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Article ; Online: Ferrielectricity in the Archetypal Antiferroelectric, PbZrO

Yao, Yulian / Naden, Aaron / Tian, Mengkun / Lisenkov, Sergey / Beller, Zachary / Kumar, Amit / Kacher, Josh / Ponomareva, Inna / Bassiri-Gharb, Nazanin

Advanced materials (Deerfield Beach, Fla.)

2022 Volume 35, Issue 3, Page(s) e2206541

Abstract: Antiferroelectric materials, where the transition between antipolar and polar phase is controlled by external electric fields, offer exceptional energy storage capacity with high efficiencies, giant electrocaloric effect, and superb electromechanical ... ...

Abstract	Antiferroelectric materials, where the transition between antipolar and polar phase is controlled by external electric fields, offer exceptional energy storage capacity with high efficiencies, giant electrocaloric effect, and superb electromechanical response. PbZrO
Language	English
Publishing date	2022-12-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202206541
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Article ; Online: Microbiota functional activity biosensors for characterizing nutrient metabolism in vivo.

Wesener, Darryl A / Beller, Zachary W / Peters, Samantha L / Rajabi, Amir / Dimartino, Gianluca / Giannone, Richard J / Hettich, Robert L / Gordon, Jeffrey I

eLife

2021 Volume 10

Abstract: Methods for measuring gut microbiota biochemical activities in vivo are needed to characterize its functional states in health and disease. To illustrate one approach, an arabinan-containing polysaccharide was isolated from pea fiber, its structure ... ...

Abstract	Methods for measuring gut microbiota biochemical activities in vivo are needed to characterize its functional states in health and disease. To illustrate one approach, an arabinan-containing polysaccharide was isolated from pea fiber, its structure defined, and forward genetic and proteomic analyses used to compare its effects, versus unfractionated pea fiber and sugar beet arabinan, on a human gut bacterial strain consortium in gnotobiotic mice. We produced 'Microbiota Functional Activity Biosensors' (MFABs) consisting of glycans covalently linked to the surface of fluorescent paramagnetic microscopic glass beads. Three MFABs, each containing a unique glycan/fluorophore combination, were simultaneously orally gavaged into gnotobiotic mice, recovered from their intestines, and analyzed to directly quantify bacterial metabolism of structurally distinct arabinans in different human diet contexts. Colocalizing pea-fiber arabinan and another polysaccharide (glucomannan) on the bead surface enhanced in vivo degradation of glucomannan. MFABs represent a potentially versatile platform for developing new prebiotics and more nutritious foods.
MeSH term(s)	Animals ; Biosensing Techniques/methods ; Gastrointestinal Microbiome/physiology ; Germ-Free Life ; Male ; Mice ; Mice, Inbred C57BL ; Polysaccharides/analysis ; Polysaccharides/metabolism ; Prebiotics
Chemical Substances	Polysaccharides ; Prebiotics
Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.64478
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Article ; Online: A benzodiazepine activator locks K

Schreiber, Julian A / Möller, Melina / Zaydman, Mark / Zhao, Lu / Beller, Zachary / Becker, Sebastian / Ritter, Nadine / Hou, Panpan / Shi, Jingyi / Silva, Jon / Wrobel, Eva / Strutz-Seebohm, Nathalie / Decher, Niels / Schmitt, Nicole / Meuth, Sven G / Düfer, Martina / Wünsch, Bernhard / Cui, Jianmin / Seebohm, Guiscard

Communications biology

2022 Volume 5, Issue 1, Page(s) 301

Abstract: Loss-of-function mutations in ... ...

Abstract	Loss-of-function mutations in K
MeSH term(s)	Benzodiazepines/pharmacology ; Ion Channel Gating ; Mutation
Chemical Substances	Benzodiazepines (12794-10-4)
Language	English
Publishing date	2022-04-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-03229-8
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Article ; Online: Inducible CRISPR-targeted "knockdown" of human gut

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 39, Page(s) e2311422120

Abstract: Understanding how members of the human gut microbiota prioritize nutrient resources is one component of a larger effort to decipher the mechanisms defining microbial community robustness and resiliency in health and disease. This knowledge is ... ...

Abstract	Understanding how members of the human gut microbiota prioritize nutrient resources is one component of a larger effort to decipher the mechanisms defining microbial community robustness and resiliency in health and disease. This knowledge is foundational for development of microbiota-directed therapeutics. To model how bacteria prioritize glycans in the gut, germfree mice were colonized with 13 human gut bacterial strains, including seven saccharolytic
MeSH term(s)	Humans ; Animals ; Mice ; Bacteroides/genetics ; Polysaccharides ; Bacteroides thetaiotaomicron/genetics ; Biological Assay ; Diet, Western
Chemical Substances	Polysaccharides
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2311422120
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Article ; Online: Successful use of minimal incision superficialization technique for arteriovenous fistula maturation.

Inkollu, Sashi / Wellen, Jason / Beller, Zachary / Zhang, Tracy / Vachharajani, Neeta / Shenoy, Surendra

Journal of vascular surgery

2016 Volume 63, Issue 4, Page(s) 1018–1025

Abstract: Background: Successful cannulation is an important prerequisite for a functional arteriovenous fistula (AVF). Reasons for unsuccessful cannulation of an AVF are multifactorial and poorly evaluated. In our experience, a needle access segment (NAS) with a ...

Abstract	Background: Successful cannulation is an important prerequisite for a functional arteriovenous fistula (AVF). Reasons for unsuccessful cannulation of an AVF are multifactorial and poorly evaluated. In our experience, a needle access segment (NAS) with a length of 10 cm, <5 mm deep from the skin surface, and >6 mm diameter assessed objectively using duplex Doppler ultrasound (DDUS) imaging, in a fistula with brachial artery flow >500 mL/min, permits consistent cannulation. This report provides observational data on the NAS of the outflow veins after fistula creation and a detailed long-term outcome on AVFs that needed superficialization of the NAS using minimal incision superficialization technique (MIST) to make them suitable for cannulation. This report is based on prospectively collected data with a longitudinal follow-up in a large patient cohort. Methods: A prospective database was used to analyze consecutive patients undergoing AVF until the study end point. All patients underwent a protocol-based maturation evaluation using color DDUS imaging. Unsuitable NAS were surgically corrected using superficialization (by MIST or lipectomy) of deeply situated veins or NAS reconstruction. Results: Between February 1, 2007, and May 31, 2013, 617 new AVF surgeries were performed. Outflow vein superficialization (MIST or lipectomy) or NAS reconstruction was necessary in 226 of 585 procedures (38.6%) included in this analysis. Of these, 162 (72%) were performed using MIST, 50 (22%) with a single long incision, and 14 (6%) using lipectomy technique. Technical success for MIST was 100%, and only two fistulae failed to mature. The vein depth of 9.2 ± 3.2 mm during initial vessel mapping was similar to the pre-MIST depth of 9.1 ± 3.8 mm. Depth of NAS improved to 3.1 ± 1.0 mm after MIST. The secondary patency after MIST at 6, 12, 24, 48, and 60 months was 98%, 93.3%, 88.1%, 83.3%, and 80.9%. During the 400.8 post-MIST functional fistula-years, only 0.63 procedures per year were required to maintain AVF patency. Conclusions: Our data suggest that maturation of AVFs using objective criteria based on DDUS provides an opportunity to identify NAS problems in outflow veins before cannulation. Most of the of the AVF outflow veins (71.7%) could be transposed or superficialized using MIST, with excellent long-term outcomes.
MeSH term(s)	Adult ; Aged ; Arteriovenous Shunt, Surgical/adverse effects ; Arteriovenous Shunt, Surgical/methods ; Catheterization ; Databases, Factual ; Female ; Follow-Up Studies ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Postoperative Complications/surgery ; Prospective Studies ; Punctures ; Renal Dialysis ; Reoperation ; Time Factors ; Treatment Outcome ; Upper Extremity/blood supply ; Vascular Patency
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2015.10.063
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Zs.A 1933: Show issues

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Article ; Online: Bioremediation of a Common Product of Food Processing by a Human Gut Bacterium.

Wolf, Ashley R / Wesener, Darryl A / Cheng, Jiye / Houston-Ludlam, Alexandra N / Beller, Zachary W / Hibberd, Matthew C / Giannone, Richard J / Peters, Samantha L / Hettich, Robert L / Leyn, Semen A / Rodionov, Dmitry A / Osterman, Andrei L / Gordon, Jeffrey I

Cell host & microbe

2019 Volume 26, Issue 4, Page(s) 463–477.e8

Abstract: Dramatic increases in processed food consumption represent a global health threat. Maillard reaction products (MRPs), which are common in processed foods, form upon heat-induced reaction of amino acids with reducing sugars and include advanced glycation ... ...

Abstract	Dramatic increases in processed food consumption represent a global health threat. Maillard reaction products (MRPs), which are common in processed foods, form upon heat-induced reaction of amino acids with reducing sugars and include advanced glycation end products with deleterious health effects. To examine how processed foods affect the microbiota, we fed gnotobiotic mice, colonized with 54 phylogenetically diverse human gut bacterial strains, defined sugar-rich diets containing whey as the protein source or a matched amino acid mixture. Whey or ϵ-fructoselysine, an MRP in whey and many processed foods, selectively increases Collinsella intestinalis absolute abundance and induces Collinsella expression of genomic loci directing import and metabolism of ϵ-fructoselysine to innocuous products. This locus is repressed by glucose in C. aerofaciens, whose abundance decreases with whey, but is not repressed in C. intestinalis. Identifying gut organisms responding to and degrading potentially harmful processed food components has implications for food science, microbiome science, and public health.
MeSH term(s)	Actinobacteria/genetics ; Actinobacteria/metabolism ; Animals ; Fast Foods/analysis ; Food Quality ; Food Safety ; Gastrointestinal Microbiome ; Germ-Free Life ; Glycation End Products, Advanced/metabolism ; Humans ; Lysine/analogs & derivatives ; Lysine/metabolism ; Maillard Reaction ; Mice ; Mice, Inbred C57BL ; Whey Proteins/metabolism
Chemical Substances	Glycation End Products, Advanced ; Whey Proteins ; fructosyl-lysine (21291-40-7) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2019-10-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2019.09.001
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Zs.A 6578: Show issues

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Article ; Online: Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans.

Patnode, Michael L / Beller, Zachary W / Han, Nathan D / Cheng, Jiye / Peters, Samantha L / Terrapon, Nicolas / Henrissat, Bernard / Le Gall, Sophie / Saulnier, Luc / Hayashi, David K / Meynier, Alexandra / Vinoy, Sophie / Giannone, Richard J / Hettich, Robert L / Gordon, Jeffrey I

Cell

2019 Volume 179, Issue 1, Page(s) 59–73.e13

Abstract: Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe- ... ...

Abstract	Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with a defined consortium of human-gut-derived bacterial strains and fed different combinations of 34 food-grade fibers added to a representative low-fiber diet consumed in the United States. Bioactive carbohydrates in fiber preparations targeting particular Bacteroides species were identified using community-wide quantitative proteomic analyses of bacterial gene expression coupled with forward genetic screens. Deliberate manipulation of community membership combined with administration of retrievable artificial food particles, consisting of paramagnetic microscopic beads coated with dietary polysaccharides, disclosed the contributions of targeted species to fiber degradation. Our approach, including the use of bead-based biosensors, defines nutrient-harvesting strategies that underlie, as well as alleviate, competition between Bacteroides and control the selectivity of MDF components.
MeSH term(s)	Animals ; Bacteroides/genetics ; Diet/methods ; Dietary Fiber/metabolism ; Dietary Fiber/pharmacology ; Feces/microbiology ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/physiology ; Gene Expression Regulation, Bacterial/drug effects ; Germ-Free Life/physiology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Microbial Interactions/drug effects ; Polysaccharides/metabolism ; Polysaccharides/pharmacology ; Proteomics/methods
Chemical Substances	Dietary Fiber ; Polysaccharides
Language	English
Publishing date	2019-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2019.08.011
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Interspecies Competition Impacts Targeted Manipulation of Human Gut Bacteria by Fiber-Derived Glycans

Cell. 2019 Sept. 19, v. 179, no. 1

2019

Abstract	Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with a defined consortium of human-gut-derived bacterial strains and fed different combinations of 34 food-grade fibers added to a representative low-fiber diet consumed in the United States. Bioactive carbohydrates in fiber preparations targeting particular Bacteroides species were identified using community-wide quantitative proteomic analyses of bacterial gene expression coupled with forward genetic screens. Deliberate manipulation of community membership combined with administration of retrievable artificial food particles, consisting of paramagnetic microscopic beads coated with dietary polysaccharides, disclosed the contributions of targeted species to fiber degradation. Our approach, including the use of bead-based biosensors, defines nutrient-harvesting strategies that underlie, as well as alleviate, competition between Bacteroides and control the selectivity of MDF components.
Keywords	Bacteroides ; bioactive compounds ; biosensors ; foods ; gene expression ; genetic testing ; germ-free animals ; humans ; intestinal microorganisms ; low fiber diet ; mice ; polysaccharides ; proteomics ; United States
Language	English
Dates of publication	2019-0919
Size	p. 59-73.e13.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2019.08.011
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Article ; Online: Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel.

Zaydman, Mark A / Kasimova, Marina A / McFarland, Kelli / Beller, Zachary / Hou, Panpan / Kinser, Holly E / Liang, Hongwu / Zhang, Guohui / Shi, Jingyi / Tarek, Mounir / Cui, Jianmin

eLife

2014 Volume 3, Page(s) e03606

Abstract: Voltage-gated ion channels generate electrical currents that control muscle contraction, encode neuronal information, and trigger hormonal release. Tissue-specific expression of accessory (β) subunits causes these channels to generate currents with ... ...

Abstract	Voltage-gated ion channels generate electrical currents that control muscle contraction, encode neuronal information, and trigger hormonal release. Tissue-specific expression of accessory (β) subunits causes these channels to generate currents with distinct properties. In the heart, KCNQ1 voltage-gated potassium channels coassemble with KCNE1 β-subunits to generate the IKs current (Barhanin et al., 1996; Sanguinetti et al., 1996), an important current for maintenance of stable heart rhythms. KCNE1 significantly modulates the gating, permeation, and pharmacology of KCNQ1 (Wrobel et al., 2012; Sun et al., 2012; Abbott, 2014). These changes are essential for the physiological role of IKs (Silva and Rudy, 2005); however, after 18 years of study, no coherent mechanism explaining how KCNE1 affects KCNQ1 has emerged. Here we provide evidence of such a mechanism, whereby, KCNE1 alters the state-dependent interactions that functionally couple the voltage-sensing domains (VSDs) to the pore.
MeSH term(s)	Animals ; Female ; Ion Channel Gating ; KCNQ1 Potassium Channel/metabolism ; Models, Molecular ; Permeability ; Potassium Channels, Voltage-Gated/metabolism ; Protein Interaction Domains and Motifs ; Protein Structure, Tertiary ; Protein Subunits/metabolism ; Xenopus
Chemical Substances	KCNQ1 Potassium Channel ; Potassium Channels, Voltage-Gated ; Protein Subunits
Language	English
Publishing date	2014-12-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.03606
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