Article ; Online: Next generation nerve guides: materials, fabrication, growth factors, and cell delivery.
Tissue engineering. Part B, Reviews
2012 Volume 18, Issue 2, Page(s) 116–128
Abstract: Nerve guides are increasingly being used surgically to repair acute peripheral nerve injuries. This is not only due to an increase in the number of commercially available devices, but also clinical acceptance. However, regeneration distance is typically ... ...
| Abstract | Nerve guides are increasingly being used surgically to repair acute peripheral nerve injuries. This is not only due to an increase in the number of commercially available devices, but also clinical acceptance. However, regeneration distance is typically limited to 20-25 mm, in part due to the basic tubular design. A number of experimental studies have shown improvements in nerve regeneration distance when conduits incorporate coatings, internal scaffolds, topographical cues, or the delivery of support cells. Current studies on designing nerve guides for maximizing nerve regeneration focus both on cell-containing and cell-free devices, the latter being clinically attractive as "off the shelf" products. Arguably better results are obtained when conduits are used in conjunction with support cells (e.g., Schwann cells or stem cells) that can improve regeneration distance and speed of repair, and provide informative experimental data on how Schwann and neuronal cells respond in regenerating injured nerves. In this review we discuss the range of current nerve guides commercially available and appraise experimental studies in the context of the future design of nerve guides for clinical use. |
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| MeSH term(s) | Animals ; Biocompatible Materials/pharmacology ; Cell Transplantation ; Guided Tissue Regeneration/methods ; Humans ; Intercellular Signaling Peptides and Proteins/pharmacology ; Peripheral Nerve Injuries/therapy ; Surface Properties/drug effects | |||||
| Chemical Substances | Biocompatible Materials ; Intercellular Signaling Peptides and Proteins | |||||
| Language | English | |||||
| Publishing date | 2012-04 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 2420584-9 | |||||
| ISSN | 1937-3376 ; 1937-3368 | |||||
| ISSN (online) | 1937-3376 | |||||
| ISSN | 1937-3368 | |||||
| DOI | 10.1089/ten.TEB.2011.0498 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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