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  1. AU="Belal, Ahmed"
  2. AU="Prasher, Parteek"
  3. AU=Hasan Anamul
  4. AU="Janzic, Urska"
  5. AU="Moussavi-Baygi, Ruhollah"
  6. AU=Joffe Russell T
  7. AU="Szerencsés, Viktória"
  8. AU="Venkatesan, Vettriselvi"
  9. AU="Houzé, Sandrine"
  10. AU="Cox, Caitlin"
  11. AU="Sheng, Xin-Qing"
  12. AU="Marrink, Siewert J"
  13. AU="Boland, Fiona"
  14. AU="Semcesen, Liana N"
  15. AU="Beah, Peter Y"
  16. AU="Zakzuk, Josefina"
  17. AU="Buchner, Denise"
  18. AU="Xueting Feng"
  19. AU="Chen, Si-Rui"
  20. AU="Hoffmann, Sven"
  21. AU="Kang, Kyung Jun"
  22. AU="Brinks, Henriette L"

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  1. Artikel ; Online: Atlantoaxial dislocation in the setting of NMLFS.

    Abughofah, Yousaf / Witten, Andrew J / Belal, Ahmed / Wilson, Saul

    European journal of medical genetics

    2024  , Seite(n) 104947

    Abstract: Background: Nablus mask-like facial syndrome (NMFLS) is an extremely rare genetic syndrome characterized by facial dysmorphia as well as developmental delay. In the present report we describe a potential association between non-traumatic atlanto- ... ...

    Abstract Background: Nablus mask-like facial syndrome (NMFLS) is an extremely rare genetic syndrome characterized by facial dysmorphia as well as developmental delay. In the present report we describe a potential association between non-traumatic atlanto-occipital dislocation and NMFLS in an 11-year old female lacking typical facial features of NMFLS.
    Case description: An 11-year-old female with autism presented with symptoms of persistent headache and vomiting as well as neck stiffness. Further investigation and CT imaging revealed congenital malformation of the skull base and craniocervical junction with complete posterior subluxation of the left occipital condyle. MRI findings later corroborated the findings on CT.
    Conclusions: The patient was successfully treated with occipitocervical fusion. The findings in this case suggest the possibility that atlanto-occipital instability and generalized occipitocervical may be associated with NMFLS.
    Sprache Englisch
    Erscheinungsdatum 2024-05-08
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports
    ZDB-ID 2184135-4
    ISSN 1878-0849 ; 1769-7212
    ISSN (online) 1878-0849
    ISSN 1769-7212
    DOI 10.1016/j.ejmg.2024.104947
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  2. Artikel ; Online: Choroid plexus cauterization to treat inadequate abdominal cerebrospinal fluid absorption: case report.

    Zima, Laura A / Belal, Ahmed M / Sandberg, David I

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2021  Band 38, Heft 4, Seite(n) 817–820

    Abstract: Introduction: Inadequate absorption of cerebrospinal fluid (CSF) in the setting of high CSF production is a relatively rare cause of shunt malfunction.: Case report: We present the unique case of a 3-year-old boy who developed sterile ascites and ... ...

    Abstract Introduction: Inadequate absorption of cerebrospinal fluid (CSF) in the setting of high CSF production is a relatively rare cause of shunt malfunction.
    Case report: We present the unique case of a 3-year-old boy who developed sterile ascites and abdominal distension in a delayed fashion after shunt placement. The shunt was externalized, and the patient was noted to have high CSF output. Bilateral choroid plexus cauterization resulted in a significant decrease in CSF production and enabled the shunt to be re-inserted into the abdomen.
    Mesh-Begriff(e) Abdomen/surgery ; Cautery/methods ; Cerebrospinal Fluid ; Child, Preschool ; Choroid Plexus/surgery ; Humans ; Hydrocephalus/surgery ; Male ; Ventriculostomy/methods
    Sprache Englisch
    Erscheinungsdatum 2021-07-26
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-021-05298-2
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  3. Artikel ; Online: Acoustic Photometry of Biomedical Parameters for Association with Diabetes and Covid-19

    Abdulrahman Imad / Noreha Abdul Malik / Belal Ahmed Hamida / Gan Hong Hong Seng / Sheroz Khan

    Emerging Science Journal, Vol 6, Iss 0, Pp 42-

    2022  Band 56

    Abstract: Because of their mortality rate, diabetes and COVID-19 are serious diseases. Moreover, people with diabetes are at a higher risk of developing COVID-19 complications. This article therefore proposes a single, non-invasive system that can help people with ...

    Abstract Because of their mortality rate, diabetes and COVID-19 are serious diseases. Moreover, people with diabetes are at a higher risk of developing COVID-19 complications. This article therefore proposes a single, non-invasive system that can help people with diabetes and COVID-19 to monitor their health parameters by measuring oxygen saturation (SPO2), heart rate, and body temperature. This is in contrast to other pulse oximeters and previous work reported in the literature. A Max30102 sensor, consisting of two light-emitting diodes (LEDs), can serve as a transmission spectrum to enable three synchronous parameter measurements. Hence, the Max30102 sensor facilitates identification of the relationship between COVID-19 and diabetes in a cost-effective manner. Fifty subjects (20 healthy, 20 diabetic, and 10 with COVID-19), aged 18-61 years, were recruited to provide data on heart rate, body temperature, and oxygen saturation, measured in a variety of activities and scenarios. The results showed accuracy of ±97% for heart rate, ±98% for body temperature, and ±99% for oxygen saturation with an enhanced time efficiency of 5-7 seconds in contrast to a commercialized pulse oximeter, which took 10-12 seconds. The results were then compared with those of commercially available pulse oximetry (Oxitech Pulse Oximeter) and a thermometer (Medisana Infrared Thermometer). These results revealed that uncontrolled diabetes can be as dangerous as COVID-19 in terms of high resting heart rate and low oxygen saturation. Doi:10.28991/esj-2022-SPER-04 Full Text: PDF
    Schlagwörter max30102 sensor ; diabetes ; covid-19 ; oxygen saturation ; heart rate ; body temperature ; Technology (General) ; T1-995 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Ital Publication
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Cervical Spine Injury in Children and Adolescents.

    Jea, Andrew / Belal, Ahmed / Zaazoue, Mohamed A / Martin, Jonathan

    Pediatric clinics of North America

    2021  Band 68, Heft 4, Seite(n) 875–894

    Abstract: Complaints related to the neck are common following mild pediatric trauma. Although significant cervical spine injuries are most often seen and evaluated in the emergency room or inpatient setting, the primary care provider is faced with the evaluation ... ...

    Abstract Complaints related to the neck are common following mild pediatric trauma. Although significant cervical spine injuries are most often seen and evaluated in the emergency room or inpatient setting, the primary care provider is faced with the evaluation of lower acuity complaints. We provide a review to assist with the efficient evaluation of these patients to facilitate decisions regarding return to play, the need for imaging, and need for referral to subspecialty providers.
    Mesh-Begriff(e) Adolescent ; Athletic Injuries/diagnostic imaging ; Athletic Injuries/epidemiology ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/injuries ; Child ; Evidence-Based Medicine ; Humans ; Postoperative Period ; Risk Factors ; Spinal Injuries/diagnostic imaging ; Spinal Injuries/enzymology ; Wounds, Nonpenetrating/diagnostic imaging ; Wounds, Nonpenetrating/epidemiology
    Sprache Englisch
    Erscheinungsdatum 2021-07-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 215711-1
    ISSN 1557-8240 ; 0031-3955
    ISSN (online) 1557-8240
    ISSN 0031-3955
    DOI 10.1016/j.pcl.2021.04.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Postoperative Cutaneous Manifestations as the First Presentation of COVID-19 Infection or a Postvaccination Sequel.

    El Minawi, Hisham / Abdelgawad, Ahmed / El Saloussy, Yasmeen / Abdelgawad, Belal Ahmed

    Plastic and reconstructive surgery. Global open

    2022  Band 10, Heft 2, Seite(n) e4163

    Abstract: Since its first emergence, coronavirus disease 2019 (COVID-19) took the world by surprise, causing more than two million deaths and 100 million infections to date. The virus's most prevalent clinical symptoms have become well known, yet the rarer ... ...

    Abstract Since its first emergence, coronavirus disease 2019 (COVID-19) took the world by surprise, causing more than two million deaths and 100 million infections to date. The virus's most prevalent clinical symptoms have become well known, yet the rarer symptoms, on the other hand, need to be more widely recognized. Various studies have reflected the possibilities of potential skin lesions being the presenting signs of COVID-19 infection. Acquaintance with the cutaneous presentations of COVID-19 may help in early diagnosis and management of infected patients. Herein we report two cases that presented for plastic surgical interventions in which skin manifestations were the first indicators of COVID-19 infection or postvaccination sequel. The cases were operated upon in different hospitals by different surgical teams.
    Sprache Englisch
    Erscheinungsdatum 2022-02-23
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004163
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  6. Artikel ; Online: Insights on the in-vitro binding interaction between donepezil and bovine serum albumin.

    El Gammal, Reem N / Elmansi, Heba / El-Emam, Ali A / Belal, Fathalla / Elzahhar, Perihan A / Belal, Ahmed S F / Hammouda, Mohammed E A

    BMC chemistry

    2023  Band 17, Heft 1, Seite(n) 31

    Abstract: In this work, the binding mechanism between donepezil (DNP) and bovine serum albumin (BSA) was established using several techniques, including fluorimetry, UV- spectrophotometry, synchronous fluorimetry (SF), fourier transform infrared (FTIR), ... ...

    Abstract In this work, the binding mechanism between donepezil (DNP) and bovine serum albumin (BSA) was established using several techniques, including fluorimetry, UV- spectrophotometry, synchronous fluorimetry (SF), fourier transform infrared (FTIR), fluorescence resonance energy transfer (FRET) besides molecular docking study. The fluorescence quenching mechanism of DNP-BSA binding was a combined dynamic and static quenching. The thermodynamic parameters, binding forces, binding constant, and the number of binding sites were determined using a different range of temperature settings. Van't Hoff's equation was used to calculate the reaction parameters, including enthalpy change (ΔH
    Sprache Englisch
    Erscheinungsdatum 2023-04-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ISSN 2661-801X
    ISSN (online) 2661-801X
    DOI 10.1186/s13065-023-00944-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment.

    El-Yazbi, Ahmed F / Elrewiny, Mohamed A / Habib, Hosam M / Eid, Ali H / Elzahhar, Perihan A / Belal, Ahmed S F

    Molecular pharmacology

    2023  Band 104, Heft 5, Seite(n) 187–194

    Abstract: Cardiovascular complications of diabetes and obesity remain a major cause for morbidity and mortality worldwide. Despite significant advances in the pharmacotherapy of metabolic disease, the available approaches do not prevent or slow the progression of ... ...

    Abstract Cardiovascular complications of diabetes and obesity remain a major cause for morbidity and mortality worldwide. Despite significant advances in the pharmacotherapy of metabolic disease, the available approaches do not prevent or slow the progression of complications. Moreover, a majority of patients present with significant vascular involvement at early stages of dysfunction prior to overt metabolic changes. The lack of disease-modifying therapies affects millions of patients globally, causing a massive economic burden due to these complications. Significantly, adipose tissue inflammation was implicated in the pathogenesis of metabolic syndrome, diabetes, and obesity. Specifically, perivascular adipose tissue (PVAT) and perirenal adipose tissue (PRAT) depots influence cardiovascular and renal structure and function. Accumulating evidence implicates localized PVAT/PRAT inflammation as the earliest response to metabolic impairment leading to cardiorenal dysfunction. Increased mitochondrial uncoupling protein 1 (UCP1) expression and function lead to PVAT/PRAT hypoxia and inflammation as well as vascular, cardiac, and renal dysfunction. As UCP1 function remains an undruggable target so far, modulation of the augmented UCP1-mediated PVAT/PRAT thermogenesis constitutes a lucrative target for drug development to mitigate early cardiorenal involvement. This can be achieved either by subtle targeted reduction in UCP-1 expression using innovative proteolysis activating chimeric molecules (PROTACs) or by supplementation with cyclocreatine phosphate, which augments the mitochondrial futile creatine cycling and thus decreases UCP1 activity, enhances the efficiency of oxygen use, and reduces hypoxia. Once developed, these molecules will be first-in-class therapeutic tools to directly interfere with and reverse the earliest pathology underlying cardiac, vascular, and renal dysfunction accompanying the early metabolic deterioration. SIGNIFICANCE STATEMENT: Adipose tissue dysfunction plays a major role in the pathogenesis of metabolic diseases and their complications. Although mitochondrial alterations are common in metabolic impairment, it was only recently shown that the early stages of metabolic challenge involve inflammatory changes in select adipose depots associated with increased uncoupling protein 1 thermogenesis and hypoxia. Manipulating this mode of thermogenesis can help mitigate the early inflammation and the consequent cardiorenal complications.
    Mesh-Begriff(e) Humans ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, Brown/pathology ; Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Obesity/complications ; Obesity/metabolism ; Thermogenesis ; Inflammation/complications ; Inflammation/metabolism ; Hypoxia/metabolism ; Hypoxia/pathology ; Kidney Diseases/drug therapy ; Kidney Diseases/etiology ; Kidney Diseases/metabolism ; Uncoupling Protein 1/metabolism
    Chemische Substanzen Uncoupling Protein 1
    Sprache Englisch
    Erscheinungsdatum 2023-08-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 124034-1
    ISSN 1521-0111 ; 0026-895X
    ISSN (online) 1521-0111
    ISSN 0026-895X
    DOI 10.1124/molpharm.123.000704
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Buch: Bedouins by the lake

    Belal, Ahmed

    environment, change, and sustainability in southern Egypt

    2009  

    Verfasserangabe Ahmed Belal ... [et al.]
    Schlagwörter Bedouins/History. ; Sustainable development ; Nasser, Lake (Egypt and Sudan)
    Sprache Englisch
    Umfang xv, 184 p. :, ill., maps ;, 24 cm.
    Verlag American University in Cairo Press
    Erscheinungsort Cairo ; New York
    Dokumenttyp Buch
    ISBN 9789774161988 ; 977416198X
    Datenquelle NAL Katalog (AGRICOLA)

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  9. Artikel ; Online: Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes.

    Elzahhar, Perihan A / Orioli, Rebecca / Hassan, Nayera W / Gobbi, Silvia / Belluti, Federica / Labib, Hala F / El-Yazbi, Ahmed F / Nassra, Rasha / Belal, Ahmed S F / Bisi, Alessandra

    European journal of medicinal chemistry

    2024  Band 266, Seite(n) 116138

    Abstract: As a new approach to the management of inflammatory disorders, a series of chromone-based derivatives containing a (carbamate)hydrazone moiety was designed and synthesized. The compounds were assessed for their ability to inhibit COX-1/2, 15-LOX, and ... ...

    Abstract As a new approach to the management of inflammatory disorders, a series of chromone-based derivatives containing a (carbamate)hydrazone moiety was designed and synthesized. The compounds were assessed for their ability to inhibit COX-1/2, 15-LOX, and mPGES-1, as a combination that should effectively impede the arachidonate pathway. Results revealed that the benzylcarbazates (2a-c) demonstrated two-digit nanomolar COX-2 inhibitory activities with reasonable selectivity indices. They also showed appreciable 15-LOX inhibition, in comparison to quercetin. Further testing of these compounds for mPGES-1 inhibition displayed promising activities. Intriguingly, compounds 2a-c were capable of suppressing edema in the formalin-induced rat paw edema assay. They exhibited an acceptable gastrointestinal safety profile regarding ulcerogenic liabilities in gross and histopathological examinations. Additionally, upon treatment with the test compounds, the expression of the anti-inflammatory cytokine IL-10 was elevated, whereas that of TNF-α, iNOS, IL-1β, and COX-2 were downregulated in LPS-challenged RAW264.7 macrophages. Docking experiments into the three enzymes showed interesting binding profiles and affinities, further substantiating their biological activities. Their in silico physicochemical and pharmacokinetic parameters were advantageous.
    Mesh-Begriff(e) Rats ; Animals ; Cyclooxygenase 2/metabolism ; Lipoxygenase Inhibitors/chemistry ; Cyclooxygenase 1/metabolism ; Anti-Inflammatory Agents/pharmacology ; Arachidonic Acids ; Edema/chemically induced ; Edema/drug therapy ; Molecular Docking Simulation ; Cyclooxygenase 2 Inhibitors/pharmacology ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Arachidonate 5-Lipoxygenase/metabolism ; Structure-Activity Relationship
    Chemische Substanzen Cyclooxygenase 2 (EC 1.14.99.1) ; Lipoxygenase Inhibitors ; Cyclooxygenase 1 (EC 1.14.99.1) ; Anti-Inflammatory Agents ; Arachidonic Acids ; Cyclooxygenase 2 Inhibitors ; Arachidonate 5-Lipoxygenase (EC 1.13.11.34)
    Sprache Englisch
    Erscheinungsdatum 2024-01-10
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116138
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  10. Artikel ; Online: Histopathological correlation of brain tumor recurrence vs. radiation effect post-radiosurgery as detected by MRI contrast clearance analysis: a validation study.

    Goulenko, Victor / Madhugiri, Venkatesh Shankar / Bregy, Amade / Recker, Matthew / Lipinski, Lindsay / Fabiano, Andrew / Fenstermaker, Robert / Plunkett, Robert / Abad, Ajay / Belal, Ahmed / Alberico, Ronald / Qiu, Jingxin / Prasad, Dheerendra

    Journal of neuro-oncology

    2024  

    Abstract: Purpose: The differentiation between adverse radiation effects (ARE) and tumor recurrence or progression (TRP) is a major decision-making point in the follow-up of patients with brain tumors. The advent of immunotherapy, targeted therapy and ... ...

    Abstract Purpose: The differentiation between adverse radiation effects (ARE) and tumor recurrence or progression (TRP) is a major decision-making point in the follow-up of patients with brain tumors. The advent of immunotherapy, targeted therapy and radiosurgery has made this distinction difficult to achieve in several clinical situations. Contrast clearance analysis (CCA) is a useful technique that can inform clinical decisions but has so far only been histologically validated in the context of high-grade gliomas.
    Methods: This is a series of 7 patients, treated between 2018 and 2023, for various brain pathologies including brain metastasis, atypical meningioma, and high-grade glioma. MRI with contrast clearance analysis was used to inform clinical decisions and patients underwent surgical resection as indicated. The histopathology findings were compared with the CCA findings in all cases.
    Results: All seven patients had been treated with gamma knife radiosurgery and were followed up with periodic MR imaging. All patients underwent CCA when the necessity to distinguish tumor recurrence from radiation necrosis arose, and subsequently underwent surgery as indicated. Concordance of CCA findings with histological findings was found in all cases (100%).
    Conclusions: Based on prior studies on GBM and the surgical findings in our series, delayed contrast extravasation MRI findings correlate well with histopathology across a wide spectrum of brain tumor pathologies. CCA can provide a quick diagnosis and have a direct impact on patients' treatment and outcomes.
    Sprache Englisch
    Erscheinungsdatum 2024-05-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-024-04697-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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