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  1. Article ; Online: In Vitro Effects of Methylprednisolone over Oligodendroglial Cells

    Ulises Gómez-Pinedo / Jordi A. Matías-Guiu / Denise Ojeda-Hernandez / Sarah de la Fuente-Martin / Ola Mohamed-Fathy Kamal / Maria Soledad Benito-Martin / Belen Selma-Calvo / Paloma Montero-Escribano / Jorge Matías-Guiu

    Cells, Vol 12, Iss 1515, p

    Foresight to Future Cell Therapies

    2023  Volume 1515

    Abstract: The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or ... ...

    Abstract The implantation of oligodendrocyte precursor cells may be a useful therapeutic strategy for targeting remyelination. However, it is yet to be established how these cells behave after implantation and whether they retain the capacity to proliferate or differentiate into myelin-forming oligodendrocytes. One essential issue is the creation of administration protocols and determining which factors need to be well established. There is controversy around whether these cells may be implanted simultaneously with corticosteroid treatment, which is widely used in many clinical situations. This study assesses the influence of corticosteroids on the capacity for proliferation and differentiation and the survival of human oligodendroglioma cells. Our findings show that corticosteroids reduce the capacity of these cells to proliferate and to differentiate into oligodendrocytes and decrease cell survival. Thus, their effect does not favour remyelination; this is consistent with the results of studies with rodent cells. In conclusion, protocols for the administration of oligodendrocyte lineage cells with the aim of repopulating oligodendroglial niches or repairing demyelinated axons should not include corticosteroids, given the evidence that the effects of these drugs may undermine the objectives of cell transplantation.
    Keywords multiple sclerosis ; HOG cells ; oligodendrocyte precursor cells ; oligodendrocytes ; corticosteroids ; demyelination ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The Integration of Cell Therapy and Biomaterials as Treatment Strategies for Remyelination

    Eneritz López-Muguruza / Natalia Villar-Gómez / Jordi A. Matias-Guiu / Belen Selma-Calvo / Lidia Moreno-Jiménez / Francisco Sancho-Bielsa / Juan Lopez-Carbonero / María Soledad Benito-Martín / Silvia García-Flores / Natalia Bonel-García / Ola Mohamed-Fathy Kamal / Denise Ojeda-Hernández / Jorge Matías-Guiu / Ulises Gómez-Pinedo

    Life, Vol 12, Iss 474, p

    2022  Volume 474

    Abstract: Multiple sclerosis (MS) is a chronic degenerative autoimmune disease of the central nervous system that causes inflammation, demyelinating lesions, and axonal damage and is associated with a high rate of early-onset disability. Disease-modifying ... ...

    Abstract Multiple sclerosis (MS) is a chronic degenerative autoimmune disease of the central nervous system that causes inflammation, demyelinating lesions, and axonal damage and is associated with a high rate of early-onset disability. Disease-modifying therapies are used to mitigate the inflammatory process in MS but do not promote regeneration or remyelination; cell therapy may play an important role in these processes, modulating inflammation and promoting the repopulation of oligodendrocytes, which are responsible for myelin repair. The development of genetic engineering has led to the emergence of stable, biocompatible biomaterials that may promote a favorable environment for exogenous cells. This review summarizes the available evidence about the effects of transplantation of different types of stem cells reported in studies with several animal models of MS and clinical trials in human patients. We also address the advantages of combining cell therapy with biomaterials.
    Keywords Multiple sclerosis ; remyelination ; cell therapy ; biomaterials ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Hippocampal subfield abnormalities and biomarkers of pathologic brain changes

    Maria Díez-Cirarda / Miguel Yus-Fuertes / Rafael Sanchez-Sanchez / Javier J. Gonzalez-Rosa / Gabriel Gonzalez-Escamilla / Lidia Gil-Martínez / Cristina Delgado-Alonso / Maria Jose Gil-Moreno / Maria Valles-Salgado / Fatima Cano-Cano / Denise Ojeda-Hernandez / Natividad Gomez-Ruiz / Silvia Oliver-Mas / María Soledad Benito-Martín / Manuela Jorquera / Sarah de la Fuente / Carmen Polidura / Belén Selma-Calvo / Juan Arrazola /
    Jorge Matias-Guiu / Ulises Gomez-Pinedo / Jordi A. Matias-Guiu

    EBioMedicine, Vol 94, Iss , Pp 104711- (2023)

    from SARS-CoV-2 acute infection to post-COVID syndromeResearch in context

    2023  

    Abstract: Summary: Background: Cognitive deficits are among the main disabling symptoms in COVID-19 patients and post-COVID syndrome (PCS). Within brain regions, the hippocampus, a key region for cognition, has shown vulnerability to SARS-CoV-2 infection. ... ...

    Abstract Summary: Background: Cognitive deficits are among the main disabling symptoms in COVID-19 patients and post-COVID syndrome (PCS). Within brain regions, the hippocampus, a key region for cognition, has shown vulnerability to SARS-CoV-2 infection. Therefore, in vivo detailed evaluation of hippocampal changes in PCS patients, validated on post-mortem samples of COVID-19 patients at the acute phase, would shed light into the relationship between COVID-19 and cognition. Methods: Hippocampal subfields volume, microstructure, and perfusion were evaluated in 84 PCS patients and compared to 33 controls. Associations with blood biomarkers, including glial fibrillary acidic protein (GFAP), myelin oligodendrocyte glycoprotein (MOG), eotaxin-1 (CCL11) and neurofilament light chain (NfL) were evaluated. Besides, biomarker immunodetection in seven hippocampal necropsies of patients at the acute phase were contrasted against eight controls. Findings: In vivo analyses revealed that hippocampal grey matter atrophy is accompanied by altered microstructural integrity, hypoperfusion, and functional connectivity changes in PCS patients. Hippocampal structural and functional alterations were related to cognitive dysfunction, particularly attention and memory. GFAP, MOG, CCL11 and NfL biomarkers revealed alterations in PCS, and showed associations with hippocampal volume changes, in selective hippocampal subfields. Moreover, post mortem histology showed the presence of increased GFAP and CCL11 and reduced MOG concentrations in the hippocampus in post-mortem samples at the acute phase. Interpretation: The current results evidenced that PCS patients with cognitive sequalae present brain alterations related to cognitive dysfunction, accompanied by a cascade of pathological alterations in blood biomarkers, indicating axonal damage, astrocyte alterations, neuronal injury, and myelin changes that are already present from the acute phase. Funding: Nominative Grant FIBHCSC 2020 COVID-19. Department of Health, Community of Madrid. Instituto de ...
    Keywords Post-COVID syndrome ; Cognition ; Hippocampus ; Neuroimaging ; Blood biomarkers ; Histopathology ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain

    Ulises Gómez-Pinedo / Jordi A. Matías-Guiu / María Soledad Benito-Martín / Lidia Moreno-Jiménez / Inmaculada Sanclemente-Alamán / Belen Selma-Calvo / Sara Pérez-Suarez / Francisco Sancho-Bielsa / Alejandro Canales-Aguirre / Juan Carlos Mateos-Díaz / Mercedes A. Hernández-Sapiéns / Edwin E. Reza-Zaldívar / Doddy Denise Ojeda-Hernández / Lucía Vidorreta-Ballesteros / Paloma Montero-Escribano / Jorge Matías-Guiu

    International Journal of Molecular Sciences, Vol 22, Iss 10738, p

    2021  Volume 10738

    Abstract: Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over ...

    Abstract Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over time. Several experimental studies have introduced OPCs to the brain via direct injection or intrathecal administration. In this study, we used the nose-to brain pathway to deliver oligodendrocyte lineage cells (human oligodendroglioma (HOG) cells), which behave similarly to OPCs in vitro. To this end, we administered GFP-labelled HOG cells intranasally to experimental animals, which were subsequently euthanised at 30 or 60 days. Our results show that the intranasal route is a viable route to the CNS and that HOG cells administered intranasally migrate preferentially to niches of OPCs (clusters created during embryonic development and adult life). Our study provides evidence, albeit limited, that HOG cells either form clusters or adhere to clusters of OPCs in the brains of experimental animals.
    Keywords multiple sclerosis ; HOG cells ; oligodendrocyte precursor cells ; oligodendrocytes ; intranasal administration ; demyelination ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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