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Article: Daily routine and habits during COVID-19 lockdown in Italy: An observational survey.

Maritan, Yuri / Pisaniello, Diletta Maria / Belvedere, Annalisa / Battain, Pier Carlo

The British journal of occupational therapy

2022 Volume 86, Issue 3, Page(s) 215–235

Abstract: Introduction: Between March-May 2020, the Italian Government applied restrictive measures to reduce the risk of contagion, fostering a potential condition of occupational deprivation.: Methods: A digital survey was administered in June 2020 including ...

Abstract	Introduction: Between March-May 2020, the Italian Government applied restrictive measures to reduce the risk of contagion, fostering a potential condition of occupational deprivation. Methods: A digital survey was administered in June 2020 including closed and open questions. The goal was to report how the first Italian lockdown affected daily routine. Results: 648 surveys were valid. Most respondents were workers and spent lockdown at home. Before quarantine, the most representative occupations were working and housekeeping; the significant ones were working and meeting friends/relatives. Wellbeing meant meeting friends/relatives and hobbies/interests. During lockdown, respondents dedicated themselves to housekeeping and working; meaningful occupations were working and cooking. All data was stratified according to age and perceived wellbeing; open questions were categorized by the researchers. Discussion: A daily routine in compliance with lockdown restrictions required a change in habits. Time was used for occupations not strictly contentful; finance and work gained significance. It is to hypothesize that the idea of wellbeing was deeply altered. Conclusions: The study focuses on a slice of everyday life in times of emergency, it highlights people adaptability and their experiences according to age and future plans. Occupational justice emerges as a strong topic: the environment influences wellbeing, habits, and self-perception.
Language	English
Publishing date	2022-12-24
Publishing country	England
Document type	Journal Article
ZDB-ID	390834-3
ISSN	0308-0226 ; 0029-800X
ISSN	0308-0226 ; 0029-800X
DOI	10.1177/03080226221113471
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Article ; Online: Deep brain stimulation of the anterior nucleus of the thalamus increases slow wave activity in non-rapid eye movement sleep.

Buenzli, Jana C / Werth, Esther / Baumann, Christian R / Belvedere, Anina / Renzel, Roland / Stieglitz, Lennart H / Imbach, Lukas L

Epilepsia

2023 Volume 64, Issue 8, Page(s) 2044–2055

Abstract: Objective: Previous studies suggest that intermittent deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) affects physiological sleep architecture. Here, we investigated the impact of continuous ANT DBS on sleep in epilepsy ... ...

Abstract	Objective: Previous studies suggest that intermittent deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) affects physiological sleep architecture. Here, we investigated the impact of continuous ANT DBS on sleep in epilepsy patients in a multicenter crossover study in 10 patients. Methods: We assessed sleep stage distribution, delta power, delta energy, and total sleep time in standardized 10/20 polysomnographic investigations before and 12 months after DBS lead implantation. Results: In contrast to previous studies, we found no disruption of sleep architecture or alterations of sleep stage distribution under active ANT DBS (p = .76). On the contrary, we observed more consolidated and deeper slow wave sleep (SWS) under continuous high-frequency DBS as compared to baseline sleep prior to DBS lead implantation. In particular, biomarkers of deep sleep (delta power and delta energy) showed a significant increase post-DBS as compared to baseline (36.67 ± 13.68 μV Significance: From a clinical perspective, these findings suggest that patients with sleep disruption under cyclic ANT DBS could benefit from an adaptation of stimulation parameters to more superior contacts and continuous mode stimulation.
MeSH term(s)	Humans ; Deep Brain Stimulation ; Cross-Over Studies ; Eye Movements ; Anterior Thalamic Nuclei ; Sleep ; Drug Resistant Epilepsy/therapy
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/epi.17657
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Zs.A 517: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 475: Show issues

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Article: Percutaneous Drainage vs. Surgery as Definitive Treatment for Anastomotic Leak after Intestinal Resection in Patients with Crohn's Disease.

Belvedere, Angela / Dajti, Gerti / Larotonda, Cristina / Angelicchio, Laura / Rizzello, Fernando / Gionchetti, Paolo / Poggioli, Gilberto / Rottoli, Matteo

Journal of clinical medicine

2023 Volume 12, Issue 4

Abstract: Background: Anastomotic leak (AL) remains one of the most relevant complications after intestinal resection for Crohn's disease (CD). While surgery has always been considered the standard treatment for perianastomotic collection, percutaneous drainage ( ... ...

Abstract	Background: Anastomotic leak (AL) remains one of the most relevant complications after intestinal resection for Crohn's disease (CD). While surgery has always been considered the standard treatment for perianastomotic collection, percutaneous drainage (PD) has been proposed as a potential alternative. Methods: Retrospective study in consecutive patients treated with either PD or surgery for AL after intestinal resection for CD between 2004 and 2022. AL was defined as a perianastomotic fluid collection confirmed by radiological findings. Patients with generalized peritonitis or clinical instability were excluded. Primary aim: To compare the success rate of PD vs. surgery. Secondary aims: To compare the outcomes at 90 days after the procedures; to identify the variables associated with the indication for PD. Results: A total of 47 patients were included, of which 25 (53%) underwent PD and 22 (47%) surgery. The success rate was 84% in the PD and 95% in the surgery group ( Conclusion: The present study suggests that PD is a safe and effective procedure to treat anastomotic leak and perianastomotic collection in CD patients. PD should be indicated in all eligible patients as an effective alternative to surgery.
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12041392
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Article ; Online: Natural Radioactivity in Raw Building Materials for Underground Parking Lots and Assessment of Radiological Health Risk for the Population.

Caridi, Francesco / Paladini, Giuseppe / Mottese, Antonio Francesco / Praticò, Filippo Giammaria / Faggio, Giuliana / Messina, Giacomo / Belvedere, Alberto / Marguccio, Santina / D'Agostino, Maurizio / Majolino, Domenico / Venuti, Valentina

International journal of environmental research and public health

2024 Volume 21, Issue 3

Abstract: This article reports the results of an investigation into the activity concentration of natural radionuclides in raw building materials for underground parking lots, together with the assessment of the radiation hazard for the public related to exposure ... ...

Abstract	This article reports the results of an investigation into the activity concentration of natural radionuclides in raw building materials for underground parking lots, together with the assessment of the radiation hazard for the public related to exposure to ionizing radiations. To this purpose, high-purity germanium (HPGe) γ-ray spectrometry was employed in order to quantify the average specific activity of
MeSH term(s)	Humans ; Radioactivity ; Radiation Monitoring/methods ; Radioisotopes/analysis ; Radiologic Health ; Spectrometry, Gamma ; Construction Materials/analysis ; Thorium/analysis ; Potassium Radioisotopes/analysis ; Radium/analysis ; Soil Pollutants, Radioactive/analysis
Chemical Substances	Radioisotopes ; Thorium (60YU5MIG9W) ; Potassium Radioisotopes ; Radium (W90AYD6R3Q) ; Soil Pollutants, Radioactive
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph21030315
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Article ; Online: Assessment of the Radiological Health Risk Due to the

Caridi, Francesco / Paladini, Giuseppe / Spoto, Sebastiano Ettore / Marguccio, Santina / D'Agostino, Maurizio / Belvedere, Alberto / Crupi, Vincenza / Venuti, Valentina / Majolino, Domenico

International journal of environmental research and public health

2022 Volume 19, Issue 16

Abstract: In this article, the authors report experimental results obtained for the assessment of ... ...

Abstract	In this article, the authors report experimental results obtained for the assessment of the
MeSH term(s)	Drinking Water ; Radiation Monitoring/methods ; Radiologic Health ; Radium/analysis ; Scintillation Counting/methods ; Water Pollutants, Radioactive/analysis
Chemical Substances	Drinking Water ; Water Pollutants, Radioactive ; Radium (W90AYD6R3Q)
Language	English
Publishing date	2022-08-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19169829
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Article ; Online: Diabetes has no additional impact on retinal ganglion cell loss in a mouse model of spontaneous glaucoma.

Maestroni, Silvia / Belvedere, Arianna / Viganò, Ilaria / Meoni, Cesare / Di Matteo, Federico / Gabellini, Daniela / Bandello, Francesco / Pierro, Luisa / Zerbini, Gianpaolo

European journal of ophthalmology

2022 Volume 33, Issue 3, Page(s) 1418–1424

Abstract: Purpose: There is no valid medical treatment for diabetic retinopathy mostly because its pathogenesis remains largely unknown. Early stages of diabetic retinopathy, just like glaucoma, are characterized by the loss of retinal ganglion cells. Whether the ...

Abstract	Purpose: There is no valid medical treatment for diabetic retinopathy mostly because its pathogenesis remains largely unknown. Early stages of diabetic retinopathy, just like glaucoma, are characterized by the loss of retinal ganglion cells. Whether the two diseases may share a similar pathogenic background is unknown. Methods: To clarify this issue the thickness of retinal nerve fiber layer was studied Results: At 16 weeks of age retinal nerve fiber layer was significantly thinner in Ins2Akita mice confirming the neurodegenerative impact of diabetes. Number of retinal ganglion cells and retina's surface covered by neurofilaments were similar in normoglycemic and diabetic DBA/2J mice with the exception of the superior quadrant where the number of retinal ganglion cells was increased in animals with glaucoma + diabetes. Conclusions: In presence of glaucoma, diabetes is unable to induce further retinal ganglion cells loss. The hypothesis that the mechanism leading to retinal ganglion cells loss may be shared by the two diseases cannot be ruled out. Whether early diabetes-driven retinal neurodegeneration could be prevented by neuroprotective treatment proven to be effective in case of glaucoma, remains to be clarified.
MeSH term(s)	Mice ; Animals ; Retinal Ganglion Cells/pathology ; Diabetic Retinopathy/metabolism ; Mice, Inbred DBA ; Mice, Inbred C57BL ; Glaucoma/diagnosis ; Glaucoma/metabolism ; Disease Models, Animal ; Diabetes Mellitus/metabolism
Language	English
Publishing date	2022-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721221145980
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Zs.A 3342: Show issues

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Article ; Online: Inflammatory Bowel Disease Onset During Secukinumab Treatment: Real Concern or Just an Expression of Dysregulated Immune Response?

Fries, Walter / Belvedere, Alessandra / Cappello, Maria / Orlando, Ambrogio / Trifirò, Gianluca

Clinical drug investigation

2019 Volume 39, Issue 8, Page(s) 799–803

Abstract: Background: Up to December 2018, eight cases of new-onset inflammatory bowel disease (IBD) were reported in the literature in patients being treated with secukinumab, an interleukin-17A antagonist prescribed for dermatologic or rheumatologic indications. ...

Abstract	Background: Up to December 2018, eight cases of new-onset inflammatory bowel disease (IBD) were reported in the literature in patients being treated with secukinumab, an interleukin-17A antagonist prescribed for dermatologic or rheumatologic indications. The duration of secukinumab treatment ranged from a single administration to 12 months of treatment. Objective: The aim of our investigation was to estimate the cumulative incidence of new-onset IBD in patients treated with secukinumab for either dermatologic or rheumatologic indications. Methods: We carried out a survey among the dermatology and rheumatology centres in the Sicilian region (Italy) in order to identify the number of patients treated with secukinumab in the previous 24 months (November 2016-November 2018), and to understand how many of these patients eventually developed IBD after the start of secukinumab therapy. Results: Overall, four cases of IBD during secukinumab treatment were identified, with higher variability in time to onset compared with what has been previously reported, i.e. from 1 month to 5 years of secukinumab exposure. Overall, 434 patients were treated with secukinumab in Sicily between November 2016 and November 2018, and approximately 1% of these patients developed new-onset IBD. Conclusions: Careful clinical examination of patients with respect to possible susceptibility to IBD prior to secukinumab therapy is advised.
MeSH term(s)	Adolescent ; Adult ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal, Humanized ; Dermatologic Agents/adverse effects ; Female ; Humans ; Incidence ; Inflammatory Bowel Diseases/chemically induced ; Interleukin-17/antagonists & inhibitors ; Italy ; Male ; Middle Aged ; Young Adult
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Dermatologic Agents ; Interleukin-17 ; secukinumab (DLG4EML025)
Language	English
Publishing date	2019-06-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	1220136-4
ISSN	1179-1918 ; 0114-2402 ; 1173-2563
ISSN (online)	1179-1918
ISSN	0114-2402 ; 1173-2563
DOI	10.1007/s40261-019-00803-7
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Zs.A 2807: Show issues

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Article ; Online: A real world investigation on prevalence, clinical features, and therapy of inflammatory bowel disease in the city of Messina, Italy.

Belvedere, Alessandra / Scoglio, Riccardo / Viola, Anna / Costantino, Giuseppe / Sitibondo, Aldo / Muscianisi, Marco / Inferrera, Santi / Alibrandi, Angela / Fries, Walter

Acta bio-medica : Atenei Parmensis

2021 Volume 92, Issue 2, Page(s) e2021161

Abstract: Background: The absence of a national register of inflammatory bowel diseases (IBD) hinders effective health care planning in Italy.: Aims: to investigate prevalence of IBD in the city of Messina, Italy, based on General Practitioner (GP) records, ... ...

Abstract	Background: The absence of a national register of inflammatory bowel diseases (IBD) hinders effective health care planning in Italy. Aims: to investigate prevalence of IBD in the city of Messina, Italy, based on General Practitioner (GP) records, and to establish current treatments prescribed by different health care providers. Methods: data were extracted from GP databases with the help of disease-specific healthcare cost exemption codes combined with ICD9 codes for ulcerative colitis (UC) and Crohn's disease (CD), and prescription for mesalazine. Disease and treatment-related data were collected together with information on employment status and the current healthcare provider. Results: Eighty-six GPs participated covering a population of 100,834 people. IBD prevalence (419/105) was 80% higher than estimates of the Regional Health Authorities. Incidence showed a seven-fold increase over the past 30 years. Only 51% of CD and 26% of UC patients were followed by a dedicated IBD centre with more frequent prescriptions of immunomodulators and biologics (p<0.001) compared to GPs. Conclusions: Real world data show much higher figures on IBD prevalence than administrative estimates. Differences in therapeutic approaches between IBD-specialists and non-specialists may reflect poor confidence in managing immunosuppressive therapies by the latter, but may lead to inadequate therapy and cancer surveillance.
MeSH term(s)	Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/epidemiology ; Crohn Disease ; Humans ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/therapy ; Italy/epidemiology ; Prevalence
Language	English
Publishing date	2021-05-12
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v92i2.9593
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Article: Massive infection of Cystidicoloides ephemeridarum in brown trout Salmo trutta with skeletal deformities.

Iaria, C / Spanò, N / Smeriglio, A / Capparucci, F / De Benedetto, G / Lanteri, G / Marino, F / Macheda, S / Macrì, F / Belvedere, A / D'Agostino, M / Caridi, F / Marguccio, S / Salvo, A / Acri, G / Siclari, A / Brundo, M V / Trombetta, D

Diseases of aquatic organisms

2021 Volume 143, Page(s) 159–168

Abstract: We investigated the cause of skeletal deformities found in brown trout from the Aspromonte mountain area in Reggio Calabria, Italy. Toxicological, histopathological and parasitological analyses were carried out on 14 fish with evident macro-morphological ...

Abstract	We investigated the cause of skeletal deformities found in brown trout from the Aspromonte mountain area in Reggio Calabria, Italy. Toxicological, histopathological and parasitological analyses were carried out on 14 fish with evident macro-morphological alterations from 2 different locations in the same river, and 4 control fish without morphological alterations from a different river (far from the first river but still within the area under study). Histopathological and radiological observations confirmed severe skeletal deformities in the specimens investigated. Parasitological examinations highlighted the presence of the nematode Cystidicoloides ephemeridarum, found only within the gastrointestinal tract of specimens showing deformities. Moreover, a direct correlation between parasite number and fish size was found. Given the low heavy metal levels and the presence of a massive parasitosis in teleosts showing deformities, we postulate a correlation between skeletal deformities and nematode infestation: the parasites caused a serious vitamin and mineral deficiency in the fish, which led to a dysplastic vertebral column. The low calcium levels found in malformed specimens compared with negative controls effectively confirm this hypothesis.
MeSH term(s)	Animals ; Fish Diseases ; Italy ; Trout
Language	English
Publishing date	2021-02-25
Publishing country	Germany
Document type	Journal Article
ISSN	0177-5103
ISSN	0177-5103
DOI	10.3354/dao03559
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Article: Topical nerve growth factor prevents neurodegenerative and vascular stages of diabetic retinopathy.

Zerbini, Gianpaolo / Maestroni, Silvia / Leocani, Letizia / Mosca, Andrea / Godi, Michela / Paleari, Renata / Belvedere, Arianna / Gabellini, Daniela / Tirassa, Paola / Castoldi, Valerio / Viganò, Ilaria / Galbiati, Silvia / Turco, Valentina / Lambiase, Alessandro / Rama, Paolo

Frontiers in pharmacology

2022 Volume 13, Page(s) 1015522

Abstract: Specific and effective preventive treatment for diabetic retinopathy (DR) is presently unavailable, mostly because the early stages of the complication have been, until recently, poorly understood. The recent demonstration that the vascular phase of DR ... ...

Abstract	Specific and effective preventive treatment for diabetic retinopathy (DR) is presently unavailable, mostly because the early stages of the complication have been, until recently, poorly understood. The recent demonstration that the vascular phase of DR is preceded and possibly caused by the neurodegeneration of retinal ganglion cells suggests that DR could, at least theoretically, be prevented through an early neuroprotective approach. The aims of our study were to clarify the natural history of diabetes-driven retinal neurodegeneration and to verify the possibility to prevent DR using topical nerve growth factor (NGF). The results of the study show that retinal neurodegeneration, characterized by the loss of retinal ganglion cells represents a relatively early phenomenon of diabetes (between 5 and 16 weeks of age), which tends to be self-limiting in the long run. Neurodegeneration is followed by the development of DR-related vascular dysfunctions, as confirmed by the development of acellular capillaries and the loss of retinal pericytes. Both retinal neurodegeneration and subsequent vascular dysfunction can be successfully prevented by topical NGF administration. These findings suggest that: 1) The first stage of DR consists in a self-limiting retinal neurodegeneration 2) The demonstrated effectiveness of topical NGF in the prevention of DR could be rapidly translated into clinical practice.
Language	English
Publishing date	2022-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1015522
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