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  1. Article ; Online: The

    Gregoire, Elodie P / De Cian, Marie-Cécile / Migale, Roberta / Perea-Gomez, Aitana / Schaub, Sébastien / Bellido-Carreras, Natividad / Stévant, Isabelle / Mayère, Chloé / Neirijnck, Yasmine / Loubat, Agnès / Rivaud, Paul / Sopena, Miriam Llorian / Lachambre, Simon / Linssen, Margot M / Hohenstein, Peter / Lovell-Badge, Robin / Nef, Serge / Chalmel, Frédéric / Schedl, Andreas /
    Chaboissier, Marie-Christine

    Science (New York, N.Y.)

    2023  Volume 382, Issue 6670, Page(s) 600–606

    Abstract: Sex determination in mammals depends on the differentiation of the supporting lineage of the gonads into Sertoli or pregranulosa cells that govern testis and ovary development, respectively. Although the Y-linked testis-determining ... ...

    Abstract Sex determination in mammals depends on the differentiation of the supporting lineage of the gonads into Sertoli or pregranulosa cells that govern testis and ovary development, respectively. Although the Y-linked testis-determining gene
    MeSH term(s) Animals ; Female ; Male ; Mice ; Ovary/growth & development ; Sex Determination Processes/genetics ; Sex-Determining Region Y Protein/genetics ; Sex-Determining Region Y Protein/metabolism ; Testis/growth & development ; WT1 Proteins/genetics ; WT1 Proteins/metabolism ; Protein Isoforms
    Chemical Substances Sex-Determining Region Y Protein ; WT1 protein, mouse ; WT1 Proteins ; Protein Isoforms
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.add8831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 77: Show issues

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  2. Article ; Online: Salmonella Typhimurium Infection Along the Porcine Gastrointestinal Tract and Associated Lymphoid Tissues

    Bellido-Carreras, Natividad / Argüello, Héctor / Zaldívar-López, Sara / Jiménez-Marín, Ángeles / Martins, Rodrigo P. / Arce, Cristina / Morera, Luis / Carvajal, Ana / Garrido, Juan J.

    Veterinary Pathology. 2019 Sept., v. 56, no. 5 p.681-690

    2019  

    Abstract: Salmonella is a major foodborne pathogen and pork is one of the main sources of human salmonellosis. Understanding the pathogenesis and progression of the infection within the host is of interest to establish potential approaches to control the disease ... ...

    Abstract Salmonella is a major foodborne pathogen and pork is one of the main sources of human salmonellosis. Understanding the pathogenesis and progression of the infection within the host is of interest to establish potential approaches to control the disease in pigs. The present study evaluates factors such as intestinal colonization, fecal shedding, and pathogen persistence by 2 studies using experimental challenge with Salmonella Typhimurium in weaned pigs and euthanasia at different time points (1, 2, and 6 and 2, 14, and 30 days postinfection [dpi], respectively). Histopathology of intestine at early time points (1 dpi and 2 dpi) showed severe damage to the epithelium together with an increase in polymorphonuclear cells and macrophages (P < .001), particularly in jejunum and ileum. Large quantities of Salmonella were detected within the contents of the ileum, cecum, and colon in early infection. Salmonella could also be observed in the medulla of tonsils and mesenteric lymph nodes. From 6 dpi onward, signs of recovery were observed, with progressive restoration of the epithelium, reduction of the inflammatory infiltrate, and elimination of Salmonella from the mucosa. Concentration of Salmonella in feces and ileum content decreased, but shedding did not cease even at 4 weeks after infection. Persistence of the bacteria in mesenteric lymph nodes was identified within the connective tissue at 14 and 30 dpi. Our results demonstrate a recovery of the disease after an initial acute phase but also show persistence within the lumen and surrounding lymphoid tissue. These findings are relevant to developing effective control strategies.
    Keywords Salmonella Typhimurium ; animal pathology ; cecum ; colon ; digestive tract ; euthanasia ; feces ; food pathogens ; histopathology ; humans ; ileum ; jejunum ; lymph ; macrophages ; mucosa ; pathogen survival ; pathogenesis ; pork ; salmonellosis ; swine ; foodborne diseases ; immunohistochemistry ; intestine ; lymph node ; porcine ; experimental infection
    Language English
    Dates of publication 2019-09
    Size p. 681-690.
    Publishing place SAGE Publications
    Document type Article ; Online
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/0300985819843682
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.

    Mayère, Chloé / Regard, Violaine / Perea-Gomez, Aitana / Bunce, Corey / Neirijnck, Yasmine / Djari, Cyril / Bellido-Carreras, Natividad / Sararols, Pauline / Reeves, Richard / Greenaway, Simon / Simon, Michelle / Siggers, Pam / Condrea, Diana / Kühne, Françoise / Gantar, Ivana / Tang, Furong / Stévant, Isabelle / Batti, Laura / Ghyselinck, Norbert B /
    Wilhelm, Dagmar / Greenfield, Andy / Capel, Blanche / Chaboissier, Marie-Christine / Nef, Serge

    Science advances

    2022  Volume 8, Issue 21, Page(s) eabm0972

    Abstract: Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here, we investigated the origin, ... ...

    Abstract Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here, we investigated the origin, specification, and subsequent sex-specific differentiation of a previously uncharacterized population of supporting-like cells (SLCs) in the developing mouse gonads. The SLC lineage is closely related to the coelomic epithelium and specified as early as E10.5, making it the first somatic lineage to be specified in the bipotential gonad. SLC progenitors are localized within the genital ridge at the interface with the mesonephros and initially coexpress
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abm0972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Salmonella Typhimurium

    Bellido-Carreras, Natividad / Argüello, Héctor / Zaldívar-López, Sara / Jiménez-Marín, Ángeles / Martins, Rodrigo P / Arce, Cristina / Morera, Luis / Carvajal, Ana / Garrido, Juan J

    Veterinary pathology

    2019  Volume 56, Issue 5, Page(s) 681–690

    Abstract: ... ...

    Abstract Salmonella
    MeSH term(s) Animals ; Feces/microbiology ; Gastrointestinal Diseases/microbiology ; Gastrointestinal Diseases/veterinary ; Gastrointestinal Tract/microbiology ; Lymphoid Tissue/microbiology ; Salmonella Infections, Animal/microbiology ; Salmonella typhimurium/isolation & purification ; Swine ; Swine Diseases/microbiology
    Language English
    Publishing date 2019-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188012-3
    ISSN 1544-2217 ; 0300-9858
    ISSN (online) 1544-2217
    ISSN 0300-9858
    DOI 10.1177/0300985819843682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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