Article ; Online: Seroconversion and Abundance of IgG Antibodies against S1-RBD of SARS-CoV-2 and Neutralizing Activity in the Chilean Population.
Journal of immunology research
2021 Volume 2021, Page(s) 6680337
Abstract: COVID-19 is a pandemic caused by SARS-CoV-2. In Chile, half a million people have been infected and more than 16,000 have died from COVID-19. As part of the clinical trial NCT04384588, we quantified IgG against S1-RBD of SARS-CoV-2 (anti-RBD) in ... ...
Abstract | COVID-19 is a pandemic caused by SARS-CoV-2. In Chile, half a million people have been infected and more than 16,000 have died from COVID-19. As part of the clinical trial NCT04384588, we quantified IgG against S1-RBD of SARS-CoV-2 (anti-RBD) in recovered people in Santiago and evaluated their suitability as COVID-19 convalescent plasma donors. ELISA and a luminescent SARS-CoV-2 pseudotype were used for IgG and neutralizing antibody quantification. 72.9% of the convalescent population (468 of 639) showed seroconversion (5-55 |
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MeSH term(s) | Adolescent ; Adult ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/blood ; Antibodies, Viral/therapeutic use ; COVID-19/immunology ; COVID-19/therapy ; Chile ; Female ; Humans ; Immunization, Passive/methods ; Immunoglobulin G/blood ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2/physiology ; Seroconversion ; Spike Glycoprotein, Coronavirus/immunology ; Young Adult ; COVID-19 Serotherapy |
Chemical Substances | Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus |
Language | English |
Publishing date | 2021-02-19 |
Publishing country | Egypt |
Document type | Clinical Trial ; Journal Article |
ZDB-ID | 2817541-4 |
ISSN | 2314-7156 ; 2314-7156 |
ISSN (online) | 2314-7156 |
ISSN | 2314-7156 |
DOI | 10.1155/2021/6680337 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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