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Article ; Online: Safety Assessment for Thoracoscopic Day Case Surgery in Children with Congenital Pulmonary Malformation.

Mariani, Aurora / Peycelon, Matthieu / Clermidi, Pauline / Bellon, Myriam / Skhiri, Alia / Bonnard, Arnaud

Journal of laparoendoscopic & advanced surgical techniques. Part A

2018 Volume 28, Issue 9, Page(s) 1129–1134

Abstract: Background: No data exist evaluating the utilization and safety of outpatient thoracoscopy in children. The aim of this study was to investigate the safety of outpatient thoracoscopy and to assess parental opinions on the advantages and disadvantages of ...

Abstract	Background: No data exist evaluating the utilization and safety of outpatient thoracoscopy in children. The aim of this study was to investigate the safety of outpatient thoracoscopy and to assess parental opinions on the advantages and disadvantages of a pediatric thoracoscopy outpatient setting. Methods: A retrospective review of data from patients treated by thoracoscopy for congenital pulmonary malformation between 2013 and 2016 was performed. Study focused on patients who underwent outpatient thoracoscopy. All were placed in a flank position and underwent a three-port (5-mm optical trocar and two 5-mm trocars) thoracoscopy. Insufflation pressure required was 5 mmHg with bilateral lung ventilation. Pain control was provided with multimodal postoperative analgesia and the use of paravertebral block for regional analgesia. No drain was inserted. Outcomes of interest included 30-day overall morbidity, readmission, reoperation, and parental opinions through a phone call questionnaire. Results: A total of 37 thoracoscopies were identified; 11 (30%) with a median age of 5.3 months (4.2-12.3) were performed as an outpatient procedure (10 sequestration, 1 bronchogenic cyst). Median operating time was 51 minutes (34-87). No conversion and no transfusion occurred. No complications occurred (no morbidity, no readmission, and no reoperation). According to parents' view the outpatient setting has no disadvantages. Conclusion: This first analysis of a small monocentric dataset demonstrates that pediatric patients can safely undergo thoracoscopy, an outpatient procedure, with a high rate of parental satisfaction.
MeSH term(s)	Ambulatory Surgical Procedures ; Attitude to Health ; Bronchogenic Cyst/surgery ; Bronchopulmonary Sequestration/surgery ; Feasibility Studies ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Parents ; Patient Safety ; Retrospective Studies ; Risk Assessment ; Thoracoscopy/methods ; Treatment Outcome
Language	English
Publishing date	2018-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1381909-4
ISSN	1557-9034 ; 1092-6429
ISSN (online)	1557-9034
ISSN	1092-6429
DOI	10.1089/lap.2017.0721
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Article ; Online: Muscle relaxation for tracheal intubation during paediatric anaesthesia: A meta-analysis and trial sequential analysis.

Julien-Marsollier, Florence / Michelet, Daphné / Bellon, Myriam / Horlin, Anne-Laure / Devys, Jean-Michel / Dahmani, Souhayl

European journal of anaesthesiology

2017 Volume 34, Issue 8, Page(s) 550–561

Abstract: Background: Muscle relaxation for tracheal intubation during paediatric anaesthesia remains a subject of debate.: Objective: The aim of the current meta-analysis was to investigate the effect of muscle relaxants (MR) compared with opioids on ... ...

Abstract	Background: Muscle relaxation for tracheal intubation during paediatric anaesthesia remains a subject of debate. Objective: The aim of the current meta-analysis was to investigate the effect of muscle relaxants (MR) compared with opioids on intubation conditions in children. Design: Meta-analysis of randomised controlled studies. Data sources: Exhaustive literature analysis. Eligibility criteria: Clinical trials, with no high-risk bias, that examined the effect of MR in comparison with opioids on intubation conditions (excellent: primary outcome, acceptable: secondary outcome) in children were included. Results: Excellent intubation conditions were not significantly different in their occurrence between children receiving MR or opioids, risk ratio [95% Confidence Interval] = 1.17 [0.96, 1.43], I = 36%, number of studies = 5, number of patients = 226. However, trial sequential analysis indicated the lack of power of this result and the need for more trials to provide certainty for this outcome (81 patients needed in future trials). Acceptable intubation conditions were more frequent when administering MR, risk ratio = 1.25 [1.06, 1.47], I = 70%, number of studies = 6, number of patients = 362. This effect was confirmed using the trial sequential analysis. Grading of Recommendations Assessment, Development and Evaluation analysis found a low and moderate quality of evidences for excellent and acceptable intubation conditions, respectively. Conclusion: The current meta-analysis shows that the use of MR during tracheal intubation might improve the quality of intubation conditions. Further studies, including at least 81 children, are required to confirm this and determine the impact of MR on complications related to intubation.
MeSH term(s)	Analgesics, Opioid/administration & dosage ; Anesthesia, General/methods ; Anesthesia, General/standards ; Child ; Clinical Trials as Topic/methods ; Humans ; Intubation, Intratracheal/methods ; Intubation, Intratracheal/standards ; Muscle Relaxants, Central/administration & dosage ; Muscle Relaxation/drug effects ; Muscle Relaxation/physiology
Chemical Substances	Analgesics, Opioid ; Muscle Relaxants, Central
Language	English
Publishing date	2017-01-26
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	605770-6
ISSN	1365-2346 ; 0265-0215
ISSN (online)	1365-2346
ISSN	0265-0215
DOI	10.1097/EJA.0000000000000608
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Article ; Online: Fast track pediatric thoracic surgery: Toward day-case surgery?

Clermidi, Pauline / Bellon, Myriam / Skhiri, Alia / Jaby, Olivier / Vitoux, Christine / Peuchmaur, Michel / Bonnard, Arnaud

Journal of pediatric surgery

2017 Volume 52, Issue 11, Page(s) 1800–1805

Abstract: Purpose: Thoracoscopic lung resection for congenital pulmonary airway malformation (CPAM) is a safe technique for children. Our purpose was to evaluate the feasibility of a fast-track protocol in such cases.: Methods: From September 2007 to May 2016, ...

Abstract	Purpose: Thoracoscopic lung resection for congenital pulmonary airway malformation (CPAM) is a safe technique for children. Our purpose was to evaluate the feasibility of a fast-track protocol in such cases. Methods: From September 2007 to May 2016, 101 patients underwent a thoracoscopic pulmonary resection of which 83 for CPAM (lobectomy, wedge resection or sequestrectomy). We retrospectively reviewed the characteristics of surgical procedure, postoperative management and complications through three time periods (September 2007-December 2009: n=14, January 2010-March 2013: n=30, April 2013-May 2016: n=39) corresponding to management protocols modifications introducing fast-track pathways. Results: Through the 3 time periods, median postoperative hospital stay decreases (4, 3, 2days successively, P=0.02). In the third time period, 4 patients underwent surgery in day-case surgery. The overall and surgical complication rates, mainly related to air leakage, remain stable through the 3 time periods (14%, P=0.41 and 10%, P=0.52 respectively). Among the 13 patients without postoperative pleural drainage, one required secondary drainage after a partial resection of an emphysema. Conclusion: Fast-track protocol for children undergoing uncomplicated thoracic surgery for CPAM seems feasible without extra morbidity. Selected patient undergoing thoracoscopic resection of the lung may benefit from the absence of pleural drainage and can be operated on in day-case surgery. Level of evidence: Level III.
Language	English
Publishing date	2017-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2017.02.005
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Article ; Online: Efficacy of the Game Ready

Bellon, Myriam / Michelet, Daphné / Carrara, Nils / Vacher, Thomas / Gafsou, Benjamin / Ilhareborde, Brice / Mazda, Keyvan / Ferrero, Emmanuelle / Simon, Anne-Laure / Julien-Marsollier, Florence / Dahmani, Souhayl

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2019 Volume 28, Issue 6, Page(s) 1257–1264

Abstract: Purpose: The aim of this study was to investigate the opioid-sparing effect of a cooling brace after surgical correction of idiopathic surgery in children.: Methods: We compared two consecutive cohorts of patients before and after introducing this ... ...

Abstract	Purpose: The aim of this study was to investigate the opioid-sparing effect of a cooling brace after surgical correction of idiopathic surgery in children. Methods: We compared two consecutive cohorts of patients before and after introducing this technique in our institution. Management of patients was standardized. The primary objective of the study was to investigate the morphine consumption during the first postoperative day. Secondary outcomes were opioid consumption at day 3, pain intensity (at days 1 and 3), the mobilization in the standing position and duration of hospitalization. Results: This study included 23 and 22 patients in the control and the cooling cohorts. Cooling brace was associated with a significant decrease in morphine consumption at day 1 (1.7 [0.9, 3.3] versus 1.2 [0.5, 3.2] mg kg Conclusion: The use of this cooling brace allows decreasing the opioid use after surgical correction of idiopathic surgery in children. The current results strongly suggest an interest of this technique in the postoperative management of patients. These slides can be retrieved under Electronic Supplementary Material.
MeSH term(s)	Adolescent ; Analgesia/methods ; Analgesics, Opioid/administration & dosage ; Braces ; Child ; Drug Administration Schedule ; Female ; Humans ; Hypothermia, Induced/methods ; Length of Stay/statistics & numerical data ; Male ; Morphine/administration & dosage ; Pain Measurement/methods ; Pain, Postoperative/therapy ; Postoperative Care/methods ; Postoperative Period ; Prospective Studies ; Scoliosis/surgery
Chemical Substances	Analgesics, Opioid ; Morphine (76I7G6D29C)
Language	English
Publishing date	2019-01-31
Publishing country	Germany
Document type	Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-019-05886-6
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Article ; Online: Correction to: Efficacy of the Game Ready

Bellon, Myriam / Michelet, Daphné / Carrara, Nils / Vacher, Thomas / Gafsou, Benjamin / Ilharreborde, Brice / Mazda, Keyvan / Ferrero, Emmanuelle / Simon, Anne-Laure / Julien-Marsollier, Florence / Dahmani, Souhayl

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2019 Volume 28, Issue 5, Page(s) 1254

Abstract: Unfortunately, one co-author name was incorrectly published in the original publication. The complete correct name of the co-author is given below. ...

Abstract	Unfortunately, one co-author name was incorrectly published in the original publication. The complete correct name of the co-author is given below.
Language	English
Publishing date	2019-03-30
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-019-05950-1
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Article: Efficacy of Intraoperative Dexmedetomidine Compared with Placebo for Postoperative Pain Management: A Meta-Analysis of Published Studies.

Bellon, Myriam / Le Bot, Alix / Michelet, Daphnée / Hilly, Julie / Maesani, Mathieu / Brasher, Christopher / Dahmani, Souhayl

Pain and therapy

2016 Volume 5, Issue 1, Page(s) 63–80

Abstract: Introduction: Dexmedetomidine (Dex) has sedative, analgesic, and anesthetic-sparing effects. This meta-analysis examines demonstrated intraoperative and postoperative effects of intraoperative Dex administration during pediatric surgery.: Methods: A ... ...

Abstract	Introduction: Dexmedetomidine (Dex) has sedative, analgesic, and anesthetic-sparing effects. This meta-analysis examines demonstrated intraoperative and postoperative effects of intraoperative Dex administration during pediatric surgery. Methods: A search for randomized placebo-controlled trials was conducted to identify clinical trials examining intraoperative Dex use in children, infants, and neonates. Primary outcome was postoperative opioid consumption; secondary outcomes were: postoperative pain intensity and postoperative nausea and vomiting (PONV). Results: Fourteen randomized controlled trials performed during painful procedures were analyzed. Intraoperative Dex administration was associated with significantly reduced postoperative opioid consumption in the postanesthesia care unit [PACU; risk ratio (RR) = 0.31 (0.17, 0.59), I (2) = 76%, p < 0.0001 and cumulative z score using trial sequential analysis], decreased pain intensity in PACU [standardized mean difference (SMD) = -1.18 (-1.88, -0.48), I (2) = 91%, p < 0.0001] but had no effect upon PONV incidence [RR = 0.67 (0.41, 1.08), I (2) = 0%, p = 0.48]. Subgroup analyses found administering Dex during adenotonsillectomy and using a bolus <0.5 µg/kg (irrespective to the use of a continuous administration) without effects on studies outcomes. Heterogeneity was high among results and a high suspicion of publication bias was present for all analyzed outcomes. Conclusions: This meta-analysis shows that intraoperative Dex administration in children reduces postoperative opioids consumption and postoperative pain in PACU. According to our results, optimal bolus dose was found to be ≥0.5 µg/kg. Future studies have to explore this particular point and the postoperative analgesic effects of Dex during longer periods.
Language	English
Publishing date	2016-02-10
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2701614-6
ISSN	2193-651X ; 2193-8237
ISSN (online)	2193-651X
ISSN	2193-8237
DOI	10.1007/s40122-016-0045-2
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Article ; Online: Accuracy of the sleep-related breathing disorder scale to diagnose obstructive sleep apnea in children: a meta-analysis.

Michelet, Daphné / Julien-Marsollier, Florence / Vacher, Thomas / Bellon, Myriam / Skhiri, Alia / Bruneau, Béatrice / Fournier, Julien / Diallo, Thierno / Luce, Virginie / Brasher, Christopher / Dahmani, Souhayl

Sleep medicine

2018 Volume 54, Page(s) 78–85

Abstract: Objectives: The main objective of this meta-analysis was to assess the accuracy of the Sleep-Related Breathing Disorder (SRBD) Scale in the diagnosis of obstructive sleep apnea syndrome (OSAS) in children.: Patients/methods: A literature search of ... ...

Abstract	Objectives: The main objective of this meta-analysis was to assess the accuracy of the Sleep-Related Breathing Disorder (SRBD) Scale in the diagnosis of obstructive sleep apnea syndrome (OSAS) in children. Patients/methods: A literature search of studies comparing SRBD to polysomnography for the diagnosis of OSAS in children was performed. Risks of biases were quantified using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Analyses determined the summary receiver operator characteristic area under the curve (SROC), the pooled sensitivity (Se), the specificity (Sp), and the positive and negative likelihood ratios (LR+ and LR-). Results were graded and are expressed as means [95% confidence interval]. Post-test probabilities were computed for various populations. Results: Eleven studies were included; and two were considered to have high risk of bias. The SROC was 0.73 [CI: 0.63; 0.82]. The combined Se, Sp, LR+ and LR- were: 0.72 [CI: 0.68; 0.77], 0.59 [CI: 0.56; 0.63], 1.74 [CI: 1.32; 2.30], 0.53 [CI: 0.39; 0.71], respectively. Sub-group analyses displayed similar results in comparison to overall results. GRADE evidence for the overall analysis was low to moderate. Finally, pre-test to post-test probabilities were estimated to be: 3.5%-1%, 50%-30% and 75%-30%, for the general population, the obese patients and the patients assigned for surgical treatment of OSAS, respectively. Conclusions: The current meta-analysis indicates that the SRBD scale has acceptable accuracy in detecting patients with OSAS. It may be useful when evaluating patients with suspected OSAS before surgery. Study registration: PROSPERO database (CRD42018088216).
MeSH term(s)	Child ; Humans ; Polysomnography ; Sensitivity and Specificity ; Sleep Apnea, Obstructive/diagnosis ; Surveys and Questionnaires
Language	English
Publishing date	2018-10-28
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2018.09.027
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Article ; Online: Paediatric minimally invasive abdominal and urological surgeries: Current trends and perioperative management.

Bellon, Myriam / Skhiri, Alia / Julien-Marsollier, Florence / Malbezin, Serge / Thierno, Diallo / Hilly, Julie / ElGhoneimi, Alaa / Bonnard, Arnaud / Michelet, Daphné / Dahmani, Souhayl

Anaesthesia, critical care & pain medicine

2017 Volume 37, Issue 5, Page(s) 453–457

Abstract: Minimally invasive surgery during abdominal, thoracic and urological procedures has become the standard management of many surgical interventions in adults. Recent development of smaller devices has allowed the management of many paediatric surgeries ... ...

Abstract	Minimally invasive surgery during abdominal, thoracic and urological procedures has become the standard management of many surgical interventions in adults. Recent development of smaller devices has allowed the management of many paediatric surgeries using these minimally invasive techniques. However, the lack of knowledge of (a) adequate management of haemodynamic and respiratory alterations occurring during those procedures and (b) postoperative advantages of these techniques over open surgeries, still impairs their development. The current review aimed to clarify mechanisms of those haemodynamic and respiratory alterations, propose easy rules in order to overcome them and shed the light on potential postoperative advantages of minimally invasive surgery in paediatrics.
MeSH term(s)	Abdomen/surgery ; Adolescent ; Child ; Child, Preschool ; Humans ; Infant ; Infant, Newborn ; Minimally Invasive Surgical Procedures/methods ; Minimally Invasive Surgical Procedures/trends ; Pediatrics/methods ; Pediatrics/trends ; Perioperative Care ; Urologic Surgical Procedures/methods ; Urologic Surgical Procedures/trends
Language	English
Publishing date	2017-12-09
Publishing country	France
Document type	Journal Article ; Review
ISSN	2352-5568
ISSN (online)	2352-5568
DOI	10.1016/j.accpm.2017.11.013
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Article ; Online: Epidemiology and complications of anaesthesia in the French centres that participated to NECTARINE: A secondary analysis.

Dahmani, Souhayl / Laffargue, Anne / Dadure, Christophe / De Queiroz, Mathilde / Julien-Marsollier, Florence / Michelet, Daphné / Veyckemans, Francis / Amory, Catherine / Ludot, Hugues / Bert, Dina / Godart, Juliette / Dupont, Hervé / Urbina, Benjamin / Baujard, Catherine / Roulleau, Philippe / Staiti, Giuseppe / Bordes, Maryline / Nouette Gaulain, Karine / Hamonic, Yann /

Semjen, François / Jacqmarcq, Olivier / Lejus-Bourdeau, Caroline / Magne, Cécile / Petry, Léa / Ros, Lilica / Zang, Aurélien / Bennis, Mehdi / Coustets, Bernard / Fesseau, Rose / Constant, Isabelle / Khalil, Eliane / Sabourdin, Nada / Audren, Noémie / Descarpentries, Thomas / Fabre, Fanny / Legrand, Aurélien / Druot, Emilie / Orliaguet, Gilles / Sabau, Lucie / Uhrig, Lynn / De La Briere, François / Jonckheer, Karin / Mission, Jean-Paul / Scordo, Lucia / Couchepin, Caroline / De La Arena, Pablo / Hertz, Laurent / Pirat, Philippe / Sola, Chrystelle / Bellon, Myriam / Depret-Donatien, Véronique / Lesage, Anne

Anaesthesia, critical care & pain medicine

2022 Volume 41, Issue 2, Page(s) 101036

Abstract: Introduction: Neonatal and infant anaesthesia are associated with a high risk of perioperative complications. The aim of the current study was to describe those risks in France using the French data from the NECTARINE study.: Material and methods: ... ...

Abstract	Introduction: Neonatal and infant anaesthesia are associated with a high risk of perioperative complications. The aim of the current study was to describe those risks in France using the French data from the NECTARINE study. Material and methods: Data from the French centres that participated to the NECTARINE study were analysed. The primary goal of the study was the description of patients' characteristics, procedures and perioperative management and their comparison with the results of the European NECTARINE study. Secondary outcomes were the description of major perioperative complications and death. Results: Overall, 926 procedures collected in 15 centres (all teaching hospitals) were analysed. Comparison between the French and European NECTARINE cohorts found few differences related to patients' characteristics and procedures. The rate of interventions for critical events (respiratory, haemodynamic, and metabolic) was similar between the two cohorts. Near-infrared spectroscopy monitoring was used in 12% of procedures. Nearly none of the thresholds for these interventions met the published standards. By day 30, complications (respiratory, haemodynamic, metabolic, renal, and liver failure) and death were observed in 14.4% [95% CI 11.6-16.4]% and 1.8% [95% CI 1.1-2.9] of cases, respectively. Discussion: Although the health status of the patients in the French cohort was less severe, procedures, management and postoperative complications and mortality rates were similar to the European cohort. However, thresholds for interventions were often inadequate in both cohorts. Efforts should be undertaken to improve the knowledge and use of new monitoring devices in this population.
MeSH term(s)	Anesthesia/adverse effects ; Cohort Studies ; France/epidemiology ; Humans ; Infant ; Infant, Newborn ; Postoperative Complications/epidemiology ; Prospective Studies
Language	English
Publishing date	2022-02-16
Publishing country	France
Document type	Journal Article
ISSN	2352-5568
ISSN (online)	2352-5568
DOI	10.1016/j.accpm.2022.101036
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