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  1. Article: Percutaneous Drainage vs. Surgery as Definitive Treatment for Anastomotic Leak after Intestinal Resection in Patients with Crohn's Disease.

    Belvedere, Angela / Dajti, Gerti / Larotonda, Cristina / Angelicchio, Laura / Rizzello, Fernando / Gionchetti, Paolo / Poggioli, Gilberto / Rottoli, Matteo

    Journal of clinical medicine

    2023  Volume 12, Issue 4

    Abstract: Background: Anastomotic leak (AL) remains one of the most relevant complications after intestinal resection for Crohn's disease (CD). While surgery has always been considered the standard treatment for perianastomotic collection, percutaneous drainage ( ... ...

    Abstract Background: Anastomotic leak (AL) remains one of the most relevant complications after intestinal resection for Crohn's disease (CD). While surgery has always been considered the standard treatment for perianastomotic collection, percutaneous drainage (PD) has been proposed as a potential alternative.
    Methods: Retrospective study in consecutive patients treated with either PD or surgery for AL after intestinal resection for CD between 2004 and 2022. AL was defined as a perianastomotic fluid collection confirmed by radiological findings. Patients with generalized peritonitis or clinical instability were excluded.
    Primary aim: To compare the success rate of PD vs. surgery. Secondary aims: To compare the outcomes at 90 days after the procedures; to identify the variables associated with the indication for PD.
    Results: A total of 47 patients were included, of which 25 (53%) underwent PD and 22 (47%) surgery. The success rate was 84% in the PD and 95% in the surgery group (
    Conclusion: The present study suggests that PD is a safe and effective procedure to treat anastomotic leak and perianastomotic collection in CD patients. PD should be indicated in all eligible patients as an effective alternative to surgery.
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12041392
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  2. Article ; Online: Day-case laparoscopic cholecystectomy: analysis of the factors allowing early discharge.

    Tebala, Giovanni Domenico / Belvedere, Angela / Keane, Sean / Khan, Abdul Qayyum / Osman, Abdelsalam

    Updates in surgery

    2017  Volume 69, Issue 4, Page(s) 461–469

    Abstract: Despite a number of studies have already demonstrated that majority of patients can be safely discharged early after laparoscopic cholecystectomy, this approach did not gain widespread diffusion yet. The present study was set up to assess safety and ... ...

    Abstract Despite a number of studies have already demonstrated that majority of patients can be safely discharged early after laparoscopic cholecystectomy, this approach did not gain widespread diffusion yet. The present study was set up to assess safety and feasibility of 24 h or same-day discharge after laparoscopic cholecystectomy and to identify the prognostic factors. Perioperative variables of 229 patients undergoing cholecystectomy have been analyzed. Primary endpoints were: postoperative length of stay, rate of patients discharged within 24 h, and rate of those discharged on the same day. Secondary endpoints were rate of 30-day readmission and rate of 30-day postoperative complications. Two-hundred twenty-three cases have been started by laparoscopy. Conversion rate was 3.1%. Overall mean postoperative stay was 1.8 ± 3.5 days (median 1 day). Seventy-eight percent of patients have been discharged within 24 h, and 22.3% have been discharged on the same day. Postoperative morbidity was 2.2%. Readmission rate was 3.9%. At univariate analysis, factors related to early discharge were age (more or less than 65), diagnosis (simple symptomatic gallstones vs complicated gallstones), ASA score, timing of operation (elective vs emergency), history of CBD stones, laparoscopic operation, and use of drain. No single factor was significantly related to readmission rate, but the use of drains in laparoscopic cases. At multivariate analysis, only elective operation, simple symptomatic gallstones, no history of CBD stones, laparoscopic approach, and no abdominal drain resulted independently associated with discharge within 24 h from the operation. The predictive models are all fit and significant. Early postoperative discharge within 24 h should be considered in all patients with simple symptomatic gallstones who had laparoscopic cholecystectomy. Same-day discharge should be considered if no drain was left at the end of the operation.
    MeSH term(s) Aged ; Cholecystectomy, Laparoscopic/adverse effects ; Cholecystectomy, Laparoscopic/methods ; Cholecystectomy, Laparoscopic/standards ; Cholecystectomy, Laparoscopic/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Patient Discharge/statistics & numerical data ; Time Factors
    Language English
    Publishing date 2017-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-017-0433-0
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  3. Article ; Online: How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? Results from a single Italian centre.

    Rottoli, Matteo / Bernante, Paolo / Belvedere, Angela / Balsamo, Francesca / Garelli, Silvia / Giannella, Maddalena / Cascavilla, Alessandra / Tedeschi, Sara / Ianniruberto, Stefano / Rosselli Del Turco, Elena / Tonetti, Tommaso / Ranieri, Vito Marco / Poggioli, Gilberto / Manzoli, Lamberto / Pagotto, Uberto / Viale, Pierluigi / Bartoletti, Michele

    European journal of endocrinology

    2020  Volume 183, Issue 4, Page(s) 389–397

    Abstract: Objective: Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems to aggravate the course of disease, the actual impact of the BMI and the cutoff which increases illness ... ...

    Abstract Objective: Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems to aggravate the course of disease, the actual impact of the BMI and the cutoff which increases illness severity are still under investigation. The aim of the study was to analyze whether the BMI represented a risk factor for respiratory failure, admission to the intensive care unit (ICU) and death.
    Research design and methods: A retrospective cohort study of 482 consecutive COVID-19 patients hospitalised between March 1 and April 20, 2020. Logistic regression analysis and Cox proportion Hazard models including demographic characteristics and comorbidities were carried out to predict the endpoints within 30 days from the onset of symptoms.
    Results: Of 482 patients, 104 (21.6%) had a BMI ≥ 30 kg/m2. At logistic regression analysis, a BMI between 30 and 34.9 kg/m2 significantly increased the risk of respiratory failure (OR: 2.32; 95% CI: 1.31-4.09, P = 0.004) and admission to the ICU (OR: 4.96; 95% CI: 2.53-9.74, P < 0.001). A significantly higher risk of death was observed in patients with a BMI ≥ 35 kg/m2 (OR: 12.1; 95% CI: 3.25-45.1, P < 0.001).
    Conclusions: Obesity is a strong, independent risk factor for respiratory failure, admission to the ICU and death among COVID-19 patients. A BMI ≥ 30 kg/m2 identifies a population of patients at high risk for severe illness, whereas a BMI ≥ 35 kg/m2 dramatically increases the risk of death.
    MeSH term(s) Adult ; Aged ; Betacoronavirus ; Body Mass Index ; COVID-19 ; Comorbidity ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Female ; Hospitalization ; Humans ; Intensive Care Units ; Italy/epidemiology ; Logistic Models ; Male ; Middle Aged ; Obesity/epidemiology ; Obesity/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Proportional Hazards Models ; Respiratory Insufficiency/epidemiology ; Respiratory Insufficiency/virology ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publishing country England
    Document type Evaluation Study ; Journal Article
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1530/EJE-20-0541
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  4. Article: How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? Results from a single Italian centre

    Rottoli, Matteo / Bernante, Paolo / Belvedere, Angela / Balsamo, Francesca / Garelli, Silvia / Giannella, Maddalena / Cascavilla, Alessandra / Tedeschi, Sara / Ianniruberto, Stefano / Rosselli Del Turco, Elena / Tonetti, Tommaso / Ranieri, Vito Marco / Poggioli, Gilberto / Manzoli, Lamberto / Pagotto, Uberto / Viale, Pierluigi / Bartoletti, Michele

    Eur J Endocrinol

    Abstract: Objective: Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems to aggravate the course of disease, the actual impact of the BMI and the cutoff which increases illness severity ...

    Abstract Objective: Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems to aggravate the course of disease, the actual impact of the BMI and the cutoff which increases illness severity are still under investigation. The aim of the study was to analyze whether the BMI represented a risk factor for respiratory failure, admission to the intensive care unit (ICU) and death. Research design and methods: A retrospective cohort study of 482 consecutive COVID-19 patients hospitalised between March 1 and April 20, 2020. Logistic regression analysis and Cox proportion Hazard models including demographic characteristics and comorbidities were carried out to predict the endpoints within 30 days from the onset of symptoms. Results: Of 482 patients, 104 (21.6%) had a BMI ≥ 30 kg/m2. At logistic regression analysis, a BMI between 30 and 34.9 kg/m2 significantly increased the risk of respiratory failure (OR: 2.32; 95% CI: 1.31-4.09, P = 0.004) and admission to the ICU (OR: 4.96; 95% CI: 2.53-9.74, P < 0.001). A significantly higher risk of death was observed in patients with a BMI ≥ 35 kg/m2 (OR: 12.1; 95% CI: 3.25-45.1, P < 0.001). Conclusions: Obesity is a strong, independent risk factor for respiratory failure, admission to the ICU and death among COVID-19 patients. A BMI ≥ 30 kg/m2 identifies a population of patients at high risk for severe illness, whereas a BMI ≥ 35 kg/m2 dramatically increases the risk of death.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #648847
    Database COVID19

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  5. Article ; Online: How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? Results from a single Italian centre

    Rottoli, Matteo / Bernante, Paolo / Belvedere, Angela / Balsamo, Francesca / Garelli, Silvia / Giannella, Maddalena / Cascavilla, Alessandra / Tedeschi, Sara / Ianniruberto, Stefano / Rosselli Del Turco, Elena / Tonetti, Tommaso / Ranieri, Vito Marco / Poggioli, Gilberto / Manzoli, Lamberto / Pagotto, Uberto / Viale, Pierluigi / Bartoletti, Michele

    2020  

    Abstract: Objective Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems to aggravate the course of disease, the actual impact of the body mass index (BMI) and the cutoff which increases ...

    Abstract Objective Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems to aggravate the course of disease, the actual impact of the body mass index (BMI) and the cutoff which increases illness severity are still under investigation. The aim of the study was to analyze whether the BMI represented a risk factor f qor respiratory failure, admission to the intensive care unit (ICU) and death. Research Design and Methods A retrospective cohort study of 482 consecutive COVID-19 patients hospitalised between March 1 and April 20, 2020. Logistic regression analysis and Cox proportion Hazard models including demographic characteristics and comorbidities were carried out to predict the endpoints within 30 days from the onset of symptoms. Results Of 482 patients, 104 (21.6%) had a BMI ≥ 30 kg/m2. At logistic regression analysis, a BMI between 30 and 34.9 kg/m2 significantly increased the risk of respiratory failure (OR: 2.32; 95% CI: 1.31-4.09, p=0.004), and admission to the ICU (OR: 4.96; 95% CI: 2.53-9.74, p<0.001). A significantly higher risk of death was observed in patients with a BMI ≥ 35 kg/m2 (OR: 12.1; 95% CI: 3.25-45.1, p<0.001). Conclusions Obesity is a strong, independent risk factor for respiratory failure, admission to the ICU and death among COVID-19 patients. Whereas a BMI ≥ 30 kg/m2 identifies a population of patients at high risk for severe illness, a BMI ≥ 35 kg/m2 dramatically increases the risk of death.
    Keywords COVID-19 - obesity - outcomes - respiratory failure - death - ICU admission - BMI ; covid19
    Subject code 610
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: How important is obesity as a risk factor for respiratory failure, intensive care admission and death in hospitalised COVID-19 patients? Results from a single Italian centre

    Rottoli, Matteo / Bernante, Paolo / Belvedere, Angela / Balsamo, Francesca / Garelli, Silvia / Giannella, Maddalena / Cascavilla, Alessandra / Tedeschi, Sara / Ianniruberto, Stefano / Rosselli Del Turco, Elena / Tonetti, Tommaso / Ranieri, Vito Marco / Poggioli, Gilberto / Manzoli, Lamberto / Pagotto, Uberto / Viale, Pierluigi / Bartoletti, Michele

    European Journal of Endocrinology

    2020  Volume 183, Issue 4, Page(s) 389–397

    Abstract: Objective: Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems to aggravate the course of disease, the actual impact of the BMI and the cutoff which increases illness severity ...

    Abstract Objective: Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems to aggravate the course of disease, the actual impact of the BMI and the cutoff which increases illness severity are still under investigation. The aim of the study was to analyze whether the BMI represented a risk factor for respiratory failure, admission to the intensive care unit (ICU) and death. Research design and methods: A retrospective cohort study of 482 consecutive COVID-19 patients hospitalised between March 1 and April 20, 2020. Logistic regression analysis and Cox proportion Hazard models including demographic characteristics and comorbidities were carried out to predict the endpoints within 30 days from the onset of symptoms. Results: Of 482 patients, 104 (21.6%) had a BMI ≥ 30 kg/m 2 . At logistic regression analysis, a BMI between 30 and 34.9 kg/m 2 significantly increased the risk of respiratory failure (OR: 2.32; 95% CI: 1.31–4.09, P = 0.004) and admission to the ICU (OR: 4.96; 95% CI: 2.53–9.74, P < 0.001). A significantly higher risk of death was observed in patients with a BMI ≥ 35 kg/m 2 (OR: 12.1; 95% CI: 3.25–45.1, P < 0.001). Conclusions: Obesity is a strong, independent risk factor for respiratory failure, admission to the ICU and death among COVID-19 patients. A BMI ≥ 30 kg/m 2 identifies a population of patients at high risk for severe illness, whereas a BMI ≥ 35 kg/m 2 dramatically increases the risk of death.
    Keywords Endocrinology, Diabetes and Metabolism ; Endocrinology ; General Medicine ; covid19
    Publisher Bioscientifica
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1183856-5
    ISSN 1479-683X ; 0804-4643
    ISSN (online) 1479-683X
    ISSN 0804-4643
    DOI 10.1530/eje-20-0541
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Obesity Is One of the Strongest Risk Factor for Respiratory Failure and Death in COVID-19 Patients

    Rottoli, Matteo / Bernante, Paolo / Belvedere, Angela / Tonetti, Tommaso / Garelli, Silvia / Giannella, Maddalena / Cascavilla, Alessandra / Tedeschi, Sara / Ianniruberto, Stefano / Del Turco, Elena Rosselli / Cristini, Francesco / Barchiesi, Francesco / Bussini, Linda / Codeluppi, Mauro / Puoti, Massimo / aracino, Annalisa / Nardi, Elena / Pagotto, Uberto / Poggioli, Gilberto /
    Ranieri, Vito Marco / Viale, Pierluigi / Bartoletti, Michele

    SSRN Electronic Journal ; ISSN 1556-5068

    A Retrospective Multicentric Cohort Study

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3578779
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  8. Article ; Online: Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago.

    Perrone, Gennaro / Giuffrida, Mario / Abu-Zidan, Fikri / Kruger, Vitor F / Livrini, Marco / Petracca, Gabriele Luciano / Rossi, Giorgio / Tarasconi, Antonio / Tian, Brian W C A / Bonati, Elena / Mentz, Ricardo / Mazzini, Federico N / Campana, Juan P / Gasser, Elisabeth / Kafka-Ritsch, Reinhold / Felsenreich, Daniel M / Dawoud, Christopher / Riss, Stefan / Gomes, Carlos Augusto /
    Gomes, Felipe Couto / Gonzaga, Ricardo Alessandro Teixeira / Canton, Cassio Alfred Brattig / Pereira, Bruno Monteiro / Fraga, Gustavo P / Zem, Leticia Gonçalves / Cordeiro-Fonseca, Vinicius / de Mesquita Tauil, Renato / Atanasov, Boyko / Belev, Nikolay / Kovachev, Nikola / Meléndez, L Juan José / Dimova, Ana / Dimov, Stefan / Zelić, Zdravko / Augustin, Goran / Bogdanić, Branko / Morić, Trpimir / Chouillard, Elie / Bajul, Melinda / De Simone, Belinda / Panis, Yves / Esposito, Francesco / Notarnicola, Margherita / Lauka, Lelde / Fabbri, Anna / Hentati, Hassen / Fnaiech, Iskander / Aurélien, Venara / Bougard, Marie / Roulet, Maxime / Demetrashvili, Zaza / Pipia, Irakli / Merabishvili, Giorgi / Bouliaris, Konstantinos / Koukoulis, Georgios / Doudakmanis, Christos / Xenaki, Sofia / Chrysos, Emmanuel / Kokkinakis, Stamatios / Vassiliu, Panteleimon / Michalopoulos, Nikolaos / Margaris, Ioannis / Kechagias, Aristotelis / Avgerinos, Konstantinos / Katunin, Jevgeni / Lostoridis, Eftychios / Nagorni, Eleni-Aikaterini / Pujante, Antonio / Mulita, Francesk / Maroulis, Ioannis / Vailas, Michail / Marinis, Athanasios / Siannis, Ioannis / Bourbouteli, Eirini / Manatakis, Dimitrios K / Tasis, Nikolaos / Acheimastos, Vasileios / Maria, Sotiropoulou / Stylianos, Kapiris / Kuzeridis, Harilaos / Korkolis, Dimitrios / Fradelos, Evangelos / Kavalieratos, George / Petropoulou, Thalia / Polydorou, Andreas / Papacostantinou, Ioannis / Triantafyllou, Tania / Kimpizi, Despina / Theodorou, Dimitrios / Toutouzas, Konstantinos / Chamzin, Alexandros / Frountzas, Maximos / Schizas, Dimitrios / Karavokyros, Ioannis / Syllaios, Athanasios / Charalabopoulos, Alexandros / Boura, Maria / Baili, Efstratia / Ioannidis, Orestis / Loutzidou, Lydia / Anestiadou, Elissavet / Tsouknidas, Ioannis / Petrakis, Georgios / Polenta, Eleni / Bains, Lovenish / Gupta, Rahul / Singh, Sudhir K / Khanduri, Archana / Bala, Miklosh / Kedar, Asaf / Pisano, Marcello / Podda, Mauro / Pisanu, Adolfo / Martines, Gennaro / Trigiante, Giuseppe / Lantone, Giuliano / Agrusa, Antonino / Di Buono, Giuseppe / Buscemi, Salvatore / Veroux, Massimiliano / Gioco, Rossella / Veroux, Gastone / Oragano, Luigi / Zonta, Sandro / Lovisetto, Federico / Feo, Carlo V / Pesce, Antonio / Fabbri, Nicolò / Lantone, Giulio / Marino, Fabio / Perrone, Fabrizio / Vincenti, Leonardo / Papagni, Vincenzo / Picciariello, Arcangelo / Rossi, Stefano / Picardi, Biagio / Del Monte, Simone Rossi / Visconti, Diego / Osella, Giulia / Petruzzelli, Luca / Pignata, Giusto / Andreuccetti, Jacopo / D'Alessio, Rossella / Buonfantino, Massimo / Guaitoli, Eleonora / Spinelli, Stefano / Sampietro, Gianluca Matteo / Corbellini, Carlo / Lorusso, Leonardo / Frontali, Alice / Pezzoli, Isabella / Bonomi, Alessandro / Chierici, Andrea / Cotsoglou, Christian / Manca, Giuseppe / Delvecchio, Antonella / Musa, Nicola / Casati, Massimiliano / Letizia, Laface / Abate, Emmanuele / Ercolani, Giorgio / D'Acapito, Fabrizio / Solaini, Leonardo / Guercioni, Gianluca / Cicconi, Simone / Sasia, Diego / Borghi, Felice / Giraudo, Giorgio / Sena, Giuseppe / Castaldo, Pasquale / Cardamone, Eugenia / Portale, Giuseppe / Zuin, Matteo / Spolverato, Ylenia / Esposito, Marialusia / Isernia, Roberta Maria / Di Salvo, Maria / Manunza, Romina / Esposito, Giuseppe / Agus, Marcello / Asti, Emanuele Luigi Giuseppe / Bernardi, Daniele Tiziano / Tonucci, Tommaso Panici / Luppi, Davide / Casadei, Massimiliano / Bonilauri, Stefano / Pezzolla, Angela / Panebianco, Annunziata / Laforgia, Rita / De Luca, Maurizio / Zese, Monica / Parini, Dario / Jovine, Elio / De Sario, Giuseppina / Lombardi, Raffaele / Aprea, Giovanni / Palomba, Giuseppe / Capuano, Marianna / Argenio, Giulio / Orio, Gianluca / Armellino, Mariano Fortunato / Troian, Marina / Guerra, Martina / Nagliati, Carlo / Biloslavo, Alan / Germani, Paola / Aizza, Giada / Monsellato, Igor / Chahrour, Ali Chaouki / Anania, Gabriele / Bombardini, Cristina / Bagolini, Francesco / Sganga, Gabriele / Fransvea, Pietro / Bianchi, Valentina / Boati, Paolo / Ferrara, Francesco / Palmieri, Francesco / Cianci, Pasquale / Gattulli, Domenico / Restini, Enrico / Cillara, Nicola / Cannavera, Alessandro / Nita, Gabriela Elisa / Sarnari, Jlenia / Roscio, Francesco / Clerici, Federico / Scandroglio, Ildo / Berti, Stefano / Cadeo, Alessandro / Filippelli, Alice / Conti, Luigi / Grassi, Carmine / Cattaneo, Gaetano Maria / Pighin, Marina / Papis, Davide / Gambino, Giovanni / Bertino, Vanessa / Schifano, Domenico / Prando, Daniela / Fogato, Luisella / Cavallo, Fabio / Ansaloni, Luca / Picheo, Roberto / Pontarolo, Nicholas / Depalma, Norma / Spampinato, Marcello / D'Ugo, Stefano / Lepre, Luca / Capponi, Michela Giulii / Campa, Rossella Domenica / Sarro, Giuliano / Dinuzzi, Vincenza Paola / Olmi, Stefano / Uccelli, Matteo / Ferrari, Davide / Inama, Marco / Moretto, Gianluigi / Fontana, Michele / Favi, Francesco / Picariello, Erika / Rampini, Alessia / Barberis, Andrea / Azzinnaro, Antonio / Oliva, Alba / Totaro, Luigi / Benzoni, Ilaria / Ranieri, Valerio / Capolupo, Gabriella Teresa / Carannante, Filippo / Caricato, Marco / Ronconi, Maurizio / Casiraghi, Silvia / Casole, Giovanni / Pantalone, Desire / Alemanno, Giovanni / Scheiterle, Maximilian / Ceresoli, Marco / Cereda, Marco / Fumagalli, Chiara / Zanzi, Federico / Bolzon, Stefano / Guerra, Enrico / Lecchi, Francesca / Cellerino, Paola / Ardito, Antonella / Scaramuzzo, Rosa / Balla, Andrea / Lepiane, Pasquale / Tartaglia, Nicola / Ambrosi, Antonio / Pavone, Giovanna / Palini, Gian Marco / Veneroni, Simone / Garulli, Gianluca / Ricci, Claudio / Torre, Beatrice / Russo, Iris Shari / Rottoli, Matteo / Tanzanu, Marta / Belvedere, Angela / Milone, Marco / Manigrasso, Michele / De Palma, Giovanni Domenico / Piccoli, Micaela / Pattacini, Gianmaria Casoni / Magnone, Stefano / Bertoli, Paolo / Pisano, Michele / Massucco, Paolo / Palisi, Marco / Luzzi, Andrea-Pierre / Fleres, Francesco / Clarizia, Guglielmo / Spolini, Alessandro / Kobe, Yoshiro / Toma, Takayuki / Shimamura, Fumihiko / Parker, Robert / Ranketi, Sinkeet / Mitei, Mercy / Svagzdys, Saulius / Pauzas, Henrikas / Zilinskas, Justas / Poskus, Tomas / Kryzauskas, Marius / Jakubauskas, Matas / Zakaria, Andee Dzulkarnaen / Zakaria, Zaidi / Wong, Michael Pak-Kai / Jusoh, Asri Che / Zakaria, Muhammad Nazreen / Cruz, Daniel Rios / Elizalde, Aurea Barbara Rodriguez / Reynaud, Alejandro Bañon / Hernandez, Edgard Efren Lozada / Monroy, Jose Maria Victor Palomo / Hinojosa-Ugarte, Diego / Quiodettis, Martha / Du Bois, María Esther / Latorraca, José / Major, Piotr / Pędziwiatr, Michał / Pisarska-Adamczyk, Magdalena / Walędziak, Maciej / Kwiatkowski, Andrzej / Czyżykowski, Łukasz / da Costa, Silvia Dantas / Pereira, Bela / Ferreira, Ana Rita Oliveira / Almeida, Filipe / Rocha, Ricardo / Carneiro, Carla / Perez, Diego Pita / Carvas, João / Rocha, Catarina / Ferreira, Cátia / Marques, Rita / Fernandes, Urânia / Leao, Pedro / Goulart, André / Pereira, Rita Gonçalves / Patrocínio, Sara 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Raquel / Mendoza-Moreno, Fernando / Nisa, Francisca García-Moreno / Díez-Alonso, Manuel / Rodas, María Elisa Valle / Agundez, María Carmona / Andrés, María Inmaculada Pérez / Moreira, Claudia Cristina Lopes / Perez, Aintzane Lizarazu / Ponce, Iñigo Augusto / González-Castillo, Ana María / Membrilla-Fernández, Estela / Salvans, Silvia / Serradilla-Martín, Mario / Pardo, Pablo Sancho / Rivera-Alonso, Daniel / Dziakova, Jana / Huguet, Jose Mugüerza / Valle, Naila Pagès / Ruiz, Enrique Colás / Valcárcel, Cristina Rey / Moreno, Cristina Ruiz / Salazar, Yeniffer Tatiana Moreno / García, Juan Jesús Rubio / Micó, Silvia Sevila / López, Joaquín Ruiz / Farré, Silvia Pérez / Gomez, Maite Santamaria / Petit, Nuria Mestres / Titos-García, Alberto / Aranda-Narváez, Jose Manuel / Romacho-López, Laura / Sánchez-Guillén, Luis / Aranaz-Ostariz, Veronica / Bosch-Ramírez, Marina / Martínez-Pérez, Aleix / Martínez-López, Elías / Sebastián-Tomás, Juan Carlos / Jimenez-Riera, Granada / Jimenez-Vega, Javier / Cuellar, Jose Aurelio Navas / Campos-Serra, Andrea / Muñoz-Campaña, Anna / Gràcia-Roman, Raquel / Alegre, Javier Martínez / Pinto, Francisca Lima / O'Sullivan, Sara Nuñez / Antona, Francisco Blanco / Jiménez, Beatriz Muñoz / López-Sánchez, Jaime / Carmona, Zahira Gómez / Fernández, Rocio Torres / Sierra, Isabel Blesa / de León, Laura Román García / Moreno, Verónica Polaino / Iglesias, Eva / Cumplido, Paola Lora / Bravo, Altea Arango / Simó, Ignacio Rey / Domínguez, Carlota López / Caamaño, Aloia Guerreiro / Lozano, Rafael Calleja / Martínez, Manuel Durán / Torres, Álvaro Naranjo / de Quiros, Javier Tomas Morales Bernaldo / Pellino, Gianluca / Cloquell, Miriam Moratal / Moller, Elsa García / Jalal-Eldin, Sami / Abdoun, Ahmed K / Hamid, Hytham K S / Lohsiriwat, Varut / Mongkhonsupphawan, Aitsariya / Baraket, Oussama / Ayed, Karim / Abbassi, Imed / Ali, Ali Ben / Ammar, Houssem / Kchaou, Ali / Tlili, Ahmed / Zribi, Imen / Colak, Elif / Polat, Suleyman / Koylu, Zehra Alan / Guner, Ali / Usta, Mehmet Arif / Reis, Murat Emre / Mantoglu, Baris / Gonullu, Emre / Akin, Emrah / Altintoprak, Fatih / Bayhan, Zulfu / Firat, Necattin / Isik, Arda / Memis, Ufuk / Bayrak, Mehmet / Altıntaş, Yasemin / Kara, Yasin / Bozkurt, Mehmet Abdussamet / Kocataş, Ali / Das, Koray / Seker, Ahmet / Ozer, Nazmi / Atici, Semra Demirli / Tuncer, Korhan / Kaya, Tayfun / Ozkan, Zeynep / Ilhan, Onur / Agackiran, Ibrahim / Uzunoglu, Mustafa Yener / Demirbas, Eren / Altinel, Yuksel / Meric, Serhat / Hacım, Nadir Adnan / Uymaz, Derya Salim / Omarov, Nail / Balık, Emre / Tebala, Giovanni D / Khalil, Hany / Rana, Mridul / Khan, Mansoor / Florence, Charlotte / Swaminathan, Christie / Leo, Cosimo Alex / Liasis, Lampros / Watfah, Josef / Trostchansky, Ivan / Delgado, Edward / Pontillo, Marcelo / Latifi, Rifat / Coimbra, Raul / Edwards, Sara / Lopez, Ana / Velmahos, George / Dorken, Ander / Gebran, Anthony / Palmer, Amanda / Oury, Jeffrey / Bardes, James M / Seng, Sirivan Suon / Coffua, Lauren S / Ratnasekera, Asanthi / Egodage, Tanya / Echeverria-Rosario, Karla / Armento, Isabella / Napolitano, Lena M / Sangji, Naveen F / Hemmila, Mark / Quick, Jacob A / Austin, Tyler R / Hyman, Theodore S / Curtiss, William / McClure, Amanda / Cairl, Nicholas / Biffl, Walter L / Truong, Hung P / Schaffer, Kathryn / Reames, Summer / Banchini, Filippo / Capelli, Patrizio / Coccolini, Federico / Sartelli, Massimo / Bravi, Francesca / Vallicelli, Carlo / Agnoletti, Vanni / Baiocchi, Gian Luca / Catena, Fausto

    World journal of emergency surgery : WJES

    2024  Volume 19, Issue 1, Page(s) 14

    Abstract: Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute ... ...

    Abstract Background: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA.
    Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up.
    Results: 564 patients (43.1%) were females. The mean age was 65.9 ± 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo ≥ 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (≤ 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections.
    Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception.
    MeSH term(s) Female ; Humans ; Middle Aged ; Aged ; Aged, 80 and over ; Male ; Emergencies ; Prospective Studies ; Postoperative Complications/etiology ; Anastomosis, Surgical/methods ; Colorectal Neoplasms/surgery
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 2233734-9
    ISSN 1749-7922 ; 1749-7922
    ISSN (online) 1749-7922
    ISSN 1749-7922
    DOI 10.1186/s13017-024-00543-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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Forlani, Stefano / Francone, Elisa / Frattaruolo, Colomba / Frio, Federico / Gagliano, Annalisa / Gagliardi, Filippo / Gahunia, Sukhpreet / Gaino, Francesca / Gala, Tanzeela / Galfrascoli, Elisa / Galimberti, Luca / Gallagher, Phoebe / Galleano, Raffaele / Galván-Pérez, Armando / Gammeri, Emanuele / Ganau, Mario / Garcés-García, Raúl / Garulli, Gianluca / Gascon-Ferrer, Isabel / Gattolin, Andrea / Gaujoux, Sebastien / Gentilli, Sergio / Georgiades, Fanourios / Ghanbari, Amir / Ghosh, Dhruv / Giacometti, Marco / Giblin, Anna-Victoria / Gilbert, Catherine / Giménez, Clara / Giorgakis, Emmanouil / Gipponi, Manuel / Glen, Paul / Goatly, Giles / Gobatti, Davide / Godbole, Chintamani / Gohil, Kajal / Gómez, Marcos / Gomez-Rosado, Juan-Carlos / Gonullu, Emre / Gonzalez-Gonzalez, Enrique / Gordini, Luca / Gracia, Isabel / Gracia-Roche, Carlos / Granieri, Stefano / Green, Susanna / Grivon, Manuela / Grove, Thomas / Guaglio, Marcello / Guaitoli, Eleonora / Guglielmi, Alfredo / Guha, Soumya / Gustavino, Claudio / Habeeb, Amir / Hagger, Robert / Hakmi, Hazim / Halkias, Constantine / Hall, Claire / Hampton, Matthew / Handa, Siddhartha / Hansen, Laura / Haq, Iram / Harky, Amer / Harries, Rhiannon / Harrison, Joseph / Hasan, Raashad / Hawari, Mohammad / Hawkin, Paul / Hebblethwaite, Bethany / Henriques, Susana / Heritage, Emily / Hernandez-Juara, Pilar / Herrero-Lopez, Maria / Hervieux, Erik / Heyd, Bruno / Higgs, Simon / Hitchman, Louise / Ho, Beatrice / Hogan, Aisling / Hölzle, Frank / Hossain, Tanvir / Hurt, Libor / Hutchinson, Peter / Iacob, Giulio / Iannone, Immacolata / Ibrahim, Sherif / Iovino, Domenico / Isik, Arda / Jafarova, Sevda / Jamil, Tahir / Jayaraju, Ullas / Jenner, Edward / Jimenez-Higuera, Elisa / Jimeno, Jaime / Jones, Mark / Judkins, Nicholas / Kalavrezos, Nicholas / Kalidindi, Venugopala / Kalkat, Maninder / Kamal, Mona / Kamphues, Carsten / Kang, Chong / Kara, Yasin / Karam, Edward / Karim, Ahmed / Kashora, Florence / Kearney, David / Khajuria, Apoorva / Khan, Umul / Khan, Azam / Khatri, Chetan / Kinnaman, Gabriel / Kinross, James / Kler, Aaron / Klimopoulos, Serafeim / Kocataş, Ali / Kolias, Angelos / Königsrainer, Alfred / Konsten, Joop / Kontovounisios, Christos / Kourdouli, Amar / Krishnan, Emily / Kristinsson, Sverrir / Kruijff, Schelto / Kudsk-Iversen, Søren / Kufeji, Dorothy / Kugler, Nadav / Kulkarni, Rugved / Kurihara, Hayato / Laface, Letizia / Lakkis, Zaher / Lami, Mariam / Landaluce-Olavarria, Aitor / Lapolla, Pierfrancesco / Lawani, Ismail / Lawday, Samuel / Lázaro, André / Lecolle, Katia / Leventoglu, Sezai / Li, Zoe / Liew, Ignatius / Lisi, Giorgio / Lizzi, Vincenzo / Lo, Terence / Lomiento, Daniele / Longhi, Marco / Lostis, Emilie / Lostoridis, Eftychios / Loubani, Mahmoud / Lowy-Benoliel, Alejandro / Lucianetti, Alessandro / Luke, Louis / Lunevicius, Raimundas / Luraghi, Marco / Lye, George / Mabrouk, Islam / Macchi, Alberto / MacDonald, Luisa / Machairas, Nikolaos / Madonini, Marco / Magowan, Drew / Maisonneuve, Emeline / Majkowska, Agata / Majkowski, Lawrence / Mak, Jason / Malabarba, Stefano / Malerba, Michele / Mannan, Syed / Manson, Joanna / Mansuri, Ahmer / Mantoglu, Baris / Manu, Nichola / Maqsood, Afnan / Marano, Alessandra / Marchbank, Adrian / Marcos-Santos, Pablo / Marrano, Enrico / Martin, Janet / Martin, Emmeline / Martin, Guy / Martin-Albo, Lorena / Martín-Román, Lorena / Martinelli, Fabio / Martínez-dePaz, Fernando / Martinez-German, Antonio / Martinez-Pinedo, Carlos / Martins, Ricardo / Marwan, Hisham / Marzi, Federica / Mathieu, Pierre / Matute-Najarro, Maria-Soledad / Maw, Andrew / Mazingi, Dennis / Mazzaferro, Vincenzo / McCanny, Andrew / McKenzie, Katherine / McLarty, Nicola / McPherson, Iain / Medina, Esther / Mediratta, Saniya / Medone, Marzia / Mehra, Gautam / Mele, Simone / Melero-Cortés, Lidia / Mendoza-Moreno, Fernando / Meneghini, Simona / Mercante, Giuseppe / Merdrignac, Aude / Merola, Stephen / Metallidis, Symeon / Michel, Martin / Migliore, Marco / Mihanovic, Jakov / Miller, Douglas / Mingoli, Andrea / Minto, Gary / Mirabella, Antonello / Misra, Nikhil / Mitrasinovic, Stefan / Miu, Victor / Moawad, Nader / Mochet, Sylvie / Modabber, Ali / Mohammad, Adam / Mohan, Midhun / Moliner-Sánchez, Carmen / Mongelli, Francesco / Monteleone, Michela / Montuori, Mauro / Moore, Rachel / Mora-Guzmán, Ismael / Morales, Xavier / Morales, Dieter / Morelli, Luca / Morelli, Lucia / Morgan, Richard / Morris, Chris / Mortini, Pietro / Mosca, Angelo / Motter, Dema / Moug, Susan / Mukherjee, Samrat / Najdy, Manhal / Nakas, Apostolos / Namazov, Ilgar / Naredla, Pradyumna / Nasef, Emmhamed / Nassa, Heeam / Nath, Rahul / Navarro-Sánchez, Antonio / Nazarian, Scarlet / Negri, Giampiero / Nehra, Deepika / Neil-Dwyer, Jason / Neri, Jacopo / Newton, Katy / Nikaj, Herald / Niquen, Milagros / Nobile, Sara / Nogueiro, Jorge / Ntirenganya, Faustin / Nugent, Michael / Núñez, Jordi / Ocaña, Juan / Okechukwu, Valentine / Oliva-Mompean, Fernando / Oliveira, Ana / Ollat, Didier / Onos, Lavinia / Osagie-Clouard, Liza / Osman, Khabab / Ottolina, Jessica / Ourieff, Jared / Outani, Oumaima / Oyewole, Bankole / Ozben, Volkan / Pacheco-Sanchez, David / Padilla-Valverde, David / Pai, Madhava / Paiella, Salvatore / Paisley, Samuel / Palini, Gianmarco / Palmeri, Matteo / Panahi, Pedram / Parente, Alessandro / Parlanti, Daniele / Parmar, Chetan / Pascual, Angela / Patel, Mahul / Pathak, Abhijit / Patil, Sangram / Pattyn, Piet / Peckham-Cooper, Adam / Pedrazzani, Corrado / Pellino, Gianluca / Peluso, Chiara / Pereira, André / Pereira-Neves, António / Perez-Diaz, Md / Pérez-González, Marta

    an international cohort study

    2020  

    Keywords covid19
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection

    Nepogodiev, Dmitri / Glasbey, James C / Li, Elizabeth / Omar, Omar M / Simoes, Joana FF / Abbott, Tom EF / Alser, Osaid / Arnaud, Alexis P / Bankhead-Kendall, Brittany K / Breen, Kerry A / Cunha, Miguel F / Davidson, Giana H / Di Saverio, Salomone / Gallo, Gaetano / Griffiths, Ewen A / Gujjuri, Rohan R / Hutchinson, Peter J / Kaafarani, Haytham MA / Lederhuber, Hans /
    Löffler, Markus W / Mashbari, Hassan N / Minaya-Bravo, Ana / Morton, Dion G / Moszkowicz, David / Pata, Francesco / Tsoulfas, George / Venn, Mary L / Bhangu, Aneel / Cox, Daniel / Roslani, April C / Alakaloko, Felix / de Vries, Jean-Paul PM / Aaraj, Mahmoud A / Abbott, Sarah J / Abdalla, Mutwakil OM / Abdelaal, Ahmed S / Ademuyiwa, Adesoji O / Aherne, Thomas M / Ali, Osman M / Alkadeeki, Ghadah Z / Almeida, Ana C / Alrahawy, Mahmoud M / Ambler, Graeme K / Alameer, Ehab / Andreani, Stefano M / De Andrés-Asenjo, Beatriz / Antonanzas, Leyre Lopez / Aoun, Salah G / Ashoush, Fouad M / Augestad, Knut Magne / Avellana, Rocio B / Ayeni, Funbi A / Ayorinde, John OO / Babu, Bheemanakone H / Baig, Mirza MAS / Bajomo, Oreoluwa M / Baker, Olivia J / Baker, Markus P / Baldwin, Alexander J / Ban, Vin Shen / Baron, Ryan D / Barranquero, Alberto G / Barry, Conor P / DI Bartolomeo, Alessandro / Bass, Gary A / Bath, Michael F / Batjer, H Hunt / Beamish, Andrew J / Belgaumkar, Ajay P / Bence, Matthew N / Benson, Ruth A / Bernal-Sprekelsen, Juan Carlos / Bhama, Anuradha R / Bhavaraju, Avi V / Biffl, Walter L / Blundell, Chris M / Boddy, Alexander P / Borgstein, Alexander BJ / Bosanquet, David C / Bosch, Karen D / Bouhuwaish, Ahmad EM / Bozkurt, Mehmet A / Brathwaite, Collin EM / Brown, Benjamin C / Brown, Oliver D / Brown, Allison K / Buarque, Igor Lima / Bueno-Cañones, Alejandro D / Bulugma, Mustafa R / Burke, Joshua R / Byrne, Matthew HV / Cagigal-Ortega, Elima P / Callcut, Rachael A / DI Candido, Francesca / Canova, Michaela E / Carlos, William J / Caruana, Edward J / Cato, Liam D / Catton, Andrew B / Ceretti, Andrea Pisani / Chase, Thomas JG / Chiara, Francesco Di / Chowdhury, Abeed H / Chung, Eric A / Cicerchia, Pierfranco M / Clough, Ethan CS / Coleman, Natasha L / Collins, Chris G / Collins, Michelle L / Colonna, Emily T / Comini, Lara V / Connolly, Tara M / Coughlin, Patrick A / Cruzado, Laura Fernández-Gomez / Davidson, Brian R / Davies, Richard J / Davies, Emma J / Davis, Niall F / Dawson, Brett E / Dean, Benjamin JF / Delgado, Maria Garcia-Conde / Diaz, Jose J / Dickson, Kathryn E / Diez-Alonso, Manuel M / Dixon, Jan R / Doe, Matthew J / Drake, Thomas D / Drake, Frederick T / Duffy, John P / Dunne, Declan FJ / Dunne, Naomi JM / Durán-Muñoz-Cruzado, Virginia M / Durst, Alexander ZE / Eardley, Nicola J / Edwards, John G / Elfallal, Ahmed H / Elfiky, Mahmoud MA / Elliott, Jessie A / Emile, Sameh H / Emslie, Katy M / Endorf, Frederick W / Engel, Jamie L / Enjuto, Diego T / Etchill, Eric W / Evans, Jonathan P / Fahey, Brian A / Faria, Carlos S / Feo, Carlo V / Ferguson, Henry JM / Fernandez, Beatriz Dieguez / Fernandez, Andres Garcia / Fernández, Antonio J / Fernández-Pacheco, Borja Camacho / Fitzgerald, J Edward / Fonsi, Giovanni B / Font, Roser Farré / Fowler, Amy L / Franco, Gregorio Di / Fretwell, Kenneth R / Fructuoso, Lorena Sanchon / Fusai, Giuseppe K / Garcia, Miguel Hernandez / Garcia-Ureña, Miguel Angel / Gill, Charn K / Gisbertz, Suzanne S / Del Giudice, Roberto / Giuffrida, Maria Carmela / Di Giuseppe, Matteo / Gómez, María Fanjul / González, Javier Serrano / Guariglia, Claudio A / Hainsworth, Alison J / Hall, Bria J / Hall, James RW / Hammond, John S / Haqqani, Maha H / Harrison, Ewen M / Hazelton, Joshua P / van Heinsbergen, Maarten / Hill, Arnold DK / Hing, Caroline B / Hirji, Sameer A / Ho, Michael WS / Holbrook, Charlotte M / Holme, Thomas J / Hopkins, James C / Hopkinson, David N / Hossain, Fahad S / Hudson, Victoria E / Hughes, Jane L / Hwang, E. Shelley / Ibrahim, Mohamed AH / Isolani, Simone M / Jara, Pablo Galindo / Jenkinson, Michael D / Jenny, Hillary E / Jeyaretna, Deva S / Jones, Robert P / Jones, Andrew P / Jonker, Pascal KC / Jönsson, Maria L / Joyce, Doireann P / Kalkwarf, Kyle J / Kamarajah, Sivesh K / El Kassas, Mohamed / Kavanagh, Dara O / Keatley, James M / Khalefa, Mohamed A / Khan, Jim S / Kirmani, Bilal H / Kisiel, Aaron P / Kouris, Spyros Marinos / Kowal, Mikolaj R / Labib, Peter L / Larkin, John O / Lauscher, Johannes C / Leclercq, Wouter KG / Ledesma, Frances SJ / Leite-Moreira, André M / Leung, Elaine YL / Lewis, Sophia E / Lima, Maria João / Lin, Daniel J / Liu, Helen H / Lowery, Aoife J / Lozano, Saida Martel / Luney, Catriona R / Maia, Mariana Magalhães / Mariani, Nicolò M / Marino, Marco V / Marra, Angelo A / Marsh, Christopher L / Martin, Robert CG / McCluney, Simon J / McIntyre, Robert C / Mckay, Siobhan C / McKevitt, Kevin L / Meagher, Ashley D / Mehdi, Mohammad Q / Mehigan, Brian J / Gonzalez-De Miguel, Melania / De Miguel-Ardevines, Maria-Carmen / Miguel-Mendez, Carlos San / Mills, Sarah J / Mohan, Helen M / Moir, John AG / Monson, John RT / Monteiro, Joana M / Montella, Maria T / Montesinos, Cristina Soto / Morgom, Marwa M / Moura, Francisco S / Muguerza, Jose M / Murphy, Suzanne H / De Nardi, Paola / Naumann, David N / Neary, Paul C / Neely, David TA / Ng-Kamstra, Joshua S / Ngu, Albert WT / Nguyen, Truong A / Nita, George E / Nunes, Quentin M / Nygaard, Rachel M / O'Meara, Lindsay B / O'Neill, John R / Okafor, Barbara U / Olson, Steven A / Oo, Aung Y / Ormazabal, Pablo Collera / Osorio, Alexander L / Pachl, Max J / Parry, James T / Patel, Panna K / Pérez, David Díaz / Pérez, Carolina Martínez / Pérez-Sánchez, Luis E / Pevidal, Ana Nogues / Pezzuto, Anna P / Philp, Matthew M / Pinkney, Thomas D / Pollok, Joerg M / Povey, Meical G / Poza, Alfredo Alonso / Rajgor, Amarkumar D / Rao, Jagan N / Raptis, Dimitri A / Rice, Henry E / Ridgway, Paul F / Rivas, Ana Munoz / Rodriguez-Sanjuan, Juan C / Rogers, Luke J / Da Roit, Anna / Rollett, Rebecca A / Romera, Jose L / Rooney, Siobhan M / Roxo, Vanessa I / Le Roy, Bertrand / Rubio, Eduardo E / Ruiz, Carolina Castro / Ruiz, Manuel Losada / Ryan, Éanna J / Saad, Abdel Rahman / Saeed, Samerah A / Salama, Hiba A / Salamah, Abdulrauf A / Samaniego, María Gutiérrez / Sampietro, Gianluca M / Sarma, Diwakar R / Schaffer, Kathryn B / Schnitzbauer, Andreas A / Scurrah, Rachel J / Serevina, Olivia L / Serralheiro, Pedro A / Sewards, Joseph M / Shackcloth, Michael J / Shaw, Abigail V / Sheel, Andrea RG / Sica, Giuseppe S / De Simone, Veronica / Singh, Aminder A / Singh, Rabindra P / Skelly, Brendan L / Smith, Henry G / Sohail, Amir H / Spalding, Duncan R / Springford, Laurie R / Ssentongo, Anna E / Steinkamp, Pieter J / Stevens, Kent A / Stewart, Grant D / Stylianides, Nicholas A / Sullivan, Tom BB / Taher, Ahmed SA / Tamimy, Muhammad S / Tang, Alethea M / Tebala, Giovanni D / Tejero-Pintor, Francisco J / Thaha, Mohamed A / Thomas, Amy J / De Toma, Giorgio / La Torre, Filippo / Torres, Antonio J / Townshend, David N / Trout, Isobel M / Tucker, Sarah C / Ubhi, Harmony K / Vega, Viviana A / Velmahos, George C / Velopulos, Catherine G / Viswanath, Yirupaiahgari KS / Vivas, Alfredo A / Wade, Ryckie G / Wadley, Martin S / Wall, Joshua JS / Walters, Andrew M / Warren, Oliver J / Weerasinghe, Chamindri K / Wilkin, Richard JW / Williams, Katherine J / Winter, Stuart C / Wormald, Justin CR / Wright, Franklin L / Xyda, Souzana E / Young, Alastair L / Youssef, Mina MG / Yousuf, Farhat B / El Youzouri, Hanan / Zappa, Marco A / Abate, Emmanuele / Abdalaziz, Hossam / Abdelkarim, Mostafa / Abdou, Hossam / Aboelkassem-Ibrahim, Ahmad / Abuown, Ala / Acebes-Garcia, Fernando / Acharya, Metesh / Adamina, Michel / Addae-Boateng, Emmanuel / Aftab, Raiyyan / Agarwal, Arnav / Aguilar, José / Ahmed, Yousra / Aitken, Emma / Al-Azzawi, Marwa / Al-Embideen, Somya / Al-Masri, Mahmoud / Al-Najjar, Hani / Al-Sukaini, Ahmad / Alam, Ruhina / Alderson, Derek / Aliyeva, Zumrud / Aljanadi, Firas / Almasri, Murad / Alonso-Ortuño, Paula / Altintoprak, Fatih / Amira, Gamal / Amjad, Rabbia / Anania, Gabriele / Andabaka, Tatjana / Angelou, Dimitrios / Annamalai, Seethalakshmi / Annessi, Valerio / Anthoney, James / Anwar, Sibtain / Anwer, Mariyah / Aragon-Chamizo, Juan / Ardito, Antonella / Arigoni, Michele / Armao, Teodora / Arminio, Armando / Armstrong, Lara / Arnaud, Alexis / Asaad, Peter / Ashcroft, James / Ashmore, Christopher / Asqalan, Ahmad / Asti, Emanuele / Aubry, Emmanuelle / Aytac, Erman / Ayuso-Herrera, Esther / Baeza, Melody / Bailon-Cuadrado, Martin / Bakmaz, Bernarda / Baldi, Caterina / Baldini, Edoardo / Baldo, Stefano / Ballabio, Michele / Baloyiannis, Ioannis / Baltazar, Gerard / Bàmbina, Fabrizio / Bandiera, Alessandro / Barlow, Emma / Barmasse, Roberto / Barmpagianni, Christina / Baronio, Gianluca / Barra, Fabio / Bartsch, Anne-Marie / Basgaran, Amedra / Basha, Amr / Bashkirova, Varvara / Bastazza, Marco / Baumber, Rachel / Belcher, Elizabeth / Belvedere, Angela / Benítez-Linero, Inmaculada / Bergeat, Damien / Bernasconi, Matteo / Bhalla, Ashish / Bhutiani, Neal / Bianco, Federica / Bisagni, Pietro / Blake, Iain / Blanco-Colino, Ruth / Blazquez-Martin, Alma / Boal, Matthew / Bonavina, Luigi / Bonavina, Giulia / Bond-Smith, Giles / Booth, Karen / Borges, Filipe / Borghi, Felice / Bouchagier, Konstantinos / Bourke, Grainne / Boyle, Emily / Brachini, Gioia / Brain, Jessie / Brar, Amanpreet / Breckles, Lisa / Bretagnol, Frédéric / Brixton, Genevieve / Bruzzaniti, Placido / Bueser, Teofila / Burnside, Nathan / Caballero, Albert / Calcerrada-Alises, Enrique / Callahan, Miriam / Camarero, Enrique / Campagnaro, Tommaso / Campanelli, Michela / Candiani, Massimo / Cannoletta, Marina / Cantalejo-Diaz, Miguel / Cao, Han / Capelli, Patrizio / Capizzi, Vita / Carcano, Giulio / Carissimi, Francesca / Carlini, Massimo / Carlucci, Michele / Carmichael, Heather / Carrasco, Milagros / Carrillo, Mariana / Carvello, Michele / Casati, Massimiliano / Castoro, Carlo / Catalan, Vanesa / Cavaleiro, Salomé / Cellerino, Paola / Centinaio, Giovanna / Cernei, Cristina / Cerro, Cristina / Cervellera, Maurizio / Chakrabortee, Sohini / Chamberlain, Stephanie / Chan, Jeffrey / Chang, Grace / Chaudhry, Dauod / Chebaro, Alexandre / Chen, David / Chetty, Govind / Chia, Zoe / Chiappini, Ambra / Chiarugi, Massimo / Chidambaram, Swathikan / Chiozza, Matteo / Cholewa, Hanna / Chong, Clara / Choolani-Bhojwani, Ekta / Christoforidis, Dimitri / Chui, Karen / Chung, Choyin / Cirillo, Bruno / Citterio, Davide / Clermidi, Pauline / Coccolini, Federico / Colletti, Gaia / Compagnoni, Bruno / Concepción-Martín, Vanesa / Confalonieri, Marco / Connolly, Hannah / Conso, Christel / Conti, Luigi / Cooper, Zara / Corbellin, Carlo / Cordera, Fernando / Corral, Javier / Costa, Marta / Costanzi, Andrea / Cotsoglou, Christian / Cozza, Valerio / Cuming, Tamzin / Curtis, Miles / Cuschieri, Joseph / D'Agruma, Michele / D'Andrea, Giancarlo / Daliya, Prita / Dare, Oliver / Darko, Ebenezer / Day, Andrew / Dehal, Ahmed / Dehart, Dustin / Delgado-Oliver, Eduardo / Denning, Max / Desai, Anant / Desender, Liesbeth / Dester, Sara / Díaz-García, Alberto / Diaz-Peña, Patricia / Dousset, Bertrand / Doussot, Alexandre / Duchateau, Nicolas / Duff, Sarah / Dunning, Joel / Duque-Mallen, Victoria / Dziakova, Jana / Egan, Bridget / Egan, Richard / El-Ali, Abess / Elfeki, Hossam / Elhadi, Muhammed / Eljareh, Mohammed / Elkadi, Hannah / Elkady, Ramy / Elkhafeefi, Fatimah / Elmore, Ugo / Elmoslemany, Tarek / Emmerson, Oliver / Enemosah, Ibrahim / English, Camilla / English, William / Ereidge, Simon / Escartin, Jorge / Estaire-Gomez, Mercedes / Evans, Luke / Evans, Jessica / Exley, Rebecca / Fabbri, Nicoló / Falco, Giuseppe / Familiari, Pietro / Fancellu, Alessandro / Farik, Shebani / Farrell, Tony / Fehervari, Matyas / Fell, Adam / Fernandez-Camuñas, Angel / Fernández-Marín, Reyes / Fernández-Martínez, María / Ferrara, Francesco / Ferrari, Guglielmo / Ferrero, Simone / Findlay, Laura / Fiore, Marco / Fiori, Enrico / Flatman, Michael / Flindall, Ian / Flor, Blas / Fontana, Tommaso / Ford, Samuel / Ford, David / Forlani, Stefano / Francone, Elisa / Frattaruolo, Colomba / Frio, Federico / Gagliano, Annalisa / Gagliardi, Filippo / Gahunia, Sukhpreet / Gaino, Francesca / Gala, Tanzeela / Galfrascoli, Elisa / Galimberti, Luca / Gallagher, Phoebe / Galleano, Raffaele / Galván-Pérez, Armando / Gammeri, Emanuele / Ganau, Mario / Garcés-García, Raúl / Garulli, Gianluca / Gascon-Ferrer, Isabel / Gattolin, Andrea / Gaujoux, Sebastien / Gentilli, Sergio / Georgiades, Fanourios / Ghanbari, Amir / Ghosh, Dhruv / Giacometti, Marco / Giblin, Anna-Victoria / Gilbert, Catherine / Giménez, Clara / Giorgakis, Emmanouil / Gipponi, Manuel / Glen, Paul / Goatly, Giles / Gobatti, Davide / Godbole, Chintamani / Gohil, Kajal / Gómez, Marcos / Gomez-Rosado, Juan-Carlos / Gonullu, Emre / Gonzalez-Gonzalez, Enrique / Gordini, Luca / Gracia, Isabel / Gracia-Roche, Carlos / Granieri, Stefano / Green, Susanna / Grivon, Manuela / Grove, Thomas / Guaglio, Marcello / Guaitoli, Eleonora / Guglielmi, Alfredo / Guha, Soumya / Gustavino, Claudio / Habeeb, Amir / Hagger, Robert / Hakmi, Hazim / Halkias, Constantine / Hall, Claire / Hampton, Matthew / Handa, Siddhartha / Hansen, Laura / Haq, Iram / Harky, Amer / Harries, Rhiannon / Harrison, Joseph / Hasan, Raashad / Hawari, Mohammad / Hawkin, Paul / Hebblethwaite, Bethany / Henriques, Susana / Heritage, Emily / Hernandez-Juara, Pilar / Herrero-Lopez, Maria / Hervieux, Erik / Heyd, Bruno / Higgs, Simon / Hitchman, Louise / Ho, Beatrice / Hogan, Aisling / Hölzle, Frank / Hossain, Tanvir / Houston, Roy / Hurt, Libor / Hutchinson, Peter / Iacob, Giulio / Iannone, Immacolata / Ibrahim, Sherif / Iovino, Domenico / Isik, Arda / Jafarova, Sevda / Jamil, Tahir / Jayaraju, Ullas / Jenner, Edward / Jimenez-Higuera, Elisa / Jimeno, Jaime / Johnstone, Jack / Jones, Mark / Judkins, Nicholas / Kalavrezos, Nicholas / Kalidindi, Venugopala / Kalkat, Maninder / Kamal, Mona / Kamphues, Carsten / Kang, Chong / Kara, Yasin / Karam, Edward / Karim, Ahmed / Kashora, Florence / Kearney, David / Khajuria, Apoorva / Khan, Umul / Khan, Azam / Khatri, Chetan / Kinnaman, Gabriel / Kinross, James / Kler, Aaron / Klimopoulos, Serafeim / Kocataş, Ali / Kolias, Angelos / Königsrainer, Alfred / Konsten, Joop / Kontovounisios, Christos / Kourdouli, Amar / Krishnan, Emily / Kristinsson, Sverrir / Kruijff, Schelto / Kudsk-Iversen, Søren / Kufeji, Dorothy / Kugler, Nadav / Kulkarni, Rugved / Kurihara, Hayato / Laface, Letizia / Lakkis, Zaher / Lami, Mariam / Landaluce-Olavarria, Aitor / Lapolla, Pierfrancesco / Lawani, Ismail / Lawday, Samuel / Lázaro, André / Lecolle, Katia / Leventoglu, Sezai / Li, Zoe / Liew, Ignatius / Lisi, Giorgio / Lizzi, Vincenzo / Lo, Terence / Lomiento, Daniele / Longhi, Marco / Lostis, Emilie / Lostoridis, Eftychios / Loubani, Mahmoud / Lowy-Benoliel, Alejandro / Lucianetti, Alessandro / Luke, Louis / Lunevicius, Raimundas / Luraghi, Marco / Lye, George / Mabrouk, Islam / Macchi, Alberto / MacDonald, Luisa / Machairas, Nikolaos / Madonini, Marco / Magowan, Drew / Maisonneuve, Emeline / Majkowska, Agata / Majkowski, Lawrence / Mak, Jason / Malabarba, Stefano / Malerba, Michele / Mannan, Syed / Manson, Joanna / Mansuri, Ahmer / Mantoglu, Baris / Manu, Nichola / Maqsood, Afnan / Marano, Alessandra / Marchbank, Adrian / Marcos-Santos, Pablo / Marrano, Enrico / Martin, Janet / Martin, Emmeline / Martin, Guy / Martin-Albo, Lorena / Martín-Román, Lorena / Martinelli, Fabio / Martínez-dePaz, Fernando / Martinez-German, Antonio / Martinez-Pinedo, Carlos / Martins, Ricardo / Marwan, Hisham / Marzi, Federica / Mateos-Sierra, Olga / Mathieu, Pierre / Matute-Najarro, Maria-Soledad / Maw, Andrew / Mazingi, Dennis / Mazzaferro, Vincenzo / McCanny, Andrew / McKenzie, Katherine / McLarty, Nicola / McPherson, Iain / Medina, Esther / Mediratta, Saniya / Medone, Marzia / Mehra, Gautam / Mele, Simone / Melero-Cortés, Lidia / Mendoza-Moreno, Fernando / Meneghini, Simona / Mercante, Giuseppe / Merdrignac, Aude / Merola, Stephen / Metallidis, Symeon / Michel, Martin / Migliore, Marco / Mihanovic, Jakov / Miller, Douglas / Mingoli, Andrea / Minto, Gary / Mirabella, Antonello / Misra, Nikhil / Mitrasinovic, Stefan / Miu, Victor / Moawad, Nader / Mochet, Sylvie / Modabber, Ali / Mohammad, Adam / Mohan, Midhun / Moliner-Sánchez, Carmen / Mongelli, Francesco / Monteleone, Michela / Montuori, Mauro / Moore, Rachel / Mora-Guzmán, Ismael / Morales, Xavier / Morales, Dieter / Morelli, Luca / Morelli, Lucia / Morgan, Richard / Morris, Chris / Mortini, Pietro / Mosca, Angelo / Motter, Dema / Moug, Susan / Mukherjee, Samrat / Najdy, Manhal / Nakas, Apostolos / Namazov, Ilgar / Naredla, Pradyumna / Nasef, Emmhamed / Nassa, Heeam / Nath, Rahul / Navarro-Sánchez, Antonio / Nazarian, Scarlet / Negri, Giampiero / Nehra, Deepika / Neil-Dwyer, Jason / Neri, Jacopo / Newton, Katy / Nikaj, Herald / Niquen, Milagros / Nobile, Sara / Nogueiro, Jorge / Ntirenganya, Faustin / Nugent, Michael / Núñez, Jordi / Ocaña, Juan / Okechukwu, Valentine / Oliva-Mompean, Fernando / Oliveira, Ana / Ollat, Didier / Onos, Lavinia / Osagie-Clouard, Liza / Osman, Khabab / Ottolina, Jessica / Ourieff, Jared / Outani, Oumaima / Oyewole, Bankole / Ozben, Volkan / Pacheco-Sanchez, David / Padilla-Valverde, David / Pai, Madhava / Paiella, Salvatore / Paisley, Samuel / Palini, Gianmarco / Palmeri, Matteo / Panahi, Pedram / Parente, Alessandro / Parlanti, Daniele / Parmar, Chetan / Pascual, Angela / Patel, Mahul / Pathak, Abhijit / Patil, Sangram / Pattyn, Piet / Peckham-Cooper, Adam / Pedrazzani, Corrado / Pellino, Gianluca / Peluso, Chiara / Pereira, André / Pereira-Neves, António / Perez-Diaz, Md / Pérez-González, Marta / Pérez-Saborido, Baltasar / Perivoliotis, Konstantinos / Perkins, Clare / Peros, Georgios / Perotto, Ornella / Perra, Teresa / Petrone, Patrizio / Phenix, George / Picazo, Sara / Picon-Rodriguez, Rafael / Piloni, Martina / Pingarrón-Martín, Lorena / Pinotti, Enrico / Pisanu, Adolfo / Pizzini, Paolo / Pockney, Peter / Podda, Mauro / Podolsky, Dina / Poggioli, Gilberto / Pompili, Cecilia / Pontari, Michael / Porcu, Alberto / Potter, Ryan / Price, Claire / Pruvot, François-René / Pujol-Muncunill, Roger / Puppo, Andrea / Quante, Markus / Quintana-Villamandos, Begoña / Qureshi, Ali / Radenkovic, Dejan / Rakvin, Ivan / Ramallo-Solís, Irene / Ramcharan, Sean / Ramos, Diego / Ramos-Bonilla, Antonio / Ramzi, Joussi / Rathinam, Sridhar / Rausa, Emanuele / Ravaioli, Matteo / Ravindran, Sharanya / Raymond, Thomas / Razik, Aisha / Redfern, Jennifer / Reguera-Rosal, Julio / Rela, Mariam / Rey-Biel, Juan / Rey-Valcarcel, Cristina / Ribolla, Marta / Richards, Tomos / Richmond, Michael / Righini, Erminio / Rio-Gomez, Javier / Riyat, Harjoat / Rizvi, Sana / Roberts, Keith / Roberts, Matthew / Robertson, Stuart / Robertson, Ronald / Robin-Valle, Alvaro / Rochon, Melissa / Rojo, Mikel / Rolli, Luigi / Romano, Silvio / Ross, Elizabeth / Ross, Howard / Rossborough, Catherine / Rottoli, Matteo / Ruiz, Miguel / Ruiz-Grande, Fernando / Ruiz-Martin, Irene / Ruiz-Soriano, María / Ruzzenente, Andrea / Ryska, Ondrej / Saez, Carlos / Sagnotta, Andrea / Sahnan, Kapil / Sahni, Arun / Salim, Ali / Sallam, Ibrahim / Salvia, Roberto / Samadov, Elgun / Sammarco, Giuseppe / Sampaio-Alves, Mafalda / Sánchez-Arteaga, Alejandro / Sanchez-Fuentes, Maria-Nieves / Sanchez-Pelaez, Daniel / Sanchez-Perez, Coral / Sanchez-Rubio, Maria / Sancho-Muriel, Jorge / Sanders, Julie / Santero-Ramirez, Maria-Pilar / Santora, Thomas / Santoro, Antonio / Santos, Irene / Santos-Sousa, Hugo / Sapienza, Paolo / Sartarelli, Lodovico / Sarveswaran, Janahan / Sasia, Diego / Saudemont, Alain / Saudi-Moro, Sef / Saxena, Shobhit / Saxena, Dolly / Sayasneh, Ahmad / Scalabre, Aurelien / Schache, Andrew / Schiavina, Riccardo / Schineis, Christian / Schreckenbach, Teresa / Scorza, Antonella / Scott, Lucy / Seegert, Sara / Seguin-Givelet, Agathe / Senent-Boza, Ana / Seymour, Keith / Shabana, Amanda / Shah, Karishma / Shah, Jigar / Shah, Preena / Shah, Sujay / Shakir, Taner / Shalaby, Mostafa / Shankar, Sushma / Shaw, Richard / Shehata, Sameh / Shenfine, Amy / Sheridan, Kelda / Sherief, Ahmed / Sherief, Mohamed / Sherif, Mohamed / Shinkwin, Michael / Shu, Sebastian / Siaw-Acheampong, Kwabena / Sileri, Pierpaolo / Singh, Abhinav / Singh, Shailendra / Sinha, Sanjay / Sinha, Deepti / Siragusa, Leandro / Sivaprakasam, Rajesh / Sivayoganathan, Sriharan / Smillie, Robert / Smith, Claire / Smith, Andrew / Smith, Christopher / Sochorova, Dana / Soggiu, Fiammetta / Sohrabi, Catrin / Solari, Francesca / Solli, Piergiorgio / Soreide, Kjetil / Spinelli, Antonino / Spoletini, Domenico / Spriano, Giuseppe / Sravanam, Sanskrithi / Ssentongo, Paddy / Stanger, Sophie / Stavroulias, Dionisios / Steel, Ben / Stella, Marco / Stewart, Robbie / Stringer, Sally / Sulen, Nina / Sundar, Sudha / Sundhu, Matthew / Suri, Avni / Syed, Arooj / Szatmary, Peter / Tabiri, Stephen / Tadross, Daniel / Taglietti, Lucio / Tansey, Rosamond / Tartaglia, Dario / Tawheed, Ahmed / Tayeh, Salim / Teles, Tobias / Testa, Valentina / Tewari, Nilanjana / Thoenissen, Philipp / Thomas, Kane / Thomin, Anne / Thrush, Jessica / Tierney, Sean / Tiwari, Abhinav / Toh, Simon / Toledo, Enrique / Tonini, Valeria / Torkington, Jared / Torquati, Alfonso / Torzilli, Guido / Totty, Joshua / Tourountzi, Paraskevi / Tousidonis, Manuel / Townend, Philip / Townsend, Catherine / Trompeter, Alex / Trotta, Francesco / Truant, Stéphanie / Trujillo-Díaz, Jeancarlos / Tsoulfas, Georgios / Turco, Celia / Turrado-Rodriguez, Victor / Turri, Giulia / Tustin, Harry / Tyler, Jayne / Tzedakis, Stylianos / Tzovaras, George / Uittenbogaart, Martine / Ullah, Ramzan / Urban, Shane / Urbani, Alessia / Usai, Antonella / Vaccarella, Gianpaolo / Valdes-Hernandez, Javier / Valsecchi, Luca / Vashisht, Rajiv / Vázquez-Fernández, Andrea / Venkatesan, Gowtham / Venn, Mary / Vera-Mansilla, Cristina / Vergari, Roberto / Vescio, Giuseppina / Vidya, Raghavan / Vieira, Paula / Vijay, Vardhini / Vimalachandran, Dale / Violante, Tommaso / Volpe, Anita / Vovola, Fernanda / Vulliamy, Paul / Wall, Rosemary / Wallwork, Kate / Ward, Alex / Warwick, David / Waseem, Saima / Weaver, Helen / Wells, Fiona / Wen, Jiaxin / West, Raha / Whitehall, Emma / Wild, Laura / Wilkins, Alex / Williams, Gethin / Williams, Matthew / Winnand, Philipp / Wong, Ken / Worku, Dawit / Wright, Naomi / Yalamanchili, Seema / Yershov, Danylo / Yildiz, Alp / Young, Richard / Yurttas, Can / Zadegan, Frederic / Zafar, Noman / Zakaria, Rasheed / Zambon, Martina / Zanini, Nicola / Zarate, Alba / Zerbib, Philippe / Zizzo, Maurizio / Zmora, Oded / Zonta, Sandro / van Berge Henegouwen, Mark I / van der Plas, Willemijn Y / Ali, Inthekab Ali Mohamed / Bakri, Nur Amalina Che / Bartolomé, Miguel Ángel Hernández / Bauset, Juan Carlos Catalá / Abou Chaar, Mohamad K / Marino Cosentino, Luigi MP / Gómez Díaz, Carlos J / Garcia Galocha, Jose L / de Gheldere, Charles A / Ataíde Gomes, Gustavo Mendonça / Beltrán de Heredia, Juan / Blazer, Dan G / Nugent, William C / Ali karar, Ali A / Borja De Lacy, F / Blas Laina, Juan luis / Shane Lester, Madan Jha / Liyanage, Aloka S D / Al Maadany, Faraj S / De Marchi, Joshua A / Ramos-De la Medina, Antonio / Mithany, Reda H M / Sanchez del Pueblo, Cristina / van Ramshorst, Gabrielle H / De Salas, Maria Marqueta / De Souza, Anthony C / Dolores Del Toro, M

    an international cohort study

    2020  

    Abstract: Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and ... ...

    Abstract Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 82·6% (219 of 265) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28-2·40], p<0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65-3·22], p<0·0001), American Society of Anesthesiologists grades 3-5 versus grades 1-2 (2·35 [1·57-3·53], p<0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01-2·39], p=0·046), emergency versus elective surgery (1·67 [1·06-2·63], p=0·026), and major versus minor surgery (1·52 [1·01-2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.
    Keywords covid19
    Subject code 610 ; 616
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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