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Article ; Online: Adaptative Strategy of Immunosuppressive Drugs Dosage Adjustments When Combined With Nirmatrelvir/Ritonavir in Solid Organ Transplant Recipients With COVID-19.

Boland, Lidvine / Devresse, Arnaud / Monchaud, Caroline / Briol, Sébastien / Belaiche, Stéphanie / Giguet, Baptiste / Couzi, Lionel / Thaunat, Olivier / Esposito, Laure / Meszaros, Magdalena / Roussoulieres, Ana / Haufroid, Vincent / Le Meur, Yannick / Lemaitre, Florian

Transplant international : official journal of the European Society for Organ Transplantation

2024 Volume 37, Page(s) 12360

Abstract: Nirmatrelvir/ritonavir is a promising option for preventing severe COVID-19 in solid organ transplant recipients with SARS-CoV-2 infection. However, concerns have arisen regarding potential drug interactions with calcineurin inhibitors (CNI). This two- ... ...

Abstract	Nirmatrelvir/ritonavir is a promising option for preventing severe COVID-19 in solid organ transplant recipients with SARS-CoV-2 infection. However, concerns have arisen regarding potential drug interactions with calcineurin inhibitors (CNI). This two-phase multicentre retrospective study, involving 113 patients on tacrolimus and 13 on cyclosporine A, aimed to assess the feasibility and outcomes of recommendations issued by The French societies of transplantation (SFT) and pharmacology (SFPT) for CNI management in this context. The study first evaluated adherence to recommendations, CNI exposure, and clinical outcomes. Notably, 96.5% of patients on tacrolimus adhered to the recommendations, maintaining stable tacrolimus trough concentrations (C
MeSH term(s)	Humans ; Tacrolimus ; Cyclosporine/therapeutic use ; Ritonavir/therapeutic use ; Ritonavir/pharmacology ; Retrospective Studies ; COVID-19 ; COVID-19 Drug Treatment ; SARS-CoV-2 ; Immunosuppressive Agents ; Calcineurin Inhibitors/therapeutic use ; Organ Transplantation ; Transplant Recipients ; Antiviral Agents/therapeutic use ; Lactams ; Leucine ; Nitriles ; Proline
Chemical Substances	nirmatrelvir (7R9A5P7H32) ; Tacrolimus (WM0HAQ4WNM) ; Cyclosporine (83HN0GTJ6D) ; Ritonavir (O3J8G9O825) ; Immunosuppressive Agents ; Calcineurin Inhibitors ; Antiviral Agents ; Lactams ; Leucine (GMW67QNF9C) ; Nitriles ; Proline (9DLQ4CIU6V)
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2024.12360
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Zs.A 2358: Show issues

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Article ; Online: Clinical pharmacist and pharmaceutical interventions in HBH unit: a French observational study.

Belaiche, Stéphanie / Goulois, Stéphanie / DeBerranger, Eva / Odou, Pascal / Balagny, Sara / Décaudin, Bertrand

Acta clinica Belgica

2020 Volume 76, Issue 4, Page(s) 258–263

Abstract: ... ...

Abstract	Objectives
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Drug Prescriptions ; Female ; Humans ; Male ; Middle Aged ; Pharmaceutical Preparations ; Pharmacists ; Pharmacy ; Pharmacy Service, Hospital ; Young Adult
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2020-01-23
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	390201-8
ISSN	2295-3337 ; 0001-5512 ; 1784-3286
ISSN (online)	2295-3337
ISSN	0001-5512 ; 1784-3286
DOI	10.1080/17843286.2020.1716148
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Article ; Online: French Recommendations for a National Competency Framework of Therapeutic Patient Education in Solid Organ Transplantation.

Monchaud, Caroline / Villeneuve, Claire / Belaiche, Stéphanie / Charbit, Marina / Colosio, Charlotte / Houssel, Pauline / Meurette, Aurélie / Nubret, Karine / Tissot, Adrien / Albouy, Marion / Esposito, Laure

Transplantation

2023 Volume 107, Issue 3, Page(s) 549–553

MeSH term(s)	Humans ; Patient Education as Topic ; Organ Transplantation ; Clinical Competence
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004354
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Roles and Impacts of the Transplant Pharmacist: A Systematic Review.

Sam, Sébastien / Guérin, Aurélie / Rieutord, André / Belaiche, Stéphanie / Bussières, Jean-François

The Canadian journal of hospital pharmacy

2018 Volume 71, Issue 5, Page(s) 324–337

Abstract: Background: Pharmacists have been involved in the care of transplant recipients for several decades, and a growing body of literature shows the beneficial effects of clinical pharmacist care on important outcomes for these patients.: Objectives: The ... ...

Abstract	Background: Pharmacists have been involved in the care of transplant recipients for several decades, and a growing body of literature shows the beneficial effects of clinical pharmacist care on important outcomes for these patients. Objectives: The primary objective was to describe the roles and impacts of pharmacists in a solid organ transplant setting. The secondary objective was to describe and rate the pharmacists' interventions. Data sources: Three databases-PubMed, Embase, and Evidence-Based Medicine Reviews-were searched from January 1, 1990, to June 16, 2015. Study selection and data extraction: All studies addressing the roles of pharmacists and the impacts of clinical pharmacy services on the care of solid organ transplant recipients were considered. Only studies providing a statistical analysis were included. Design, setting, sample size, patient characteristics, pharmacists' interventions, study bias, and outcomes were extracted for analysis. Data synthesis: Four randomized controlled trials, 4 cohort studies, 3 pre-post studies, and 1 quasi-randomized controlled trial were included in the review, representing a total of 1837 patients. Of the 12 studies included, 8 specifically focused on renal transplant, and 1 each focused on liver, lung, abdominal organ, and general solid organ transplant. The pivotal pharmacist activities leading to the main patient outcomes were medication counselling ( Conclusion: Currently available evidence suggests that pharmacists can improve patient outcomes in the solid organ transplant setting. Adherence, morbidity, costs, and medication errors were identified as the main outcomes that were improved by pharmaceutical interventions. Transplant programs need to invest more in this resource.
Language	English
Publishing date	2018-10-31
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	413450-3
ISSN	1920-2903 ; 0008-4123
ISSN (online)	1920-2903
ISSN	0008-4123
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Article: Does DDI-Predictor Help Pharmacists to Detect Drug-Drug Interactions and Resolve Medication Issues More Effectively?

Moreau, Fanny / Simon, Nicolas / Walther, Julia / Dambrine, Mathilde / Kosmalski, Gaetan / Genay, Stéphanie / Perez, Maxime / Lecoutre, Dominique / Belaiche, Stéphanie / Rousselière, Chloé / Tod, Michel / Décaudin, Bertrand / Odou, Pascal

Metabolites

2021 Volume 11, Issue 3

Abstract: The characterization of drug-drug interactions (DDIs) may require the use of several different tools, such as the thesaurus issued by our national health agency (i.e., ANSM), the metabolic pathways table from the Geneva University Hospital (GUH), and DDI- ...

Abstract	The characterization of drug-drug interactions (DDIs) may require the use of several different tools, such as the thesaurus issued by our national health agency (i.e., ANSM), the metabolic pathways table from the Geneva University Hospital (GUH), and DDI-Predictor (DDI-P). We sought to (i) compare the three tools' respective abilities to detect DDIs in routine clinical practice and (ii) measure the pharmacist intervention rate (PIR) and physician acceptance rate (PAR) associated with the use of DDI-P. The three tools' respective DDI detection rates (in %) were measured. The PIRs and PARs were compared by using the area under the curve ratio given by DDI-P (R
Language	English
Publishing date	2021-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11030173
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Article ; Online: Factors associated with the variability of calcineurin inhibitor blood levels in kidney recipients grafted for more than 1 year.

Belaiche, Stéphanie / Décaudin, Bertrand / Dharancy, Sébastien / Gautier, Sophie / Noel, Christian / Odou, Pascal / Hazzan, Marc

Fundamental & clinical pharmacology

2017 Volume 32, Issue 1, Page(s) 88–97

Abstract: The study of calcineurin inhibitor (CNI) blood level variability to evaluate adherence in transplantation has improved over the years. The aim of our study was to assess factors associated with this variability using the coefficient of variation (CV). A ... ...

Abstract	The study of calcineurin inhibitor (CNI) blood level variability to evaluate adherence in transplantation has improved over the years. The aim of our study was to assess factors associated with this variability using the coefficient of variation (CV). A cross-sectional sample of kidney recipients grafted for more than 1 year was recruited. We recorded clinical data, data from a clinical pharmacist interview and from six questionnaires measuring adherence, satisfaction, behaviours, beliefs, perception of the illness and social vulnerability. A total of 408 recipients were enrolled (61.2% male, mean age 54) and divided into two groups: low variability CV < 30% (n = 302), high variability CV ≥ 30% (n = 106). In univariate analysis, hospital-home distance, cyclosporine, time since transplantation and presence of discrepancies in drug regimen were associated with a greater risk of CV ≥ 30%. In contrast, tacrolimus QD conferred a lower risk of CV ≥ 30%. In multivariate analysis, only the presence of discrepancies remained significant: (OR 3.2 [1.21-9.01]; P = 0.022). Discrepancies in drug regimen appear as the main risk factor associated with CNI blood variability. The clinical pharmacist's input is an accurate and simple way of detecting non-adherence which is not revealed in self-report questionnaires.
MeSH term(s)	Adult ; Calcineurin Inhibitors/administration & dosage ; Calcineurin Inhibitors/blood ; Chi-Square Distribution ; Cross-Sectional Studies ; Cyclosporine/administration & dosage ; Cyclosporine/blood ; Drug Administration Schedule ; Drug Monitoring ; Female ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/blood ; Kidney Transplantation/adverse effects ; Logistic Models ; Male ; Medication Adherence ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Patient Satisfaction ; Risk Factors ; Surveys and Questionnaires ; Tacrolimus/administration & dosage ; Tacrolimus/blood ; Time Factors ; Treatment Outcome
Chemical Substances	Calcineurin Inhibitors ; Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D) ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2017-11-10
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	639134-5
ISSN	1472-8206 ; 0767-3981
ISSN (online)	1472-8206
ISSN	0767-3981
DOI	10.1111/fcp.12328
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Zs.A 2247: Show issues

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Article ; Online: Factors relevant to medication non-adherence in kidney transplant: a systematic review.

Belaiche, Stephanie / Décaudin, Bertrand / Dharancy, Sébastien / Noel, Christian / Odou, Pascal / Hazzan, Marc

International journal of clinical pharmacy

2017 Volume 39, Issue 3, Page(s) 582–593

Abstract: Background Medication non-adherence is a major issue after transplant that can lead to misdiagnosis, rejection, poor health affecting quality of life, graft loss or death. Several estimations of adherence and related factors have previously been ... ...

Abstract	Background Medication non-adherence is a major issue after transplant that can lead to misdiagnosis, rejection, poor health affecting quality of life, graft loss or death. Several estimations of adherence and related factors have previously been described but conclusions leave doubt as to the most accurate assessment method. Aim of the review To identify the factors most relevant to medication non-adherence in kidney transplant in current clinical practice. Method This systematic review is registered in the PROSPERO data base and follows the Prisma checklist. Articles in English in three databases from January 2009 to December 2014 were analysed. A synthesis was made to target adherence assessment methods, their prevalence and significance. Results Thirty-seven studies were analysed rates of non-adherence fluctuating from 1.6 to 96%. Assessment methods varied from one study to another, although self-reports were mainly used. It appears that youth (≤50 years old), male, low social support, unemployment, low education, ≥3 months post graft, living donor, ≥6 comorbidities, ≥5 drugs/d, ≥2 intakes/d, negative beliefs, negative behavior, depression and anxiety were the factors significantly related to non-adherence. Conclusion As there are no established guidelines, consideration should be given to more than one approach to identify medication non-adherence although self-reports should remain the cornerstone of adherence assessment.
Language	English
Publishing date	2017-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2601204-2
ISSN	2210-7711 ; 2210-7703 ; 0928-1231
ISSN (online)	2210-7711
ISSN	2210-7703 ; 0928-1231
DOI	10.1007/s11096-017-0436-4
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Article ; Online: Impact du pharmacien clinicien sur la iatrogénie médicamenteuse chez le patient greffé rénal.

Flamme-Obry, Fabienne / Belaiche, Stéphanie / Hazzan, Marc / Ramdan, Nassima / Noël, Christian / Odou, Pascal / Décaudin, Bertrand

Nephrologie & therapeutique

2018 Volume 14, Issue 2, Page(s) 91–98

Abstract: Introduction: Drug related problems (DRP) can lead to severe consequences in kidney recipients. The aim of the study was to assess the impact of the clinical pharmacist interventions on the incidence of DRP.: Method: The number of DRP were evaluated ... ...

Title translation	Clinical pharmacist and medication reconciliation in kidney transplantation.
Abstract	Introduction: Drug related problems (DRP) can lead to severe consequences in kidney recipients. The aim of the study was to assess the impact of the clinical pharmacist interventions on the incidence of DRP. Method: The number of DRP were evaluated according to 3periods: Without intervention, with medication reconciliation at admission, and with medication reconciliation at admission associated with an interview with the clinical pharmacist at discharge. Results: Patients concerned were mainly men, 55years old (median age), stage3 of CKD, transplanted for less than 3months or more than 1year, with cardiovascular risk factors and receiving an average of 9drugs/day. Among the DRP, 20% were avoidable and severe in most cases. In period1, 27.7% patients had at least 1DRP, in period2, 21.3% patients had at least 1DRP, and in period3, 17.4% of patients had at least 1DRP (P=0.03). One hundred and ten patients had medication reconciliation at admission with a mean of 0.6unintentional discrepancies per patient (omission in 81% of cases). The main drugs involved concerned the digestive-metabolic (24.5%), cardiovascular (23%), and nervous (23%) system. Sixty-eight interviews at discharge were realized and revealed self-medication habits. Conclusion: Our study shows that medication reconciliation at admission associated with an interview with the clinical pharmacist at discharge can help to reduce DRP in kidney recipients. Further studies are needed to confirm our results.
MeSH term(s)	Drug-Related Side Effects and Adverse Reactions ; Female ; Humans ; Kidney Transplantation/adverse effects ; Male ; Medication Errors/prevention & control ; Medication Errors/statistics & numerical data ; Medication Reconciliation/methods ; Middle Aged ; Patient Discharge ; Pharmacists/statistics & numerical data ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/surgery
Language	French
Publishing date	2018-02-22
Publishing country	France
Document type	Journal Article
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1016/j.nephro.2017.04.004
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Zs.A 6298: Show issues

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Article ; Online: Identification of drug-related problems in ambulatory chronic kidney disease patients: a 6-month prospective study.

Belaiche, Stéphanie / Romanet, Thierry / Allenet, Benoît / Calop, Jean / Zaoui, Philippe

Journal of nephrology

2012 Volume 25, Issue 5, Page(s) 782–788

Abstract: Background: Drug-related problems (DRPs) are common in chronic kidney disease (CKD) patients. We developed a 2-step consultation including a clinical pharmacist (CP) session and a nephrologist conventional care consultation to explore the feasibility of ...

Abstract	Background: Drug-related problems (DRPs) are common in chronic kidney disease (CKD) patients. We developed a 2-step consultation including a clinical pharmacist (CP) session and a nephrologist conventional care consultation to explore the feasibility of a pilot drug-oriented disease management program in controlling iatrogenic side effects. Methods: Drug inventory was estimated by a CP before each nephrology consultation. CP interventions were based on the French Society of Clinical Pharmacy intervention tools. Results: In this 6-month prospective study, 67 CKD patients were enrolled: 77% with stage 3 or 4 CKD (by Kidney Disease Improving Global Outcomes criteria), 66% males, 76% with diabetes, median age 70 years (range 59-75), with a mean 2.6 ± 1.2 comorbidities and 10 ± 3.5 medications. We registered 142 DRPs, in 93% of patients, which mainly concerned untreated indications (31.7%) and incorrect dosages (19%). The most frequent pharmaceutical interventions concerned addition of drug (34%) and adaptation of dose (25.5%). The main drugs involved concerned the cardiovascular (33%), digestive-metabolic (26.9%) and hematopoietic (19.9%) systems. DRPs correlated significantly with a higher number of medications (p=0.049) and with older patient age (p=0.0027). Furthermore, patients' knowledge was evaluated in 41 patients (61%) by the CP with a systematic questionnaire. Three at-risk situations were described: 80.5% of patients interviewed were unaware of the beneficial impact of their treatment, 85% were not aware of medical situations at risk and 68% declared self-medication habits. Conclusion: A formatted CP evaluation coupled with a renal consultation was able to detect a higher level of DRPs, to reinforce educational messages and to propose immediate changes in the therapeutic project.
MeSH term(s)	Age Factors ; Aged ; Ambulatory Care ; Comorbidity ; Cooperative Behavior ; Drug-Related Side Effects and Adverse Reactions ; Feasibility Studies ; Female ; France/epidemiology ; Health Knowledge, Attitudes, Practice ; Hospitals, University ; Humans ; Iatrogenic Disease/epidemiology ; Iatrogenic Disease/prevention & control ; Interdisciplinary Communication ; Male ; Medication Reconciliation ; Middle Aged ; Patient Care Team ; Patient Education as Topic ; Pharmacists ; Pharmacy Service, Hospital ; Pilot Projects ; Polypharmacy ; Program Evaluation ; Prospective Studies ; Referral and Consultation ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Self Medication ; Severity of Illness Index ; Surveys and Questionnaires ; Time Factors
Language	English
Publishing date	2012-09
Publishing country	Italy
Document type	Evaluation Studies ; Journal Article
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.5301/jn.5000063
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Article ; Online: Transition et transfert de la néphrologie pédiatrique à la néphrologie adulte : recommandations de la filière maladies rénales rares ORKiD.

Lemoine, Sandrine / Radenac, Jennifer / Baudouin, Véronique / Belaiche, Stéphanie / Bertholet-Thomas, Aurélia / Buebuyck, Nathalie / Broux, Françoise / Burtey, Stéphane / Champion, Gérard / Charbit, Marina / Cochat, Pierre / De Parscau, Loïc / Delmas, Yahsou / Dunand, Olivier / Essig, Marie / Guebre-Egziabher, Fitsum / Langellier-Bellevue, Béatrice / Leclerc, Anne-Laure / Merieau, Élodie /

Moulin, Bruno / Perrin, Justine / Rousiot, Dominique / Sartoris, Béatrice / Servais, Aude / Nagra, Arvind / Novo, Robert

Nephrologie & therapeutique

2021 Volume 17, Issue 2, Page(s) 137–142

Title translation	Recommendations for management of patients from pediatrics unit to adult unit: Transition and transfer program.
MeSH term(s)	Adult ; Child ; Hospital Units ; Humans ; Pediatrics ; Transition to Adult Care
Language	French
Publishing date	2021-01-30
Publishing country	France
Document type	Practice Guideline ; Journal Article
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1016/j.nephro.2020.10.009
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