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Article ; Online: The spectrum of cell death in sarcoma.

Belyaeva, Elizaveta / Loginova, Nina / Schroeder, Brett A / Goldlust, Ian S / Acharya, Arbind / Kumar, Sandeep / Timashev, Peter / Ulasov, Ilya

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 162, Page(s) 114683

Abstract: The balance between cell death and cell survival is a highly coordinated process by which cells break down and remove unnecessary or harmful materials in a controlled, highly regulated, and compartmentalized manner. Cell exposure to various stresses, ... ...

Abstract	The balance between cell death and cell survival is a highly coordinated process by which cells break down and remove unnecessary or harmful materials in a controlled, highly regulated, and compartmentalized manner. Cell exposure to various stresses, such as oxygen starvation, a lack of nutrients, or exposure to radiation, can initiate autophagy. Autophagy is a carefully orchestrated process with multiple steps, each regulated by specific genes and proteins. Autophagy proteins impact cellular maintenance and cell fate in response to stress, and targeting this process is one of the most promising methods of anti-tumor therapy. It is currently not fully understood how autophagy affects different types of tumor cells, which makes it challenging to predict outcomes when this process is manipulated. In this review, we will explore the mechanisms of autophagy and investigate it as a potential and promising therapeutic target for aggressive sarcomas.
MeSH term(s)	Humans ; Cell Death ; Sarcoma ; Starvation ; Autophagy/physiology ; Apoptosis/genetics
Language	English
Publishing date	2023-04-07
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114683
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Article ; Online: Bone marrow findings of idiopathic Multicentric Castleman disease: A histopathologic analysis and systematic literature review.

Belyaeva, Elizaveta / Rubenstein, Ayelet / Pierson, Sheila K / Dalldorf, Delaney / Frank, Dale / Lim, Megan S / Fajgenbaum, David C

Hematological oncology

2022 Volume 40, Issue 2, Page(s) 191–201

Abstract: Idiopathic multicentric Castleman disease (iMCD) is a polyclonal lymphoproliferative disorder characterized by constitutional symptoms, generalized lymphadenopathy, cytopenias, and multi-organ dysfunction due to excessive cytokines, notably Interleukin-6. ...

Abstract	Idiopathic multicentric Castleman disease (iMCD) is a polyclonal lymphoproliferative disorder characterized by constitutional symptoms, generalized lymphadenopathy, cytopenias, and multi-organ dysfunction due to excessive cytokines, notably Interleukin-6. Idiopathic multicentric Castleman disease is often sub-classified into iMCD-TAFRO, which is associated with thrombocytopenia (T), anasarca (A), fever/elevated C-reactive protein (F), renal dysfunction (R), and organomegaly (O), and iMCD not otherwise specified (iMCD-NOS), which is typically associated with thrombocytosis and hypergammaglobulinemia. The diagnosis of iMCD is challenging as consensus clinico-pathological diagnostic criteria were only recently established and include several non-specific lymph node histopathological features. Identification of further clinico-pathological features commonly found in iMCD could contribute to more accurate and timely diagnoses. We set out to characterize bone marrow (BM) histopathological features in iMCD, assess differences between iMCD-TAFRO and iMCD-NOS, and determine if these findings are specific to iMCD. Examination of BM specimens from 24 iMCD patients revealed a high proportion with hypercellularity, megakaryocytic atypia, reticulin fibrosis, and plasmacytosis across patients with both iMCD-NOS and iMCD-TAFRO with significantly more megakaryocytic hyperplasia (p = 0.001) in the iMCD-TAFRO cases. These findings were also consistent with BM findings from 185 published cases of iMCD-NOS and iMCD-TAFRO. However, these findings are relatively nonspecific as they can be seen in various other infectious, malignant, and autoimmune diseases.
MeSH term(s)	Bone Marrow/pathology ; Castleman Disease/diagnosis ; Castleman Disease/pathology ; Fever/diagnosis ; Fever/pathology ; Humans ; Lymph Nodes/pathology ; Thrombocytopenia
Language	English
Publishing date	2022-02-18
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	604884-5
ISSN	1099-1069 ; 0278-0232
ISSN (online)	1099-1069
ISSN	0278-0232
DOI	10.1002/hon.2969
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Zs.A 1816: Show issues

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Article: Carbonic Anhydrase Inhibitors Induce Ferroptosis through Inhibition of AKT/FTH1 Signaling in Ewing Sarcoma Tumor Cells.

Fayzullina, Darya / Yakushov, Semyon / Kantserova, Kamilla / Belyaeva, Elizaveta / Aniskin, Denis / Tsibulnikov, Sergey / Fayzullina, Nafisa / Kalinin, Stanislav / Romantsova, Olga / Timashev, Peter S / Schroeder, Brett A / Ulasov, Ilya V

Cancers

2023 Volume 15, Issue 21

Abstract: Ewing sarcoma (ES) is one of the most frequent types of malignant tumors among children. The active metabolic state of ES cells presents a new potential target for therapeutic interventions. As a primary regulator of cellular homeostasis, carbonic ... ...

Abstract	Ewing sarcoma (ES) is one of the most frequent types of malignant tumors among children. The active metabolic state of ES cells presents a new potential target for therapeutic interventions. As a primary regulator of cellular homeostasis, carbonic anhydrases (CAs; EC 4.2.1.1) have emerged as promising molecular targets for the development of anticancer drugs. Within the present study, we tested the commercial drug acetazolamide and our previously discovered inhibitors to target the CAII isoform, which was overexpressed and positively correlated with ES patient relapse. We employed molecular biology tests to identify effective inhibitors of CAII that can induce ferroptosis by downregulating FTH1 expression in ES cells. In vitro, we have also demonstrated their ability to reduce cell proliferation, decrease invasion, and induce apoptosis- or autophagy-related cell death. Using Western blotting, we confirmed the induction of cathepsin B in cells treated with CA inhibitors. It was found that the suppression of cathepsin B expression during the treatment reduces the anticancer efficacy of selected CAII inhibitors. These experiments highlighted profound antitumor activity of CAII inhibitors attributive to their remarkable ability to trigger ferroptosis in Ewing sarcoma cells without causing substantial host damage. The obtained results suggest that cytosolic CAII may be a prospective target for ES treatment, and CAII inhibitors can be considered as potential single-agent or combination antitumor agents to be used in the treatment of ES.
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15215225
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Article ; Online: Isoforms of autophagy-related proteins: role in glioma progression and therapy resistance.

Belyaeva, Elizaveta / Kharwar, Rajesh Kumar / Ulasov, Ilya V / Karlina, Irina / Timashev, Petr / Mohammadinejad, Reza / Acharya, Arbind

Molecular and cellular biochemistry

2021 Volume 477, Issue 2, Page(s) 593–604

Abstract: Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to ...

Abstract	Autophagy is the process of recycling and utilization of degraded organelles and macromolecules in the cell compartments formed during the fusion of autophagosomes with lysosomes. During autophagy induction the healthy and tumor cells adapt themselves to harsh conditions such as cellular stress or insufficient supply of nutrients in the cell environment to maintain their homeostasis. Autophagy is currently seen as a form of programmed cell death along with apoptosis and necroptosis. In recent years multiple studies have considered the autophagy as a potential mechanism of anticancer therapy in malignant glioma. Although, subsequent steps in autophagy development are known and well-described, on molecular level the mechanism of autophagosome initiation and maturation using autophagy-related proteins is under investigation. This article reviews current state about the mechanism of autophagy, its molecular pathways and the most recent studies on roles of autophagy-related proteins and their isoforms in glioma progression and its treatment.
MeSH term(s)	Apoptosis ; Autophagosomes/genetics ; Autophagosomes/metabolism ; Autophagy ; Autophagy-Related Proteins/genetics ; Autophagy-Related Proteins/metabolism ; Glioma/genetics ; Glioma/metabolism ; Glioma/therapy ; Humans ; Neoplasm Proteins/metabolism
Chemical Substances	Autophagy-Related Proteins ; Neoplasm Proteins
Language	English
Publishing date	2021-12-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-021-04308-w
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Article: A Case Report with Severe Thrombocytopenia Induced by Axitinib.

Koksal, Ulkuhan I / Goffin, Janeiro / Lewis, Brian / Sartor, Oliver A / Belyaeva, Elizaveta / Socola, Francisco / Barata, Pedro C

Case reports in hematology

2020 Volume 2020, Page(s) 7520783

Abstract: Axitinib is an oral, second-generation tyrosine kinase inhibitor that is selective for vascular endothelial growth factor receptors (VEGFR). This agent is approved as monotherapy or in combination with immune checkpoint inhibitors for the treatment of ... ...

Abstract	Axitinib is an oral, second-generation tyrosine kinase inhibitor that is selective for vascular endothelial growth factor receptors (VEGFR). This agent is approved as monotherapy or in combination with immune checkpoint inhibitors for the treatment of metastatic renal cell carcinoma. Axitinib is associated with a safety profile very similar to other anti-VEGFR inhibitors but usually with fewer hematologic adverse events, due to the selectivity for VEGF. In this report, we presented a rare case of grade 4 axitinib-induced thrombocytopenia, not observed with other antiangiogenic therapies. We discuss the differential diagnostic work-up, the necessary multidisciplinary approach, and the successful management of the case.
Language	English
Publishing date	2020-02-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2627639-2
ISSN	2090-6579 ; 2090-6560
ISSN (online)	2090-6579
ISSN	2090-6560
DOI	10.1155/2020/7520783
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Article ; Online: Development and characterization of chimera of yellow fever virus vaccine strain and Tick-Borne encephalitis virus.

PloS one

2023 Volume 18, Issue 5, Page(s) e0284823

Abstract: Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no ... ...

Abstract	Tick-borne encephalitis virus (TBEV) is one of the most threatening pathogens which affects the human central nervous system (CNS). TBEV circulates widely in Northern Eurasia. According to ECDC, the number of TBE cases increase annually. There is no specific treatment for the TBEV infection, thus vaccination is the main preventive measure. Despite the existence of several inactivated vaccines currently being licensed, the development of new TBEV vaccines remains a leading priority in countries endemic to this pathogen. Here we report new recombinant virus made by infectious subgenomic amplicon (ISA) approach using TBEV and yellow fever virus vaccine strain (YF17DD-UN) as a genetic backbone. The recombinant virus is capable of effective replication in mammalian cells and induce TBEV-neutralizing antibodies in mice. Unlike the original vector based on the yellow fever vaccine strain, chimeric virus became neuroinvasive in doses of 107-106 PFU and can be used as a model of flavivirus neuroinvasiveness, neurotropism and neurovirulence. These properties of hybrid structures are the main factors limiting their practical use as vaccines platforms.
MeSH term(s)	Humans ; Animals ; Mice ; Yellow Fever Vaccine/genetics ; Encephalitis Viruses, Tick-Borne ; Yellow fever virus/genetics ; Viral Vaccines ; Encephalitis, Tick-Borne ; Mammals
Chemical Substances	Yellow Fever Vaccine ; Viral Vaccines
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0284823
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Article ; Online: Giant cystic sacral schwannoma mimicking tarlov cyst: a case report.

Attiah, Mark A / Syre, Peter P / Pierce, John / Belyaeva, Elizaveta / Welch, William C

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2016 Volume 25 Suppl 1, Page(s) 84–88

Abstract: Purpose: To present a rare case of a giant schwannoma of the sacrum mimicking a Tarlov cyst.: Methods: A 58-year-old woman had a 1-year history of low back pain. MRI revealed a large cystic mass in the sacral canal with bony erosion. Radiological ... ...

Abstract	Purpose: To present a rare case of a giant schwannoma of the sacrum mimicking a Tarlov cyst. Methods: A 58-year-old woman had a 1-year history of low back pain. MRI revealed a large cystic mass in the sacral canal with bony erosion. Radiological diagnosis of Tarlov cyst was made. Results: The patient underwent surgical treatment for the lesion, which revealed a solid mass. Histopathological examination of the tumor confirmed the diagnosis of schwannoma. The postoperative course was uneventful and the patient has had significant improvement in her pain 1 month postoperatively. Conclusion: Giant cystic schwannoma of the sacrum is a very rare diagnosis overlooked by practitioners for more common cystic etiologies, but its treatment is significantly different. Care should be taken to include this diagnosis in a differential for a cystic sacral mass.
Language	English
Publishing date	2016-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-015-4128-2
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Zs.A 3437: Show issues

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Article ; Online: Dynamics of SARS-CoV-2 Major Genetic Lineages in Moscow in the Context of Vaccine Prophylaxis.

Gushchin, Vladimir A / Pochtovyi, Andrei A / Kustova, Daria D / Ogarkova, Darya A / Tarnovetskii, Ivan Y / Belyaeva, Elizaveta D / Divisenko, Elizaveta V / Vasilchenko, Lyudmila A / Shidlovskaya, Elena V / Kuznetsova, Nadezhda A / Tkachuk, Artem P / Slutskiy, Egor A / Speshilov, Gleb I / Komarov, Andrei G / Tsibin, Alexander N / Zlobin, Vladimir I / Logunov, Denis Y / Gintsburg, Alexander L

International journal of molecular sciences

2022 Volume 23, Issue 23

Abstract: Findings collected over two and a half years of the COVID-19 pandemic demonstrated that the level immunity resulting from vaccination and infection is insufficient to stop the circulation of new genetic variants. The short-term decline in morbidity was ... ...

Abstract	Findings collected over two and a half years of the COVID-19 pandemic demonstrated that the level immunity resulting from vaccination and infection is insufficient to stop the circulation of new genetic variants. The short-term decline in morbidity was followed by a steady increase. The early identification of new genetic lineages that will require vaccine adaptation in the future is an important research target. In this study, we summarised data on the variability of genetic line composition throughout the COVID-19 pandemic in Moscow, Russia, and evaluated the virological and epidemiological features of dominant variants in the context of selected vaccine prophylaxes. The prevalence of the Omicron variant highlighted the low effectiveness of the existing immune layer in preventing infection, which points to the necessity of optimising the antigens used in vaccines in Moscow. Logistic growth curves showing the rate at which the new variant displaces the previously dominant variants may serve as early indicators for selecting candidates for updated vaccines, along with estimates of efficacy, reduced viral neutralising activity against the new strains, and viral load in previously vaccinated patients.
Language	English
Publishing date	2022-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232314670
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Article: Dermatofibrosarcoma protuberans (DFSP) with fibrosarcomatous changes in a patient with psoriasis treated with adalimumab.

Belyaeva, Elizaveta A / Elenitsas, Rosalie / Roth, Rudolf / Miller, Christopher / Gelfand, Joel M

JAAD case reports

2015 Volume 1, Issue 5, Page(s) 272–273

Language	English
Publishing date	2015-11-12
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2015.06.007
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Article ; Online: Detection of SARS-CoV-2 in Neonatal Autopsy Tissues and Placenta.

Reagan-Steiner, Sarah / Bhatnagar, Julu / Martines, Roosecelis B / Milligan, Nicholas S / Gisondo, Carly / Williams, Frank B / Lee, Elizabeth / Estetter, Lindsey / Bullock, Hannah / Goldsmith, Cynthia S / Fair, Pamela / Hand, Julie / Richardson, Gillian / Woodworth, Kate R / Oduyebo, Titilope / Galang, Romeo R / Phillips, Rebecca / Belyaeva, Elizaveta / Yin, Xiao-Ming /

Meaney-Delman, Dana / Uyeki, Timothy M / Roberts, Drucilla J / Zaki, Sherif R

Emerging infectious diseases

2022 Volume 28, Issue 3, Page(s) 510–517

Abstract: Severe coronavirus disease in neonates is rare. We analyzed clinical, laboratory, and autopsy findings from a neonate in the United States who was delivered at 25 weeks of gestation and died 4 days after birth; the mother had asymptomatic severe acute ... ...

Abstract	Severe coronavirus disease in neonates is rare. We analyzed clinical, laboratory, and autopsy findings from a neonate in the United States who was delivered at 25 weeks of gestation and died 4 days after birth; the mother had asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and preeclampsia. We observed severe diffuse alveolar damage and localized SARS-CoV-2 by immunohistochemistry, in situ hybridization, and electron microscopy of the lungs of the neonate. We localized SARS-CoV-2 RNA in neonatal heart and liver vascular endothelium by using in situ hybridization and detected SARS-CoV-2 RNA in neonatal and placental tissues by using reverse transcription PCR. Subgenomic reverse transcription PCR suggested viral replication in lung/airway, heart, and liver. These findings indicate that in utero SARS-CoV-2 transmission contributed to this neonatal death.
MeSH term(s)	Autopsy ; COVID-19 ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Lung ; Placenta ; Pregnancy ; Pregnancy Complications, Infectious ; RNA, Viral/genetics ; SARS-CoV-2
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2803.211735
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