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  1. Article ; Online: Management of Locally Advanced Laryngeal Cancer-From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe.

    Cîrstea, Anca-Ionela / Berteșteanu, Șerban Vifor Gabriel / Scăunașu, Răzvan-Valentin / Popescu, Bogdan / Bejenaru, Paula Luiza / Simion-Antonie, Catrinel Beatrice / Berteșteanu, Gloria Simona / Diaconu, Teodora Elena / Taher, Petra Bianca / Rujan, Simona-Andreea / Oașă, Irina-Doinița / Grigore, Raluca

    International journal of environmental research and public health

    2023  Volume 20, Issue 6

    Abstract: Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to ... ...

    Abstract Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to December 2022) with 152 patients diagnosed with laryngeal cancer from a tertiary hospital in Romania. The average age of the patients was 62 years old for both sexes, with a range from 44 to 83 years. The most frequent symptom was dysphonia with or without dyspnea in 142 cases (93.42%), followed by dyspnea alone in nine patients (5.92%) and dysphagia in one case (0.66%). Surgical treatment in this study consisted of partial laryngectomy (CO
    MeSH term(s) Male ; Female ; Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Laryngeal Neoplasms/epidemiology ; Laryngeal Neoplasms/surgery ; Retrospective Studies ; Tertiary Care Centers ; Laryngectomy/methods ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20064737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Quality-of-Life Assessment after Head and Neck Oncological Surgery for Advanced-Stage Tumours.

    Bejenaru, Paula Luiza / Popescu, Bogdan / Oancea, Alina Lavinia Antoaneta / Simion-Antonie, Catrinel Beatrice / Berteșteanu, Gloria Simona / Condeescu-Cojocarița, Mihnea / Cîrstea, Anca Ionela / Oașă, Irina Doinița / Schipor-Diaconu, Teodora Elena / Popescu, Dan / Grigore, Raluca

    Journal of clinical medicine

    2022  Volume 11, Issue 16

    Abstract: Squamous cell carcinoma of the head and neck (HNSCC) is a common malignancy often diagnosed in the advanced stage with a complex negative influence on the patient's quality of life (QoL). Given its multi-modal treatment, the first step is to adequately ... ...

    Abstract Squamous cell carcinoma of the head and neck (HNSCC) is a common malignancy often diagnosed in the advanced stage with a complex negative influence on the patient's quality of life (QoL). Given its multi-modal treatment, the first step is to adequately balance the needs of the patient, and the second step includes the consultations, interventions, and care provided by the medical team, with the purpose of improving the overall management of the HNSCC. Current attempts to develop and validate quality-of-life instruments specific to cancers of the head and neck have been reported, and certain questionnaires are now available. We performed a retrospective study in a tertiary centre, involving 89 patients who survived 3 years after HNSCC surgery. A patient-related outcome measurement was made using the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-H&N35 instruments to assess QoL at admission and 3 years after treatment. The 3-year survivors reported an overall improvement in QoL compared with those in the pre-treatment period. The unique details of head and neck cancer treatments outline the importance of considering the characteristics of the patient population in quality-of-life research and also identify how quality-of-life data can contribute to the care provided by the multi-disciplinary team involved in a patient's follow-up.
    Language English
    Publishing date 2022-08-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11164875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Role of Biomaterials in Upper Digestive Tract Transoral Reconstruction.

    Grigore, Raluca / Popescu, Bogdan / Berteşteanu, Şerban Vifor Gabriel / Nichita, Cornelia / Oașă, Irina Doinita / Munteanu, Gloria Simona / Nicolaescu, Alexandru / Bejenaru, Paula Luiza / Simion-Antonie, Catrinel Beatrice / Ene, Dragoș / Ene, Răzvan

    Materials (Basel, Switzerland)

    2021  Volume 14, Issue 6

    Abstract: This study aims to establish whether the use of biomaterials, particularly polydimethylsiloxane (PDMS), for surgical reconstruction of the esophagus with templates, Montgomery salivary tube, after radical oncology surgery for malignant neoplasia is an ... ...

    Abstract This study aims to establish whether the use of biomaterials, particularly polydimethylsiloxane (PDMS), for surgical reconstruction of the esophagus with templates, Montgomery salivary tube, after radical oncology surgery for malignant neoplasia is an optimal choice for patients' safety and for optimal function preservation and organ rehabilitation. Structural analysis by Raman spectrometry and biomechanical properties with dynamic mechanical analysis are performed for fatigue strength and toughness, essential factors in durability of a prosthesis in the reconstruction practice of the esophagus. Nanocomposites with silicone elastomers and nanoparticles used in implantable devices and in reconstruction surgery present risks of infection and fatigue strength when required to perform a mechanical effort for long periods of time. This report takes into account the effect of silver (Ag) nanoparticles on the fatigue strength using polydimethylsiloxane (PDMS) matrix, representative for silicon elastomers used in implantable devices. PDMS with 5% (wt) Ag nanoparticles of 100-150 nm during mechanical fatigue testing at shear strength loses elasticity properties after 400 loading-unloading cycles and up to 15% shear strain. The fatigue strength, toughness, maximum shear strength, as well as clinical properties are key issues in designing Montgomery salivary tube and derivates with appropriate biomechanical behavior for each patient. Prosthesis design needs to indulge both clinical outcomes as well as design methods and research in the field of biomaterials.
    Language English
    Publishing date 2021-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma14061436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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