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  1. Book: From megakaryocytes to platelets

    Behnke, Olav / Forer, Arthur

    platelet morphogenesis takes place in the bloodstream

    (European journal of haematology : Supplement ; 61)

    1998  

    Author's details by Olav Behnke and Arthur Forer
    Series title European journal of haematology : Supplement ; 61
    European journal of haematology
    European journal of haematology ; Supplement
    Collection European journal of haematology
    European journal of haematology ; Supplement
    Keywords Thrombozyt ; Morphogenese
    Subject Morphogenie ; Formbildung ; Blutplättchen ; Platelet ; Thrombozyten
    Language English
    Size 23 S. : Ill., graph. Darst.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT008742144
    ISBN 87-16-15639-0 ; 978-87-16-15639-6
    Database Catalogue ZB MED Medicine, Health

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    Zs A 323 -Suppl.61- not available for loan Zeitschriften-Lesesaal

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  2. Article: A PRELIMINARY REPORT ON "MICROTUBULES" IN UNDIFFERENTIATED AND DIFFERENTIATED VERTEBRATE CELLS.

    BEHNKE, O

    Journal of ultrastructure research

    2003  Volume 11, Page(s) 139–146

    MeSH term(s) Blood Vessels ; Cytoplasm ; Electrons ; Eosinophils ; Fetus ; Ganglia ; Intestine, Small ; Intestines ; Lymphatic System ; Lymphocytes ; Macrophages ; Mast Cells ; Microscopy ; Microscopy, Electron ; Microtubules ; Muscle, Smooth ; Muscles ; Nerve Tissue ; Pancreas ; Rats ; Research ; Trachea ; Vertebrates
    Language English
    Publishing date 2003-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219306-1
    ISSN 1878-2345 ; 0022-5320
    ISSN (online) 1878-2345
    ISSN 0022-5320
    DOI 10.1016/s0022-5320(64)80098-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: DEMONSTRATION OF ACID PHOSPHATASE-CONTAINING GRANULES AND CYTOPLASMIC BODIES IN THE EPITHELIUM OF FOETAL RAT DUODENUM DURING CERTAIN STAGES OF DIFFERENTIATION.

    BEHNKE, O

    The Journal of cell biology

    2000  Volume 18, Page(s) 251–265

    Abstract: Dense cytoplasmic bodies surrounded by one or two unit membranes and containing mitochondria, vesicles, ribosomes, rough and smooth surfaced endoplasmic reticulum, and lamellated membranes (myelin figures) have been observed in the differentiating mucosa ...

    Abstract Dense cytoplasmic bodies surrounded by one or two unit membranes and containing mitochondria, vesicles, ribosomes, rough and smooth surfaced endoplasmic reticulum, and lamellated membranes (myelin figures) have been observed in the differentiating mucosa of the duodenum of rat foetuses by electron microscopy. Generally, the cytoplasmic components in the bodies seem to be in varying stages of disintegration. The bodies are found in greatest number on the 17th and 18th day of gestation, i.e. at the onset of differentiation. At this period of development the epithelium is stratified, and the villus formation is initiated by invagination of the epithelium by buds of mesenchyme followed by a splitting of the epithelium along the sides of the invaginations. When the villi have formed, the stratified epithelium has changed to the simple columnar type and the dense bodies have largely disappeared. Simultaneously, the lumen has widened considerably. In a parallel study with the light microscope, frozen sections incubated for the demonstration of acid phosphatase activity revealed the reaction product to be localized in bodies of the same size and distribution as the dense bodies found by electron microscopy. Hence, it seems that the bodies are altered and enlarged lysosomes (cytolysomes) active during the intensive differentiative events in the small intestine during the last part of intra-uterine life.
    MeSH term(s) Acid Phosphatase ; Animals ; Cell Biology ; Cell Differentiation ; Cell Division ; Cytoplasm ; Cytoplasmic Granules ; Duodenum ; Electrons ; Embryology ; Epithelium ; Fetus ; Lysosomes ; Microscopy ; Microscopy, Electron ; Mitochondria ; Rats ; Research ; Ribosomes
    Chemical Substances Acid Phosphatase (EC 3.1.3.2)
    Language English
    Publishing date 2000-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.18.2.251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Blood platelet heterogeneity: a functional hierarchy in the platelet population.

    Behnke, O

    British journal of haematology

    1995  Volume 91, Issue 4, Page(s) 991–999

    Abstract: The platelet population in man and rat can be divided into two classes of about equal size based on the presence/absence of a p-nitrophenylphosphatase, which probably is a phosphotyrosine phosphatase (PTPase). Phosphorylation of tyrosines on several ... ...

    Abstract The platelet population in man and rat can be divided into two classes of about equal size based on the presence/absence of a p-nitrophenylphosphatase, which probably is a phosphotyrosine phosphatase (PTPase). Phosphorylation of tyrosines on several platelet proteins is implicated in platelet activation, and I carried out in vitro and in vivo experiments on rats to determine whether PTPase positive and negative platelets differed in their reaction time. I used adhesion to collagen in vitro and in vivo (longitudinal slits in aorta and vena portae) and platelet aggregates in clots formed in vivo. I present evidence that PTPase negative platelets react the fastest, most conspicuously seen in the arterial bleeding under high flow conditions, where the first platelets to respond and adhere are predominantly PTPase negative.
    MeSH term(s) 4-Nitrophenylphosphatase/physiology ; Animals ; Blood Platelets/classification ; Blood Platelets/enzymology ; Blood Platelets/physiology ; Collagen/metabolism ; Hemostasis/physiology ; In Vitro Techniques ; Platelet Activation/physiology ; Platelet Adhesiveness ; Rats ; Rats, Wistar
    Chemical Substances Collagen (9007-34-5) ; 4-Nitrophenylphosphatase (EC 3.1.3.41)
    Language English
    Publishing date 1995-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/j.1365-2141.1995.tb05424.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Formation of Fusiform Proplatelets and their Transformation to Discoid Platelets.

    Behnke, O

    Platelets

    1993  Volume 4, Issue 5, Page(s) 262–267

    Abstract: Blood platelets are produced in the circulation by fragmentation of long, slender processes of cytoplasm formed from the megakaryocyte, the parent cell of platelets. Fragmentation occurs at local constrictions, forming 6 to 15 µm long, fusiform fragments ...

    Abstract Blood platelets are produced in the circulation by fragmentation of long, slender processes of cytoplasm formed from the megakaryocyte, the parent cell of platelets. Fragmentation occurs at local constrictions, forming 6 to 15 µm long, fusiform fragments (elongated proplatelets). The fusiforms transform into the circular, disc-shaped mature platelet by curving into a ring, which closes by fusion at the tips. The hole in the ring is finally filled in by a centripetal flow of membrane from the periphery. It is presumed that the curving of the fusiform is mediated by curving of its contained bundle of microtubules, which becomes the marginal bundle of the disc-shaped platelet. When curving begins in the fusiform, microtubules are closely associated with a membraneous tubule that becomes the submarginal tubule of the dense tubular system.
    Language English
    Publishing date 1993
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.3109/09537109309013226
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  6. Article: Degrading and non-degrading pathways in fluid-phase (non-adsorptive) endocytosis in human blood platelets.

    Behnke, O

    Journal of submicroscopic cytology and pathology

    1992  Volume 24, Issue 2, Page(s) 169–178

    Abstract: A morphological study of the endocytic pathways in non-activated human blood platelets has been made using fibrinogen-stabilized colloidal gold as a fluid-phase marker, and acid phosphatase as a marker for lysosomes. Two pathways of constitutive ... ...

    Abstract A morphological study of the endocytic pathways in non-activated human blood platelets has been made using fibrinogen-stabilized colloidal gold as a fluid-phase marker, and acid phosphatase as a marker for lysosomes. Two pathways of constitutive endocytosis were demonstrated: one pathway was mediated by clathrin coated vesicles which formed at the platelet surface and the surface-connected, canalicular membrane system and which fuse with and deliver their contents to the platelets' secretory alpha-granules. The other pathway follows a degrading, endosomal-lysosomal route and appears to be clathrin independent. Endosomes containing marker particles originate from the surface-connected canalicular system, through which ambient fluid percolates. An account is given of the pleomorphism of platelet lysosomes, and evidence is presented for a lysosomal, focal autophagia in platelets which may be linked to platelet senescence. Lysosomes in non-activated platelets are thus involved in the same processes as lysosomes in other cells.
    MeSH term(s) Alkaline Phosphatase/isolation & purification ; Blood Platelets/physiology ; Blood Platelets/ultrastructure ; Coated Pits, Cell-Membrane/physiology ; Coated Pits, Cell-Membrane/ultrastructure ; Cytoplasmic Granules/physiology ; Cytoplasmic Granules/ultrastructure ; Endocytosis/physiology ; Fibrinogen/metabolism ; Golgi Apparatus/physiology ; Golgi Apparatus/ultrastructure ; Histocytochemistry ; Humans ; Lysosomes/physiology ; Lysosomes/ultrastructure ; Membrane Fusion ; Microspheres
    Chemical Substances Fibrinogen (9001-32-5) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 1992-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 392518-3
    ISSN 1122-9497 ; 0022-4782
    ISSN 1122-9497 ; 0022-4782
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  7. Article: Coated pits and vesicles transfer plasma components to platelet granules.

    Behnke, O

    Thrombosis and haemostasis

    1989  Volume 62, Issue 2, Page(s) 718–722

    Abstract: Electron microscopy of mammalian blood platelets after contrast enhancement with tannic acid after an initial fixation in glutaraldehyde and osmium reveals numerous coated pits (c.p.) and vesicles (c.v.), indicating a process of receptor-mediated ... ...

    Abstract Electron microscopy of mammalian blood platelets after contrast enhancement with tannic acid after an initial fixation in glutaraldehyde and osmium reveals numerous coated pits (c.p.) and vesicles (c.v.), indicating a process of receptor-mediated endocytosis. The c.p. may be located at any site of the plasma membrane or the canalicular, surface connected membrane system. C.v. fuse with platelet granules without losing their coat. Evidence for a continuous transfer of ambient fluid to granules via c.p. and c.v. was obtained by the use of fluid-phase markers. It is proposed that the endocytic process may play a role in blood platelet activation.
    MeSH term(s) Animals ; Blood Platelets/physiology ; Blood Platelets/ultrastructure ; Coated Pits, Cell-Membrane/physiology ; Coated Pits, Cell-Membrane/ultrastructure ; Cytoplasmic Granules ; Endocytosis/physiology ; Endosomes/physiology ; Humans ; Mice ; Microscopy, Electron ; Rats ; Swine
    Language English
    Publishing date 1989-09-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Charm, beauty and top at HERA

    Behnke, Olaf / Geiser, Achim / Lisovyi, Mykhailo

    (DESY ; 15,085)

    2015  

    Author's details O. Behnke, A. Greiser, M. Lisovyi
    Series title DESY ; 15,085
    Language English
    Size 103 S, graph. Darst
    Publisher DESY
    Publishing place Hamburg
    Document type Book
    Note 2. Verf. in der Vorlage auch: A. Greiser
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article: YOUR "THIRD HAND" IN MOUNTING SERIAL SECTIONS ON GRIDS FOR ELECTRON MICROSCOPY.

    BEHNKE, O / ROSTGAARD, J

    Stain technology

    2003  Volume 39, Page(s) 205–208

    MeSH term(s) Computer Systems ; Electrodes ; Electrons ; Equipment and Supplies ; Histological Techniques ; Microscopy ; Microscopy, Electron
    Language English
    Publishing date 2003-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204773-1
    ISSN 0038-9153
    ISSN 0038-9153
    DOI 10.3109/10520296409061230
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  10. Article: Platelet adhesion to native collagens involves proteoglycans and may be a two-step process.

    Behnke, O

    Thrombosis and haemostasis

    1987  Volume 58, Issue 2, Page(s) 786–789

    Abstract: Adhesion of rat blood platelets to native rat tail collagen fibrils was studied in the electron microscope under conditions that preserved collagen-associated proteoglycans (CAPG). The CAPG molecules were aligned in chain-like configurations that ... ...

    Abstract Adhesion of rat blood platelets to native rat tail collagen fibrils was studied in the electron microscope under conditions that preserved collagen-associated proteoglycans (CAPG). The CAPG molecules were aligned in chain-like configurations that encircled the fibrils with a 65 nm period; they appeared to coat the fibrils completely and extended 60-100 nm away from the fibril. The initial platelet-fibril contact occurred between the platelet glycocalyx and the CAPG of the fibrils i.e. between two surfaces with net-negative charges. When close contact was established between the fibril surface proper and the platelet membrane, CAPG were not identified in the area of contact, and the collagen-platelet distance was reduced to a approximately 10-12 nm wide gap traversed by delicate links in register with fibril periodicities.
    MeSH term(s) Animals ; Binding Sites ; Blood Platelets/metabolism ; Blood Platelets/ultrastructure ; Collagen/metabolism ; In Vitro Techniques ; Microscopy, Electron ; Platelet Adhesiveness ; Proteoglycans/metabolism ; Rats
    Chemical Substances Proteoglycans ; Collagen (9007-34-5)
    Language English
    Publishing date 1987-08-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
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