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Article ; Online: Circadian variations in the elderly: A scoping review.

Ferreira, Luciana L / Rosatto, Nadia / Marzullo, Paolo / Bellan, Mattia

2024 Volume 41, Issue 3, Page(s) 311–328

Abstract: The circadian clock plays important roles in several physiological processes. With aging, some of these circadian rhythms have been shown to be disrupted and suggested contributing to age-related diseases. The aim of this scoping review was to examine ... ...

Abstract	The circadian clock plays important roles in several physiological processes. With aging, some of these circadian rhythms have been shown to be disrupted and suggested contributing to age-related diseases. The aim of this scoping review was to examine and map the existing evidence of circadian differences between young and older people in body fluid composition. Literature search was carried out on PubMed, Embase, Scopus and OpenGrey. The studies were screened based on inclusion and exclusion criteria by two independent reviewers and the results were summarized tabularly and narratively. The review process resulted in the identification of 1889 publications, of which 42 were eligible for inclusion. Forty-eight parameters or families of parameters were identified, including cortisol and melatonin, sex hormones, thyroid-related hormones, steroids and aldosterone. However, many were reported by only a single study. The results from the studies were heterogeneous. Even though the majority suggested the flattening of several circadian oscillations in the elderly population, this was not always observed for all the parameters analyzed, and some contradictory results were found. This review revealed a substantial number of publications that explored this research question, but further studies would be important to elucidate the clinical significance of these alterations.
MeSH term(s)	Humans ; Aged ; Circadian Rhythm/physiology ; Melatonin ; Aging/physiology ; Hydrocortisone
Chemical Substances	Melatonin (JL5DK93RCL) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.1080/07420528.2024.2327456
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Article ; Online: Commenting on Paraneoplastic Arthritides: Insights to Pathogenesis, Diagnostic Approach, and Treatment.

Bellan, Mattia / Sainaghi, Pier Paolo

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

2021 Volume 27, Issue 8S, Page(s) S879

MeSH term(s)	Arthritis ; Autoantibodies ; Humans ; Rheumatic Diseases
Chemical Substances	Autoantibodies
Language	English
Publishing date	2021-05-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1283266-2
ISSN	1536-7355 ; 1076-1608
ISSN (online)	1536-7355
ISSN	1076-1608
DOI	10.1097/RHU.0000000000001448
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Zs.A 4815: Show issues

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Article: Idiopathic Pulmonary Fibrosis and Post-COVID-19 Lung Fibrosis: Links and Risks.

Patrucco, Filippo / Solidoro, Paolo / Gavelli, Francesco / Apostolo, Daria / Bellan, Mattia

Microorganisms

2023 Volume 11, Issue 4

Abstract: Idiopathic pulmonary fibrosis (IPF) is considered the paradigmatic example of chronic progressive fibrosing disease; IPF does not result from a primary immunopathogenic mechanism, but immune cells play a complex role in orchestrating the fibrosing ... ...

Abstract	Idiopathic pulmonary fibrosis (IPF) is considered the paradigmatic example of chronic progressive fibrosing disease; IPF does not result from a primary immunopathogenic mechanism, but immune cells play a complex role in orchestrating the fibrosing response. These cells are activated by pathogen-associated or danger-associated molecular patterns generating pro-fibrotic pathways or downregulating anti-fibrotic agents. Post-COVID pulmonary fibrosis (PCPF) is an emerging clinical entity, following SARS-CoV-2 infection; it shares many clinical, pathological, and immune features with IPF. Similarities between IPF and PCPF can be found in intra- and extracellular physiopathological pro-fibrotic processes, genetic signatures, as well as in the response to antifibrotic treatments. Moreover, SARS-CoV-2 infection can be a cause of acute exacerbation of IPF (AE-IPF), which can negatively impact on IPF patients' prognosis. In this narrative review, we explore the pathophysiological aspects of IPF, with particular attention given to the intracellular signaling involved in the generation of fibrosis in IPF and during the SARS-CoV-2 infection, and the similarities between IPF and PCPF. Finally, we focus on COVID-19 and IPF in clinical practice.
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11040895
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Article ; Online: The Potential Role of Vitamin D Supplementation in Cognitive Impairment Prevention.

Zeqaj, Iris / Piffero, Roberto / Calzaducca, Elisa / Pirisi, Mario / Bellan, Mattia

CNS & neurological disorders drug targets

2023 Volume 23, Issue 5, Page(s) 628–637

Abstract: Background: Vitamin D is implicated in many processes in the central nervous system (CNS), such as neurogenesis, neurotransmitter synthesis, synaptogenesis and protection against oxidative stress, thereby exerting a neuroprotective effect.: Objective!# ...

Abstract	Background: Vitamin D is implicated in many processes in the central nervous system (CNS), such as neurogenesis, neurotransmitter synthesis, synaptogenesis and protection against oxidative stress, thereby exerting a neuroprotective effect. Objective: In the present review, we aimed to evaluate the potential benefit(s) of vitamin D supplementation for CNS aging in different clinical contexts. Methods: We performed a literature search, looking for clinical trials and randomized clinical trials evaluating the effect of vitamin D supplementation on different endpoints related to cognitive outcomes. Results: Firstly, we identified 16 papers dealing with the impact of vitamin D supplementation on cognitive function in healthy subjects; the current literature suggests a real role for vitamin D supplementation in the prevention of cognitive decay in this clinical setting. Conversely, two papers suggest that vitamin D supplementation may be beneficial in patients with mild cognitive impairment (MCI). Finally, current data on vitamin D in Alzheimer's disease are contradictory. Conclusion: Vitamin D supplementation may improve the cognitive outcomes of patients with MCI, whereas there is no evidence that it may prevent dementia or modulate the course of Alzheimer's disease.
MeSH term(s)	Humans ; Vitamin D/therapeutic use ; Vitamin D/pharmacology ; Cognitive Dysfunction/prevention & control ; Cognitive Dysfunction/drug therapy ; Dietary Supplements ; Alzheimer Disease/prevention & control ; Alzheimer Disease/drug therapy
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2023-03-27
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2228394-8
ISSN	1996-3181 ; 1871-5273
ISSN (online)	1996-3181
ISSN	1871-5273
DOI	10.2174/1871527322666230328130417
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Article ; Online: COVID‑19: different waves and different outcomes.

Patrucco, Filippo / Bellan, Mattia / Solidoro, Paolo

Polish archives of internal medicine

2022 Volume 132, Issue 10

MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2
Language	English
Publishing date	2022-10-21
Publishing country	Poland
Document type	Editorial ; Comment
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16352
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Zs.A 360: Show issues

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Article: A Review: The Potential Involvement of Growth Arrest-Specific 6 and Its Receptors in the Pathogenesis of Lung Damage and in Coronavirus Disease 2019.

Apostolo, Daria / Ferreira, Luciana L / Di Tizio, Alice / Ruaro, Barbara / Patrucco, Filippo / Bellan, Mattia

Microorganisms

2023 Volume 11, Issue 8

Abstract: The tyrosine kinase receptors of the TAM family-Tyro3, Axl and Mer-and their main ligand Gas6 (growth arrest-specific 6) have been implicated in several human diseases, having a particularly important role in the regulation of innate immunity and ... ...

Abstract	The tyrosine kinase receptors of the TAM family-Tyro3, Axl and Mer-and their main ligand Gas6 (growth arrest-specific 6) have been implicated in several human diseases, having a particularly important role in the regulation of innate immunity and inflammatory response. The Gas6/TAM system is involved in the recognition of apoptotic debris by immune cells and this mechanism has been exploited by viruses for cell entry and infection. Coronavirus disease 2019 (COVID-19) is a multi-systemic disease, but the lungs are particularly affected during the acute phase and some patients may suffer persistent lung damage. Among the manifestations of the disease, fibrotic abnormalities have been observed among the survivors of COVID-19. The mechanisms of COVID-related fibrosis remain elusive, even though some parallels may be drawn with other fibrotic diseases, such as idiopathic pulmonary fibrosis. Due to the still limited number of scientific studies addressing this question, in this review we aimed to integrate the current knowledge of the Gas6/TAM axis with the pathophysiological mechanisms underlying COVID-19, with emphasis on the development of a fibrotic phenotype.
Language	English
Publishing date	2023-08-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11082038
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Article ; Online: Role of the Gas6/TAM System as a Disease Marker and Potential Drug Target.

Sainaghi, Pier Paolo / Bellan, Mattia / Nerviani, Alessandra

Disease markers

2021 Volume 2021, Page(s) 2854925

MeSH term(s)	Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Biomarkers/metabolism ; Gene Expression ; Hematologic Neoplasms/diagnosis ; Hematologic Neoplasms/drug therapy ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/immunology ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/immunology ; Immunologic Factors/therapeutic use ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/immunology ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/genetics ; Liver Cirrhosis/immunology ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/genetics ; Lupus Erythematosus, Systemic/immunology ; Molecular Targeted Therapy ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/immunology ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/immunology ; Sjogren's Syndrome/diagnosis ; Sjogren's Syndrome/drug therapy ; Sjogren's Syndrome/genetics ; Sjogren's Syndrome/immunology ; c-Mer Tyrosine Kinase/antagonists & inhibitors ; c-Mer Tyrosine Kinase/genetics ; c-Mer Tyrosine Kinase/immunology
Chemical Substances	Biomarkers ; Immunologic Factors ; Intercellular Signaling Peptides and Proteins ; Proto-Oncogene Proteins ; growth arrest-specific protein 6 ; MERTK protein, human (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; TYRO3 protein, human (EC 2.7.10.1) ; axl receptor tyrosine kinase (EC 2.7.10.1) ; c-Mer Tyrosine Kinase (EC 2.7.10.1)
Language	English
Publishing date	2021-01-13
Publishing country	United States
Document type	Editorial
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2021/2854925
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Zs.A 1856: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Commenting on "Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study" by Jacob A. Winther and colleagues.

Castello, Luigi Mario / Bellan, Mattia

Respiratory research

2018 Volume 19, Issue 1, Page(s) 35

Abstract: We would like to comment on the article entitled "Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study" by Jacob A. Winther and colleagues, in the ...

Abstract	We would like to comment on the article entitled "Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study" by Jacob A. Winther and colleagues, in the light of the results of a multicentric study published in 2014 by Vetrone F. et al., in which 336 patients with dyspnea were enrolled in the Emergency Departments of three University Hospitals in Italy.These two studies confirm the prognostic role of copeptin in patients with dyspnea due to heart failure but, while Winther et al. performed the copeptin measurements only at admission, Vetrone et al. evaluated the time-course of copeptin plasma concentration from the admission to the hospital discharge. The results showed a better performance of copeptin measured at discharge as prognostic biomarker compared to copeptin at hospital admission; similarly, a lower reduction or an increase in copeptin concentration from admission to discharge was a strong prognostic predictor of unfavorable outcome. In our opinion this is a very important result, opening new perspectives for the use of copeptin as prognostic marker in HF patients.
MeSH term(s)	Acute Disease ; Biomarkers/blood ; Glycopeptides/blood ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Humans ; Multicenter Studies as Topic/methods ; Prognosis ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology
Chemical Substances	Biomarkers ; Glycopeptides ; copeptins
Language	English
Publishing date	2018-03-01
Publishing country	England
Document type	Letter
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-9921
ISSN (online)	1465-993X
ISSN	1465-9921
DOI	10.1186/s12931-018-0738-7
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Article ; Online: Serum biomarkers in idiopathic pulmonary fibrosis.

Patrucco, Filippo / Bellan, Mattia / Solidoro, Paolo

Panminerva medica

2020 Volume 63, Issue 2, Page(s) 199–200

MeSH term(s)	Biomarkers/blood ; Disease Progression ; Humans ; Idiopathic Pulmonary Fibrosis/blood ; Idiopathic Pulmonary Fibrosis/diagnosis
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-08-05
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123572-2
ISSN	1827-1898 ; 0031-0808
ISSN (online)	1827-1898
ISSN	0031-0808
DOI	10.23736/S0031-0808.20.04049-5
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Article ; Online: Measure of lung dielectric proprieties in patients with Idiopathic Pulmonary Fibrosis: correlation with clinical, radiological and pulmonary functional parameters.

Patrucco, Filippo / Albera, Carlo / Bellan, Mattia / Zava, Martina / Gavelli, Francesco / Balbo, Piero Emilio / Solidoro, Paolo

Respiratory medicine

2023 Volume 217, Page(s) 107370

Abstract: Background: Dielectric properties of biological tissues are biophysical parameters; in lung they change with amount of air, blood and parenchyma. Remote Dielectric Sensing (ReDS™) technology measures dielectric properties of lung tissues quantifying the ...

Abstract	Background: Dielectric properties of biological tissues are biophysical parameters; in lung they change with amount of air, blood and parenchyma. Remote Dielectric Sensing (ReDS™) technology measures dielectric properties of lung tissues quantifying the content of fluids inside the scan volume. We aimed to evaluate the reliability of ReDS™ measure in Idiopathic Pulmonary Fibrosis (IPF) patients and in healthy volunteers, and to investigate the correlation of ReDS™ score with clinical, radiological and functional parameters. Methods: We conducted a prospective observational study, including 52 patients with diagnosis of IPF and 17 healthy volunteers; for each patient we recorded: complete functional evaluation, dyspnoea score (mMRC scale), Usual Interstitial Pneumonia (UIP) Computed Tomography (CT) pattern (UIP definite or probable) and ReDS™ measure (expressed in %). Results: ReDS™ measure was reported as correct both in patients and controls, the firsts with higher scores (33.8% vs 29.1%, p = 0.003). In IPF patients we observed a significant inverse correlation with ReDS™ score and Forced Vital Capacity (FVC), Vital Capacity (VC) and Total Lung Capacity (TLC) measures and, when we considered only patients with UIP definite CT pattern, the correlation was inverse with FVC, VC, TLC, DLCO. In IPF patients the higher was mMRC dyspnoea index, the higher was ReDS™ score. No significant correlations were observed between ReDS™ score and functional parameters in healthy controls. Discussion: We demonstrated a correlation of ReDS™ scores with some functional (mainly indicative or diagnostic for restriction) and clinical parameters in IPF patients; the score was correlated with density of tissues possibly quantifying tissue fibrosis in IPF patients.
MeSH term(s)	Humans ; Reproducibility of Results ; Lung/diagnostic imaging ; Idiopathic Pulmonary Fibrosis/diagnostic imaging ; Vital Capacity ; Dyspnea/etiology ; Retrospective Studies
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2023.107370
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