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Article ; Online: The Application of Graphene Oxide Nanoarchitectures in the Treatment of Cancer: Phototherapy, Immunotherapy, and the Development of Vaccines.

Bhattacharya, Sankha / Belemkar, Sateesh / Prajapati, Bhupendra

2024

Abstract: Nanoparticles have been crucial in redesigning tumour eradication techniques, and recent advances in cancer research have accelerated the creation and integration of multifunctional nanostructures. In the fight against treatment resistance, which has ... ...

Abstract	Nanoparticles have been crucial in redesigning tumour eradication techniques, and recent advances in cancer research have accelerated the creation and integration of multifunctional nanostructures. In the fight against treatment resistance, which has reduced the effectiveness of traditional radiation and chemotherapy, this paradigm change is of utmost importance. Graphene oxide (GO) is one of several nanoparticles made of carbon that has made a splash in the medical field. It offers potential new ways to treat cancer thanks to its nanostructures, which can precisely transfer genetic elements and therapeutic chemicals to tumour areas. Encapsulating genes, protecting them from degradation, and promoting effective genetic uptake by cancer cells are two of GO nanostructures' greatest strengths, in addition to improving drug pharmacokinetics and bioavailability by concentrating therapeutic compounds at particular tumour regions. In addition, photodynamic treatment (PDT) and photothermal therapy (PTT), which use GO nanoparticles to reduce carcinogenesis, have greatly slowed tumour growth due to GO's phototherapy capabilities. In addition to their potential medical uses, GO nanoparticles are attractive vaccine candidates due to their ability to stimulate cellular and innate immunity. These nanoparticles can be used to detect, diagnose, and eradicate cancer because they respond to certain stimuli. The numerous advantages of GO nanoparticles for tumour eradication are attributed in large part to their primary route of internalisation through endocytosis, which guarantees accurate delivery to target locations. The revolutionary potential of multifunctional nanostructures in cancer treatment is highlighted in this extensive compendium that examines current oncological breakthroughs.
Language	English
Publishing date	2024-02-15
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0109298673288750240117115141
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Article ; Online: pH-sensitive nanoparticles of enhanced epigallocatechin-3-gallate in colorectal cancer therapy.

Bhattacharya, Sankha / Sangave, Preeti Chidambar / Belemkar, Sateesh / Anjum, Md Meraj

Nanomedicine (London, England)

2024

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2277839-1
ISSN	1748-6963 ; 1743-5889
ISSN (online)	1748-6963
ISSN	1743-5889
DOI	10.2217/nnm-2023-0342
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Article ; Online: An update on Alzheimer's disease: Immunotherapeutic agents, stem cell therapy and gene editing.

Patwardhan, Aryaman Girish / Belemkar, Sateesh

Life sciences

2021 Volume 282, Page(s) 119790

Abstract: Alzheimer's disease is a chronic lifestyle ailment whose occurrence has come to light with the increasing life expectancy due to better healthcare. The patient burden for AD is set to double by the year 2060 and advancement in research is of utmost ... ...

Abstract	Alzheimer's disease is a chronic lifestyle ailment whose occurrence has come to light with the increasing life expectancy due to better healthcare. The patient burden for AD is set to double by the year 2060 and advancement in research is of utmost importance to combat this problem. AD is characterized by the pathological hallmarks of amyloid plaques and neurofibrillary tangles. The disease has been implicated to have a genetic predisposition. The current treatment strategies are at best ameliorative in nature and offer no substantive cure. Immunotherapeutic approaches employed have shown few therapeutic benefits but the accelerated approval of aducanumab by the US-FDA shows clinical benefit merit. In addition, newer therapeutic approaches are the need of the hour. This review aims to highlight the pathology of the disease, followed by an insight into newer approaches like stem cell therapy and gene editing, focusing on possible CRISPR mediated targets.
MeSH term(s)	Alzheimer Disease/genetics ; Alzheimer Disease/immunology ; Alzheimer Disease/therapy ; Animals ; Gene Editing/methods ; Genetic Therapy/methods ; Humans ; Immunotherapy/methods ; Stem Cell Transplantation/methods
Language	English
Publishing date	2021-07-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119790
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Article: An update on Alzheimer's disease: Immunotherapeutic agents, stem cell therapy and gene editing

Patwardhan, Aryaman Girish / Belemkar, Sateesh

Life sciences. 2021 Oct. 01, v. 282

2021

Abstract	Alzheimer's disease is a chronic lifestyle ailment whose occurrence has come to light with the increasing life expectancy due to better healthcare. The patient burden for AD is set to double by the year 2060 and advancement in research is of utmost importance to combat this problem. AD is characterized by the pathological hallmarks of amyloid plaques and neurofibrillary tangles. The disease has been implicated to have a genetic predisposition. The current treatment strategies are at best ameliorative in nature and offer no substantive cure. Immunotherapeutic approaches employed have shown few therapeutic benefits but the accelerated approval of aducanumab by the US-FDA shows clinical benefit merit. In addition, newer therapeutic approaches are the need of the hour. This review aims to highlight the pathology of the disease, followed by an insight into newer approaches like stem cell therapy and gene editing, focusing on possible CRISPR mediated targets.
Keywords	Alzheimer disease ; amyloid ; genes ; genetic predisposition to disease ; health services ; immunotherapy ; lifestyle ; longevity ; patients ; stem cells
Language	English
Dates of publication	2021-1001
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119790
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Article ; Online: A New Strategy for the Software-Assisted LC Separations of Ketoconazole and Its Impurities.

Agrawal, Roopali / Belemkar, Sateesh / Bonde, Chandrakant

Journal of chromatographic science

2022 Volume 61, Issue 5, Page(s) 418–427

Abstract: Analytical quality by design and the use of dissimilar chromatographic systems can be employed to accelerate chromatographic separations. Herein, a software (S-Matrix)-assisted platform was used to proficiently screen, optimize and select the optimal ... ...

Abstract	Analytical quality by design and the use of dissimilar chromatographic systems can be employed to accelerate chromatographic separations. Herein, a software (S-Matrix)-assisted platform was used to proficiently screen, optimize and select the optimal parameters for the chromatographic separation of ketoconazole and its related impurities. This approach evaluated the various chromatographic parameters in a stepwise manner based on the statistical tools and provided an in-depth understanding of the critical parameters influencing the peak selectivities and separations. It was demonstrated that dissimilar conditions, such as different stationary phases, mobile phase pH and organic modifiers (i.e., critical method variables), can improve the peak resolution, while the critical quality attributes can provide conditions appropriate for quantification purposes via a quality target analytical method. Furthermore, an orthogonal method was established to support the primary method. The orthogonality between the two methods was defined by the correlation matrix between the two systems using the Pearson correlation coefficient and was found to be 0.12. Using the optimized method, the primary method was validated as per International Council for Harmonization in the range of 0.05-1.0% for impurities and 80.0-120.0% for ketoconazole, thereby indicating the suitability of the method for use in quality control laboratories.
Language	English
Publishing date	2022-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80141-0
ISSN	1945-239X ; 0021-9665
ISSN (online)	1945-239X
ISSN	0021-9665
DOI	10.1093/chromsci/bmac049
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Article ; Online: Toxicity profiling of the ethanolic extract of Citrullus lanatus seed in rats: behavioral, biochemical and histopathological aspects.

Belemkar, Sateesh / Shendge, Parshuram Nivrutti

Bioscience reports

2020 Volume 41, Issue 1

Abstract: Citrullus lanatus (Cucurbitaceae) is conventionally used for the treatment of urinary tract infection, renal stones, hypertension, diabetes and diarrhoea. Current study evaluates acute and 28 days repeated toxicity ethanolic extract of C. lanatus seed ( ... ...

Abstract	Citrullus lanatus (Cucurbitaceae) is conventionally used for the treatment of urinary tract infection, renal stones, hypertension, diabetes and diarrhoea. Current study evaluates acute and 28 days repeated toxicity ethanolic extract of C. lanatus seed (EECLS) in Wistar rats to measure its safety profile. The single dose (2000 mg/kg BW) of EECLS was administered while in 28 days repeated study 250, 500 and 1000 mg/kg BW were administered orally in rats. Parameters such as biochemical, haematological and histopathological were analysed in subacute toxicity study. During study, no apparent sign of toxicity, behavioural changes and mortality were detected in acutely exposed animals. In 28 days repeated toxicity study, rats did not show significant changes in behaviour, gross pathology, body weight, biochemical and haematological parameters. Abridged serum glucose and cholesterol levels during the study designate their roles in treatment of hyperglycaemic and hyperlipidaemic conditions. No significant difference was observed in histopathology of liver and kidneys of treated rats. The current investigation demonstrated that EECLS is non-toxic below 1000 mg/kg BW and provides protection to some body organs. The data propose that LD50 of EECLS was greater than 2000 mg/kg BW and the no observed adverse effect level (NOAEL) of EECLS was at the dose of 1000 mg/kg in rats. Taken together, our finding suggests that, EECLS is safe and provides some protection to body organs; also, its extract can be used for further preclinical and clinical evaluation for its therapeutic activity.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Body Weight/drug effects ; Citrullus/embryology ; Clinical Chemistry Tests/methods ; Dose-Response Relationship, Drug ; Ethanol/chemistry ; Kidney/drug effects ; Kidney/pathology ; Liver/drug effects ; Liver/pathology ; No-Observed-Adverse-Effect Level ; Plant Extracts/administration & dosage ; Plant Extracts/toxicity ; Rats ; Rats, Wistar ; Seeds/chemistry ; Toxicity Tests, Acute
Chemical Substances	Plant Extracts ; Ethanol (3K9958V90M)
Language	English
Publishing date	2020-12-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20202345
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Article ; Online: Acute and 28-day oral toxicity studies of methanolic extract of

Shendge, Parshuram Nivrutti / Belemkar, Sateesh

Drug and chemical toxicology

2019 Volume 44, Issue 5, Page(s) 493–501

Abstract: Lagenaria ... ...

Abstract	Lagenaria siceraria
MeSH term(s)	Administration, Oral ; Animals ; Cucurbitaceae/chemistry ; Dose-Response Relationship, Drug ; Female ; Fruit ; Lethal Dose 50 ; Male ; Methanol/chemistry ; Plant Extracts/administration & dosage ; Plant Extracts/toxicity ; Rats ; Rats, Wistar ; Toxicity Tests, Acute ; Toxicity Tests, Subacute
Chemical Substances	Plant Extracts ; Methanol (Y4S76JWI15)
Language	English
Publishing date	2019-05-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	548368-2
ISSN	1525-6014 ; 0148-0545
ISSN (online)	1525-6014
ISSN	0148-0545
DOI	10.1080/01480545.2019.1617302
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Article ; Online: An Overview of Recent Findings that Shed Light on the Connection between Fat and Cancer.

Pandit, Parth / Shirke, Chaitanya / Bhatia, Nirav / Godad, Angel / Belemkar, Sateesh / Patel, Jayshree / Zine, Sandip

Endocrine, metabolic & immune disorders drug targets

2023 Volume 24, Issue 2, Page(s) 178–193

Abstract: Obesity and cancer have been found to have a direct link in epidemiological studies. Obesity raises the risk of cancer and associated chronic disorders. Furthermore, an imbalance of adipokines, like leptins, plays a crucial role in neoplasm pathogenesis, ...

Abstract	Obesity and cancer have been found to have a direct link in epidemiological studies. Obesity raises the risk of cancer and associated chronic disorders. Furthermore, an imbalance of adipokines, like leptins, plays a crucial role in neoplasm pathogenesis, cell migration, and thereby, cancer metastasis. Also, leptin increases human epidermal growth factor receptor 2 (HER2) protein levels through the STAT3-mediated (signal transducer and activator of transcription) upregulation of heat shock protein (Hsp90) in breast cancer cells. It has been noticed that insulin and insulin-like growth factors (IGFs) act as mitosis activators in the host and cancerous breast epithelial cells. The condition of hyperinsulinemia explains the positive association between colorectal cancer and obesity. Furthermore, in prostate cancer, an alteration in sex hormone levels, testosterone and dihydrotestosterone, has been reported to occur, along with increased oxidative stress, which is the actual cause of the tumors. Whereas, there have been two interconnected factors that play a crucial role in the psychological cycle concerned with lung cancer. The review article focuses on all the prospects of etiological mechanisms that have found linkage with obesity and breast, colon, lung, and prostate cancers. Furthermore, the article has also highlighted how these new insights into the processes occur and, due to which reasons, obesity contributes to tumorigenesis. This review provides a detailed discussion on the progression, which can assist in the development of new and innovative techniques to interfere in this process, and it has been supported with insights based on evidence literature on approved clinical treatments for obesity and cancer.
MeSH term(s)	Male ; Humans ; Leptin/metabolism ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Breast Neoplasms/metabolism ; Obesity/metabolism ; Adipokines ; Prostatic Neoplasms/complications ; Testosterone
Chemical Substances	Leptin ; Adipokines ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-07-25
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/1871530323666230724141942
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Article: Therapeutic Potential of

Shendge, Parshuram Nivrutti / Belemkar, Sateesh

Frontiers in pharmacology

2018 Volume 9, Page(s) 1177

Abstract: ... Luffa ... ...

Abstract	Luffa acutangula
Language	English
Publishing date	2018-10-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2018.01177
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Article: A Stepwise Strategy Employing Automated Screening for Reversed-Phase Chromatographic Separation of Itraconazole and Its Impurities

Agrawal, Roopali / Belemkar, Sateesh / Bonde, Chandrakant

Chromatographia. 2019 Dec., v. 82, no. 12

2019

Abstract: The development of methods for the chromatographic separation of complex mixtures is often challenging, and an organized approach is required to rapidly achieve the desired separation. Herein, software (S-Matrix Fusion)-assisted platform is used to ... ...

Abstract	The development of methods for the chromatographic separation of complex mixtures is often challenging, and an organized approach is required to rapidly achieve the desired separation. Herein, software (S-Matrix Fusion)-assisted platform is used to effectively screen, optimize, and select optimal parameters for the separation of itraconazole and its 15 impurities. The employed platform exploits dissimilar chromatographic systems, uses a diverse set of columns with enormous selectivity differences, and evaluates a wide range of aqueous mobile phase pH and organic modifiers for screening experiments. The wide range of selectivity ensures the identification and resolution of critical analytes, while the combination of dissimilar systems and automated screening statistical software increases the speed, efficiency, and level of understanding of critical parameters influencing separation. Automated screening using the described platform allows the establishment of a mass-compatible ultra-high-performance liquid chromatography method capable of separating all impurities. Multivariate robustness of critical parameters such as buffer concentration, flow rate, column temperature, and gradient is evaluated to identify the operational range of the method. Moreover, the optimized method is validated following the International Conference on Harmonization (ICH) guidelines, evaluated in terms of specificity, analysis repeatability, intermediate precision, linearity, accuracy, limit of quantification, limit of detection, solution stability, and range, and concluded to be fit for purpose in the quality control laboratories for release, stability, and investigation purposes.
Keywords	automation ; computer software ; detection limit ; high performance liquid chromatography ; itraconazole ; pH ; quality control ; screening ; temperature ; ultra-performance liquid chromatography
Language	English
Dates of publication	2019-12
Size	p. 1767-1775.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	80097-1
ISSN	0009-5893
ISSN	0009-5893
DOI	10.1007/s10337-019-03802-0
Database	NAL-Catalogue (AGRICOLA)

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