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  1. Article ; Online: Next steps on managing pulmonary exacerbations: Is the future less, shorter and or more targeted treatments?

    Smith, Daniel J / Bell, Scott C

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2022  Volume 21, Issue 5, Page(s) 739–740

    MeSH term(s) Cystic Fibrosis/therapy ; Disease Progression ; Forecasting ; Humans ; Lung ; Pulmonary Disease, Chronic Obstructive ; Respiratory Tract Infections
    Language English
    Publishing date 2022-08-28
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2022.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6028: Show issues Location:
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    Zs.MO 459: Show issues

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  2. Article ; Online: Cystic Fibrosis: A Disease in Transformation, yet More Work to Be Done!

    Ramsey, Bonnie W / Bell, Scott C

    American journal of respiratory and critical care medicine

    2021  Volume 205, Issue 5, Page(s) 487–489

    MeSH term(s) Cystic Fibrosis ; Humans
    Language English
    Publishing date 2021-12-28
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202112-2782ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Early Intervention of Cystic Fibrosis Pulmonary Exacerbations Based on Home Monitoring. eICE through the Looking Glass.

    Bell, Scott C

    American journal of respiratory and critical care medicine

    2017  Volume 196, Issue 9, Page(s) 1090–1092

    Language English
    Publishing date 2017-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201706-1207ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Nontuberculous Mycobacteria in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Regulator Modulators.

    Burke, Andrew / Thomson, Rachel M / Wainwright, Claire E / Bell, Scott C

    Seminars in respiratory and critical care medicine

    2023  Volume 44, Issue 2, Page(s) 287–296

    Abstract: Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, ... ...

    Abstract Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, though recent work has suggested clustered clonal infections do occur and transmission potential demonstrated among pwCF attending CF specialist centers. Guidelines for the screening, diagnosis, and identification of NTM and management of pwCF have been published. The emergence of CF-specific therapies, in particular cystic fibrosis transmembrane regulator (CFTR) modulator drugs, have led to significant improvement in the health and well-being of pwCF and may lead to challenges in sampling the lower respiratory tract including to screen for NTM. This review highlights the epidemiology, modes of acquisition, screening and diagnosis, therapeutic approaches in the context of improved clinical status for pwCF, and the clinical application of CFTR modulator therapies.
    MeSH term(s) Humans ; Cystic Fibrosis/drug therapy ; Nontuberculous Mycobacteria ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/epidemiology
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1759883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A Systematic Literature Review of Indoor Air Disinfection Techniques for Airborne Bacterial Respiratory Pathogens.

    Nguyen, Thi Tham / Johnson, Graham R / Bell, Scott C / Knibbs, Luke D

    International journal of environmental research and public health

    2022  Volume 19, Issue 3

    Abstract: Interrupting the transmission of airborne (<≈5 µm) respiratory pathogens indoors is not a new challenge, but it has attracted unprecedented interest due to the COVID-19 pandemic during 2020-2021. However, bacterial respiratory pathogens with known or ... ...

    Abstract Interrupting the transmission of airborne (<≈5 µm) respiratory pathogens indoors is not a new challenge, but it has attracted unprecedented interest due to the COVID-19 pandemic during 2020-2021. However, bacterial respiratory pathogens with known or potential airborne transmission account for an appreciable proportion of the communicable disease burden globally. We aimed to systematically review quantitative, laboratory-based studies of air disinfection techniques for airborne respiratory bacteria. Three databases (PubMed, Web of Science, Scopus) were searched, following PRISMA guidelines. A total of 9596 articles were identified, of which 517 were assessed in detail and of which 26 met the inclusion and quality assessment criteria. Seven air disinfection techniques, including UV-C light, filtration, and face masks, among others, were applied to 13 different bacterial pathogens. More than 80% of studies suggested that air disinfection techniques were more effective at inactivating or killing bacteria than the comparator or baseline condition. However, it was not possible to compare these techniques because of methodological heterogeneity and the relatively small number of the studies. Laboratory studies are useful for demonstrating proof-of-concept and performance under controlled conditions. However, the generalisability of their findings to person-to-person transmission in real-world settings is unclear for most of the pathogens and techniques we assessed.
    MeSH term(s) Air Microbiology ; Air Pollution, Indoor ; Bacteria ; COVID-19 ; Disinfection ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review ; Systematic Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19031197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A new phase of CFTR treatment for cystic fibrosis?

    Bell, Scott C

    The Lancet. Respiratory medicine

    2015  Volume 3, Issue 9, Page(s) 662–663

    MeSH term(s) Cystic Fibrosis/drug therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/administration & dosage ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Female ; Genetic Therapy/methods ; Humans ; Male ; Plasmids/administration & dosage
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(15)00282-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
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  7. Article ; Online: Infection risks for patients from healthcare workers with cystic fibrosis - Reply.

    Bell, Scott C / Stuart, Rhonda L

    Respirology (Carlton, Vic.)

    2019  Volume 24, Issue 4, Page(s) 393–394

    MeSH term(s) Cystic Fibrosis ; Health Personnel ; Humans ; Infections ; Workplace
    Language English
    Publishing date 2019-02-04
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13489
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    Zs.A 4957: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Prevention of chronic infection with Pseudomonas aeruginosa infection in cystic fibrosis.

    Zemanick, Edith T / Bell, Scott C

    Current opinion in pulmonary medicine

    2019  Volume 25, Issue 6, Page(s) 636–645

    Abstract: Purpose of review: This review provides an update on definitions of chronicity of infection, approaches to airway sampling to detect infection, strategies for Pseudomonas aeruginosa eradication, impact of cystic fibrosis transmembrane regulator protein ( ...

    Abstract Purpose of review: This review provides an update on definitions of chronicity of infection, approaches to airway sampling to detect infection, strategies for Pseudomonas aeruginosa eradication, impact of cystic fibrosis transmembrane regulator protein (CFTR) modulators and future challenges for clinical trials.
    Recent findings: Rates of P. aeruginosa have decreased over the past two decades with establishment of effective eradication protocols. Definitions of chronic P. aeruginosa infection have required adaptation for healthier populations. Although molecular (PCR) approaches to early P. aeruginosa detection are sensitive, to date, earlier diagnosis has not impacted on clinical outcomes. Despite eradication regimens, some people with early P. aeruginosa fail to clear their infection. Most people also experience a recurrence and eventual transition to chronic infection. Several recent studies sought to address this gap. CFTR modulators (predominantly ivacaftor) demonstrated reduced P. aeruginosa density, although infection may persist or recur demonstrating the need for continued antiinfective therapies in the modulator era.
    Summary: Future studies of approaches to P. aeruginosa eradication will be complex due to expanded availability and ongoing competitive clinical trials of CFTR modulators. Studies to address optimal eradication therapy, particularly in adults, will be required, though adequate recruitment to power these studies may prove challenging.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Chloride Channel Agonists/pharmacology ; Chronic Disease ; Cystic Fibrosis/complications ; Cystic Fibrosis/microbiology ; Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Humans ; Pseudomonas Infections/physiopathology ; Pseudomonas Infections/therapy ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/isolation & purification
    Chemical Substances Anti-Bacterial Agents ; Chloride Channel Agonists ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2019-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000000616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Emerging Nonpulmonary Complications for Adults With Cystic Fibrosis: Adult Cystic Fibrosis Series.

    Chin, Melanie / Brennan, Amanda L / Bell, Scott C

    Chest

    2021  Volume 161, Issue 5, Page(s) 1211–1224

    Abstract: Improved treatments for cystic fibrosis (CF)-related lung disease have resulted in increased longevity, but also increased prevalence and severity of extrapulmonary manifestations of CF, treatment-related complications, age-related conditions, and ... ...

    Abstract Improved treatments for cystic fibrosis (CF)-related lung disease have resulted in increased longevity, but also increased prevalence and severity of extrapulmonary manifestations of CF, treatment-related complications, age-related conditions, and psychosocial effects of longstanding chronic disease. Likewise, the recognition of mild CF phenotypes has changed the landscape of CF disease. This review outlines our current understanding of the common extrapulmonary complications of CF, as well as the changing landscape and future directions of the extrapulmonary complications experienced by patients with CF.
    MeSH term(s) Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Forecasting ; Humans ; Prevalence
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 349: Show issues

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  10. Article: Nontuberculous Mycobacteria in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Regulator Modulators

    Burke, Andrew / Thomson, Rachel M. / Wainwright, Claire E. / Bell, Scott C.

    Seminars in Respiratory and Critical Care Medicine

    (Cystic Fibrosis)

    2023  Volume 44, Issue 02, Page(s) 287–296

    Abstract: Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, ... ...

    Series title Cystic Fibrosis
    Abstract Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, though recent work has suggested clustered clonal infections do occur and transmission potential demonstrated among pwCF attending CF specialist centers. Guidelines for the screening, diagnosis, and identification of NTM and management of pwCF have been published. The emergence of CF-specific therapies, in particular cystic fibrosis transmembrane regulator (CFTR) modulator drugs, have led to significant improvement in the health and well-being of pwCF and may lead to challenges in sampling the lower respiratory tract including to screen for NTM. This review highlights the epidemiology, modes of acquisition, screening and diagnosis, therapeutic approaches in the context of improved clinical status for pwCF, and the clinical application of CFTR modulator therapies.
    Keywords cystic fibrosis ; nontuberculous mycobacteria ; complex ; CFTR modulator ; epidemiology ; environmental exposure
    Language English
    Publishing date 2023-01-17
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0042-1759883
    Database Thieme publisher's database

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