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  1. AU="Bellomo, Chiara"
  2. AU="Jeon, Soo Min"
  3. AU="Rotaru, Mihaela"
  4. AU="Hakami, Mohammed Ageeli"
  5. AU="Garduño, Eugenio"
  6. AU="Kumar Vijay, Ajay"
  7. AU="Concheiro, Marta"
  8. AU="Kang, Ji-Hoon"
  9. AU="González-Gómez, Julio César"
  10. AU="Eisinger, Felix"
  11. AU="van Arkel, Gijs H J"
  12. AU="Dukkipati, Haripriya"
  13. AU="Mansoor, Farheen"
  14. AU="Stanton, Clive"
  15. AU=Herholz K AU=Herholz K
  16. AU="Marichal, Axel"
  17. AU="Camon, Ana M"
  18. AU="Randall, Michael D"

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  1. Artikel ; Online: Reaction with Water Vapor Defines Surface Reconstruction and Membranolytic Activity of Quartz Milled in Different Molecular Environments.

    Bellomo, Chiara / Lagostina, Valeria / Pavan, Cristina / Paganini, Maria Cristina / Turci, Francesco

    Small (Weinheim an der Bergstrasse, Germany)

    2023  , Seite(n) e2308369

    Abstract: Industrial processing of quartz ( ... ...

    Abstract Industrial processing of quartz (SiO
    Sprache Englisch
    Erscheinungsdatum 2023-12-15
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202308369
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Top-Down Preparation of Nanoquartz for Toxicological Investigations.

    Bellomo, Chiara / Pavan, Cristina / Fiore, Gianluca / Escolano-Casado, Guillermo / Mino, Lorenzo / Turci, Francesco

    International journal of molecular sciences

    2022  Band 23, Heft 23

    Abstract: Occupational exposure to quartz dust is associated with fatal diseases. Quartz dusts generated by mechanical fracturing are characterized by a broad range of micrometric to nanometric particles. The contribution of this nanometric fraction to the overall ...

    Abstract Occupational exposure to quartz dust is associated with fatal diseases. Quartz dusts generated by mechanical fracturing are characterized by a broad range of micrometric to nanometric particles. The contribution of this nanometric fraction to the overall toxicity of quartz is still largely unexplored, primarily because of the strong electrostatic adhesion forces that prevent isolation of the nanofraction. Furthermore, fractured silica dust exhibits special surface features, namely nearly free silanols (NFS), which impart a membranolytic activity to quartz. Nanoquartz can be synthetized via bottom-up methods, but the surface chemistry of such crystals strongly differs from that of nanoparticles resulting from fracturing. Here, we report a top-down milling procedure to obtain a nanometric quartz that shares the key surface properties relevant to toxicity with fractured quartz. The ball milling was optimized by coupling the dry and wet milling steps, using water as a dispersing agent, and varying the milling times and rotational speeds. Nanoquartz with a strong tendency to form submicrometric agglomerates was obtained. The deagglomeration with surfactants or simulated body fluids was negligible. Partial lattice amorphization and a bimodal crystallite domain size were observed. A moderate membranolytic activity, which correlated with the number of NFS, signaled coherence with the previous toxicological data. A membranolytic nanoquartz for toxicological investigations was obtained.
    Sprache Englisch
    Erscheinungsdatum 2022-12-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232315425
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Nearly free silanols drive the interaction of crystalline silica polymorphs with membranes: Implications for mineral toxicity.

    Pavan, Cristina / Escolano-Casado, Guillermo / Bellomo, Chiara / Cananà, Stefania / Tomatis, Maura / Leinardi, Riccardo / Mino, Lorenzo / Turci, Francesco

    Frontiers in chemistry

    2023  Band 10, Seite(n) 1092221

    Abstract: Crystalline silica (CS) is a well-known hazardous material that causes severe diseases including silicosis, lung cancer, and autoimmune diseases. However, the hazard associated to crystalline silica is extremely variable and depends on some specific ... ...

    Abstract Crystalline silica (CS) is a well-known hazardous material that causes severe diseases including silicosis, lung cancer, and autoimmune diseases. However, the hazard associated to crystalline silica is extremely variable and depends on some specific characteristics, including crystal structure and surface chemistry. The crystalline silica polymorphs share the SiO
    Sprache Englisch
    Erscheinungsdatum 2023-01-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2022.1092221
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Molecular recognition between membrane epitopes and nearly free surface silanols explains silica membranolytic activity

    Pavan, Cristina / Sydor, Matthew J. / Bellomo, Chiara / Leinardi, Riccardo / Cananà, Stefania / Kendall, Rebekah L. / Rebba, Erica / Corno, Marta / Ugliengo, Piero / Mino, Lorenzo / Holian, Andrij / Turci, Francesco

    Colloids and surfaces. 2022 Sept., v. 217

    2022  

    Abstract: Inhaled crystalline silica causes inflammatory lung diseases, but the mechanism for its unique activity compared to other oxides remains unclear, preventing the development of potential therapeutics. Here, the molecular recognition mechanism between ... ...

    Abstract Inhaled crystalline silica causes inflammatory lung diseases, but the mechanism for its unique activity compared to other oxides remains unclear, preventing the development of potential therapeutics. Here, the molecular recognition mechanism between membrane epitopes and “nearly free silanols” (NFS), a specific subgroup of surface silanols, is identified and proposed as a novel broad explanation for particle toxicity in general. Silica samples having different bulk and surface properties, specifically different amounts of NFS, are tested with a set of membrane systems of decreasing molecular complexity and different charge. The results demonstrate that NFS content is the primary determinant of membrane disruption causing red blood cell lysis and changes in lipid order in zwitterionic, but not in negatively charged liposomes. NFS-rich silica strongly and irreversibly adsorbs zwitterionic self-assembled phospholipid structures. This selective interaction is corroborated by density functional theory and supports the hypothesis that NFS recognize membrane epitopes that exhibit a positive quaternary amino and negative phosphate group. These new findings define a new paradigm for deciphering particle-biomembrane interactions that will support safer design of materials and what types of treatments might interrupt particle-biomembrane interactions.
    Schlagwörter density functional theory ; epitopes ; erythrocytes ; lungs ; phosphates ; phospholipids ; silica ; therapeutics ; toxicity ; zwitterions
    Sprache Englisch
    Erscheinungsverlauf 2022-09
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2022.112625
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel ; Online: Enhanced and specific epoxidation activity of P450 BM3 mutants for the production of high value terpene derivatives.

    Correddu, Danilo / Helmy Aly, Sabrina / Di Nardo, Giovanna / Catucci, Gianluca / Prandi, Cristina / Blangetti, Marco / Bellomo, Chiara / Bonometti, Elisabetta / Viscardi, Guido / Gilardi, Gianfranco

    RSC advances

    2022  Band 12, Heft 52, Seite(n) 33964–33969

    Abstract: Terpenes are natural molecules of valuable interest for different industrial applications. Cytochromes P450 enzymes can functionalize terpenoids to form high value oxidized derivatives in a green and sustainable manner, representing a valid alternative ... ...

    Abstract Terpenes are natural molecules of valuable interest for different industrial applications. Cytochromes P450 enzymes can functionalize terpenoids to form high value oxidized derivatives in a green and sustainable manner, representing a valid alternative to chemical catalysis. In this work, an enhanced and specific epoxidation activity of cytochrome P450 BM3 mutants was found for the terpenes geraniol and linalool. This is the first report showing the epoxidation of linalool by P450 BM3 and its mutant A2 (Asp251Gly/Gln307His) with the formation of valuable oxide derivatives, highlighting the relevance of this enzymes for industrial applications.
    Sprache Englisch
    Erscheinungsdatum 2022-11-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra06029a
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Molecular recognition between membrane epitopes and nearly free surface silanols explains silica membranolytic activity.

    Pavan, Cristina / Sydor, Matthew J / Bellomo, Chiara / Leinardi, Riccardo / Cananà, Stefania / Kendall, Rebekah L / Rebba, Erica / Corno, Marta / Ugliengo, Piero / Mino, Lorenzo / Holian, Andrij / Turci, Francesco

    Colloids and surfaces. B, Biointerfaces

    2022  Band 217, Seite(n) 112625

    Abstract: Inhaled crystalline silica causes inflammatory lung diseases, but the mechanism for its unique activity compared to other oxides remains unclear, preventing the development of potential therapeutics. Here, the molecular recognition mechanism between ... ...

    Abstract Inhaled crystalline silica causes inflammatory lung diseases, but the mechanism for its unique activity compared to other oxides remains unclear, preventing the development of potential therapeutics. Here, the molecular recognition mechanism between membrane epitopes and "nearly free silanols" (NFS), a specific subgroup of surface silanols, is identified and proposed as a novel broad explanation for particle toxicity in general. Silica samples having different bulk and surface properties, specifically different amounts of NFS, are tested with a set of membrane systems of decreasing molecular complexity and different charge. The results demonstrate that NFS content is the primary determinant of membrane disruption causing red blood cell lysis and changes in lipid order in zwitterionic, but not in negatively charged liposomes. NFS-rich silica strongly and irreversibly adsorbs zwitterionic self-assembled phospholipid structures. This selective interaction is corroborated by density functional theory and supports the hypothesis that NFS recognize membrane epitopes that exhibit a positive quaternary amino and negative phosphate group. These new findings define a new paradigm for deciphering particle-biomembrane interactions that will support safer design of materials and what types of treatments might interrupt particle-biomembrane interactions.
    Mesh-Begriff(e) Epitopes ; Silanes/chemistry ; Silicon Dioxide/chemistry ; Surface Properties
    Chemische Substanzen Epitopes ; Silanes ; silanol (079V3J9O3X) ; Silicon Dioxide (7631-86-9)
    Sprache Englisch
    Erscheinungsdatum 2022-06-14
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2022.112625
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Carborane-BODIPY Dyads: New Photoluminescent Materials through an Efficient Heck Coupling.

    Bellomo, Chiara / Chaari, Mahdi / Cabrera-González, Justo / Blangetti, Marco / Lombardi, Chiara / Deagostino, Annamaria / Viñas, Clara / Gaztelumendi, Nerea / Nogués, Carme / Nuñez, Rosario / Prandi, Cristina

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2018  Band 24, Heft 58, Seite(n) 15622–15630

    Abstract: A small library of carborane-BODIPY/aza-BODIPY dyads were efficiently synthesized by means of a novel convergent synthetic approach, the key step of which is a Pd-catalyzed Heck coupling reaction. The structural characterization and photoluminescence ... ...

    Abstract A small library of carborane-BODIPY/aza-BODIPY dyads were efficiently synthesized by means of a novel convergent synthetic approach, the key step of which is a Pd-catalyzed Heck coupling reaction. The structural characterization and photoluminescence properties of the newly synthesized dyads were evaluated. The presence of the carborane did not significantly alter the photophysical patterns of the BODIPY or aza-BODIPY in the final fluorophores, but it produced a decrease of the emission fluorescent quantum yields that was in the range from 1.4 % for aza-BODIPY to 48 % for BODIPY-dyads. The carborane-BODIPY dyads were successfully incorporated into cells, especially compounds 2, 4 and 13, demonstrating their cytoplasmic localization. The fluorescent and biocompatibility properties make these compounds good candidates for in vitro cell tracking.
    Sprache Englisch
    Erscheinungsdatum 2018-09-19
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1478547-x
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201802901
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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