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Article ; Online: On a Linear Gromov-Wasserstein Distance.

Beier, Florian / Beinert, Robert / Steidl, Gabriele

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2022 Volume 31, Page(s) 7292–7305

Abstract: Gromov-Wasserstein distances are generalization of Wasserstein distances, which are invariant under distance preserving transformations. Although a simplified version of optimal transport in Wasserstein spaces, called linear optimal transport (LOT), was ... ...

Abstract	Gromov-Wasserstein distances are generalization of Wasserstein distances, which are invariant under distance preserving transformations. Although a simplified version of optimal transport in Wasserstein spaces, called linear optimal transport (LOT), was successfully used in practice, there does not exist a notion of linear Gromov-Wasserstein distances so far. In this paper, we propose a definition of linear Gromov-Wasserstein distances. We motivate our approach by a generalized LOT model, which is based on barycentric projection maps of transport plans. Numerical examples illustrate that the linear Gromov-Wasserstein distances, similarly as LOT, can replace the expensive computation of pairwise Gromov-Wasserstein distances in applications like shape classification.
Language	English
Publishing date	2022-11-23
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2022.3221286
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online ; Thesis: Plasticity in the sensorimotor system and innovative sensorimotor training in frailty

Beier, Florian [Verfasser] / Flor, Herta [Akademischer Betreuer]

2023

Author's details	Florian Beier ; Betreuer: Herta Flor
Keywords	Psychologie ; Psychology
Subject code	sg150
Language	English
Publisher	Universitätsbibliothek Heidelberg
Publishing place	Heidelberg
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Sensory and motor correlates of frailty: dissociation between frailty phenotype and frailty index.

Beier, Florian / Löffler, Martin / Nees, Frauke / Hausner, Lucrezia / Frölich, Lutz / Flor, Herta

BMC geriatrics

2022 Volume 22, Issue 1, Page(s) 755

Abstract: Background: Frailty has been associated with a decline in sensory and motor function. However, given that different frailty measures were shown to overlap but also differ in their diagnostic properties, sensory and motor correlates of frailty might be ... ...

Abstract	Background: Frailty has been associated with a decline in sensory and motor function. However, given that different frailty measures were shown to overlap but also differ in their diagnostic properties, sensory and motor correlates of frailty might be different depending on the operationalization of frailty. Our objective was to identify sensory and motor determinants of frailty and compare the results between frailty phenotype (FP) and frailty index (FI). Methods: Data from 44 pre-frail and frail subjects aged 65 and above were used. Frailty was measured using the FP and the FI. Sensory function in the visual, auditory, and tactile domain was assessed using visual acuity, absolute hearing threshold and mechanical detection threshold. Upper extremity motor performance was evaluated by the Purdue Pegboard Test and the Short Physical Performance Battery was used to assess lower extremity motor function. Multiple logistic regression models were employed to determine associations of sensory and motor function with frailty vs. pre-frailty for both frailty measures. Results: The frailty measures were moderately correlated (0.497, p ≤ 0.01) and had a Kappa agreement of 0.467 (p = 0.002). Using the FP, frailty was significantly associated with reduced upper extremity motor function only (OR = 0.50, 95% CI 0.29-0.87, p = 0.014). Frailty as assessed by the FI was significantly related to higher hearing thresholds (OR = 1.21, 95% CI 1.02-1.43, p = 0.027) and reduced lower extremity performance (OR = 0.32, 95% CI 0.13-0.77, p = 0.012). Conclusion: Frailty is related to reduced performance in measures of sensory and motor function. However, traditional measures of frailty might be differentially sensitive to capture sensory and motor decline, possibly contributing to the much-observed discordance between the diagnostic instruments. This should be taken into account by researchers and clinicians when planning and evaluating therapeutic interventions for frailty. Trial registration: ClinicalTrials.gov NCT03666039 . Registered 11 September 2018 - Retrospectively registered.
MeSH term(s)	Aged ; Frail Elderly ; Frailty/diagnosis ; Frailty/epidemiology ; Humans ; Phenotype
Language	English
Publishing date	2022-09-15
Publishing country	England
Document type	Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-022-03416-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Promoting neuroplasticity and neuropsychological functioning in frailty through an app-based sensorimotor training: study protocol for a randomized trial.

Beier, Florian / Löffler, Martin / Nees, Frauke / Hausner, Lucrezia / Frölich, Lutz / Flor, Herta

BMC geriatrics

2021 Volume 21, Issue 1, Page(s) 343

Abstract: Background: Frailty is characterized by an age-related decline in multiple physiological systems, leading to a high vulnerability to stressors, adverse health outcomes, and low quality of life. Neuroscientific models of pathological aging emphasize the ... ...

Abstract	Background: Frailty is characterized by an age-related decline in multiple physiological systems, leading to a high vulnerability to stressors, adverse health outcomes, and low quality of life. Neuroscientific models of pathological aging emphasize the loss of sensorimotor stimulation and reduced neuromodulatory capacities as core processes in age-related cognitive and bodily decline, which may be associated with maladaptive plastic changes in the brain. We plan to increase sensorimotor stimulation in frail persons through a newly developed app-based training program and link the training trials to biological and psychological correlates of age-associated vulnerability and health indices. Methods: We will conduct a randomized trial, applying an app-based sensorimotor home training (N = 30) in people suffering from frailty. An app-based relaxation training will serve as an active control condition (N = 30). Both interventions will last for 90 days each. The sensorimotor training includes unimodal and multimodal sensory discrimination tasks in the visual, auditory, and tactile domain, as well as sensorimotor precision tasks. The tasks will be implemented using an adaptive training algorithm and enriched with motivational components embedded in a virtual training environment. We expect a pre-post reduction of frailty status and associated functional decline related to refinement of representational maps within the sensorimotor system and improved sensorimotor function such as extremity function. Secondary analyses will study the influence of BDNF genotype as moderating variable. Additional outcomes will include measures of perceptual and cognitive functioning, quality of life as well as BDNF serum levels. Measurements will take place before training (baseline), after 60 days (assessment 1), and at the end of the training after 90 days (assessment 2). Discussion: In our randomized trial, we aim to characterize a multidimensional concept of frailty and to target maladaptive behaviors and neuroplasticity using an app-based sensorimotor training. This type of intervention might provide further knowledge and new possibilities for preventing decline and preserving function in older adults. Trial registration: ClinicalTrials.gov NCT03666039 . Registered 11 September 2018 - Retrospectively registered. Protocol version: Version 4 revised (issue date: 19 May 2021).
MeSH term(s)	Aged ; Aging ; Frailty/diagnosis ; Frailty/therapy ; Humans ; Mobile Applications ; Neuronal Plasticity ; Quality of Life
Language	English
Publishing date	2021-06-03
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-021-02293-9
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Article: Sensory and motor correlates of frailty

Beier, Florian / Löffler, Martin / Nees, Frauke / Hausner, Lucrezia / Frölich, Lutz / Flor, Herta

BMC Geriatrics

Dissociation between frailty phenotype and frailty index

2022

Title translation	Sensorische und motorische Korrelate von Gebrechlichkeit: Dissoziation zwischen Gebrechlichkeitsphänotyp und Gebrechlichkeitsindex
Abstract	Background: Frailty has been associated with a decline in sensory and motor function. However, given that different frailty measures were shown to overlap but also differ in their diagnostic properties, sensory and motor correlates of frailty might be different depending on the operationalization of frailty. Our objective was to identify sensory and motor determinants of frailty and compare the results between frailty phenotype (FP) and frailty index (FI). Methods: Data from 44 pre-frail and frail subjects aged 65 and above were used. Frailty was measured using the FP and the FI. Sensory function in the visual, auditory, and tactile domain was assessed using visual acuity, absolute hearing threshold and mechanical detection threshold. Upper extremity motor performance was evaluated by the Purdue Pegboard Test and the Short Physical Performance Battery was used to assess lower extremity motor function. Multiple logistic regression models were employed to determine associations of sensory and motor function with frailty vs. pre-frailty for both frailty measures. Results: The frailty measures were moderately correlated (0.497, p <= 0.01) and had a Kappa agreement of 0.467 (p = 0.002). Using the FP, frailty was significantly associated with reduced upper extremity motor function only (OR = 0.50, 95% CI 0.29-0.87, p = 0.014). Frailty as assessed by the FI was significantly related to higher hearing thresholds (OR = 1.21, 95% CI 1.02-1.43, p = 0.027) and reduced lower extremity performance (OR = 0.32, 95% CI 0.13-0.77, p = 0.012). Conclusion: Frailty is related to reduced performance in measures of sensory and motor function. However, traditional measures of frailty might be differentially sensitive to capture sensory and motor decline, possibly contributing to the much-observed discordance between the diagnostic instruments. This should be taken into account by researchers and clinicians when planning and evaluating therapeutic interventions for frailty.
Keywords	Aging ; Altern ; Auditory Thresholds ; Gesundheitliche Beeinträchtigungen ; Health Impairments ; Hörschwellen ; Leistung (Ausführung) ; Motor Performance ; Motorische Leistung ; Perception ; Performance ; Phenotypes ; Phänotypen ; Tactual Perception ; Taktile Wahrnehmung ; Testing Methods ; Testmethoden ; Visual Perception ; Visuelle Wahrnehmung ; Wahrnehmung
Language	English
Document type	Article
ZDB-ID	2059865-8
ISSN	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-022-03416-6
Database	PSYNDEX

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Article ; Online: Reduced tactile sensitivity is associated with mild cognitive impairment.

Löffler, Annette / Beier, Florian / Bekrater-Bodmann, Robin / Hausner, Lucrezia / Desch, Simon / Silvoni, Stefano / Kleinböhl, Dieter / Löffler, Martin / Nees, Frauke / Frölich, Lutz / Flor, Herta

EBioMedicine

2023 Volume 99, Page(s) 104896

Abstract: Background: Sensory impairment has been related to age-associated cognitive decline. While these associations were investigated primarily in the auditory and visual domain, other senses such as touch have rarely been studied. Thus, it remains open ... ...

Abstract	Background: Sensory impairment has been related to age-associated cognitive decline. While these associations were investigated primarily in the auditory and visual domain, other senses such as touch have rarely been studied. Thus, it remains open whether these results are specific for particular sensory domains, or rather point to a fundamental role of sensory deficits in cognitive decline. Methods: Data from 31 participants with mild cognitive impairment (MCI), 46 participants with frailty, and 23 non-clinical control participants (NCCs) were included. We assessed sensory function using visual acuity and contrast sensitivity, hearing threshold, and mechanical detection threshold. Cognitive function in participants with MCI was assessed using associative memory performance. Group differences on sensory thresholds were tested using analyses of covariance with age, sex, and years of education as covariates. Associations between measures within participants with MCI were evaluated using Spearman correlations. Findings: We found a significant difference in mechanical detection threshold between the groups (p < 0.001, η Interpretation: Our results indicate that reduced tactile sensitivity is related to cognitive decline. Prospective studies should investigate the age-related alterations of multimodal sensory processes and their contribution to dementia-related processes. Funding: Deutsche Forschungsgemeinschaft (FL 156/41-1) and a grant of the Hector-Stiftung II, Weinheim, Germany.
MeSH term(s)	Humans ; Frailty ; Touch ; Prospective Studies ; Cognitive Dysfunction/complications ; Cognition ; Neuropsychological Tests
Language	English
Publishing date	2023-12-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2023.104896
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Article ; Online: Effects of an app-based sensorimotor training in promoting neuroplasticity and neuropsychological functioning in frailty: A randomized controlled trial.

Beier, Florian / Löffler, Martin / Nees, Frauke / Bekrater-Bodmann, Robin / Silvoni, Stefano / Desch, Simon / Löffler, Annette / Hausner, Lucrezia / Frölich, Lutz / Flor, Herta

Archives of gerontology and geriatrics

2023 Volume 115, Page(s) 105202

Abstract: Background: Loss of sensorimotor stimulation and maladaptive plastic changes of the brain may play a major role in problematic aging phenomena such as frailty. However, it is not clear if interventions specifically targeting neuroplasticity can reverse ... ...

Abstract	Background: Loss of sensorimotor stimulation and maladaptive plastic changes of the brain may play a major role in problematic aging phenomena such as frailty. However, it is not clear if interventions specifically targeting neuroplasticity can reverse or slow the development of frailty. Objectives: We compared the effect of a tablet-based neuroplasticity-oriented sensorimotor training (experimental group, EG) and a tablet-based relaxation training (control group, CG) on frailty and sensorimotor brain function. Methods: Interventions consisted of daily 30 min sessions distributed over 90 days. Assessments took place at baseline, after 60 days, and after 90 days. A total of N = 48 frail older adults (EG: n = 24; CG: n = 24) were assigned to the two groups and reassessed after 60 days. Primary outcomes included frailty phenotype (FP) and frailty index (FI). Sensorimotor brain activity was evaluated using functional magnetic resonance imaging and single-pulse transcranial magnetic stimulation. Results: After 60 days of training, both groups showed a reduction in the number of FP criteria (p < 0.001) with a trend towards a significant time-by-group interaction (p = 0.058) indicating a stronger reduction of frailty in the EG (p < 0.001) compared to the CG (p = 0.039). In addition, pain was significantly reduced in the EG but not the CG. No significant effects were found for measures of brain function. Discussion: We provided initial evidence that a neuroplasticity-oriented sensorimotor training could be beneficial in counteracting frailty as well as chronic pain. Further studies are needed to determine the potentially underlying neuroplastic mechanisms and the influence of plasticity-related biomarkers as well as their clinical significance. Trial registration: ClinicalTrials.gov NCT03666039 (registered 11 September 2018).
MeSH term(s)	Humans ; Aged ; Frailty ; Mobile Applications ; Frail Elderly/psychology ; Brain ; Neuronal Plasticity
Language	English
Publishing date	2023-09-17
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603162-6
ISSN	1872-6976 ; 0167-4943
ISSN (online)	1872-6976
ISSN	0167-4943
DOI	10.1016/j.archger.2023.105202
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Article: Promoting neuroplasticity and neuropsychological functioning in frailty through an app-based sensorimotor training

Beier, Florian / Löffler, Martin / Nees, Frauke / Hausner, Lucrezia / Frölich, Lutz / Flor, Herta

BMC Geriatrics

Study protocol for a randomized trial

2021 Volume 21, Issue 1, Page(s) No

Title translation	Förderung der Neuroplastizität und der neuropsychologischen Funktionen bei Gebrechlichkeit durch ein App-basiertes sensomotorisches Training: Studienprotokoll für eine randomisierte Studie
Abstract	Background: Frailty is characterized by an age-related decline in multiple physiological systems, leading to a high vulnerability to stressors, adverse health outcomes, and low quality of life. Neuroscientific models of pathological aging emphasize the loss of sensorimotor stimulation and reduced neuromodulatory capacities as core processes in age-related cognitive and bodily decline, which may be associated with maladaptive plastic changes in the brain. We plan to increase sensorimotor stimulation in frail persons through a newly developed app-based training program and link the training trials to biological and psychological correlates of age-associated vulnerability and health indices. Methods: We will conduct a randomized trial, applying an app-based sensorimotor home training (N = 30) in people suffering from frailty. An app-based relaxation training will serve as an active control condition (N = 30). Both interventions will last for 90 days each. The sensorimotor training includes unimodal and multimodal sensory discrimination tasks in the visual, auditory, and tactile domain, as well as sensorimotor precision tasks. The tasks will be implemented using an adaptive training algorithm and enriched with motivational components embedded in a virtual training environment. We expect a pre-post reduction of frailty status and associated functional decline related to refinement of representational maps within the sensorimotor system and improved sensorimotor function such as extremity function. Secondary analyses will study the influence of BDNF genotype as moderating variable. Additional outcomes will include measures of perceptual and cognitive functioning, quality of life, as well as BDNF serum levels. Measurements will take place before training (baseline), after 60 days (assessment 1), and at the end of the training after 90 days (assessment 2). Discussion: In our randomized trial, we aim to characterize a multidimensional concept of frailty and to target maladaptive behaviors and neuroplasticity using an app-based sensorimotor training. This type of intervention might provide further knowledge and new possibilities for preventing decline and preserving function in older adults.
Keywords	Aging ; Altern ; Brain Derived Neurotrophic Factor ; Digital Interventions ; Digitale Interventionen ; Entspannungstherapie ; Home Environment ; Häusliche Umwelt ; Mobile Applications ; Mobile Apps ; Neural Plasticity ; Neuronale Plastizität ; Perceptual Motor Processes ; Relaxation Therapy ; Sensumotorische Prozesse ; Training
Language	English
Document type	Article
ZDB-ID	2059865-8
ISSN	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-021-02293-9
Database	PSYNDEX

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Book ; Online ; Thesis: Einfluß von internen Kardioversionsschocks und Amiodaron auf die Erregungsausbreitung im rechten Vorhof und Koronarsinus bei Vorhofflimmern

Beier, Florian

eine elektrophysiologische Untersuchung mit dem Multielektroden-Basket-Katheter

2002

Author's details	Florian Beier
Language	German
Size	Online-Ressource
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Techn. Univ., Diss--München, 2003
Database	Former special subject collection: coastal and deep sea fishing

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Article: Effects of an app-based sensorimotor training in promoting neuroplasticity and neuropsychological functioning in frailty

Beier, Florian / Löffler, Martin / Nees, Frauke / Bekrater-Bodmann, Robin / Silvoni, Stefano / Desch, Simon / Löffler, Annette / Hausner, Lucrezia / Frölich, Lutz / Flor, Herta

Archives of Gerontology and Geriatrics

A randomized controlled trial

2023

Abstract: Abstract not released by publisher. ...

Title translation	Auswirkungen eines App-basierten sensomotorischen Trainings zur Förderung der Neuroplastizität und des neuropsychologischen Funktionsniveaus bei Gebrechlichkeit: Eine randomisierte kontrollierte Studie
Abstract	Abstract not released by publisher.
Keywords	Aging ; Altern ; Cerebral Blood Flow ; Cognitive Ability ; Digital Interventions ; Digitale Interventionen ; Functional Status ; Funktionsstatus ; Gesundheitliche Beeinträchtigungen ; Health Impairments ; Kognitive Fähigkeiten ; Mobile Applications ; Mobile Apps ; Mobile Gesundheitsangebote ; Mobile Health ; Neural Plasticity ; Neuronale Plastizität ; Perceptual Motor Processes ; Phenotypes ; Phänotypen ; Sensumotorische Prozesse ; Somatosensorisch evozierte Potenziale ; Somatosensory Evoked Potentials ; Training ; Zerebrale Durchblutung
Language	English
Document type	Article
ZDB-ID	603162-6
ISSN	0167-4943
ISSN	0167-4943
DOI	10.1016/j.archger.2023.105202
Database	PSYNDEX

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