribution of social impacts when designating PAs. The findings in this paper will assist practitioners in this regard by proposing approaches to the consideration of the distribution of social impacts when designing the boundaries of PAs alongside typical ecological and socio-economic criteria.
    MeSH term(s) Humans ; Ecosystem ; Social Change ; Bayes Theorem ; Quality of Life ; Conservation of Natural Resources
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2024170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: UK Oral and Maxillofacial Surgery trainees join the specialist list at a similar age to other surgical specialists.

    Douglas, J / Begley, A / Magennis, P

    The British journal of oral & maxillofacial surgery

    2020  Volume 58, Issue 10, Page(s) 1268–1272

    Abstract: It is 11 years since Cameron and Westcott published 'Maxillofacial training is no longer than other surgical specialties' ...

    Abstract It is 11 years since Cameron and Westcott published 'Maxillofacial training is no longer than other surgical specialties'
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Education, Dental, Graduate ; Humans ; Middle Aged ; Specialization ; Specialties, Surgical ; Surgery, Oral ; United Kingdom
    Language English
    Publishing date 2020-08-08
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 605685-4
    ISSN 1532-1940 ; 0266-4356
    ISSN (online) 1532-1940
    ISSN 0266-4356
    DOI 10.1016/j.bjoms.2020.07.041
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: The unresolved role of the neurologist in providing dietary advice to people with multiple sclerosis.

    Russell, R D / Black, L J / Begley, A

    Multiple sclerosis and related disorders

    2020  Volume 44, Page(s) 102304

    Abstract: Background: People with MS often make dietary changes after diagnosis with the aim of slowing disease progression. Although people with MS commonly use the internet for information on diet and MS, neurologists are their preferred source of information. ... ...

    Abstract Background: People with MS often make dietary changes after diagnosis with the aim of slowing disease progression. Although people with MS commonly use the internet for information on diet and MS, neurologists are their preferred source of information. However, little is known about what dietary advice is provided by neurologists.
    Objectives: To explore the perceptions of neurologists about diet and MS, and to identify the type of dietary advice they provide to their patients with MS.
    Methods: In this exploratory qualitative study, 11 semi-structured interviews were conducted with neurologists in Western Australia. Audio files were transcribed verbatim, and transcripts were thematically analysed using a general inductive approach.
    Results: Four themes emerged: 1) juggling the evidence on the role of diet in MS; 2) acknowledging the risks and benefits of specific diets; 3) distancing from the diet 'gurus'; and 4) the unresolved role of the neurologist in providing dietary advice.
    Conclusion: Neurologists could meet their patients' expectations by providing evidence-based dietary advice, such as promoting the benefits of diets that adhere to national dietary guidelines, and being prepared to explain potential risks of restrictive diets. Information about healthy eating needs to be targeted to people with MS.
    MeSH term(s) Diet ; Humans ; Multiple Sclerosis ; Neurologists ; Qualitative Research
    Language English
    Publishing date 2020-06-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2020.102304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Tophaceous pseudogout of the temporomandibular joint with erosion into the middle cranial fossa.

    Houghton, D / Munir, N / Triantafyllou, A / Begley, A

    International journal of oral and maxillofacial surgery

    2020  Volume 49, Issue 10, Page(s) 1286–1289

    Abstract: This report presents a case of extensive tophaceous pseudogout involving the temporomandibular joint (TMJ), causing erosion into the middle cranial fossa. Pseudogout is a benign metabolic arthropathy caused by calcium pyrophosphate dihydrate crystal ... ...

    Abstract This report presents a case of extensive tophaceous pseudogout involving the temporomandibular joint (TMJ), causing erosion into the middle cranial fossa. Pseudogout is a benign metabolic arthropathy caused by calcium pyrophosphate dihydrate crystal deposition within joints and peri-articular tissue. Pseudogout more frequently occurs in large joints such as the knee, wrist, symphysis pubis, and shoulder. Tophaceous pseudogout involving the TMJ is rare, with only seven cases involving erosion into the middle cranial fossa reported previously. Despite skull base erosion being a rare consequence of this erosive disease, this case highlights the importance of appropriate investigation and multidisciplinary team management.
    MeSH term(s) Chondrocalcinosis/complications ; Chondrocalcinosis/diagnostic imaging ; Cranial Fossa, Middle/diagnostic imaging ; Cranial Fossa, Middle/surgery ; Diagnosis, Differential ; Humans ; Temporomandibular Joint/diagnostic imaging ; Temporomandibular Joint/surgery
    Language English
    Publishing date 2020-04-08
    Publishing country Denmark
    Document type Case Reports ; Journal Article
    ZDB-ID 353721-3
    ISSN 1399-0020 ; 0901-5027
    ISSN (online) 1399-0020
    ISSN 0901-5027
    DOI 10.1016/j.ijom.2020.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 931: Show issues Location:
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    Zs.MO 401: Show issues

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  9. Article: How to conduct a telephone consultation;An informative guide

    Coffey, D. / Begley, A.

    Dental Update

    Abstract: Telemedicine is the remote diagnosis and treatment of patients by means of telecommunications technology The advantages of telemedicine include reduced travel time/cost and enhanced access to healthcare The coronavirus pandemic in 2020 has necessitated ... ...

    Abstract Telemedicine is the remote diagnosis and treatment of patients by means of telecommunications technology The advantages of telemedicine include reduced travel time/cost and enhanced access to healthcare The coronavirus pandemic in 2020 has necessitated the rapid implementation of remote consultations across all healthcare platforms, in most cases without any formal training We present an educational framework for conducting telephone consultations in secondary care to help fill this gap There are five key steps in a telephone consultation;patient introduction, information gathering, establishing a working diagnosis and plan for clinical care, planning the next step and closing the consultation By focusing on what each step entails, this paper aims to help those new to telemedicine techniques and those responsible for training them, to shorten the learning curve CPD/clinical relevance: This article aims to help clinicians become proficient and comfortable in conducting telephone consultations by providing a structure to the consultation which they can customize to their specific setting © 2020 George Warman Publications All rights reserved
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #823820
    Database COVID19

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  10. Article ; Online: Clinical prognostic factors predicting survival of motor neuron disease patients with gastrostomy: A retrospective analysis.

    Yang, Jie / Zhao, Yun / Soares, Mario / Needham, Merrilee / Begley, Andrea / Calton, Emily

    Muscle & nerve

    2024  Volume 69, Issue 4, Page(s) 440–447

    Abstract: Introduction/aims: Enteral feeding via gastrostomy is a key intervention to prevent significant weight loss in Motor Neuron Disease (MND). The aim of this study was to explore demographic, clinical, and nutritional factors associated with survival time ... ...

    Abstract Introduction/aims: Enteral feeding via gastrostomy is a key intervention to prevent significant weight loss in Motor Neuron Disease (MND). The aim of this study was to explore demographic, clinical, and nutritional factors associated with survival time in MND patients with gastrostomy.
    Methods: The retrospective study analyzed 94 MND patients (n = 58 bulbar-onset and n = 36 limb-onset) who underwent gastrostomy between 2015 and 2021. The primary outcome was the survival time from gastrostomy insertion to death. Independent variables of interest explored were: age at gastrostomy insertion, disease onset type, known genetic cause, use of riluzole, non-invasive ventilation (NIV) use, forced vital capacity prior to gastrostomy, weight loss from diagnosis to gastrostomy insertion, and body mass index (BMI) at the time of gastrostomy insertion.
    Results: The median survival time from gastrostomy to death was 357 days (± 29.3, 95%CI: 299.5, 414.5). Kaplan-Meier method and log-rank test revealed patients with lower body mass index <18.5 kg/m
    Discussion: Preventing or minimizing weight loss from MND diagnosis and encouraging NIV use when clinically indicated are modifiable factors that may prolong the survival of MND patients with gastrostomy.
    MeSH term(s) Humans ; Retrospective Studies ; Gastrostomy/methods ; Amyotrophic Lateral Sclerosis/complications ; Prognosis ; Motor Neuron Disease/therapy ; Motor Neuron Disease/complications ; Weight Loss ; Survival Analysis
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 438353-9
    ISSN 1097-4598 ; 0148-639X
    ISSN (online) 1097-4598
    ISSN 0148-639X
    DOI 10.1002/mus.28064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 551: Show issues

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