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Book ; Online: A new transformation for embedded convolutional neural network approach toward real-time servo motor overload fault-detection

Nejad, Seyed Mohammad Hossein Abedy / Behzadi, Mohammad Amin / Taheri, Abdolrahim

2023

Abstract: Overloading in DC servo motors is a major concern in industries, as many companies face the problem of finding expert operators, and also human monitoring may not be an effective solution. Therefore, this paper proposed an embedded Artificial ... ...

Abstract	Overloading in DC servo motors is a major concern in industries, as many companies face the problem of finding expert operators, and also human monitoring may not be an effective solution. Therefore, this paper proposed an embedded Artificial intelligence (AI) approach using a Convolutional Neural Network (CNN) using a new transformation to extract faults from real-time input signals without human interference. Our main purpose is to extract as many as possible features from the input signal to achieve a relaxed dataset that results in an effective but compact network to provide real-time fault detection even in a low-memory microcontroller. Besides, fault detection method a synchronous dual-motor system is also proposed to take action in faulty events. To fulfill this intention, a one-dimensional input signal from the output current of each DC servo motor is monitored and transformed into a 3d stack of data and then the CNN is implemented into the processor to detect any fault corresponding to overloading, finally experimental setup results in 99.9997% accuracy during testing for a model with nearly 8000 parameters. In addition, the proposed dual-motor system could achieve overload reduction and provide a fault-tolerant system and it is shown that this system also takes advantage of less energy consumption.
Keywords	Computer Science - Machine Learning
Subject code	006
Publishing date	2023-04-08
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Overview of Current Therapeutics and Novel Candidates Against Influenza, Respiratory Syncytial Virus, and Middle East Respiratory Syndrome Coronavirus Infections.

Behzadi, Mohammad Amin / Leyva-Grado, Victor H

Frontiers in microbiology

2019 Volume 10, Page(s) 1327

Abstract: Emergence and re-emergence of respiratory virus infections represent a significant threat to global public health, as they occur seasonally and less frequently (such as in the case of influenza virus) as pandemic infections. Some of these viruses have ... ...

Abstract	Emergence and re-emergence of respiratory virus infections represent a significant threat to global public health, as they occur seasonally and less frequently (such as in the case of influenza virus) as pandemic infections. Some of these viruses have been in the human population for centuries and others had recently emerged as a public health problem. Influenza viruses have been affecting the human population for a long time now; however, their ability to rapidly evolve through antigenic drift and antigenic shift causes the emergence of new strains. A recent example of these events is the avian-origin H7N9 influenza virus outbreak currently undergoing in China. Human H7N9 influenza viruses are resistant to amantadines and some strains are also resistant to neuraminidase inhibitors greatly limiting the options for treatment. Respiratory syncytial virus (RSV) may cause a lower respiratory tract infection characterized by bronchiolitis and pneumonia mainly in children and the elderly. Infection with RSV can cause severe disease and even death, imposing a severe burden for pediatric and geriatric health systems worldwide. Treatment for RSV is mainly supportive since the only approved therapy, a monoclonal antibody, is recommended for prophylactic use in high-risk patients. The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging respiratory virus. The virus was first recognized in 2012 and it is associated with a lower respiratory tract disease that is more severe in patients with comorbidities. No licensed vaccines or antivirals have been yet approved for the treatment of MERS-CoV in humans. It is clear that the discovery and development of novel antivirals that can be used alone or in combination with existing therapies to treat these important respiratory viral infections are critical. In this review, we will describe some of the novel therapeutics currently under development for the treatment of these infections.
Keywords	covid19
Language	English
Publishing date	2019-06-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2019.01327
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Article: A diagnostic one-step real-time reverse transcription polymerase chain reaction method for accurate detection of influenza virus type A.

Behzadi, Mohammad Amin / Ziyaeyan, Mazyar / Alborzi, Abdolvahab

Archives of medical science : AMS

2016 Volume 12, Issue 6, Page(s) 1286–1292

Abstract: Introduction: Influenza A is known as a public health concern worldwide. In this study, a novel one-step real-time reverse transcription polymerase chain reaction (rtRT-PCR) assay was designed and optimized for the detection of influenza A viruses.: ... ...

Abstract	Introduction: Influenza A is known as a public health concern worldwide. In this study, a novel one-step real-time reverse transcription polymerase chain reaction (rtRT-PCR) assay was designed and optimized for the detection of influenza A viruses. Material and methods: The primers and probe were designed based on the analysis of 90 matrix nucleotide sequence data of influenza type A subtypes from the GenBank database of the National Center for Biotechnology Information (NCBI). The influenza virus A/Tehran/5652/2010 (H1N1 pdm09) was used as a reference. The rtRT-PCR assay was optimized, compared with that of the World Health Organization (WHO), and its analytical sensitivity, specificity and reproducibility were evaluated. In total, 64 nasopharyngeal swabs from patients with influenza-like illness (ILI) and 41 samples without ILI symptoms were tested for the virus, using conventional cell culture, direct immunofluorescence antibody (DFA) methods, and one-step rtRT-PCR with the designed primer set and probe and the WHO's. Results: The optimized assay results were similar to the WHO's. The optimized assay results were similar to WHO's, with non-significant differences for 10-10 Conclusions: Given the high specificity, sensitivity and reproducibility of this novel assay, it can serve as a reliable diagnostic tool for the detection of influenza A viruses in clinical specimens and lab experiments.
Language	English
Publishing date	2016-10-24
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2203781-0
ISSN	1734-1922
ISSN	1734-1922
DOI	10.5114/aoms.2016.62914
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Article ; Online: A cross-reactive mouse monoclonal antibody against rhinovirus mediates phagocytosis in vitro.

Behzadi, Mohammad Amin / Choi, Angela / Duehr, James / Feyznezhad, Roya / Upadhyay, Chitra / Schotsaert, Michael / Palese, Peter / Nachbagauer, Raffael

Scientific reports

2020 Volume 10, Issue 1, Page(s) 9750

Abstract: Rhinoviruses (RVs) are the main cause of the common cold worldwide. To date, more than 160 types of the virus have been recognized, categorized into three major species - A, B, and C. There are currently no approved vaccines available to prevent ... ...

Abstract	Rhinoviruses (RVs) are the main cause of the common cold worldwide. To date, more than 160 types of the virus have been recognized, categorized into three major species - A, B, and C. There are currently no approved vaccines available to prevent infection with RVs. To elicit antibodies against conserved regions located on capsid proteins of RV A viruses, mice were sequentially vaccinated with DNA plasmids encoding capsid proteins of different RV A types. After a final boost with whole virus, antibody-expressing hybridomas were generated. After isotyping, 11 monoclonal antibodies (mAbs) expressing an IgG subtype Fc-domain were selected for further expansion and purification. Three mAbs showed cross-reactivity against multiple strains of RV A viruses by ELISA, including strains A1A, A1B, A15, A16 and A49. Other mAbs had strain-specific binding patterns, with the majority of mAbs showing reactivity to RV-A15, the strain used for the final vaccination. We found that the RV-A15-specific mAbs, but not the cross-reactive mAbs, had neutralizing activity against RV-A15. An antibody dependent cellular phagocytosis (ADCP) assay revealed substantial ADCP activity for one of the cross-reactive mAbs. Epitope mapping of the neutralizing mAbs via escape mutant virus generation revealed a shared binding epitope on VP1 of RV-A15 for several neutralizing mAbs. The epitope of the ADCP-active, non-neutralizing mAb was determined by microarray analysis of peptides generated from the VP1 capsid protein. VP1-specific, cross-reactive antibodies, especially those with ADCP activity, could contribute to protection against RV infections.
MeSH term(s)	Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacology ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Capsid Proteins/immunology ; Common Cold/immunology ; Cross Reactions/immunology ; Enzyme-Linked Immunosorbent Assay ; Epitope Mapping ; Humans ; Hybridomas/immunology ; Mice ; Phagocytosis/immunology ; Phagocytosis/physiology ; Rhinovirus/genetics ; Rhinovirus/immunology ; Viral Proteins/immunology
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Capsid Proteins ; Viral Proteins
Language	English
Publishing date	2020-06-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-66600-x
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Article: Molecular diagnosis of genital tract infections among HIV-positive women in Iran.

Behzadi, Mohammad Amin / Davarpanah, Mohammad Ali / Namayandeh, Mandana / Pourabbas, Bahman / Allahyari, Soheyla / Ziyaeyan, Mazyar

Iranian journal of microbiology

2018 Volume 10, Issue 4, Page(s) 233–241

Abstract: Background and objectives: Human immunodeficiency virus (HIV)-infected women are usually at a higher risk of sexually transmitted infections (STIs) than others. The objective of this study was to characterize the prevalence of human papilloma virus (HPV) ...

Abstract	Background and objectives: Human immunodeficiency virus (HIV)-infected women are usually at a higher risk of sexually transmitted infections (STIs) than others. The objective of this study was to characterize the prevalence of human papilloma virus (HPV), herpes simplex virus (HSV), Materials and methods: In this cross-sectional study, cervical swab samples were collected from 71 HIV-infected women, aged 17-45 years (mean ± standard deviation: 31.11 ± 6.58 years), and tested for HPV, HSV, CT, and NG using PCR assays. Results: Overall, 77.5% of patients were positive for the tested STIs with the following distribution: 36 (50.7%) HPV, 7 (9.9%) HSV, 4 (5.6%) NG, and 27 (38%) CT. From those, 39 (55%) were positive for only one infection, while 16 (22.5%) were positive for multiple infections. We observed that the prevalence of all tested STIs increased by age, except for HSV which showed a slight decrease, although not statistically significant. Socio-economic factors such as low educational level, multiple sex partners, and being a sex worker significantly correlated with higher positive prevalence of STIs in the studied population. Conclusion: A high prevalence of STIs was observed among HIV-infected women in this region. These data might prompt policy makers and STI experts to focus on providing a comprehensive sex education, including participation in screening programs for STIs among high-risk groups.
Language	English
Publishing date	2018-10-25
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652849-6
ISSN	2008-4447 ; 2008-3289
ISSN (online)	2008-4447
ISSN	2008-3289
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Article: Hepatitis B virus DNA level Among the Seropositive Afghan Immigrants, Southern Iran.

Behzadi, Mohammad Amin / Ziyaeyan, Mazyar / Asaei, Sadaf

Jundishapur journal of microbiology

2014 Volume 7, Issue 5, Page(s) e10127

Abstract: Background: Diagnosis and control programs for infectious diseases among immigrants are the most important aspects of epidemiological studies for both origin and destination countries. Data about hepatitis B virus (HBV) infection among the Afghan ... ...

Abstract	Background: Diagnosis and control programs for infectious diseases among immigrants are the most important aspects of epidemiological studies for both origin and destination countries. Data about hepatitis B virus (HBV) infection among the Afghan immigrants in Iran is limited. Objectives: To the best of HBV treatment and prevention in Afghan immigrants in Iran, the present study was conducted to determine the virus DNA level, and the frequency of respective hepatitis B risk factors among the respective seropositive patients in Fars province, southern Iran. Patients and methods: A total of 64 HBsAg positive Afghan immigrants including 47 (73.4%) men and 17 (26.6%) women, with ages ranging between 15 and 74 years (mean ± standard deviation: 37.69 ± 15.02 years) participated in this study. From those, whole blood sample were collected and DNAs were extracted from the sera and analyzed by TaqMan real-time PCR assay with a set of primers and probe amplified core protein region of HBV genome. Results: HBV DNA was detected in a total of 51/64 (79.7 %) serum samples; 37 (72.5%) male and 14 (27.5%) female. The copy number of HBV DNA ranged from 5 × 10(2) to 8.49 × 10(8) copies/mL in the serum samples; median 3.8 × 10(4) copies/mL. Demographic data and risk factors were also evaluated. The comparison of viral loads between the age groups and sex indicated no significant correlation (P > 0.05). However, the serum HBV DNA level significantly decreased in the treated patient group (P = 0.03). There was no significant difference in medicine usage between the two sexes in the study population (P > 0.05). Conclusions: Considering the results, determining the HBV DNA load and evaluation of treatment response can help to reduce the costs of diagnosis and treatment procedures in such patients, as well as, decreasing the risk of HBV transmission in immigrant Afghan population. Moreover, HBV screening strategies in country border entrances among immigrant should be performed. Moreover, free vaccination and treatment programs, and improving the level of HBV knowledge among Afghan immigrants in Iran is highly recommended.
Language	English
Publishing date	2014-05-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2815501-4
ISSN	2008-4161 ; 2008-3645
ISSN (online)	2008-4161
ISSN	2008-3645
DOI	10.5812/jjm.10127
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Article: Outbreak Investigation of Brucellosis at a Kennel in Iran

Behzadi, Mohammad Amin / Mogheiseh, Asghar

Pakistan veterinary journal. 2011 Oct. 1, v. 31, no. 4

2011

Abstract: This study was undertaken to assess the seroprevalence of Brucella canis at a kennel in Iran. Serum samples (n=21) were examined for the presence of B. canis antibodies with immunochromatography assay. Out of these, 57.2% were positive for B. canis ... ...

Abstract	This study was undertaken to assess the seroprevalence of Brucella canis at a kennel in Iran. Serum samples (n=21) were examined for the presence of B. canis antibodies with immunochromatography assay. Out of these, 57.2% were positive for B. canis antibodies. All sero positive dogs were more than 2 years old. Of these, majority (75%) was female dogs and 66.6% had the history of late abortion between 40 and 55 days of gestational period accompanied with brownish or gray-green vaginal discharge. The aborted puppies usually appeared partially autolysed. Scrotal dermatitis and orchitis were the only signs in male dogs. Prevention measures were also performed to control the infection in this kennel.
Keywords	Brucella melitensis biovar Canis ; antibodies ; blood serum ; brucellosis ; dermatitis ; disease control ; immunoaffinity chromatography ; orchitis ; outbreak investigation ; puppies ; seroprevalence ; Iran
Language	English
Dates of publication	2011-1001
Size	p. 379-380.
Publishing place	Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan
Document type	Article
ISSN	0253-8318
Database	NAL-Catalogue (AGRICOLA)

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Article: Determining major genotypes of hepatitis C virus among transplant recipients by real-time polymerase chain reaction assay.

Feyznezhad, Roya / Behzadi, Mohammad Amin / Yaghobi, Ramin / Ziyaeyan, Mazyar

Jundishapur journal of microbiology

2015 Volume 8, Issue 2, Page(s) e16722

Abstract: Background: Hepatitis C virus (HCV) infection still exists as a health concern among the transplant patients. Because of the severity of the disease, different responses to treatment, and side effects resulting from long therapeutic period, ... ...

Abstract	Background: Hepatitis C virus (HCV) infection still exists as a health concern among the transplant patients. Because of the severity of the disease, different responses to treatment, and side effects resulting from long therapeutic period, determination of genotypes and viral loads can help choose the best treatment protocols. Objectives: This study aimed to determine the HCV genotypes and its distribution patterns among liver, kidney, and bone marrow recipient candidates across Iran, referred to Namazi Hospital, southern Iran. Patients and methods: A total of 101 individuals, including 44 (43.6%) liver, 55 (54.5%) kidney, and 2 (2%) bone marrow recipient candidates, with ages ranging between 5 and 74 years (Mean ±SD: 46.53 ± 13.73 y) participated in this study. From those, whole blood sample were collected and anti-HCV antibodies, RNA detection, and genotyping were performed on plasma using commercial chromatographic immunoassay, TaqMan one-step real-time polymerase chain reaction (RT-PCR), and genotyping RT-PCR kits, respectively. The frequencies of anti-HCV antibodies, RNA, various genotypes, and the viral load were compared with respect to gender, age, and transplant recipient groups. Results: Of 101 individuals, 47 (46.5%) were positive for anti-HCV antibodies and 34 (33.7%) for RNA with a significant difference (P < 0.05). RNA copy number ranged from 4.6 × 103 to 3.11 × 107 copies/mL, median: 2.92 × 106 copies/mL, with no statistical differences in all groups. Analyses revealed no significant differences between the frequencies of anti-HCV antibodies or RNA in different groups. The frequencies of the genotypes 1 (50%) and 3 (35.3%) were higher than those of the genotypes 2 (2.9%), 4 (2.9%), and undetermined one (8.8%). Genotype 1 was significantly more prevalent in liver transplant recipients, those older than 40 years, and male cases (P < 0.05). Conclusions: Considering the high frequency of genotypes 1 and 3 among the studied groups, it is suggested that before and after transplantation programs be improved to manage and treat the disease efficiently, based on the standard protocols for such genotypes in the region. Accordingly, the occurrence of post-transplant complications due to immunosuppression among all the recipients as well as reinfection in HCV infected liver transplant patients can be diminished.
Language	English
Publishing date	2015-02-20
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2815501-4
ISSN	2008-4161 ; 2008-3645
ISSN (online)	2008-4161
ISSN	2008-3645
DOI	10.5812/jjm.16722
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Article ; Online: Seroprevalence of viral hepatitis A, B, C, D and E viruses in the Hormozgan province southern Iran.

Behzadi, Mohammad Amin / Leyva-Grado, Victor Hugo / Namayandeh, Mandana / Ziyaeyan, Atoosa / Feyznezhad, Roya / Dorzaban, Hedayat / Jamalidoust, Marzieh / Ziyaeyan, Mazyar

BMC infectious diseases

2019 Volume 19, Issue 1, Page(s) 1027

Abstract: Background: Viral hepatitis is a global public health problem affecting millions of people worldwide, causing thousands of deaths due to acute and persistent infection, cirrhosis, and liver cancer. Providing updated serologic data can improve both ... ...

Abstract	Background: Viral hepatitis is a global public health problem affecting millions of people worldwide, causing thousands of deaths due to acute and persistent infection, cirrhosis, and liver cancer. Providing updated serologic data can improve both surveillance and disease control programs. This study is aimed to determine the seroprevalence of markers for viral hepatitis (A, B, C, D and E) and the epidemiology of such infections in the general population of southern Iran's Hormozgan province. Methods: Between 2016 and 2017, a total of 562 individuals with ages ranging from 1 to 86 years, who visited governmental public laboratories for routine check-ups, were tested for the presence of serological markers to hepatitis virus types A to E using enzyme-linked immunosorbent assays. Results: The overall anti-hepatitis A virus (HAV) antibody seroprevalence was 93.2% (524/562). The prevalence of anti-hepatitis E virus (HEV) antibodies was 15.8% (89/562) among which 1.6% (9/562) of the seropositive individuals also had evidence of recent exposure to the virus (IgM positivity). Two and a half percent (14/562) were positive for hepatitis B surface (HBs) antigen, whereas 11.6% (65/562) tested positive for anti-hepatitis B core (HBc) antibodies. Among anti-HBc positive patients, 11% (7/65) had HBs Ag and 5% (3/65) were positive for anti-hepatitis D virus (HDV) antibodies. The prevalence of anti-hepatitis C virus (HCV) antibodies was 0.7% (4/562). The seroprevalence of anti-HAV, HEV IgG, anti-HBc antibodies, and HBs Ag increased with age. Conclusion: The present study confirms a high seroprevalence of HAV infection among the examined population and reveals high levels of endemicity for HEV in the region. Planned vaccination policies against HAV should be considered in all parts of Iran. In addition, improvements on public sanitation and hygiene management of drinking water sources for the studied area are recommended.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Child ; Child, Preschool ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Hepatitis Antibodies/blood ; Hepatitis B Surface Antigens/blood ; Hepatitis B virus/immunology ; Hepatitis Viruses/immunology ; Hepatitis, Viral, Human/epidemiology ; Hepatitis, Viral, Human/immunology ; Hepatitis, Viral, Human/prevention & control ; Humans ; Infant ; Iran/epidemiology ; Male ; Middle Aged ; Prevalence ; Seroepidemiologic Studies ; Vaccination ; Young Adult
Chemical Substances	Biomarkers ; Hepatitis Antibodies ; Hepatitis B Surface Antigens
Language	English
Publishing date	2019-12-03
Publishing country	England
Document type	Journal Article
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-019-4661-4
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Article: An Influenza Virus Hemagglutinin-Based Vaccine Platform Enables the Generation of Epitope Specific Human Cytomegalovirus Antibodies.

Behzadi, Mohammad Amin / Stein, Kathryn R / Bermúdez-González, Maria Carolina / Simon, Viviana / Nachbagauer, Raffael / Tortorella, Domenico

Vaccines

2019 Volume 7, Issue 2

Abstract: Human cytomegalovirus (CMV) is a highly prevalent pathogen with ~60%-90% seropositivity in adults. CMV can contribute to organ rejection in transplant recipients and is a major cause of birth defects in newborns. Currently, there are no approved vaccines ...

Abstract	Human cytomegalovirus (CMV) is a highly prevalent pathogen with ~60%-90% seropositivity in adults. CMV can contribute to organ rejection in transplant recipients and is a major cause of birth defects in newborns. Currently, there are no approved vaccines against CMV. The epitope of a CMV neutralizing monoclonal antibody against a conserved region of the envelope protein gH provided the basis for a new CMV vaccine design. We exploited the influenza A virus as a vaccine platform due to the highly immunogenic head domain of its hemagglutinin envelope protein. Influenza A variants were engineered by reverse genetics to express the epitope of an anti-CMV gH neutralizing antibody that recognizes native gH into the hemagglutinin antigenic Sa site. We determined that the recombinant influenza variants expressing 7, 10, or 13 residues of the anti-gH neutralizing antibody epitope were recognized and neutralized by the anti-gH antibody 10C10. Mice vaccinated with the influenza/CMV chimeric viruses induced CMV-specific antibodies that recognized the native gH protein and inhibited virus infection. In fact, the influenza variants expressing 7-13 gH residues neutralized a CMV infection at ~60% following two immunizations with variants expressing the 13 residue gH peptide produced the highest levels of neutralization. Collectively, our study demonstrates that a variant influenza virus inserted with a gH peptide can generate a humoral response that limits a CMV infection.
Language	English
Publishing date	2019-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines7020051
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