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  1. Article ; Online: Costs Analysis of Fibrin Sealant for Prevention of Anastomotic Leakage in Lower Colorectal Surgery

    Panda S / Connolly MP / Ramirez MG / Beltrán de Heredia J

    Risk Management and Healthcare Policy, Vol Volume 13, Pp 5-

    2020  Volume 11

    Abstract: Saswat Panda, 1 Mark P Connolly, 1, 2 Manuel G Ramirez, 3 Juan Beltrán de Heredia 4 1Global Market Access Solutions LLC, Charlotte, NC, USA; 2University of Groningen, Department of Pharmacy, Unit of Pharmacoeconomics, Groningen, Netherlands; 3Global HEOR ...

    Abstract Saswat Panda, 1 Mark P Connolly, 1, 2 Manuel G Ramirez, 3 Juan Beltrán de Heredia 4 1Global Market Access Solutions LLC, Charlotte, NC, USA; 2University of Groningen, Department of Pharmacy, Unit of Pharmacoeconomics, Groningen, Netherlands; 3Global HEOR Advanced Surgery, Baxter Health Care Corporation, Deerfield, MA, USA; 4General Surgery Department, Hospital Clinico Valladolid, Valladolid, SpainCorrespondence: Mark P ConnollyGlobal Market Access Solutions LLC, Charlotte, NC, USAEmail mark@gmasoln.comIntroduction: Postoperative anastomotic leaks remain a common and serious complication of colorectal surgeries and are a major cause of mortality and morbidity of these procedures. Anastomotic leaks (AL) have been extensively studied; however, there has been no significant reduction in their prevalence over time. In addition, there is a significant economic burden from AL attributed to the need for repeat surgery, radiologic intervention and lengthened hospital stay. We conducted a comparative cost analysis of patients undergoing colorectal surgery with anastomosis, with the application of fibrin sealant (FS) to the sutured anastomosis versus not treating the sutured anastomosis with FS.Methods: The deterministic decision-tree model was populated with clinical data including operating room time, hospitalization days, occurrence of AL, need for revision surgery, blood products and radiologic interventions to treat the AL in lower colorectal surgery. A systematic literature review was conducted to identify appropriate studies with these variables.Results: The average cost per case treated lower colorectal surgery with fibrin sealant glue 10 mL Tisseel® and those not treated with a fibrin sealant after suturing the anastomoses was € 3233 and € 4130, respectively, for resource expenses paid by the healthcare system. This would suggest potential savings of € 897 per surgery, achieved through the application of FS to the sutured anastomosis for preventing AL following colorectal surgery.Conclusion: Application of FS to ...
    Keywords fibrin sealant ; anastomoses ; cost analysis ; budget impact ; colorectal surgery ; colorectal cancer ; Public aspects of medicine ; RA1-1270
    Subject code 670
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Costs Analysis of Fibrin Sealant for Prevention of Anastomotic Leakage in Lower Colorectal Surgery.

    Panda, Saswat / Connolly, Mark P / Ramirez, Manuel G / Beltrán de Heredia, Juan

    Risk management and healthcare policy

    2020  Volume 13, Page(s) 5–11

    Abstract: Introduction: Postoperative anastomotic leaks remain a common and serious complication of colorectal surgeries and are a major cause of mortality and morbidity of these procedures. Anastomotic leaks (AL) have been extensively studied; however, there has ...

    Abstract Introduction: Postoperative anastomotic leaks remain a common and serious complication of colorectal surgeries and are a major cause of mortality and morbidity of these procedures. Anastomotic leaks (AL) have been extensively studied; however, there has been no significant reduction in their prevalence over time. In addition, there is a significant economic burden from AL attributed to the need for repeat surgery, radiologic intervention and lengthened hospital stay. We conducted a comparative cost analysis of patients undergoing colorectal surgery with anastomosis, with the application of fibrin sealant (FS) to the sutured anastomosis versus not treating the sutured anastomosis with FS.
    Methods: The deterministic decision-tree model was populated with clinical data including operating room time, hospitalization days, occurrence of AL, need for revision surgery, blood products and radiologic interventions to treat the AL in lower colorectal surgery. A systematic literature review was conducted to identify appropriate studies with these variables.
    Results: The average cost per case treated lower colorectal surgery with fibrin sealant glue 10 mL Tisseel
    Conclusion: Application of FS to the sutured anastomosis in lower colorectal surgery resulted in a decrease in post-operative AL, and cost savings based on a reduction in hospitalization days, a reduction needing: revision surgery, radiologic intervention and blood products to treat AL.
    Language English
    Publishing date 2020-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2495128-6
    ISSN 1179-1594
    ISSN 1179-1594
    DOI 10.2147/RMHP.S221008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality.

    Martín-Fernández, Marta / Heredia-Rodríguez, María / González-Jiménez, Irene / Lorenzo-López, Mario / Gómez-Pesquera, Estefanía / Poves-Álvarez, Rodrigo / Álvarez, F Javier / Jorge-Monjas, Pablo / Beltrán-DeHeredia, Juan / Gutiérrez-Abejón, Eduardo / Herrera-Gómez, Francisco / Guzzo, Gabriella / Gómez-Sánchez, Esther / Tamayo-Velasco, Álvaro / Aller, Rocío / Pelosi, Paolo / Villar, Jesús / Tamayo, Eduardo

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 4

    Abstract: Background: Despite growing interest in treatment strategies that limit oxygen exposure in ICU patients, no studies have compared conservative oxygen with standard oxygen in postsurgical patients with sepsis/septic shock, although there are indications ... ...

    Abstract Background: Despite growing interest in treatment strategies that limit oxygen exposure in ICU patients, no studies have compared conservative oxygen with standard oxygen in postsurgical patients with sepsis/septic shock, although there are indications that it may improve outcomes. It has been proven that high partial pressure of oxygen in arterial blood (PaO
    Methods: We performed a secondary analysis of a prospective observational study in 454 patients who underwent major surgery admitted into a single ICU. Patients were stratified in two groups whether they had hyperoxemia, defined as PaO
    Results: In patients with PaO
    Conclusions: Oxygenation with a PaO
    MeSH term(s) Adult ; Humans ; Intensive Care Units ; Procalcitonin ; Prognosis ; Prospective Studies ; Sepsis ; Shock, Septic
    Chemical Substances Procalcitonin
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-021-03875-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Experimental study of arterial reactions against certain plastics.

    VILLALOBOS MIER, E / BELTRAN DE HEREDIA, J M / PUENTE DOMINGUEZ, J L

    Angiologia

    2014  Volume 1, Issue 6, Page(s) 337–347

    Title translation Estudio experimental de las reacciones arteriales frente a determinados plásticos.
    MeSH term(s) Arteries ; Cardiovascular System ; Humans ; Plastics
    Chemical Substances Plastics
    Language Spanish
    Publishing date 2014-01-04
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 123881-4
    ISSN 0003-3170
    ISSN 0003-3170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Case report: Amyand's hernia, diagnosis to consider in a routine procedure.

    Benavides de la Rosa, Diana Fernanda / López de Cenarruzabeitia, Íñigo / Moreno Racionero, Francisca / Merino Peñacoba, Luis María / Beltrán de Heredia, Juan

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2015  Volume 107, Issue 11, Page(s) 708–709

    Abstract: Amyand hernia is a rare entity that is generally an unexpected intraoperative finding. The decision to perform prophylactic appendectomy, must take into account individual factors that may increase morbidity in a short, medium or long term future. ...

    Abstract Amyand hernia is a rare entity that is generally an unexpected intraoperative finding. The decision to perform prophylactic appendectomy, must take into account individual factors that may increase morbidity in a short, medium or long term future.
    MeSH term(s) Aged ; Appendectomy ; Appendix/pathology ; Appendix/surgery ; Diagnosis, Differential ; Hernia, Inguinal/diagnosis ; Hernia, Inguinal/pathology ; Hernia, Inguinal/surgery ; Humans ; Male
    Language English
    Publishing date 2015-11
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2015.3816/2015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Advanced oxidation of cork-processing wastewater using Fenton's reagent: kinetics and stoichiometry

    Beltran de Heredia, J / Dominguez, J.R / Lopez, R

    Journal of chemical technology and biotechnology. 2004 Apr., v. 79, no. 4

    2004  

    Language English
    Dates of publication 2004-04
    Size p. 407-412.
    Document type Article
    ZDB-ID 1479465-2
    ISSN 1097-4660 ; 0268-2575
    ISSN (online) 1097-4660
    ISSN 0268-2575
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Treatment of cork process wastewater by a successive chemical-physical method

    Beltran de Heredia, J / Dominguez, J.R / Lopez, R

    Journal of agricultural and food chemistry. 2004 July 14, v. 52, no. 14

    2004  

    Abstract: In cork processing, the operation of boiling the raw cork generates large volumes of wastewater which are more often than not released directly into the environment untreated. Even when the wastewater is treated, this is usually by retention in ... ...

    Abstract In cork processing, the operation of boiling the raw cork generates large volumes of wastewater which are more often than not released directly into the environment untreated. Even when the wastewater is treated, this is usually by retention in evaporation ponds. This procedure, however, causes bad odors and may pollute surface water and groundwater. The present study evaluates a physicochemical method involving Fenton oxidation and coagulation/flocculation for the removal of chemical oxygen demand (COD), total polyphenols (TP), and aromatic compounds (A) from cork manufacturing process wastewater. The experimental variables studied were the dosages of iron salts (from 0.001 to 0.2 mol/L) and hydrogen peroxide (between 0.06 and 1 mol/L). The integrated Fenton-coagulation/flocculation process reduced the COD of the effluent by from 22% to 85%. The removal of total polyphenols ranged from 4% to 98%, and of aromatic compounds from 2% to 97%. A further two experiments were performed modifying the manner in which the reagents were added, splitting the reagent dose (of hydrogen peroxide and ferrous salt) into two and three fractions. Finally, an economic study was made of the chemical costs deriving from the application of this purification system. The cost of a treatment with an [H2O2]o/CODo ratio of 1.8 g/g (splitting the reagent dose into three fractions) that yields a COD removal of 73% was estimated to be 11.5 euros/m3 of wastewater.
    Keywords cork ; boiling ; wastewater ; wastewater treatment ; oxidation ; iron ; hydrogen peroxide ; coagulation ; flocculation ; chemical oxygen demand ; polyphenols ; aromatic compounds
    Language English
    Dates of publication 2004-0714
    Size p. 4501-4507.
    Document type Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Hemorragia digestiva incohercible por metástasis pancreática de cáncer renal.

    Velayos Jiménez, B / Beltrán de Heredia, J / del Olmo, L / García Castaño, J / Fernández, L / González, J M

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2006  Volume 98, Issue 3, Page(s) 222–224

    Title translation Persistent intestinal bleeding secondary to pancreatic metastasis from renal cell carcinoma.
    MeSH term(s) Aged ; Carcinoma, Renal Cell/complications ; Carcinoma, Renal Cell/secondary ; Gastrointestinal Hemorrhage/etiology ; Humans ; Kidney Neoplasms/pathology ; Male ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/secondary
    Language Spanish
    Publishing date 2006-05-15
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.4321/s1130-01082006000300013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Diagnóstico simultáneo de adenocarcinoma y GIST gástricos.

    Rubiales, A S / Ovelar, Y / Beltrán de Heredia, J / del Valle, M L

    Anales de medicina interna (Madrid, Spain : 1984)

    2001  Volume 22, Issue 12, Page(s) 606–607

    Title translation Synchronous diagnosis of gastric adenocarcinoma and GIST.
    MeSH term(s) Adenocarcinoma/diagnosis ; Aged ; Gastrointestinal Stromal Tumors/diagnosis ; Humans ; Male ; Neoplasms, Multiple Primary/diagnosis ; Stomach Neoplasms/diagnosis
    Language Spanish
    Publishing date 2001-09-15
    Publishing country Spain
    Document type Case Reports ; Letter
    ZDB-ID 639013-4
    ISSN 0212-7199
    ISSN 0212-7199
    DOI 10.4321/s0212-71992005001200016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A nossa experiência nos traumatismos vasculares causados por cornos de touros.

    Vaquero, Carlos / Arce, Nuria / González-Fajardo, José / Beltrán de Heredia, Juan / Carrera, Santiago

    Revista portuguesa de cirurgia cardio-toracica e vascular : orgao oficial da Sociedade Portuguesa de Cirurgia Cardio-Toracica e Vascular

    2008  Volume 15, Issue 4, Page(s) 217–220

    Abstract: Vascular trauma caused by bull horn injuries can be regarded as a subgroup of vascular traumatology, due to its particular etiology, mechanism of action, associated injuries and surgical management. In this paper, the authors report their experience in ... ...

    Title translation Our experience in the surgical management of bull horn vascular injuries.
    Abstract Vascular trauma caused by bull horn injuries can be regarded as a subgroup of vascular traumatology, due to its particular etiology, mechanism of action, associated injuries and surgical management. In this paper, the authors report their experience in the management of 56 such injuries, for the last 20 years, analysing the annual frequency (more common in summer time), the nature of the injury, the most commonly affected vessels and the surgical reconstruction or revascularization methods employed. The quality of results are discussed according some variable, such as is the case of the precocity of the repair, the degree of contamination, the occurence of post operative infections and the nature of the reconstructive or revascularization method employed. Finnaly, a comparison with similar reports already published in the literature is made.
    MeSH term(s) Adult ; Athletic Injuries/surgery ; Blood Vessels/injuries ; Humans ; Male ; Vascular Surgical Procedures/methods
    Language Portuguese
    Publishing date 2008-10
    Publishing country Portugal
    Document type English Abstract ; Journal Article
    ISSN 0873-7215
    ISSN 0873-7215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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