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  1. Article ; Online: Biventricular catheterization combined with pressure-volume loop monitoring provides insight into the dynamic effects of left ventricular assist devices ramp on right ventricular function.

    Garmany, Armin / Inglis, Sara S / Behfar, Atta / Rosenbaum, Andrew N

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2024  Volume 103, Issue 5, Page(s) 799–802

    Abstract: Ramp studies are utilized for speed optimization of continuous flow left ventricular assist devices (CF-LVADs). We here report the utility of combined left and right heart catheterization during a ramp study to ensure a comprehensive understanding of the ...

    Abstract Ramp studies are utilized for speed optimization of continuous flow left ventricular assist devices (CF-LVADs). We here report the utility of combined left and right heart catheterization during a ramp study to ensure a comprehensive understanding of the hemodynamic implications on both ventricles. Pressure-volume loop (PV loop) monitoring uncovered compromised systolic and mildly compromised right ventricular function with increasing LVAD speeds, despite improvement in left ventricular unloading. These findings informed patient management and highlight the potential utility of PV loop monitoring as an adjunct to left and right heart catheterization during ramp studies of next-generation LVADs.
    MeSH term(s) Humans ; Heart-Assist Devices ; Ventricular Function, Right ; Treatment Outcome ; Hemodynamics ; Cardiac Catheterization ; Heart Failure/diagnosis ; Heart Failure/therapy ; Ventricular Function, Left
    Language English
    Publishing date 2024-03-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.30993
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  2. Article ; Online: Left Internal Mammary Artery as an Endocrine Organ: Insights Into Graft Biology and Long-term Impact Following Coronary Artery Bypass Grafting.

    Shadrin, Ilya Y / Holmes, David R / Behfar, Atta

    Mayo Clinic proceedings

    2023  Volume 98, Issue 1, Page(s) 150–162

    Abstract: The left internal mammary artery (LIMA) is considered the criterion standard vessel for use in coronary artery bypass grafting. In recent decades, countless studies have documented its superiority over other arterial and venous coronary artery bypass ... ...

    Abstract The left internal mammary artery (LIMA) is considered the criterion standard vessel for use in coronary artery bypass grafting. In recent decades, countless studies have documented its superiority over other arterial and venous coronary artery bypass grafting conduits, although the full mechanisms for this superiority remain unknown. A growing body of literature has unveiled the importance of extracellular vesicles known as exosomes in cardiovascular signaling and various pathologic states. In this review, we briefly compare the clinical longevity of the LIMA relative to other conduits, explore the effects of varying grafting techniques on clinical and angiographic outcomes, and provide physiologic insights into graft function on a cellular and molecular level. Finally, we explore exosome signaling as it pertains to atherosclerosis in support of the LIMA as an "endocrine organ."
    MeSH term(s) Humans ; Mammary Arteries/transplantation ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/methods ; Coronary Vessels/surgery ; Angiography ; Biology
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2022.10.003
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  3. Article ; Online: Erasing Paralysis.

    Sabbah, Michael / Behfar, Atta

    Mayo Clinic proceedings

    2020  Volume 95, Issue 2, Page(s) 224–225

    MeSH term(s) Etoposide ; Humans ; Mesenchymal Stem Cells ; Paralysis ; Spinal Cord Injuries
    Chemical Substances Etoposide (6PLQ3CP4P3)
    Language English
    Publishing date 2020-02-07
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2019.12.020
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  4. Article ; Online: A Comparative Study of Two Topical Treatments for Photoaging of the Hands.

    Wyles, Saranya / Eaton Jankov, Laura / Copeland, Karen / Bucky, Louis P / Paradise, Chris / Behfar, Atta

    Plastic and reconstructive surgery

    2023  

    Abstract: Background: Multiple effective treatments exist for correction of skin photoaging. Topical L-ascorbic acid (Vitamin C) is a well-known anti-oxidant and topical human platelet extract (HPE), a novel off-the-shelf cosmetic ingredient has shown positive ... ...

    Abstract Background: Multiple effective treatments exist for correction of skin photoaging. Topical L-ascorbic acid (Vitamin C) is a well-known anti-oxidant and topical human platelet extract (HPE), a novel off-the-shelf cosmetic ingredient has shown positive results in recent clinical studies. HPE is a leukocyte-depleted allogeneic product derived from U.S.-sourced, pooled, apheresed platelets produced with consistent batch quality, purity, and effect.
    Aims: The authors sought to characterize the effect of topical HPE (plated ) Intense Serum (Rion Aesthetics, Rochester, MN) compared to vitamin C (C E Ferulic® with 15% L-Ascorbic Acid, SkinCeuticals, L'Oréal, Paris) in skin rejuvenation of dorsal hands after 12 to 26-weeks twice daily use.
    Methods: This prospective, longitudinal study sought to compare the effectiveness of two known treatments for skin rejuvenation. Evaluations at baseline, 6, 12, and 26 weeks included photo documentation to assess common skin concerns related to aging.
    Results: For age-related skin appearance on the dorsal hands, topical HPE was non-inferior to topical vitamin C for improvement in brown spot fractional area, wrinkle fractional area, and improvement in luminosity at 12 weeks after twice-daily topical use.
    Conclusions: HPE performed as well as vitamin C to rejuvenate the skin on the dorsal hands after 12 to 26 weeks of twice daily topical use. Both topical serums may yield similar or superior results than invasive procedures, such as intense pulsed light (IPL), in reducing brown spots on the dorsal hands. These topical products work equally well in both sexes. Skin improvements lasted through 6 months.
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208012-6
    ISSN 1529-4242 ; 0032-1052 ; 0096-8501
    ISSN (online) 1529-4242
    ISSN 0032-1052 ; 0096-8501
    DOI 10.1097/PRS.0000000000011240
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  5. Article ; Online: Exosomes: the latest in regenerative aesthetics.

    Vyas, Krishna S / Kaufman, Joely / Munavalli, Girish S / Robertson, Kiran / Behfar, Atta / Wyles, Saranya P

    Regenerative medicine

    2023  Volume 18, Issue 2, Page(s) 181–194

    Abstract: Regenerative aesthetics is a burgeoning field for skin rejuvenation and skin health restoration. Exosomes, or extracellular vesicles, represent a new and minimally invasive addition to the regenerative aesthetic toolbox. These nano-sized vesicles contain ...

    Abstract Regenerative aesthetics is a burgeoning field for skin rejuvenation and skin health restoration. Exosomes, or extracellular vesicles, represent a new and minimally invasive addition to the regenerative aesthetic toolbox. These nano-sized vesicles contain bioactive cargo with crucial roles in intercellular communication. Exosome technology, while still in its infancy, is now leveraged in regenerative aesthetic medicine due to its multifaceted role in targeting root causes of skin aging and improving overall tissue homeostasis. The main considerations for practice utilization include variation in exosome purification, isolation, storage, scalability and reproducibility. This review aims at highlighting the current and emerging landscape of exosomes in aesthetic medicine including skin rejuvenation and hair restoration.
    MeSH term(s) Exosomes ; Reproducibility of Results ; Regenerative Medicine ; Skin ; Esthetics
    Language English
    Publishing date 2023-01-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2022-0134
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  6. Article ; Online: Mass Customized Outlook for Regenerative Heart Failure Care.

    Yamada, Satsuki / Bartunek, Jozef / Behfar, Atta / Terzic, Andre

    International journal of molecular sciences

    2021  Volume 22, Issue 21

    Abstract: Heart failure pathobiology is permissive to reparative intent. Regenerative therapies exemplify an emerging disruptive innovation aimed at achieving structural and functional organ restitution. However, mixed outcomes, complexity in use, and ... ...

    Abstract Heart failure pathobiology is permissive to reparative intent. Regenerative therapies exemplify an emerging disruptive innovation aimed at achieving structural and functional organ restitution. However, mixed outcomes, complexity in use, and unsustainable cost have curtailed broader adoption, mandating the development of novel cardio-regenerative approaches. Lineage guidance offers a standardized path to customize stem cell fitness for therapy. A case in point is the molecular induction of the cardiopoiesis program in adult stem cells to yield cardiopoietic cell derivatives designed for heart failure treatment. Tested in early and advanced clinical trials in patients with ischemic heart failure, clinical grade cardiopoietic cells were safe and revealed therapeutic improvement within a window of treatment intensity and pre-treatment disease severity. With the prospect of mass customization, cardiopoietic guidance has been streamlined from the demanding, recombinant protein cocktail-based to a protein-free, messenger RNA-based single gene protocol to engineer affordable cardiac repair competent cells. Clinical trial biobanked stem cells enabled a systems biology deconvolution of the cardiopoietic cell secretome linked to therapeutic benefit, exposing a paracrine mode of action. Collectively, this new knowledge informs next generation regenerative therapeutics manufactured as engineered cellular or secretome mimicking cell-free platforms. Launching biotherapeutics tailored for optimal outcome and offered at mass production cost would contribute to advancing equitable regenerative care that addresses population health needs.
    MeSH term(s) Adult Stem Cells/cytology ; Heart Failure/rehabilitation ; Heart Failure/therapy ; Humans ; Mesenchymal Stem Cell Transplantation/methods ; Myocardial Infarction/therapy ; Regenerative Medicine/methods ; Stem Cells/cytology
    Language English
    Publishing date 2021-10-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222111394
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  7. Article ; Online: Regeneration for All: An Odyssey in Biotherapy.

    Behfar, Atta / Terzic, Andre

    European heart journal

    2019  Volume 40, Issue 13, Page(s) 1033–1035

    Language English
    Publishing date 2019-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehz095
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  8. Article ; Online: Novel Left Ventricular Unloading Strategies in Patients on Peripheral Venoarterial Extracorporeal Membrane Oxygenation Support.

    Inglis, Sara S / Rosenbaum, Andrew N / Rizzo, Skylar A / Anderson, Jason H / Yalamuri, Suraj / Spencer, Philip J / Villavicencio, Mauricio A / Behfar, Atta

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2024  Volume 70, Issue 5, Page(s) 396–403

    Abstract: The purpose of this study was to evaluate left ventricular (LV) unloading strategies in patients supported with peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO). A retrospective review was conducted of all consecutive patients ... ...

    Abstract The purpose of this study was to evaluate left ventricular (LV) unloading strategies in patients supported with peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO). A retrospective review was conducted of all consecutive patients requiring VA-ECMO support for any indication, who underwent novel LV unloading strategies with either direct left atrial venoarterial (LAVA) cannulation or pulmonary artery venoarterial (PAVA) venting, in comparison to Impella and intra-aortic balloon pump (IABP). The primary outcome was successful bridge to transplant, LV assist device, or myocardial recovery. Forty-six patients (63% male, mean age 52.8 ± 17.6 years) were included. Fourteen patients (30%) underwent novel unloading with either LAVA or PAVA, 11 patients (24%) underwent IABP placement, and 21 patients (46%) underwent Impella insertion. In the novel LV unloading cohort, 10 patients (71%) survived to hospital discharge. Four patients (29%) were weaned from ECMO and eight patients (57%) underwent cardiac transplantation. Although a trend favoring cannula-based unloading for the primary outcome was noted, the cohort was too small for statistical significance (79% LAVA/PAVA, 57% Impella, 45% IABP; p = 0.21). However, probability of survival was greater in the LAVA/PAVA cohort compared to Impella and IABP ( p < 0.05). Thus, we demonstrate the efficacy of LA and PA cannulation as an alternative LV unloading strategy for patients supported with peripheral VA-ECMO.
    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation/methods ; Male ; Middle Aged ; Female ; Retrospective Studies ; Heart-Assist Devices ; Adult ; Aged ; Intra-Aortic Balloon Pumping/methods ; Treatment Outcome ; Heart Failure/therapy ; Heart Failure/physiopathology ; Heart Failure/surgery
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000002136
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  9. Article ; Online: Listening for Thrombosis.

    Sabbah, Michael S / Rosenbaum, Andrew N / Behfar, Atta

    Mayo Clinic proceedings

    2021  Volume 96, Issue 4, Page(s) 841–843

    MeSH term(s) Acoustics ; Communication ; Heart-Assist Devices ; Humans ; Thrombosis/etiology
    Language English
    Publishing date 2021-02-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.02.021
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  10. Article ; Online: Regenerative medicine clinical readiness.

    Yamada, Satsuki / Behfar, Atta / Terzic, Andre

    Regenerative medicine

    2021  Volume 16, Issue 3, Page(s) 309–322

    Abstract: Regenerative medicine, poised to transform 21st century healthcare, has aspired to enrich care options by bringing cures to patients in need. Science-driven responsible and regulated translation of innovative technology has enabled the launch of ... ...

    Abstract Regenerative medicine, poised to transform 21st century healthcare, has aspired to enrich care options by bringing cures to patients in need. Science-driven responsible and regulated translation of innovative technology has enabled the launch of previously unimaginable care pathways adopted prudently for select serious diseases and disabilities. The collective resolve to advance the design, manufacture and validity of affordable regenerative solutions aims to democratize such health benefits for all. The objective of this Review is to outline the framework and prerequisites that underpin clinical readiness of regenerative care. Integrated research and development, specialized workforce education and accessible evidence-based practice implementation are at the core of realizing an equitable regenerative medicine vision.
    MeSH term(s) Delivery of Health Care ; Humans ; Regenerative Medicine ; Workforce
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2274500-2
    ISSN 1746-076X ; 1746-0751
    ISSN (online) 1746-076X
    ISSN 1746-0751
    DOI 10.2217/rme-2020-0178
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