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Book ; Online ; E-Book: Targeting Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases

Behl, Tapan / Singh, Sukhbir / Sharma, Neelam

Angiogenesis, Inflammation and Oxidative Stress in Chronic Diseases

(Basic and Clinical Angiogenesis Series)

2024

Author's details	Tapan Behl, Sukhbir Singh, and Neelam Sharma, editors
Series title	Basic and Clinical Angiogenesis Series
Keywords	Chronic diseases/Pathophysiology ; Chronic diseases/Prevention
Subject code	616.044
Language	English
Size	1 online resource (524 pages)
Edition	First edition.
Publisher	Elsevier Inc
Publishing place	Cambridge, MA
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-443-13588-6 ; 9780443135873 ; 978-0-443-13588-0 ; 0443135878
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Natural Products for Chronic Diseases: A Ray of Hope

Hassan, Syed Shams ul / Abdel-Daim, Mohamed M / Behl, Tapan / Bungau, Simona Gabriela

2023

Keywords	Research & information: general ; Chemistry ; guaiane dimer ; melanoma ; molecular docking ; ADMET ; MM-GBSA ; marine drugs ; diabetes mellitus ; cancer ; cardiovascular disorders ; neurodegeneration ; shrimp (Penaeus Chinensis) ; peptides ; immunosuppression gut microbiota ; cyclophosphamide ; gut health ; prostate cancer ; nummularic acid ; docking ; apoptosis ; BAX ; p53 ; echimidine ; echimidine isomers ; hepatotoxicity ; Echium plantagineum L. ; rat hepatocytes primary culture ; Fragaria indica ; α-glucosidase ; α-amylase ; antioxidant ; bioactives ; antidiabetic ; diabetes ; antibacterial activity ; total phenolic contents ; total flavonoid contents ; DPPH ; ABTS ; antidiabetic enzymes ; HPLC-UV ; GC-MS ; endogenous hydrogen sulfide ; breast cancer ; signaling pathway ; tumor growth ; Michael products ; anti-inflammatory ; analgesic ; carrageenan ; COX-2 ; 5-LOX ; Pleurospermum candollei ; natural compounds ; thrombolytic ; antibacterial ; pharmaceuticals ; berbamine ; bergapten ; carveol ; paclitaxel ; ELISA ; Western blot ; n/a
Language	English
Size	1 electronic resource (232 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030376394
ISBN	9783036569543 ; 3036569545
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Types of memory, dementia, Alzheimer's disease, and their various pathological cascades as targets for potential pharmacological drugs.

Akhtar, Ansab / Singh, Siddharth / Kaushik, Ravinder / Awasthi, Rajendra / Behl, Tapan

Ageing research reviews

2024 Volume 96, Page(s) 102289

Abstract: Alzheimer's disease (AD) is the most common type of dementia accounting for 90% of cases; however, frontotemporal dementia, vascular dementia, etc. prevails only in a minority of populations. The term dementia is defined as loss of memory which further ... ...

Abstract	Alzheimer's disease (AD) is the most common type of dementia accounting for 90% of cases; however, frontotemporal dementia, vascular dementia, etc. prevails only in a minority of populations. The term dementia is defined as loss of memory which further takes several other categories of memories like working memory, spatial memory, fear memory, and long-term, and short-term memory into consideration. In this review, these memories have critically been elaborated based on context, duration, events, appearance, intensity, etc. The most important part and purpose of the review is the various pathological cascades as well as molecular levels of targets of AD, which have extracellular amyloid plaques and intracellular hyperphosphorylated tau protein as major disease hallmarks. There is another phenomenon that either leads to or arises from the above-mentioned hallmarks, such as oxidative stress, mitochondrial dysfunction, neuroinflammation, cholinergic dysfunction, and insulin resistance. Several potential drugs like antioxidants, anti-inflammatory drugs, acetylcholinesterase inhibitors, insulin mimetics or sensitizers, etc. studied in various previous preclinical or clinical reports were put as having the capacity to act on these pathological targets. Additionally, agents directly or indirectly targeting amyloid and tau were also discussed. This could be further investigated in future research.
MeSH term(s)	Humans ; Alzheimer Disease/metabolism ; Acetylcholinesterase ; Amyloid beta-Peptides/metabolism
Chemical Substances	Acetylcholinesterase (EC 3.1.1.7) ; Amyloid beta-Peptides
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2075672-0
ISSN	1872-9649 ; 1568-1637
ISSN (online)	1872-9649
ISSN	1568-1637
DOI	10.1016/j.arr.2024.102289
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Article ; Online: The Role of Endostatin in Rheumatoid Arthritis.

Nijhawan, Priya / Behl, Tapan

Current rheumatology reviews

2020 Volume 17, Issue 1, Page(s) 68–75

Abstract: Background: Endostatin by its therapeutic value against rheumatoid arthritis has recently gained significant interest in biomedical science. A recent study revealed that various approaches have been made to prevent rheumatoid arthritis by either ... ...

Abstract	Background: Endostatin by its therapeutic value against rheumatoid arthritis has recently gained significant interest in biomedical science. A recent study revealed that various approaches have been made to prevent rheumatoid arthritis by either controlling or inhibiting the progression of angiogenesis. Objective: The main objective of the current manuscript is to enumerate the intrinsic role of endostatin in rheumatoid arthritis. Methods: A thorough and detailed review of literature from the papers published from the year 1997-2019 was studied for the preparation of the current article. Results: Endostatin is one such agent of the subfamily of ECM called as multiplexins obtained from proteolytic cleavage of XVIII and its carboxylic terminal fragments and is known for its antiangiogenic and antiproliferative property. The exact mechanism of endostatin is still unclear, but it acts by downregulating or inhibiting the responses of various factors, including Id1, Id3, matrix metalloproteinase, and Nuclear factor Kappa B that are liable for angiogenesis. The mutual effects on adipogenesis and angiogenesis, endostatin inhibits dietary-induced obesity and its related metabolic disorders, such as insulin resistance, glucose intolerance, and hepatic steatosis. Conclusion: The present review demonstrates the intrinsic usage of endostatin as a novel molecule in rheumatoid arthritis. It focuses on the status of the therapeutic potential of endostatin in inhibiting the activity of angiogenesis is also very well explored.
MeSH term(s)	Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/etiology ; Endostatins/therapeutic use ; Humans ; Neovascularization, Pathologic/complications
Chemical Substances	Endostatins
Language	English
Publishing date	2020-04-28
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	1875-6360
ISSN (online)	1875-6360
DOI	10.2174/1573397115666191127141801
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Article ; Online: Caralluma edulis

Ansari, Bushra / Behl, Tapan / Pirzada, Abdul Saboor / Khan, Haroon

Current topics in medicinal chemistry

2022 Volume 22, Issue 18, Page(s) 1501–1514

Abstract: Caralluma edulis is a well-known species of the genus Caralluma from Apocynaceae, commonly known as chunga. Caralluma species are mostly succulent perennial herbs, several of which are edible species. The plant has an outstanding therapeutic background ... ...

Abstract	Caralluma edulis is a well-known species of the genus Caralluma from Apocynaceae, commonly known as chunga. Caralluma species are mostly succulent perennial herbs, several of which are edible species. The plant has an outstanding therapeutic background in the traditional system of treatment. It has been recommended for the treatment of a number medical disorders such as hypertension, Alzheimer's disease, rheumatism, gastric problems and leprosy. Traditionally the stem was boiled in water and this extract was then used to cure diabetes. The pharmacological effects of C. edulis have also been explored in various in vitro and in vivo experiments. In this regard, the extract of the plant exhibited strong antioxidant, and analgesic activity against inflammation as well as xylene-mediated ear edema as topical effects. The significant anti-hyperlipidemic effect of the plant extract is also reported. However, the extract was found insignificant in the reversal of alloxan-induced diabetes in the rabbit model at test doses. These pharmacological effects are strongly supported by the presence of different bioactive phytochemicals in the plant. These groups of compounds include sterols, terpenoids, flavonoids, and pregnane glycosides. C. edulis is a very potential member of the genus Caralluma with strong traditional history, phytochemistry and phytopharmacology, and needs further exploration for clinically used lead compounds. In this review, we have focused on combining different reported data on the traditional uses of the plant, its phytochemical profile and pharmacological effects in different experimental assay along with subsequent future prospects.
MeSH term(s)	Animals ; Antioxidants ; Apocynaceae ; Ethnopharmacology ; Flavonoids ; Phytochemicals ; Plant Extracts ; Rabbits
Chemical Substances	Antioxidants ; Flavonoids ; Phytochemicals ; Plant Extracts
Language	English
Publishing date	2022-05-30
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2064823-6
ISSN	1873-4294 ; 1568-0266
ISSN (online)	1873-4294
ISSN	1568-0266
DOI	10.2174/1568026622666220527092825
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Article ; Online: Uncurtaining the effect of COVID-19 in diabetes mellitus: a complex clinical management approach.

Kashyap, Shilpi / Bala, Rajni / Madaan, Reecha / Behl, Tapan

Environmental science and pollution research international

2021 Volume 28, Issue 27, Page(s) 35429–35436

Abstract: The aim of the present review is to overview the common properties of corona virus and hence proofs well beginning of corona virus in persons with diabetes, and its treatment. Globally, it has been observed that according to the statistics, India has the ...

Abstract	The aim of the present review is to overview the common properties of corona virus and hence proofs well beginning of corona virus in persons with diabetes, and its treatment. Globally, it has been observed that according to the statistics, India has the second largest number of people with diabetes. Literature review has been implemented within the databases using suitable keywords. For persons suffering from diabetic disorder, the COVID-19 infection becomes a dual challenge. Diabetes is a severe metabolic situation which causes the sugar levels in the blood to increase than the normal level. Normally, communicable disease like COVID-19 is more prevailing in patients with diabetes. Diabetic patient has poor immune response to infections. The different bacterial, viral, parasitic, and mycotic infections showed increased probability in diabetic patients as compared to non-diabetic patient. All these conclusions clear out the intention that the diabetic patients are more susceptible to enhanced inflammatory response that may lead to rapid spreading of COVID-19 infection with high rate of mortality. In the present situation of pandemic, managing diabetes seems to be quite challenging and diabetic patient having COVID-19 infection should follow normal course of antihypertensive and antidiabetic drugs prescribed with the exception of sodium glucose co-transpoters-2 inhibitors which would increase the risk of dehydration and ketoacidosis. In view of above discussion, this article highlights the proposed mechanism of COVID-19 infection linking it with diabetes, antidiabetic drugs to be used in COVID-19 infection along with their advantages, and disadvantages and management of COVID-19 infection diabetic patient.
MeSH term(s)	COVID-19 ; Diabetes Mellitus/epidemiology ; Humans ; India ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-05-21
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-14480-7
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Article ; Online: Gut Microbiota Composition and Epigenetic Molecular Changes Connected to the Pathogenesis of Alzheimer's Disease.

Nagu, Priyanka / Parashar, Arun / Behl, Tapan / Mehta, Vineet

Journal of molecular neuroscience : MN

2021 Volume 71, Issue 7, Page(s) 1436–1455

Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder, and its pathogenesis is not fully known. Although there are several hypotheses, such as neuroinflammation, tau hyperphosphorylation, amyloid-β plaques, neurofibrillary tangles, and oxidative ... ...

Abstract	Alzheimer's disease (AD) is a neurodegenerative disorder, and its pathogenesis is not fully known. Although there are several hypotheses, such as neuroinflammation, tau hyperphosphorylation, amyloid-β plaques, neurofibrillary tangles, and oxidative stress, none of them completely explain the origin and progression of AD. Emerging evidence suggests that gut microbiota and epigenetics can directly influence the pathogenesis of AD via their effects on multiple pathways, including neuroinflammation, oxidative stress, and amyloid protein. Various gut microbes such as Actinobacteria, Bacteroidetes, E. coli, Firmicutes, Proteobacteria, Tenericutes, and Verrucomicrobia are known to play a crucial role in the pathogenesis of AD. These microbes and their metabolites modulate various physiological processes that contribute to AD pathogenesis, such as neuroinflammation and other inflammatory processes, amyloid deposition, cytokine storm syndrome, altered BDNF and NMDA signaling, impairing neurodevelopmental processes. Likewise, epigenetic markers associated with AD mainly include histone modifications and DNA methylation, which are under the direct control of a variety of enzymes, such as acetylases and methylases. The activity of these enzymes is dependent upon the metabolites generated by the host's gut microbiome, suggesting the significance of epigenetics in AD pathogenesis. It is interesting to know that both gut microbiota and epigenetics are dynamic processes and show a high degree of variation according to diet, stressors, and environmental factors. The bidirectional relation between the gut microbiota and epigenetics suggests that they might work in synchrony to modulate AD representation, its pathogenesis, and progression. They both also provide numerous targets for early diagnostic biomarkers and for the development of AD therapeutics. This review discusses the gut microbiota and epigenetics connection in the pathogenesis of AD and aims to highlight vast opportunities for diagnosis and therapeutics of AD.
MeSH term(s)	Alzheimer Disease/etiology ; Alzheimer Disease/genetics ; Alzheimer Disease/microbiology ; Amyloid beta-Peptides/metabolism ; Bacteria/metabolism ; Brain-Gut Axis ; Chromatin Assembly and Disassembly ; DNA Methylation ; Dysbiosis/complications ; Epigenesis, Genetic ; Gastrointestinal Microbiome ; Germ-Free Life ; Histone Code ; Humans ; Neuroinflammatory Diseases ; Neurosecretory Systems/physiology ; Oxidative Stress ; Phosphorylation ; Protein Processing, Post-Translational ; Vagus Nerve/physiology ; tau Proteins/metabolism
Chemical Substances	Amyloid beta-Peptides ; MAPT protein, human ; tau Proteins
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-021-01829-3
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Article: Exploring the Intersection of Geophysics and Diagnostic Imaging in the Health Sciences.

Singh, Rahul Kumar / Nayak, Nirlipta Priyadarshini / Behl, Tapan / Arora, Rashmi / Anwer, Md Khalid / Gulati, Monica / Bungau, Simona Gabriela / Brisc, Mihaela Cristina

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 2

Abstract: To develop diagnostic imaging approaches, this paper emphasizes the transformational potential of merging geophysics with health sciences. Diagnostic imaging technology improvements have transformed the health sciences by enabling earlier and more ... ...

Abstract	To develop diagnostic imaging approaches, this paper emphasizes the transformational potential of merging geophysics with health sciences. Diagnostic imaging technology improvements have transformed the health sciences by enabling earlier and more precise disease identification, individualized therapy, and improved patient care. This review article examines the connection between geophysics and diagnostic imaging in the field of health sciences. Geophysics, which is typically used to explore Earth's subsurface, has provided new uses of its methodology in the medical field, providing innovative solutions to pressing medical problems. The article examines the different geophysical techniques like electrical imaging, seismic imaging, and geophysics and their corresponding imaging techniques used in health sciences like tomography, magnetic resonance imaging, ultrasound imaging, etc. The examination includes the description, similarities, differences, and challenges associated with these techniques and how modified geophysical techniques can be used in imaging methods in health sciences. Examining the progression of each method from geophysics to medical imaging and its contributions to illness diagnosis, treatment planning, and monitoring are highlighted. Also, the utilization of geophysical data analysis techniques like signal processing and inversion techniques in image processing in health sciences has been briefly explained, along with different mathematical and computational tools in geophysics and how they can be implemented for image processing in health sciences. The key findings include the development of machine learning and artificial intelligence in geophysics-driven medical imaging, demonstrating the revolutionary effects of data-driven methods on precision, speed, and predictive modeling.
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14020139
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Article ; Online: Potential therapeutic effect of Chrysopogon zizanioides (Vetiver) as an anti-inflammatory agent.

Grover, Madhuri / Behl, Tapan / Bungau, Simona / Aleya, Lotfi

Environmental science and pollution research international

2021 Volume 28, Issue 13, Page(s) 15597–15606

Abstract: Vetiver has a broad history of traditional medicinal uses, but only a handful of research article has reported its utility in treating diseases. But unfortunately, no work has been reported on the anti-inflammatory activity of its plant extract and ... ...

Abstract	Vetiver has a broad history of traditional medicinal uses, but only a handful of research article has reported its utility in treating diseases. But unfortunately, no work has been reported on the anti-inflammatory activity of its plant extract and inflammatory-linked diseases. Hence, the present review focuses on investigating the several presumptions which can be put forward to explain its anti-inflammatory property. Thus, for ensuring the same, all the databases like science direct, PubMed, book chapters, and other authenticated papers were thoroughly studied to present a connection between inflammation and the plant potential. After gaining enough knowledge on pathogenesis of inflammation, it has been observed that the release of mediators from the arachidonic acid metabolism pathway and generation of oxidative and nitrogen species are presented as the main reason for the occurrence of inflammation condition. The stimulation of antioxidant enzyme system network by the plant extract reduces the level of oxidative stress, creating a balance between oxidant and antioxidant system. Moreover, its antimicrobial activity will prevent the biological source of stimulation towards injury and the CNS depressant effect will subside the pain of inflammation. Amalgamating all the factors together, the plant can be utilized as anti-inflammatory can be and also can be proved as a beneficial perspective in the treatment of inflammation-linked disorders.
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Biodegradation, Environmental ; Chrysopogon ; Oxidative Stress ; Plant Extracts/pharmacology
Chemical Substances	Anti-Inflammatory Agents ; Antioxidants ; Plant Extracts
Language	English
Publishing date	2021-02-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-12652-z
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Article ; Online: Phytochemical Screening, Antioxidant Assay and Cytotoxic Profile for Different Extracts of Chrysopogon zizanioides Roots.

Grover, Madhuri / Behl, Tapan / Virmani, Tarun

Chemistry & biodiversity

2021 Volume 18, Issue 8, Page(s) e2100012

Abstract: The Chrysopogon zizanioides plant possesses multiple traditional uses, especially in therapeutics, but only a few articles have reported its biological activity. Hence, the present study was planned to explore the phytochemical constituents, cytotoxic ... ...

Abstract	The Chrysopogon zizanioides plant possesses multiple traditional uses, especially in therapeutics, but only a few articles have reported its biological activity. Hence, the present study was planned to explore the phytochemical constituents, cytotoxic potential, radical scavenging activity, and GC/MS (Gas chromatography & Mass spectrometry) analysis of the vetiver root extracts. The roots extracted with different solvents exhibited more significant phytochemical constituents in polar solvents in comparison to non-polar ones, favoring the extraction of a greater number of components in highly polar solvents. All the extracts were tested for their cytotoxicity using SRB (Sulforhodamine B) assay. They confirmed ethanolic extract as a potent extract with GI
MeSH term(s)	Animals ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Cell Line, Tumor ; Cell Survival/drug effects ; Chlorocebus aethiops ; Chrysopogon/chemistry ; Chrysopogon/metabolism ; Gas Chromatography-Mass Spectrometry ; Humans ; Phytochemicals/chemistry ; Phytochemicals/isolation & purification ; Phytochemicals/pharmacology ; Plant Extracts/chemistry ; Plant Roots/chemistry ; Plant Roots/metabolism ; Solid Phase Extraction/methods ; Vero Cells
Chemical Substances	Antioxidants ; Phytochemicals ; Plant Extracts
Language	English
Publishing date	2021-06-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202100012
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