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Article ; Online: Development of a High-Fidelity Robot-Assisted Kidney Transplant Simulation Platform Using Three-Dimensional Printing and Hydrogel Casting Technologies.

Saba, Patrick / Belfast, Elizabeth / Melnyk, Rachel / Patel, Ankit / Kashyap, Randeep / Ghazi, Ahmed

2020 Volume 34, Issue 10, Page(s) 1088–1094

Abstract: Introduction and Objective: ...

Abstract	Introduction and Objective:
MeSH term(s)	Humans ; Hydrogels ; Kidney Transplantation ; Printing, Three-Dimensional ; Robotic Surgical Procedures ; Robotics
Chemical Substances	Hydrogels
Language	English
Publishing date	2020-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2020.0441
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Zs.A 2628: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 208: Show issues

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Article ; Online: Correction to: Mechanical and functional validation of a perfused, robot-assisted partial nephrectomy simulation platform using a combination of 3D printing and hydrogel casting.

Melnyk, Rachel / Ezzat, Bahie / Belfast, Elizabeth / Saba, Patrick / Farooq, Shamroz / Campbell, Timothy / McAleavey, Stephen / Buckley, Mark / Ghazi, Ahmed

World journal of urology

2020 Volume 38, Issue 7, Page(s) 1643

Abstract: The Eqs. 1, 2 and 3 come under the section "Kidney cortex testing" as per the original manuscript, but they have been incorrectly moved and separated into different sections in the original publication of the article. ...

Abstract	The Eqs. 1, 2 and 3 come under the section "Kidney cortex testing" as per the original manuscript, but they have been incorrectly moved and separated into different sections in the original publication of the article.
Language	English
Publishing date	2020-01-19
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-020-03089-z
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Zs.A 1832: Show issues

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Article ; Online: Mechanical and functional validation of a perfused, robot-assisted partial nephrectomy simulation platform using a combination of 3D printing and hydrogel casting.

Melnyk, Rachel / Ezzat, Bahie / Belfast, Elizabeth / Saba, Patrick / Farooq, Shamroz / Campbell, Timothy / McAleavey, Stephen / Buckley, Mark / Ghazi, Ahmed

World journal of urology

2019 Volume 38, Issue 7, Page(s) 1631–1641

Abstract: Introduction and objectives: There is a scarcity of high-fidelity, life-like, standardized and anatomically correct polymer-based kidney models for robot-assisted partial nephrectomy (RAPN) simulation training. The purpose of this technical report is to ...

Abstract	Introduction and objectives: There is a scarcity of high-fidelity, life-like, standardized and anatomically correct polymer-based kidney models for robot-assisted partial nephrectomy (RAPN) simulation training. The purpose of this technical report is to present mechanical and functional testing data as evidence for utilizing a perfused hydrogel kidney model created utilizing 3D printed injection casts for RAPN simulation and training. Methods: Anatomically correct, tumor-laden kidney models were created from 3D-printed casts designed from a patient's CT scan and injected with poly-vinyl alcohol (PVA). A variety of testing methods quantified Young's modulus in addition to comparing the functional effects of bleeding and suturing among fresh porcine kidneys and various formulations of PVA kidneys. Results: 7% PVA at three freeze-thaw cycles (7%-3FT) was found to be the formula that best replicates the mechanical properties of fresh porcine kidney tissue, where mean(± SD) values of Young's modulus of porcine tissue vs 7%-3FT samples were calculated to be 85.97(± 35) kPa vs 80.97(± 9.05) kPa, 15.7(± 1.6) kPa vs 74.56(± 10) kPa and 87.46(± 2.97) kPa vs 83.4(± 0.7) kPa for unconfined compression, indentation and elastography testing, respectively. No significant difference was seen in mean suture tension during renorrhaphy necessary to achieve observable hemostasis and capsular violation during a simulated perfusion at 120 mmHg. Conclusions: This is the first study to utilize extensive material testing analyses to determine the mechanical and functional properties of a perfused, inanimate simulation platform for RAPN, fabricated using a combination of image segmentation, 3D printing and PVA casting.
MeSH term(s)	Animals ; Hydrogels/administration & dosage ; Kidney ; Models, Anatomic ; Nephrectomy/methods ; Perfusion ; Printing, Three-Dimensional ; Robotic Surgical Procedures ; Swine
Chemical Substances	Hydrogels
Language	English
Publishing date	2019-11-02
Publishing country	Germany
Document type	Journal Article ; Technical Report ; Validation Study
ZDB-ID	380333-8
ISSN	1433-8726 ; 0724-4983
ISSN (online)	1433-8726
ISSN	0724-4983
DOI	10.1007/s00345-019-02989-z
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Article: The problem with men.

Banks, Ian / Belfast, G P

The Practitioner

2002 Volume 246, Issue 1641, Page(s) 783

MeSH term(s)	Health Promotion/organization & administration ; Hotlines ; Humans ; Male ; Men/psychology ; Patient Acceptance of Health Care/psychology ; Primary Health Care/utilization
Language	English
Publishing date	2002-12
Publishing country	England
Document type	Editorial
ZDB-ID	124095-x
ISSN	0032-6518
ISSN	0032-6518
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Zs.B 228: Show issues

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Article ; Online: Inhibition of cathepsin K increases modeling-based bone formation, and improves cortical dimension and strength in adult ovariectomized monkeys.

Pennypacker, Brenda L / Chen, Charles M / Zheng, Helen / Shih, Mei-Shu / Belfast, Mary / Samadfam, Rana / Duong, Le T

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

2014 Volume 29, Issue 8, Page(s) 1847–1858

Abstract: Treatment with the cathepsin K (CatK) inhibitor odanacatib (ODN) protects against bone loss and maintains normal biomechanical properties in the spine and hip of ovariectomized (OVX) preclinical models. Here, we characterized the effects of ODN on the ... ...

Abstract	Treatment with the cathepsin K (CatK) inhibitor odanacatib (ODN) protects against bone loss and maintains normal biomechanical properties in the spine and hip of ovariectomized (OVX) preclinical models. Here, we characterized the effects of ODN on the dynamics of cortical modeling and remodeling, and dimension and strength of the central femur in adult OVX-rhesus monkeys. Animals were treated with vehicle or ODN (6 or 30 mg/kg, once per day [q.d., p.o.]) in prevention mode for 21 months. Calcein and tetracycline double-labeling were given at 12 and 21 months, and the femoral cross-sections were subjected to dynamic histomorphometric and cement line analyses. ODN treatment significantly increased periosteal and endocortical bone formation (BFR/BS), accompanied with an increase in endocortical mineralizing surface (102%, p < 0.01) with the 6 mg/kg dose. ODN at both doses reduced remodeling hemiosteon numbers by 51% and 66% (p < 0.05), respectively, and ODN 30 mg/kg numerically reduced activation frequency without affecting wall thickness. On the same endocortical surface, ODN increased all modeling-based parameters, while reducing intracortical remodeling, consistent with the observed no treatment effects on cortical porosity. ODN 30 mg/kg markedly increased cortical thickness (CtTh, p < 0.001) and reduced marrow area (p < 0.01). Lastly, ODN treatment increased femoral structural strength (p < 0.001). Peak load was positively correlated with the increases in bone mineral content (BMC) (r(2) = 0.9057, p < 0.0001) and CtTh (r2 = 0.6866, p < 0.0001). Taken together, by reducing cortical remodeling-based and stimulating modeling-based bone formation, ODN significantly improved cortical dimension and strength in OVX monkeys. This novel mechanism of CatK inhibition in stimulating cortical formation suggests that ODN represents a novel therapeutic approach for the treatment of osteoporosis.
MeSH term(s)	Animals ; Biphenyl Compounds/administration & dosage ; Biphenyl Compounds/pharmacology ; Bone Density/drug effects ; Bone Remodeling/drug effects ; Cathepsin K/antagonists & inhibitors ; Female ; Hip/pathology ; Macaca mulatta ; Osteogenesis/drug effects ; Ovariectomy ; Spine/drug effects
Chemical Substances	Biphenyl Compounds ; Cathepsin K (EC 3.4.22.38) ; odanacatib (N673F6W2VH)
Language	English
Publishing date	2014-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632783-7
ISSN	1523-4681 ; 0884-0431
ISSN (online)	1523-4681
ISSN	0884-0431
DOI	10.1002/jbmr.2211
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Zs.A 2142: Show issues

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Article: Relationship between tightness of binding and immunogenicity in an aluminum-containing adjuvant-adsorbed hepatitis B vaccine.

Egan, Patricia M / Belfast, Mary T / Giménez, Juan A / Sitrin, Robert D / Mancinelli, Ralph J

Vaccine

2009 Volume 27, Issue 24, Page(s) 3175–3180

Abstract: Phospholipid-containing antigens, such as Hepatitis B Surface Antigen (HBsAg), adsorb to aluminum-containing adjuvants by ligand exchange of a phosphate group for a hydroxyl group on the adjuvant surface. In this study, a tightness of binding (TOB) assay ...

Abstract	Phospholipid-containing antigens, such as Hepatitis B Surface Antigen (HBsAg), adsorb to aluminum-containing adjuvants by ligand exchange of a phosphate group for a hydroxyl group on the adjuvant surface. In this study, a tightness of binding (TOB) assay was developed to characterize the strength of binding between HBsAg and aluminum hydroxyphosphate sulfate adjuvant containing two levels of phosphate. Antigen desorption was induced using either fluoride or phosphate as a competing ion. HBsAg, formulated as a monovalent or combination vaccine, showed decreased tightness of binding when the amount of phosphate in the adjuvant composition increased, indicating that there was less ligand exchange between HBsAg and the adjuvant. Furthermore, the physicochemical property of TOB was related to enhanced immunogenicity in a murine model. These data show that tightness of binding can be a useful characterization tool, and potential predictor of immunogenicity, during development of vaccines that adsorb to aluminum adjuvants via ligand exchange.
MeSH term(s)	Adjuvants, Immunologic/chemistry ; Adsorption ; Aluminum Hydroxide/chemistry ; Animals ; Hepatitis B Surface Antigens/immunology ; Hepatitis B Vaccines/chemistry ; Hepatitis B Vaccines/immunology ; Mice ; Mice, Inbred C3H ; Phosphates/chemistry ; Protein Binding ; Sodium Fluoride/chemistry
Chemical Substances	Adjuvants, Immunologic ; Hepatitis B Surface Antigens ; Hepatitis B Vaccines ; Phosphates ; Aluminum Hydroxide (5QB0T2IUN0) ; Sodium Fluoride (8ZYQ1474W7) ; aluminum hydroxyphosphate sulfate (F41V936QZM)
Language	English
Publishing date	2009-04-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2009.03.054
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article: Effect of the strength of adsorption of hepatitis B surface antigen to aluminum hydroxide adjuvant on the immune response.

Hansen, Bethany / Belfast, Mary / Soung, George / Song, Liping / Egan, Patricia M / Capen, Robert / Hogenesch, Harm / Mancinelli, Ralph / Hem, Stanley L

Vaccine

2009 Volume 27, Issue 6, Page(s) 888–892

Abstract: Hepatitis B surface antigen (HBsAg) is known to adsorb to aluminum hydroxide adjuvant (AH) by ligand exchange between its accessible phosphate groups and surface hydroxyl groups of the adjuvant. To study the effect of the binding strength, five vaccines ... ...

Abstract	Hepatitis B surface antigen (HBsAg) is known to adsorb to aluminum hydroxide adjuvant (AH) by ligand exchange between its accessible phosphate groups and surface hydroxyl groups of the adjuvant. To study the effect of the binding strength, five vaccines were prepared with AH or four samples of AH that were modified by pretreatment with different concentrations of potassium dihydrogen phosphate. The adsorptive coefficients ranged from 3660 to 250mL/mg based on the Langmuir adsorption isotherm and degrees of elution ranged from 1 to 31% when the vaccines were exposed to interstitial fluid in vitro. When tested in mice the four vaccines containing phosphate-treated AH (PTAH) induced significantly greater antibody responses than the vaccine containing AH, which had the highest adsorptive coefficient and the smallest degree of elution of HBsAg. The results indicated that antibody production is reduced when the antigen is adsorbed too strongly. Thus, the strength of adsorption of the antigen to an aluminum-containing adjuvant can affect the immunogenicity of the vaccine and should be optimized during vaccine formulation.
MeSH term(s)	Adjuvants, Immunologic/metabolism ; Adjuvants, Immunologic/pharmacology ; Adsorption ; Aluminum Hydroxide/metabolism ; Aluminum Hydroxide/pharmacology ; Animals ; Female ; Hepatitis B Antibodies/blood ; Hepatitis B Surface Antigens/immunology ; Hepatitis B Surface Antigens/metabolism ; Hepatitis B Vaccines/immunology ; Mice
Chemical Substances	Adjuvants, Immunologic ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis B Vaccines ; Aluminum Hydroxide (5QB0T2IUN0)
Language	English
Publishing date	2009-02-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2008.11.078
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Zs.MO 458: Show issues

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Article: A practical approach to optimization and validation of a HPLC assay for analysis of polyribosyl-ribitol phosphate in complex combination vaccines.

Belfast, Mary / Lu, Rong / Capen, Robert / Zhong, Jinglin / Nguyen, Mai-Anh / Gimenez, Juan / Sitrin, Robert / Mancinelli, Ralph

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2006 Volume 832, Issue 2, Page(s) 208–215

Abstract: The use of multi-factor statistical experimental design methodology minimized the vaccine material and laboratory resources required for optimization and validation of an HPLC assay for quantitation of depolymerized and total PRP. Components of the assay ...

Abstract	The use of multi-factor statistical experimental design methodology minimized the vaccine material and laboratory resources required for optimization and validation of an HPLC assay for quantitation of depolymerized and total PRP. Components of the assay selected for optimization were adjuvant dissolution, ultracentrifuge conditions including ultracentrifuge model, sample diluent, mobile phase and column oven temperature. Previous experience has shown these components of the assay to be most troublesome and therefore required optimization prior to validation. Specificity, linearity, precision, accuracy and ruggedness were confirmed through a validation of the optimized assay. The validation also established the assay to be stability indicating, by showing that changes to the integrity of the PRP-OMPC conjugate could be detected.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Polysaccharides/analysis ; Ultracentrifugation ; Vaccines, Combined/chemistry
Chemical Substances	Polysaccharides ; Vaccines, Combined ; polyribitol phosphate (51584-96-4)
Language	English
Publishing date	2006-03-07
Publishing country	Netherlands
Document type	Journal Article ; Validation Studies
ISSN	1570-0232
ISSN	1570-0232
DOI	10.1016/j.jchromb.2005.12.053
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Article ; Online: Dermatitis Secondary to Hypersensitivity to Icodextrin is a Rare Complication of Icodextrin Therapy in Peritoneal Dialysis

Ru Yu Tan MBBS (M'sia), MRCP (UK) / Elizabeth Oei MB ChB (Ed), MRCP (UK) / Marjorie WY Foo MB ChB (Belfast), MRCP (UK), FRCP (Glas), FAMS

Proceedings of Singapore Healthcare, Vol

2012 Volume 21

Abstract: Case report on dermatitis secondary to hypersensitivity to icodextrin, which is a rare complication of icodextrin therapy in peritoneal dialysis. ...

Abstract	Case report on dermatitis secondary to hypersensitivity to icodextrin, which is a rare complication of icodextrin therapy in peritoneal dialysis.
Keywords	Medicine ; R
Language	English
Publishing date	2012-06-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Herbage growth models as aids for managing intensively grazed grassland in Western Europe

Laidlaw, A.S., Agri-Food and Biosciences Institute, Belfast, Northern Ireland (United Kingdom). Applied Plant Science and Biometrics Division

Ratarstvo i povrtarstvo (Serbia)

(2010) Volume v. 47, Issue (2), Page(s) p. 451–456

Abstract: Estimates of variation in herbage growth are presented to demonstrate the problems which unforeseen variation can create for management of intensively grazed grassland in temperate Western Europe. The role of growth models in predicting herbage ... ...

Abstract	Estimates of variation in herbage growth are presented to demonstrate the problems which unforeseen variation can create for management of intensively grazed grassland in temperate Western Europe. The role of growth models in predicting herbage availability as a component in feed budgeting is described. Herbage growth model share a common structure and produce output in response to weather conditions; other also take account of soil properties. Growth models can be applied as aids to grassland management either as stand alone models or can be and integral part of a decision support system and used to predict outcomes from whole farming systems. Although the reliability of models has been well demonstrated in many instances, their value to farmers as an aid to managing grassland intensively needs to be re-enforced.
Keywords	HERBACEOUS PLANTS ; GRASSLANDS ; GRASSLAND MANAGEMENT ; GROWTH ; FEED CROPS ; CROP MANAGEMENT ; BUDGETS ; WESTERN EUROPE ; PLANTE HERBACEE ; HERBAGE ; CONDUITE DES HERBAGES ; CROISSANCE ; PLANTE FOURRAGERE ; CONDUITE DE LA CULTURE ; BUDGET ; EUROPE OCCIDENTALE ; PLANTAS HERBACEAS ; PRADERAS ; MANEJO DE PRADERAS ; CRECIMIENTO ; PLANTAS FORRAJERAS ; MANEJO DEL CULTIVO ; PRESUPUESTO ; EUROPA OCCIDENTAL ; http://www.fao.org/aos/agrovoc#c_27977 ; http://www.fao.org/aos/agrovoc#c_3366 ; http://www.fao.org/aos/agrovoc#c_3364 ; http://www.fao.org/aos/agrovoc#c_3394 ; http://www.fao.org/aos/agrovoc#c_2829 ; http://www.fao.org/aos/agrovoc#c_16094 ; http://www.fao.org/aos/agrovoc#c_1134 ; http://www.fao.org/aos/agrovoc#c_8364
Language	English
Document type	Article
ISSN	1821-3944
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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