LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Belisle, Caryn"
  2. AU="Bardiot, Dorothée"
  3. AU="Kaastra"
  4. AU="Marianne Debré"
  5. AU="Zugasti, Ana"
  6. AU="Zhou, Xunjian"
  7. AU="Montero-Vergara, Jetsy"
  8. AU="Pryce, David"
  9. AU="Stabel, Judith R"
  10. AU=Badgley C E AU=Badgley C E
  11. AU=Riback Joshua A.
  12. AU="Sethi, Ansh"
  13. AU="Tibbo, Meagan E"
  14. AU="Prechtl, Stefan"
  15. AU="Kuanyshbek, Alibek"
  16. AU="Annukka Pasanen"
  17. AU="Yi, Ling Ka"
  18. AU="Kong, Hyejin"
  19. AU="Bilio, João"
  20. AU=Hill Stephen J
  21. AU="Hatayama, Sho"
  22. AU="Ruuskanen, Suvi K"
  23. AU="Kim, Song-Rae"
  24. AU="Mizia-Stec, Katarzyna"
  25. AU="Helen V. Firth"
  26. AU=Giroux Leprieur Etienne
  27. AU="Xinhui Gao"
  28. AU="Christoph Schlapbach"
  29. AU="Akbar, Shayista"
  30. AU="Butler, Eboneé N"
  31. AU="Moura-Alves, Márcio"
  32. AU="Marcet, Ismael"
  33. AU=Eichfelder Sebastian
  34. AU=Timins M E
  35. AU="Weber, Stephan"
  36. AU=Galuska David
  37. AU="Carrieri, Mariella"
  38. AU="Hafkamp, Frederique J"
  39. AU="Jessica M. Perkins"
  40. AU="Tariq, Syeda Sumayya"
  41. AU="Meehan, Rebecca"

Suchergebnis

Treffer 1 - 10 von insgesamt 13

Suchoptionen

  1. Artikel ; Online: Low Efficacy of Medication Shortage Clinical Decision Support Alerts.

    Benson, Nicole M / Belisle, Caryn / Bates, David W / Salmasian, Hojjat

    Applied clinical informatics

    2021  Band 12, Heft 5, Seite(n) 1144–1149

    Abstract: Objective: We examined clinical decision support (CDS) alerts designed specifically for medication shortages to characterize and assess provider behavior in response to these short-term clinical situations.: Materials and methods: We conducted a ... ...

    Abstract Objective: We examined clinical decision support (CDS) alerts designed specifically for medication shortages to characterize and assess provider behavior in response to these short-term clinical situations.
    Materials and methods: We conducted a retrospective analysis of the usage of medication shortage alerts (MSAs) that included at least one alternative medication suggestion and were active for 60 or more days during the 2-year study period, January 1, 2018 to December 31, 2019, in a large health care system. We characterized ordering provider behavior in response to inpatient MSAs. We then developed a linear regression model to predict provider response to alerts using the characteristics of the ordering provider and alert frequency groupings.
    Results: During the study period, there were 67 MSAs in use that focused on 42 distinct medications in shortage. The MSAs suggested an average of 3.9 alternative medications. Adjusting for the different alerts, fellows (
    Conclusion: Our findings demonstrate that providers tended to reject MSAs, even those who were sometimes flexible about their responses. The low overall acceptance rate supports the theory that alerts appearing at the time of order entry may have limited value, as they may be presented too late in the decision-making process. Though MSAs are designed to be attention-grabbing and higher impact than traditional CDS, our findings suggest that providers rarely change their clinical decisions when presented with these alerts.
    Mesh-Begriff(e) Decision Support Systems, Clinical ; Female ; Humans ; Male ; Medical Order Entry Systems ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2021-12-01
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/s-0041-1740257
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel: Low Efficacy of Medication Shortage Clinical Decision Support Alerts

    Benson, Nicole M. / Belisle, Caryn / Bates, David W. / Salmasian, Hojjat

    Applied Clinical Informatics

    2021  Band 12, Heft 05, Seite(n) 1144–1149

    Abstract: Objective: We examined clinical decision support (CDS) alerts designed specifically for medication shortages to characterize and assess provider behavior in response to these short-term clinical situations.: Materials and Methods: We conducted a ... ...

    Abstract Objective: We examined clinical decision support (CDS) alerts designed specifically for medication shortages to characterize and assess provider behavior in response to these short-term clinical situations.
    Materials and Methods: We conducted a retrospective analysis of the usage of medication shortage alerts (MSAs) that included at least one alternative medication suggestion and were active for 60 or more days during the 2-year study period, January 1, 2018 to December 31, 2019, in a large health care system. We characterized ordering provider behavior in response to inpatient MSAs. We then developed a linear regression model to predict provider response to alerts using the characteristics of the ordering provider and alert frequency groupings.
    Results: During the study period, there were 67 MSAs in use that focused on 42 distinct medications in shortage. The MSAs suggested an average of 3.9 alternative medications. Adjusting for the different alerts, fellows ( p  = 0.004), residents ( p  = 0.03), and physician assistants ( p  = 0.02) were less likely to accept alerts on average compared with attending physicians. Further, female ordering clinicians ( p  < 0.001) were more likely to accept alerts on average compared with male ordering clinicians.
    Conclusion: Our findings demonstrate that providers tended to reject MSAs, even those who were sometimes flexible about their responses. The low overall acceptance rate supports the theory that alerts appearing at the time of order entry may have limited value, as they may be presented too late in the decision-making process. Though MSAs are designed to be attention-grabbing and higher impact than traditional CDS, our findings suggest that providers rarely change their clinical decisions when presented with these alerts.
    Schlagwörter medication shortage ; quality of care ; cost of care ; electronic health records
    Sprache Englisch
    Erscheinungsdatum 2021-10-01
    Verlag Georg Thieme Verlag KG
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/s-0041-1740257
    Datenquelle Thieme Verlag

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel ; Online: Respecting the risks of sterile compounding.

    Thompson, Ross W / Belisle, Caryn

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2015  Band 72, Heft 15, Seite(n) 1269

    Mesh-Begriff(e) Drug Compounding/standards ; Humans ; Pharmacy Service, Hospital/standards ; Practice Guidelines as Topic ; Risk Management ; Sterilization/standards ; United States
    Sprache Englisch
    Erscheinungsdatum 2015-07-06
    Erscheinungsland England
    Dokumenttyp Editorial
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.2146/ajhp150313
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 419: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel: Implementation of Pharmacy Executive Quality and Safety Walkrounds at a Tertiary Academic Medical Center.

    Alsowaida, Yazed Saleh / Kovacevic, Mary P / Belisle, Caryn / Cotugno, Michael C / Cooley, Tom / Matta, Lina / Fanikos, John / Dell'Orfano, Heather

    Hospital pharmacy

    2021  Band 57, Heft 2, Seite(n) 211–216

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2021-04-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1468893-1
    ISSN 0018-5787
    ISSN 0018-5787
    DOI 10.1177/00185787211010155
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 1758: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 21: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel: Single Center Experience with Robot Technologies for Sterile Compounding: A Retrospective Review.

    Milibari, Loay / Cotugno, Michael / Belisle, Caryn / Rocchio, Megan / Patterson, Robert F / Chacon, Pablo / Fanikos, John / Vo, Peter

    International journal of pharmaceutical compounding

    2020  Band 24, Heft 4, Seite(n) 346–351

    Abstract: The compounding of sterile medication admixtures is a labor-intensive process and subject to potential human error. The addition of robotic devices and workflow technology may mitigate some of the challenges of compounding sterile product admixtures, ... ...

    Abstract The compounding of sterile medication admixtures is a labor-intensive process and subject to potential human error. The addition of robotic devices and workflow technology may mitigate some of the challenges of compounding sterile product admixtures, especially for those associated with antineoplastic and hazardous medications. This article discusses the single-center experiences from October 2009 through August 2017 with various sterile compounding robotic technologies. The robotic devices included Intellifill  i.v., Cytocare, i.v.Station, i.v.Station ONCO, and i.v.Soft Assist. The objective of this analysis was to describe the experience with robotic technology and workflow devices in compounding sterile medication admixtures. The number of prepared doses for each device was tracked, and each device had a tool to validate the dose accuracy via specific gravity measurement. Nonhazardous preparations with a dose variation of > (+/- 10%) were considered failures. For hazardous medications, variation of > (+/- 5%) was considered a failure. Doses that were prepared manually were also analyzed. The Intellifill i.v. robot was used to compound more than 1,000,000 admixtures (75% of all compounded  products). The i.v.Station, Cytocare, i.v.Station  ONCO, and i.v.Soft Assist robots compounded 14%, 7%,  3%, and 0.7% of the total chemotherapy doses required. Identified barriers to optimal performance included device (hardware) and software failures as well as shortages with specific fluid and drug containers. The qualitative analysis was done for 36 drugs that were prepared using i.v.Station and i.v.Station ONCO. The passing rate was estimated to be 95%. Barriers to use the device included lack of the appropriate medication container, diluent supplies issues, and software failure. Robotic devices and workflow technology for compounding sterile medication admixtures were unable to produce all routine parenteral doses required daily.
    Mesh-Begriff(e) Drug Compounding ; Humans ; Pharmacy Service, Hospital ; Retrospective Studies ; Robotics ; Workflow
    Sprache Englisch
    Erscheinungsdatum 2020-07-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1092-4221
    ISSN 1092-4221
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  6. Artikel ; Online: Non-Sterile to Sterile Compounding: An Unconventional Response During the COVID-19 Pandemic.

    Belisle, Caryn D / Anger, Kevin / Kanaan, Dareen / Rocchio, Megan A / Triggs, Angela / Chacon, Pablo / Kwok, Keely / Cotugno, Michael / Morris, Charles A / Fanikos, John

    Journal of pharmacy practice

    2021  Band 36, Heft 1, Seite(n) 46–52

    Abstract: The drug supply chain has suffered many interruptions over the past decade. The COVID-19 pandemic exacerbated an already fragile infrastructure for supplying critical medications to hospitals and health-systems. The purpose of this paper is to provide ... ...

    Abstract The drug supply chain has suffered many interruptions over the past decade. The COVID-19 pandemic exacerbated an already fragile infrastructure for supplying critical medications to hospitals and health-systems. The purpose of this paper is to provide insight to the history, thought-processes, and response to critical medication shortages during the COVID-19 pandemic, with a focus on hydromorphone infusions and the action steps taken to engage in non-sterile to sterile (NSTS) compounding. Over a period of 6 weeks, we compounded 1,613 NSTS hydromorphone infusion bags. All lots were cleared for sterility, particulate, potency, and endotoxin testing by an outside FDA registered laboratory. We did not have any safety reports filed specific to the NSTS compounded hydromorphone infusion bags. Over a period of 15 weeks, 715 infusions were consumed. The drug supply chain suffers frequent interruptions and critical shortages, particularly in times of a natural disaster or a global pandemic. Non-sterile to sterile compounding is often associated with risks of inaccuracies, impurities, and contamination. There are instances in which non-sterile to sterile compounding is appropriate and should be considered in times of drug shortages to support the care of hospitalized patients.
    Mesh-Begriff(e) Humans ; COVID-19 ; Pandemics ; Hydromorphone ; Drug Compounding ; Infertility
    Chemische Substanzen Hydromorphone (Q812464R06)
    Sprache Englisch
    Erscheinungsdatum 2021-06-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/08971900211017861
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2893: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel ; Online: Longer hospitalization of patients with positive blood cultures receiving total parenteral nutrition.

    Patel, Vihas / Liu, Xiaoxia / Paul, Michael / Belisle, Caryn Domenici

    Surgical infections

    2014  Band 15, Heft 3, Seite(n) 227–232

    Abstract: Background: Total parenteral nutrition (TPN) via central venous catheters has improved nutrient delivery to patients unable to receive nutrition enterally, but its administration can be complicated by bacteremia and fungemia.: Methods: At a large ... ...

    Abstract Background: Total parenteral nutrition (TPN) via central venous catheters has improved nutrient delivery to patients unable to receive nutrition enterally, but its administration can be complicated by bacteremia and fungemia.
    Methods: At a large tertiary-care academic medical center, 245 patients with concurrent positive blood cultures, among 1,716 adult patients who received TPN over a period of three consecutive years, were divided into those in whom parenteral nutrition was continued and those in whom it was stopped after the occurrence of a positive blood culture. To determine whether continuation of TPN after a positive blood culture was associated with a statistically significantly longer hospitalization than with its discontinuation after a positive blood culture, we performed a logistic regression analysis with step-wise selection, with parenteral nutrition status as the dependent variable and type of venous access, type of pathogen responsible for a positive blood culture, recurrence of a positive blood culture, respiratory failure, shock, and length of stay as covariates.
    Results: The prevalence of positive blood cultures was 14% among all hospitalized patients given parenteral nutrition. Parenteral nutrition was continued in 60% of the patients. Baseline co-morbid and laboratory parameters were comparable in the group of patients in whom TPN was continued and the group in which it was stopped except that the white blood cell count (WBC) was lower in the former group (9.1±6.6 mm(3) vs. 12±12.1 mm(3), p=0.015). Both groups received an average of 30 kcal/kg and 1.4 g protein/kg via TPN. There was no difference in the two groups in total calories, lipids, protein, or glutamine-base received before the occurrence of a positive blood culture (p=0.86, p=0.51, p=0.79, and p=0.42, respectively). The hospital stay of the group in which TPN was continued after a positive blood culture was statistically significantly longer than that of the group in which it was discontinued (44.6±32.3 d vs. 28.2±18.5 d, p<0.001). This difference remained significant in the multivariable logistic regression analysis.
    Conclusion: Continuation of TPN after a positive blood culture was associated with statistically significantly longer hospitalization before and after adjustment for co-morbid conditions.
    Mesh-Begriff(e) Academic Medical Centers ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacteremia/epidemiology ; Blood/microbiology ; Central Venous Catheters/adverse effects ; Cohort Studies ; Female ; Fungemia/epidemiology ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Parenteral Nutrition, Total/adverse effects ; Retrospective Studies ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2014-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1440120-4
    ISSN 1557-8674 ; 1096-2964
    ISSN (online) 1557-8674
    ISSN 1096-2964
    DOI 10.1089/sur.2013.074
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5617: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  8. Artikel ; Online: Management of a parenteral opioid shortage using ASHP guidelines.

    Vo, Peter / Sylvia, Daniel A / Milibari, Loay / Stackhouse, John Ryan / Szumita, Paul / Rocchio, Megan / Cotugno, Michael / Belisle, Caryn / Morris, Charles / Goralnick, Eric / Vacanti, Joshua C / Matta, Lina / Cooley, Tom / Triggs, Angela / Silverman, Jon / Fanikos, John

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2021  Band 78, Heft 5, Seite(n) 426–435

    Abstract: Purpose: Management of an acute shortage of parenteral opioid products at a large hospital through prescribing interventions and other guideline-recommended actions is described.: Summary: In early 2018, many hospitals were faced with a shortage of ... ...

    Abstract Purpose: Management of an acute shortage of parenteral opioid products at a large hospital through prescribing interventions and other guideline-recommended actions is described.
    Summary: In early 2018, many hospitals were faced with a shortage of parenteral opioids that was predicted to last an entire year. The American Society of Health-System Pharmacists (ASHP) has published guidelines on managing drug product shortages. This article describes the application of these guidelines to manage the parenteral opioid shortage and the impact on opioid dispensing that occurred in 2018. Our approach paralleled that recommended in the ASHP guidelines. Daily dispensing reports generated from automated dispensing cabinets and from the electronic health record were used to capture dispenses of opioid medications. Opioid prescribing and utilization data were converted to morphine milligram equivalents (MME) to allow clinical leaders and hospital administrators to quickly evaluate opioid inventories and consumption. Action steps included utilization of substitute opioid therapies and conversion of opioid patient-controlled analgesia (PCA) and opioid infusions to intravenous bolus dose administration. Parenteral opioid supplies were successfully rationed so that surgical and elective procedures were not canceled or delayed. During the shortage, opioid dispensing decreased in the inpatient care areas from approximately 2.0 million MME to 1.4 million MME and in the operating rooms from 0.56 MME to 0.29 million MME. The combination of electronic health record alerts, increased utilization of intravenous acetaminophen and liposomal bupivacaine, and pharmacist interventions resulted in a 67% decline in PCA use and a 65% decline in opioid infusions.
    Conclusion: A multidisciplinary response is necessary for effective management of drug shortages through implementation of strategies and practices for notifying clinicians of shortages and identifying optimal alternative therapies.
    Mesh-Begriff(e) Administration, Intravenous ; Analgesics, Opioid/therapeutic use ; Hospitalization ; Humans ; Pharmacists ; Practice Patterns, Physicians' ; United States
    Chemische Substanzen Analgesics, Opioid
    Sprache Englisch
    Erscheinungsdatum 2021-01-20
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxaa425
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 419: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  9. Artikel ; Online: Pharmacy Response to the Boston Marathon Bombings at a Tertiary Academic Medical Center.

    Sylvester, Katelyn W / Rocchio, Megan A / Belisle, Caryn / Matta, Lina / Goralnick, Eric

    The Annals of pharmacotherapy

    2014  Band 48, Heft 8, Seite(n) 1082–1085

    Abstract: Objective: Effective crisis response requires multidisciplinary communication and rapid action. Our goals are to highlight the experience of a pharmacy department's response to the 2013 Boston Marathon bombing, to discuss the role of the pharmacist in a ...

    Abstract Objective: Effective crisis response requires multidisciplinary communication and rapid action. Our goals are to highlight the experience of a pharmacy department's response to the 2013 Boston Marathon bombing, to discuss the role of the pharmacist in a crisis response, and to identify potential learning opportunities for a future mass casualty event.
    Case summary: Our initial response targeted 3 general areas: staffing, supplies, and communication. Pharmacist and technician staffing was increased throughout the hospital, with a 6-fold increase of pharmacists to the emergency department (ED). To ensure adequate supplies were available, inventory on the ED automatic dispensing cabinets (ADC) was assessed for vaccines, antibiotics, and vasoactive medications. ED pharmacists prepared emergent intravenous medications in the ED while the sterile products room bolstered our supply of intravenous medications for patients in the ED and operating room. Overall, there was a 33% increase in the number of ADC transactions, with pharmacists representing 28% of all ADC transactions. To optimize communication, we formulated a comprehensive plan for the timely dissemination of information to the entire pharmacy staff.
    Discussion: A mass casualty event is a rare occasion, and it is vital for the pharmacy department to respond rapidly with little notification.
    Conclusion: The role of a pharmacist is unique and can most effectively triage drug information and medication distribution, especially during times of high demand and high stress.
    Sprache Englisch
    Erscheinungsdatum 2014-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/1060028014536026
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 900: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  10. Artikel: Evaluation of the maximum beyond-use-date stability of regular human insulin extemporaneously prepared in 0.9% sodium chloride in a polyvinyl chloride bag.

    Rocchio, Megan A / Belisle, Caryn D / Greenwood, Bonnie C / Cotugno, Michael C / Szumita, Paul M

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2013  Band 6, Seite(n) 389–392

    Abstract: Background: Regular human insulin 100 units added to a sufficient quantity of 0.9% sodium chloride, to yield a total volume of 100 mL within a polyvinylchloride bag, is accepted to be stable for 24 hours due to physical denaturation and chemical ... ...

    Abstract Background: Regular human insulin 100 units added to a sufficient quantity of 0.9% sodium chloride, to yield a total volume of 100 mL within a polyvinylchloride bag, is accepted to be stable for 24 hours due to physical denaturation and chemical modification. The objective of this study was to evaluate the extended stability of such extemporaneously prepared regular human insulin, stored under refrigeration, to the maximum beyond-use-date allowed by United States Pharmacopeia chapter 797.
    Methods: At time "0" three admixtures of regular human insulin were prepared by withdrawing 1 mL of regular human insulin with a concentration of 100 units/mL and adding it to a sufficient quantity of 0.9% sodium chloride for injection in a polyvinylchloride bag to yield a total volume of 100 mL. The three admixtures were stored under refrigeration (2°C-8°C [36°F-46°F]), and one sample of each admixture was withdrawn and tested in duplicate at 0, 6, 24, 48, 72, 144, 168, 192, 216, 240, 312, and 336 hours. Utilizing high performance liquid chromatography, each sample underwent immediate testing. The time points were stable if the mean concentration of the samples exceeded 90% of the equilibrium concentration at 6 hours.
    Results: The equilibrium concentration was 0.89 units/mL. Time points were stable if the mean concentration was at least 0.80 units/mL. All time points retained at least 90% of the equilibrium concentration, with the exception of hour 168 (0.79 ± 0.03 units/mL). At 192 hours the mean concentration was 0.88 ± 0.03 units/mL. At 336 hours the mean concentration was 0.91 ± 0.02 units/mL.
    Conclusion: Based on these results, regular human insulin 100 units added to 0.9% sodium chloride for injection in a polyvinylchloride bag to yield a total volume of 100 mL is stable for up to 336 hours when stored at 2°C-8°C (36°F-46°F).
    Sprache Englisch
    Erscheinungsdatum 2013-10-11
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S51843
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang