LIVIVO - Search results -

Search results

Result 1 - 10 of total 683

Search options

Article: Neurotrauma-From Injury to Repair: Clinical Perspectives, Cellular Mechanisms and Promoting Regeneration of the Injured Brain and Spinal Cord.

Stevens, Andrew R / Belli, Antonio / Ahmed, Zubair

2024 Volume 12, Issue 3

Abstract: Traumatic injury to the brain and spinal cord (neurotrauma) is a common event across populations and often causes profound and irreversible disability. Pathophysiological responses to trauma exacerbate the damage of an index injury, propagating the loss ... ...

Abstract	Traumatic injury to the brain and spinal cord (neurotrauma) is a common event across populations and often causes profound and irreversible disability. Pathophysiological responses to trauma exacerbate the damage of an index injury, propagating the loss of function that the central nervous system (CNS) cannot repair after the initial event is resolved. The way in which function is lost after injury is the consequence of a complex array of mechanisms that continue in the chronic phase post-injury to prevent effective neural repair. This review summarises the events after traumatic brain injury (TBI) and spinal cord injury (SCI), comprising a description of current clinical management strategies, a summary of known cellular and molecular mechanisms of secondary damage and their role in the prevention of repair. A discussion of current and emerging approaches to promote neuroregeneration after CNS injury is presented. The barriers to promoting repair after neurotrauma are across pathways and cell types and occur on a molecular and system level. This presents a challenge to traditional molecular pharmacological approaches to targeting single molecular pathways. It is suggested that novel approaches targeting multiple mechanisms or using combinatorial therapies may yield the sought-after recovery for future patients.
Language	English
Publishing date	2024-03-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12030643
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Changes in Brain Structure and Function in a Multisport Cohort of Retired Female and Male Athletes, Many Years after Suffering a Concussion: Implications for Neuroplasticity and Neurodegenerative Disease Pathogenesis.

Turner, Michael / Belli, Antonio / Castellani, Rudolph J

Journal of Alzheimer's disease reports

2024 Volume 8, Issue 1, Page(s) 501–516

Abstract: Background: Cumulative effects of traumatic brain injury is of increasing concern, especially with respect to its role in the etiology and pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic ... ...

Abstract	Background: Cumulative effects of traumatic brain injury is of increasing concern, especially with respect to its role in the etiology and pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Objective: Compare regional brain volume and connectivity between athletes with a history of concussion and controls. Methods: We evaluated whole-brain volumetric effects with Bayesian regression models and functional connectivity with network-based statistics, in 125 retired athletes (a mean of 11 reported concussions) and 36 matched controls. Results: Brain regions significantly lower in volume in the concussed group included the middle frontal gyrus, hippocampus, supramarginal gyrus, temporal pole, and inferior frontal gyrus. Conversely, brain regions significantly larger included the hippocampal and collateral sulcus, middle occipital gyrus, medial orbital gyrus, caudate nucleus, lateral orbital gyrus, and medial postcentral gyrus. Functional connectivity analyses revealed increased edge strength, most marked in motor domains. Numerous edges of this network strengthened in athletes were significantly weakened with concussion. Aligned to meta-analytic neuroimaging data, the observed changes suggest functional enhancement within the motor, sensory, coordination, balance, and visual processing domains in athletes, attenuated by concussive head injury with a negative impact on memory and language. Conclusions: These findings suggest that engagement in sport may benefit the brain across numerous domains, but also highlights the potentially damaging effects of concussive head injury. Future studies with longitudinal cohorts including autopsy examination are needed to determine whether the latter reflects tissue loss from brain shearing, or the onset of a progressive Alzheimer's disease like proteinopathy.
Language	English
Publishing date	2024-03-19
Publishing country	Netherlands
Document type	Journal Article
ISSN	2542-4823
ISSN (online)	2542-4823
DOI	10.3233/ADR-240021
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Does Vestibular-Ocular-Motor (VOM) Impairment Affect Time to Return to Play, Symptom Severity, Neurocognition and Academic Ability in Student-Athletes following acute Concussion?

Glendon, K / Blenkinsop, G / Belli, A / Pain, M

Brain injury

2021 Volume 35, Issue 7, Page(s) 788–797

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Athletes ; Athletic Injuries/complications ; Brain Concussion/complications ; Female ; Humans ; Male ; Return to Sport ; Students
Language	English
Publishing date	2021-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639115-1
ISSN	1362-301X ; 0269-9052
ISSN (online)	1362-301X
ISSN	0269-9052
DOI	10.1080/02699052.2021.1911001
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2242: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recovery of symptoms, neurocognitive and vestibular-ocular-motor function and academic ability after sports-related concussion (SRC) in university-aged student-athletes: a systematic review.

Glendon, K / Desai, A / Blenkinsop, G / Belli, A / Pain, M

Brain injury

2022 Volume 36, Issue 4, Page(s) 455–468

Abstract: Background: Physiological differences between a maturing and matured brain alters how Sports-Related Concussion (SRC) affects different age groups; therefore, a review specific to university-aged student-athletes is needed.: Objectives: Determine ... ...

Abstract	Background: Physiological differences between a maturing and matured brain alters how Sports-Related Concussion (SRC) affects different age groups; therefore, a review specific to university-aged student-athletes is needed. Objectives: Determine time to recovery for symptom burden, neurocognitive and Vestibular-Ocular-Motor (VOM) function and academic impact in university-aged student-athletes. Methods: Searches were conducted in PubMed, SpringerLink, PsycINFO, Science Direct, Scopus, Cochrane, Web of Science and EMBASE. Articles were included if they contained original data collected within 30 days in university-aged student-athletes, analysed SRC associated symptoms, neurocognitive or VOM function or academic ability and published in English. Two reviewers independently reviewed sources, using the Oxford Classification of Evidence-Based Medicine (CEBM) and the Downs and Black checklist, and independently extracting data before achieving consensus. Results: 58 articles met the inclusion criteria. Recovery of symptoms occurred by 7 and 3-5.3 days for neurocognition. The evidence base did not allow for a conclusion on recovery time for VOM function or academic ability. Few papers investigated recovery times at specified re-assessment time-points and have used vastly differing methodologies. Conclusions: To fully understand the implication of SRC on the university-aged student-athlete' studies using a multi-faceted approach at specific re-assessments time points are required.Systematic review registration number: CRD42019130685.
MeSH term(s)	Aged ; Athletes ; Athletic Injuries/complications ; Athletic Injuries/diagnosis ; Brain Concussion/complications ; Brain Concussion/diagnosis ; Humans ; Students ; Universities
Language	English
Publishing date	2022-04-04
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	639115-1
ISSN	1362-301X ; 0269-9052
ISSN (online)	1362-301X
ISSN	0269-9052
DOI	10.1080/02699052.2022.2051740
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2242: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Prospective study with specific Re-Assessment time points to determine time to recovery following a Sports-Related Concussion in university-aged student-athletes.

Glendon, K / Blenkinsop, G / Belli, A / Pain, M

Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

2021 Volume 52, Page(s) 287–296

Abstract: Background: Time to recovery for symptom burden and neurocognition following a Sports-Related Concussion (SRC) has previously been determined by consolidating varying re-assessment time points into a singular point, and has not been established for ... ...

Abstract	Background: Time to recovery for symptom burden and neurocognition following a Sports-Related Concussion (SRC) has previously been determined by consolidating varying re-assessment time points into a singular point, and has not been established for Vestibular-Ocular-Motor (VOM) function or academic ability. Objectives: Establish when recovery of symptom burden, neurocognition, VOM function, and academic ability occurs in university-aged student-athletes. Methods: Student-athletes completed an assessment battery (Post-Concussion Symptom Scale (PCSS), Immediate Post-Concussion Assessment and Cognitive Test (ImPACT), Vestibular Ocular-Motor Screening (VOMS), Perceived Academic Impairment Tool (PAIT)) during pre-season (n = 140), within 48 hours, 4, 8 and 14 days post-SRC and prior to Return To Play (RTP) and were managed according to the Rugby Football Union' community pathway (n = 42). Student-athletes were deemed recovered or impaired according to Reliable Change Index' (RCI) or compared to their individual baseline. Results: Symptom burden recovers by four days post-SRC on RCI and to baseline by eight days. VOM function and academic ability recovers by 8 days. Some student-athletes demonstrated worse performance at RTP on all tests by RCI and to baseline, except for on VOMS score and near point convergence by RCI change. Conclusions: Variation in individual university-aged student-athletes requires a multi-faceted approach to establish what dysfunctions post-SRC exist and when recovery occurs.
MeSH term(s)	Aged ; Athletes ; Athletic Injuries/diagnosis ; Brain Concussion/diagnosis ; Football ; Humans ; Prospective Studies ; Students ; Universities
Language	English
Publishing date	2021-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2008604-0
ISSN	1873-1600 ; 1466-853X
ISSN (online)	1873-1600
ISSN	1466-853X
DOI	10.1016/j.ptsp.2021.10.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5218: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Musculoskeletal injury or Sports-Related Concussion (SRC) in a season of rugby union does not affect performance on concussion battery testing in university-aged student-athletes.

Glendon, K / Pain, M T G / Hogervorst, E / Belli, A / Blenkinsop, G

Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine

2023 Volume 65, Page(s) 137–144

Abstract: Background: Sub-concussive and concussive impacts sustained during contact sports such as rugby may affect neurocognitive performance, vestibular-ocular-motor function, symptom burden and academic ability.: Method: Student-athletes (n = 146) ... ...

Abstract	Background: Sub-concussive and concussive impacts sustained during contact sports such as rugby may affect neurocognitive performance, vestibular-ocular-motor function, symptom burden and academic ability. Method: Student-athletes (n = 146) participating in rugby union British Universities or domestic competitions were assessed on the Immediate Post-Concussion and Cognitive Test, Post-Concussion Symptom Scale, vestibular-oculo-motor screening tool and revised perceived academic impact tool. Individual change from pre-season (July-September 2021) to 2-weeks following last exposure to contact (April-July 2022) was analysed. Results: Symptom burden significantly worsened (p=0.016) over the season. Significant improvements on verbal memory (p=0.016), visual memory (p=0.008) and motor processing speed (p=0.001) suggest a possible learning effect. Surprisingly, the number of days lost to concussion significantly and positively affected performance on verbal memory (p = 0.018) and reaction time (p = 0.027). Previous concussive events significantly predicted a worsening in symptom burden (p < 0.028), as did in-season concussive events, predicting improved verbal memory (p = 0.033) and symptom burden change (p = 0.047). Baseline performance significantly affected change on several neurocognitive tests, with low-scorers showing more improvement over the season. Conclusion: Participation in rugby union was not associated with deleterious effects on brain function. Previous concussive events and in-season factors, possibly related to learning effects, may explain improvement in cognitive function across the season.
MeSH term(s)	Humans ; Aged ; Athletic Injuries/diagnosis ; Rugby ; Universities ; Seasons ; Brain Concussion/diagnosis ; Athletes ; Students
Language	English
Publishing date	2023-12-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2008604-0
ISSN	1873-1600 ; 1466-853X
ISSN (online)	1873-1600
ISSN	1466-853X
DOI	10.1016/j.ptsp.2023.12.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5218: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: PPG and EDA dataset collected with Empatica E4 for stress assessment.

Campanella, Sara / Altaleb, Ayham / Belli, Alberto / Pierleoni, Paola / Palma, Lorenzo

Data in brief

2024 Volume 53, Page(s) 110102

Abstract: In response to challenging circumstances, the human body can experience marked levels of anxiety and distress. Wearable devices offer a means of real-time and ongoing data collection, facilitating personalized stress monitoring. Therefore, we collected ... ...

Abstract	In response to challenging circumstances, the human body can experience marked levels of anxiety and distress. Wearable devices offer a means of real-time and ongoing data collection, facilitating personalized stress monitoring. Therefore, we collected physiological signals (blood pressure volume and electrodermal activities), using Empatica E4, from 29 subjects. A personalized protocol was developed to cause cognitive, mental, and psychological stressors since they are the ones that can be experienced in working or academic environment. We also propose a pipeline to clean and process these two signals to maximize the quality of further analysis. This study aids in the comprehension of the complex connection between stress and working situations by offering a sizable dataset made up of different physiological data. It additionally enables them to create cutting-edge stress-reduction techniques and improving professional achievement while lessening the negative impact of stress on welfare.
Language	English
Publishing date	2024-01-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2024.110102
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Design and Implementation of a Framework for Smart Home Automation Based on Cellular IoT, MQTT, and Serverless Functions.

Esposito, Marco / Belli, Alberto / Palma, Lorenzo / Pierleoni, Paola

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 9

Abstract: Smart objects and home automation tools are becoming increasingly popular, and the number of smart devices that each dedicated application has to manage is increasing accordingly. The emergence of technologies such as serverless computing and dedicated ... ...

Abstract	Smart objects and home automation tools are becoming increasingly popular, and the number of smart devices that each dedicated application has to manage is increasing accordingly. The emergence of technologies such as serverless computing and dedicated machine-to-machine communication protocols represents a valuable opportunity to facilitate management of smart objects and replicability of new solutions. The aim of this paper is to propose a framework for home automation applications that can be applied to control and monitor any appliance or object in a smart home environment. The proposed framework makes use of a dedicated messages-exchange protocol based on MQTT and cloud-deployed serverless functions. Furthermore, a vocal command interface is implemented to let users control the smart object with vocal interactions, greatly increasing the accessibility and intuitiveness of the proposed solution. A smart object, namely a smart kitchen fan extractor system, was developed, prototyped, and tested to illustrate the viability of the proposed solution. The smart object is equipped with a narrowband IoT (NB-IoT) module to send and receive commands to and from the cloud. In order to evaluate the performance of the proposed solution, the suitability of NB-IoT for the transmission of MQTT messages was evaluated. The results show how NB-IoT has an acceptable latency performance despite some minimal packet loss.
Language	English
Publishing date	2023-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23094459
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A Method for Stress Detection Using Empatica E4 Bracelet and Machine-Learning Techniques.

Campanella, Sara / Altaleb, Ayham / Belli, Alberto / Pierleoni, Paola / Palma, Lorenzo

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 7

Abstract: In response to challenging circumstances, the human body can experience marked levels of anxiety and distress. To prevent stress-related complications, timely identification of stress symptoms is crucial, necessitating the need for continuous stress ... ...

Abstract	In response to challenging circumstances, the human body can experience marked levels of anxiety and distress. To prevent stress-related complications, timely identification of stress symptoms is crucial, necessitating the need for continuous stress monitoring. Wearable devices offer a means of real-time and ongoing data collection, facilitating personalized stress monitoring. Based on our protocol for data pre-processing, this study proposes to analyze signals obtained from the Empatica E4 bracelet using machine-learning algorithms (Random Forest, SVM, and Logistic Regression) to determine the efficacy of the abovementioned techniques in differentiating between stressful and non-stressful situations. Photoplethysmographic and electrodermal activity signals were collected from 29 subjects to extract 27 features which were then fed into three different machine-learning algorithms for binary classification. Using MATLAB after applying the chi-square test and Pearson's correlation coefficient on WEKA for features' importance ranking, the results demonstrated that the Random Forest model has the highest stability (accuracy of 76.5%) using all the features. Moreover, the Random Forest applying the chi-test for feature selection reached consistent results in terms of stress evaluation based on precision, recall, and F1-measure (71%, 60%, 65%, respectively).
MeSH term(s)	Humans ; Wearable Electronic Devices ; Machine Learning ; Algorithms ; Random Forest ; Data Collection
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23073565
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Concussion in facial trauma patients: a retrospective analysis of 100 patients from a UK major trauma centre.

Riley, Max / Mandair, Ravina / Belli, Antonio / Breeze, John / Toman, Emma

The British journal of oral & maxillofacial surgery

2023 Volume 61, Issue 8, Page(s) 553–557

Abstract: Concussion is a common and potentially debilitating condition. Research has shown that one-third of patients admitted with facial trauma have concurrent concussion. This study aimed to investigate the burden and management of concussion in patients ... ...

Abstract	Concussion is a common and potentially debilitating condition. Research has shown that one-third of patients admitted with facial trauma have concurrent concussion. This study aimed to investigate the burden and management of concussion in patients presenting with acute facial trauma, and to identify potential risk factors within this population. A retrospective observational study was conducted at a UK major trauma centre between 1 January 2019 and 1 February2020. One hundred randomly selected patients who attended the acute clinic responsible for managing facial trauma were identified. No parametric data were included. The Mann-Whitney test was used to detect differences for continuous data, the X
Language	English
Publishing date	2023-08-03
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2023.07.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uk I Zs.238: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito