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  1. Article ; Online: Strengths and challenges in current lung cancer care: Timeliness and diagnostic procedures in six Dutch hospitals.

    Genet, Sylvia A A M / Visser, Esther / Youssef-El Soud, Maggy / Belderbos, Huub N A / Stege, Gerben / de Saegher, Marleen E A / Westeinde, Susan C van 't / Brunsveld, Luc / Broeren, Maarten A C / van de Kerkhof, Daan / Eduati, Federica / van den Borne, Ben E E M / Scharnhorst, Volkher

    Lung cancer (Amsterdam, Netherlands)

    2024  Volume 189, Page(s) 107477

    Abstract: Objectives: Timely diagnosis of lung cancer (LC) is crucial to achieve optimal patient care and outcome. Moreover, the number of procedures required to obtain a definitive diagnosis can have a large influence on the life expectancy of a patient. Here, ... ...

    Abstract Objectives: Timely diagnosis of lung cancer (LC) is crucial to achieve optimal patient care and outcome. Moreover, the number of procedures required to obtain a definitive diagnosis can have a large influence on the life expectancy of a patient. Here, adherence with existing Dutch guidelines for timeliness and type and number of invasive and imaging procedures was assessed.
    Materials and methods: 1096 patients with suspected LC were enrolled in this multicenter prospective study (NL9146). The overall survival, time from referral to the first appointment with the pulmonologist, time to diagnosis and treatment, and the number of imaging and invasive procedures were evaluated. Patients were divided into different diagnostic groupsearly- and advanced stage non-small-cell lung cancer (NSCLC), small-cell lung cancer (SCLC), large cell neuroendocrine carcinoma of the lung (LCNEC), patients without LC and patients without a definitive diagnosis.
    Results: The majority of patients (66 %) received a definitive diagnosis within 5 weeks, although the time to diagnosis of early-stage LC patients and patients without LC was significantly longer comparted to advanced stage LC. An increase in invasive procedures was seen for early-stage LC compared to advanced stage LC and for 13 % of the advanced stage non-squamous NSCLC patients up to three additional invasive procedures were performed solely to obtain sufficient material for NGS. For patients without a definitive diagnosis, 50 % did undergo at least one invasive procedure, while 11 % did not wish to undergo any invasive procedures.
    Conclusion: These insights could aid in improved LC diagnostics and efficient implementation of new techniques like liquid biopsy and artificial intelligence. This may lead to more timely LC care, a decreased number of invasive procedures, less variability between the diagnostic trajectory of different patients and aid in obtaining a definitive diagnosis for all patients.
    MeSH term(s) Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/therapy ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/therapy ; Artificial Intelligence ; Prospective Studies ; Hospitals ; Carcinoma, Neuroendocrine ; Lung
    Language English
    Publishing date 2024-01-22
    Publishing country Ireland
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2024.107477
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  2. Article ; Online: Reply to Fekkar

    Bentvelsen, Robbert G / van Arkel, Andreas L E / Rijpstra, Tom A / Belderbos, Huub N A / van Wijngaarden, Peter / Verweij, Paul E

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 6, Page(s) 903–904

    MeSH term(s) Aspergillosis ; Aspergillus ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202006-2241LE
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  3. Article ; Online: COVID-19-associated Pulmonary Aspergillosis.

    van Arkel, Andreas L E / Rijpstra, Tom A / Belderbos, Huub N A / van Wijngaarden, Peter / Verweij, Paul E / Bentvelsen, Robbert G

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 1, Page(s) 132–135

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Fatal Outcome ; Humans ; Male ; Middle Aged ; Netherlands ; Pandemics ; Pneumonia, Viral/complications ; Pulmonary Aspergillosis/complications ; Pulmonary Aspergillosis/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202004-1038LE
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  4. Article ; Online: Liquid biopsy-based decision support algorithms for diagnosis and subtyping of lung cancer.

    Visser, Esther / Genet, Sylvia A A M / de Kock, Remco P P A / van den Borne, Ben E E M / Youssef-El Soud, Maggy / Belderbos, Huub N A / Stege, Gerben / de Saegher, Marleen E A / van 't Westeinde, Susan C / Brunsveld, Luc / Broeren, Maarten A C / van de Kerkhof, Daan / Deiman, Birgit A L M / Eduati, Federica / Scharnhorst, Volkher

    Lung cancer (Amsterdam, Netherlands)

    2023  Volume 178, Page(s) 28–36

    Abstract: Objectives: Pathologic subtyping of tissue biopsies is the gold standard for the diagnosis of lung cancer (LC), which could be complicated in cases of e.g. inconclusive tissue biopsies or unreachable tumors. The diagnosis of LC could be supported in a ... ...

    Abstract Objectives: Pathologic subtyping of tissue biopsies is the gold standard for the diagnosis of lung cancer (LC), which could be complicated in cases of e.g. inconclusive tissue biopsies or unreachable tumors. The diagnosis of LC could be supported in a minimally invasive manner using protein tumor markers (TMs) and circulating tumor DNA (ctDNA) measured in liquid biopsies (LBx). This study evaluates the performance of LBx-based decision-support algorithms for the diagnosis of LC and subtyping into small- and non-small-cell lung cancer (SCLC and NSCLC) aiming to directly impact clinical practice.
    Materials and methods: In this multicenter prospective study (NL9146), eight protein TMs (CA125, CA15.3, CEA, CYFRA 21-1, HE4, NSE, proGRP and SCCA) and ctDNA mutations in EGFR, KRAS and BRAF were analyzed in blood of 1096 patients suspected of LC. The performance of individual and combined TMs to identify LC, NSCLC or SCLC was established by evaluating logistic regression models at pre-specified positive predictive values (PPV) of ≥95% or ≥98%. The most informative protein TMs included in the multi-parametric models were selected by recursive feature elimination.
    Results: Single TMs could identify LC, NSCLC and SCLC patients with 46%, 25% and 40% sensitivity, respectively, at pre-specified PPVs. Multi-parametric models combining TMs and ctDNA significantly improved sensitivities to 65%, 67% and 50%, respectively.
    Conclusion: In patients suspected of LC, the LBx-based decision-support algorithms allowed identification of about two-thirds of all LC and NSCLC patients and half of SCLC patients. These models therefore show clinical value and may support LC diagnostics, especially in patients for whom pathologic subtyping is impossible or incomplete.
    MeSH term(s) Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Prospective Studies ; Biomarkers, Tumor ; Phosphopyruvate Hydratase ; Liquid Biopsy
    Chemical Substances antigen CYFRA21.1 ; Biomarkers, Tumor ; Phosphopyruvate Hydratase (EC 4.2.1.11)
    Language English
    Publishing date 2023-02-01
    Publishing country Ireland
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2023.01.014
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  5. Article: COVID-19-associated Pulmonary Aspergillosis

    van Arkel, Andreas L E / Rijpstra, Tom A / Belderbos, Huub N A / van Wijngaarden, Peter / Verweij, Paul E / Bentvelsen, Robbert G

    Am J Respir Crit Care Med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #739087
    Database COVID19

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  6. Article ; Online: Acute respiratoire insufficiëntie door COPD: beslissen over wel of niet beademen.

    Kant, K Merijn / Djamin, Remco S / Belderbos, Huub N A / van den Berg, Bart

    Nederlands tijdschrift voor geneeskunde

    2014  Volume 158, Page(s) A5276

    Abstract: The decision to move to a form of mechanical ventilation in patients with acute respiratory failure due to an acute exacerbation of COPD is influenced by expectations about survival and quality of life after discharge from the ICU. Physicians tend to be ... ...

    Title translation Acute respiratory insufficiency due to COPD: invasive mechanical ventilation or not?.
    Abstract The decision to move to a form of mechanical ventilation in patients with acute respiratory failure due to an acute exacerbation of COPD is influenced by expectations about survival and quality of life after discharge from the ICU. Physicians tend to be too pessimistic about the survival outcome of an ICU stay with invasive mechanical ventilation. The forced expiratory volume in 1 second (FEV1) is not an adequate prognostic parameter. In order to prevent undertreatment of patients with respiratory failure due to an exacerbation of COPD, knowledge of prognostic parameters and quality of life in these patients is very important. End of life care should be integrated into the standard care of COPD patients.
    MeSH term(s) Acute Disease ; Humans ; Prognosis ; Pulmonary Disease, Chronic Obstructive/complications ; Quality of Life ; Respiration, Artificial/methods ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/psychology ; Respiratory Insufficiency/therapy ; Terminal Care ; Treatment Outcome
    Language Dutch
    Publishing date 2014
    Publishing country Netherlands
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  7. Article ; Online: Correction of the NSE concentration in hemolyzed serum samples improves its diagnostic accuracy in small-cell lung cancer.

    Genet, Sylvia A A M / Visser, Esther / van den Borne, Ben E E M / Soud, Maggy Youssef-El / Belderbos, Huub N A / Stege, Gerben / de Saegher, Marleen E A / Eduati, Federica / Broeren, Maarten A C / van Dongen, Joost / Brunsveld, Luc / van de Kerkhof, Daan / Scharnhorst, Volkher

    Oncotarget

    2020  Volume 11, Issue 27, Page(s) 2660–2668

    Abstract: Neuron-specific enolase (NSE) is a well-known biomarker for the diagnosis, prognosis and treatment monitoring of small-cell lung cancer (SCLC). Nevertheless, its clinical applicability is limited since serum NSE levels are influenced by hemolysis, ... ...

    Abstract Neuron-specific enolase (NSE) is a well-known biomarker for the diagnosis, prognosis and treatment monitoring of small-cell lung cancer (SCLC). Nevertheless, its clinical applicability is limited since serum NSE levels are influenced by hemolysis, leading to falsely elevated results. Therefore, this study aimed to develop a hemolysis correction equation and evaluate its role in SCLC diagnostics. Two serum pools were spiked with increasing amounts of hemolysate obtained from multiple individuals. A hemolysis correction equation was obtained by analyzing the relationship between the measured NSE concentration and the degree of hemolysis. The equation was validated using intentionally hemolyzed serum samples, which showed that the correction was accurate for samples with an H-index up to 30 μmol/L. Correction of the measured NSE concentration in patients suspected of lung cancer caused an increase in AUC and a significantly lower cut-off value for SCLC detection when compared to uncorrected results. Therefore, a hemolysis correction equation should be used to correct falsely elevated NSE concentrations. Results of samples with an H-index above 30 μmol/L should not be reported to clinicians. Application of the equation illustrates the importance of hemolysis correction in SCLC diagnostics and questions the correctness of the currently used diagnostic cut-off value.
    Language English
    Publishing date 2020-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.27664
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  8. Article ; Online: Influence of Cow's Milk and Esomeprazole on the Absorption of Erlotinib: A Randomized, Crossover Pharmacokinetic Study in Lung Cancer Patients.

    Veerman, G D Marijn / Hussaarts, Koen G A M / Peric, Robert / Oomen-de Hoop, Esther / Landa, Kersten D / van der Leest, Cor H / Broerse, Suzanna D / Rutten, Hugo B / Belderbos, Huub N A / Steendam, Christi M J / Paats, Marthe S / Koolen, Stijn L W / Dingemans, Anne-Marie C / van Gelder, Teun / van Leeuwen, Roelof W F / Aerts, Joachim G J V / Mathijssen, Ron H J

    Clinical pharmacokinetics

    2020  Volume 60, Issue 1, Page(s) 69–77

    Abstract: Introduction: Erlotinib's gastrointestinal solubility and absorption are decreased by proton pump inhibitors (PPIs). Since erlotinib is a lipophilic drug, we hypothesized that concomitant intake with the fatty beverage milk may be a feasible way to ... ...

    Abstract Introduction: Erlotinib's gastrointestinal solubility and absorption are decreased by proton pump inhibitors (PPIs). Since erlotinib is a lipophilic drug, we hypothesized that concomitant intake with the fatty beverage milk may be a feasible way to increase erlotinib uptake. We performed a two-period, randomized, crossover study to investigate the influence of cow's milk with 3.9% fat on the exposure of erlotinib with and without the PPI esomeprazole in patients with non-small cell lung cancer (NSCLC). The effect of esomeprazole was studied in an additional intrapatient comparison.
    Method: Pharmacokinetic sampling was performed on days 7 and 14 during 24 consecutive hours. During the 7 days prior to pharmacokinetic sampling, erlotinib was taken daily with 250 mL of either water or milk. In the PPI arm, esomeprazole (40 mg once daily 3 h prior to erlotinib) was taken for 3 days.
    Results: Erlotinib area under the curve from time zero to 24 h (AUC
    Conclusion: Milk with 3.9% fat has no effect on the exposure to erlotinib in NSCLC patients, independent of PPI use. The combination with milk is safe and well tolerated. Concomitant esomeprazole treatment strongly decreased both erlotinib AUC
    MeSH term(s) Aged ; Animals ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; Cross-Over Studies ; Drug Interactions ; Erlotinib Hydrochloride/pharmacology ; Esomeprazole/pharmacology ; Female ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Male ; Middle Aged ; Milk/metabolism ; Proton Pump Inhibitors/pharmacokinetics ; Proton Pump Inhibitors/pharmacology
    Chemical Substances Proton Pump Inhibitors ; Erlotinib Hydrochloride (DA87705X9K) ; Esomeprazole (N3PA6559FT)
    Language English
    Publishing date 2020-06-17
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 197627-8
    ISSN 1179-1926 ; 0312-5963
    ISSN (online) 1179-1926
    ISSN 0312-5963
    DOI 10.1007/s40262-020-00910-1
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